A unifying hypothesis for scleroderma: Identifying a target cell for scleroderma

Current Rheumatology Reports

Volumn 13, Issue 1, 2011, Pages 28-36

  Mahoney Jr , William M ^a   Fleming, Jo Nadine ^a   Schwartz, Stephen M ^a  

^a UNIVERSITY OF WASHINGTON   (United States)

Author keywords

Adventitial stem cell; Fibrosis; RGS5; Type 1 interferon; Vasculopathy

Indexed keywords

ALPHA INTERFERON; BETA INTERFERON; GAMMA INTERFERON; GUANOSINE TRIPHOSPHATASE; INTERFERON REGULATORY FACTOR 1; INTERLEUKIN 12; INTERLEUKIN 13; INTERLEUKIN 4; INTERLEUKIN 4 RECEPTOR; PLATELET DERIVED GROWTH FACTOR B; PLATELET DERIVED GROWTH FACTOR RECEPTOR; RGS PROTEIN; RGS5 PROTEIN; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG; VASCULAR ENDOTHELIAL CADHERIN; VASCULOTROPIN;

ADVENTITIAL STEM CELL; ARTERIOSCLEROSIS; ARTERY INTIMA PROLIFERATION; ARTICLE; CELL DEATH; CHRONIC INFLAMMATION; CYTOKINE PRODUCTION; ENDOTHELIUM CELL; GRAFT VERSUS HOST REACTION; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HUMAN; HYPOXIA; LUNG FIBROSIS; MYOFIBROBLAST; NONHUMAN; PERICYTE; PULMONARY HYPERTENSION; RAYNAUD PHENOMENON; SCLERODERMA; SMOOTH MUSCLE FIBER; STEM CELL; VASCULAR DISEASE; VASOSPASM;

FIBROSIS; HUMANS; INTERFERON TYPE I; RGS PROTEINS; SCLERODERMA, SYSTEMIC; SIGNAL TRANSDUCTION; STEM CELLS; VASCULAR DISEASES;

EID: 79551529470     PISSN: 15233774     EISSN: 15346307     Source Type: Journal    
DOI: 10.1007/s11926-010-0152-8     Document Type: Article

References (58)

1. RA Nash PA McSweeney LJ Crofford, et al. 2007 High-dose immunosuppressive therapy and autologous hematopoietic cell transplantation for severe systemic sclerosis: long-term follow-up of the US multicenter pilot study Blood 110 1388 1396 1:CAS:528:DC%2BD2sXptFKlsLs%3D 10.1182/blood-2007-02-072389 17452515 (Pubitemid 47281441)
2. F Hansen-Smith AS Greene AW Cowley Jr JH Lombard 1990 Structural changes during microvascular rarefaction in chronic hypertension Hypertension 15 922 928 1:STN:280:DyaK3c3nslWksA%3D%3D 2351442
3. R Vracko 1982 A comparison of the microvascular lesions in diabetes mellitus with those in normal aging J Am Geriatr Soc 30 201 205 1:STN:280:DyaL387ktlCntA%3D%3D 7061790
4. L Lind H Lithell 1993 Decreased peripheral blood flow in the pathogenesis of the metabolic syndrome comprising hypertension, hyperlipidemia, and hyperinsulinemia Am Heart J 125 1494 1497 1:STN:280:DyaK3s3ktlansA%3D%3D 10.1016/0002-8703(93)90446-G 8480620 (Pubitemid 23138405)
5. LE Benjamin I Hemo E Keshet 1998 A plasticity window for blood vessel remodelling is defined by pericyte coverage of the preformed endothelial network and is regulated by PDGF-B and VEGF Development 125 1591 1598 1:CAS:528:DyaK1cXjslemsLg%3D 9521897
6. JN Fleming RA Nash DO McLeod, et al. 2008 Capillary regeneration in scleroderma: stem cell therapy reverses phenotype? PLoS One 3 e1452 10.1371/journal.pone.0001452 18197262 (Pubitemid 351248269)
7. JN Fleming RA Nash WM Mahoney Jr SM Schwartz 2009 Is scleroderma a vasculopathy? Curr Rheumatol Rep 11 103 110 10.1007/s11926-009-0015-3 19296882
8. Y Nakanishi PM Henson A Shiratsuchi 2009 Pattern recognition in phagocytic clearance of altered self Adv Exp Med Biol 653 129 138 1:CAS:528:DC%2BC3cXhtlWhsbvE 10.1007/978-1-4419-0901-5-9 19799116
9. LP Erwig PM Henson 2007 Immunological consequences of apoptotic cell phagocytosis Am J Pathol 171 2 8 1:CAS:528:DC%2BD2sXosVamu7c%3D 10.2353/ajpath.2007.070135 17591947 (Pubitemid 47339220)
10. EC Derrett-Smith A Dooley K Khan, et al. 2010 Systemic vasculopathy with altered vasoreactivity in a transgenic mouse model of scleroderma Arthritis Res Ther 12 R69 10.1186/ar2986 20398328
11. MS Wilson TA Wynn 2009 Pulmonary fibrosis: pathogenesis, etiology and regulation Mucosal Immunol 2 103 121 1:CAS:528:DC%2BD1MXhslCgur8%3D 10.1038/mi.2008.85 19129758
12. D Kim A Peck D Santer, et al. 2008 Induction of interferon-alpha by scleroderma sera containing autoantibodies to topoisomerase I: association of higher interferon-alpha activity with lung fibrosis Arthritis Rheum 58 2163 2173 1:CAS:528:DC%2BD1cXpt1Wrsrs%3D 10.1002/art.23486 18576347 (Pubitemid 351988110)
13. DB Stetson R Medzhitov 2006 Type I interferons in host defense Immunity 25 373 381 1:CAS:528:DC%2BD28XhtVOjtL%2FI 10.1016/j.immuni.2006.08.007 16979569 (Pubitemid 44354218)
14. KL Moser JA Kelly CJ Lessard JB Harley 2009 Recent insights into the genetic basis of systemic lupus erythematosus Genes Immun 10 373 379 1:CAS:528:DC%2BD1MXptVarur8%3D 10.1038/gene.2009.39 19440199
15. P Gourh SK Agarwal D Divecha, et al. 2009 Polymorphisms in TBX21 and STAT4 increase the risk of systemic sclerosis: evidence of possible gene-gene interaction and alterations in Th1/Th2 cytokines Arthritis Rheum 60 3794 3806 1:CAS:528:DC%2BC3cXhtFKhtb%2FF 10.1002/art.24958 19950257
16. R Solans JA Bosch I Esteban M Vilardell 2004 Systemic sclerosis developing in association with the use of interferon alpha therapy for chronic viral hepatitis Clin Exp Rheumatol 22 625 628 1:STN:280:DC%2BD2crhsVOlsA%3D%3D 15485018
17. H Duan J Fleming DK Pritchard, et al. 2008 Combined analysis of monocyte and lymphocyte messenger RNA expression with serum protein profiles in patients with scleroderma Arthritis Rheum 58 1465 1474 1:CAS:528:DC%2BD1cXms1egsrg%3D 10.1002/art.23451 18438864 (Pubitemid 351705936)
18. JW Bauer M Petri FM Batliwalla, et al. 2009 Interferon-regulated chemokines as biomarkers of systemic lupus erythematosus disease activity: a validation study Arthritis Rheum 60 3098 3107 1:CAS:528:DC%2BD1MXhsFOmtbfK 10.1002/art.24803 19790071
19. J Wang RA Nash B Chu, et al. 2009 Improvements in digital vasculature observed using micro magnetic resonance angiography after high-dose immunosuppression for severe systemic sclerosis Bone Marrow Transplant 44 387 389 1:STN:280:DC%2BD1MnjvFGkuw%3D%3D 10.1038/bmt.2009.35 19252528
20. DY Hui 2008 Intimal hyperplasia in murine models Curr Drug Targets 9 251 260 1:CAS:528:DC%2BD1cXjvVajt78%3D 10.2174/138945008783755601 18336244 (Pubitemid 351843607)
21. SM Schwartz CE Murry 1998 Proliferation and the monoclonal origins of atherosclerotic lesions Annu Rev Med 49 437 460 1:CAS:528:DyaK1cXhtFKqtLk%3D 10.1146/annurev.med.49.1.437 9509274 (Pubitemid 28197465)
22. WA D'Angelo JF Fries AT Masi LE Shulman 1969 Pathologic observations in systemic sclerosis (scleroderma). A study of fifty-eight autopsy cases and fifty-eight matched controls Am J Med 46 428 440 10.1016/0002-9343(69)90044-8 5780367
23. EC Leroy 1987 The vascular defect in scleroderma (systemic sclerosis) Acta Med Scand Suppl 715 165 167 1:STN:280:DyaL2s3jsl2hsA%3D%3D 3495959
24. B Folkow G Grimby O Thulesius 1958 Adaptive structural changes of the vascular walls in hypertension and their relation to the control of the peripheral resistance Acta Physiol Scand 44 255 272 1:STN:280: DyaG1M%2Fks1Gnuw%3D%3D 10.1111/j.1748-1716.1958.tb01626.x 13617022
25. J Slomp JC van Munsteren RE Poelmann, et al. 1992 Formation of intimal cushions in the ductus arteriosus as a model for vascular intimal thickening. An immunohistochemical study of changes in extracellular matrix components Atherosclerosis 93 25 39 1:STN:280:DyaK383otFGrtw%3D%3D 10.1016/0021-9150(92) 90197-O 1596302
26. H Shimokawa A Takeshita 2005 Rho-kinase is an important therapeutic target in cardiovascular medicine Arterioscler Thromb Vasc Biol 25 1767 1775 1:CAS:528:DC%2BD2MXos1ers74%3D 10.1161/01.ATV.0000176193.83629.c8 16002741 (Pubitemid 41243442)
27. JN Fleming HM Shulman RA Nash, et al. 2009 Cutaneous chronic graft-versus-host disease does not have the abnormal endothelial phenotype or vascular rarefaction characteristic of systemic sclerosis PLoS One 4 e6203 10.1371/journal.pone.0006203 19587802
28. LD Siracusa P Christner R McGrath, et al. 1993 The tight skin (Tsk) mutation in the mouse, a model for human fibrotic diseases, is tightly linked to the beta 2-microglobulin (B2m) gene on chromosome 2 Genomics 17 748 751 1:CAS:528:DyaK2cXitV2ksrg%3D 10.1006/geno.1993.1398 7902327 (Pubitemid 23282833)
29. SH Clark 2005 Animal models in scleroderma Curr Rheumatol Rep 7 150 155 1:CAS:528:DC%2BD2MXhtF2jtb7O 10.1007/s11926-005-0068-x 15760595
30. HN Claman BD Jaffee JC Huff RA Clark 1985 Chronic graft-versus-host disease as a model for scleroderma. II. Mast cell depletion with deposition of immunoglobulins in the skin and fibrosis Cell Immunol 94 73 84 1:STN:280:DyaL2M3lsV2rsA%3D%3D 10.1016/0008-8749(85)90086-3 4016962 (Pubitemid 15247795)
31. R Sgonc MS Gruschwitz H Dietrich, et al. 1996 Endothelial cell apoptosis is a primary pathogenetic event underlying skin lesions in avian and human scleroderma J Clin Invest 98 785 792 1:CAS:528:DyaK28XkvVeis7g%3D 10.1172/JCI118851 8698871
32. SM Schwartz 1997 Smooth muscle migration in atherosclerosis and restenosis J Clin Invest 100 S87 S89 1:CAS:528:DyaK2sXotVOit74%3D 9413408
33. JN Wilcox GD Cipolla FH Martin, et al. 1997 Contribution of adventitial myofibroblasts to vascular remodeling and lesion formation after experimental angioplasty in pig coronary arteries Ann N Y Acad Sci 811 437 447 1:STN:280:DyaK2szjtVWlsA%3D%3D 10.1111/j.1749-6632.1997.tb52025.x 9186621 (Pubitemid 27308351)
34. A Zalewski Y Shi AG Johnson 2002 Diverse origin of intimal cells: smooth muscle cells, myofibroblasts, fibroblasts, and beyond? Circ Res 91 652 655 1:CAS:528:DC%2BD38XoslWmuro%3D 10.1161/01.RES.0000038996.97287.9A 12386139 (Pubitemid 35204945)
35. JN Passman XR Dong SP Wu, et al. 2008 A sonic hedgehog signaling domain in the arterial adventitia supports resident Sca1+ smooth muscle progenitor cells Proc Natl Acad Sci U S A 105 9349 9354 1:CAS:528:DC%2BD1cXosFars74%3D 10.1073/pnas.0711382105 18591670
36. KJ Lavine F Long K Choi, et al. 2008 Hedgehog signaling to distinct cell types differentially regulates coronary artery and vein development Development 135 3161 3171 1:CAS:528:DC%2BD1cXhtlans77M 10.1242/dev.019919 18725519
37. K Gaengel G Genove A Armulik C Betsholtz 2009 Endothelial-mural cell signaling in vascular development and angiogenesis Arterioscler Thromb Vasc Biol 29 630 638 1:CAS:528:DC%2BD1MXktF2qtb4%3D 10.1161/ATVBAHA.107.161521 19164813
38. I Stein M Neeman D Shweiki, et al. 1995 Stabilization of vascular endothelial growth factor mRNA by hypoxia and hypoglycemia and coregulation with other ischemia-induced genes Mol Cell Biol 15 5363 5368 1:CAS:528: DyaK2MXotlant7k%3D 7565686
39. P Lindahl BR Johansson P Leveen C Betsholtz 1997 Pericyte loss and microaneurysm formation in PDGF-B-deficient mice Science 277 242 245 1:CAS:528:DyaK2sXksFCksb0%3D 10.1126/science.277.5323.242 9211853 (Pubitemid 27446080)
40. M Grunewald I Avraham Y Dor, et al. 2006 VEGF-induced adult neovascularization: recruitment, retention, and role of accessory cells Cell 124 175 189 1:CAS:528:DC%2BD28XntVGkug%3D%3D 10.1016/j.cell.2005.10.036 16413490 (Pubitemid 43069318)
41. L Diaz-Flores R Gutierrez JF Madrid, et al. 2009 Pericytes. Morphofunction, interactions and pathology in a quiescent and activated mesenchymal cell niche Histol Histopathol 24 909 969 1:CAS:528: DC%2BD1MXhtVahsr3P 19475537
42. S Sela A Itin S Natanson-Yaron, et al. 2008 A novel human-specific soluble vascular endothelial growth factor receptor 1: cell-type-specific splicing and implications to vascular endothelial growth factor homeostasis and preeclampsia Circ Res 102 1566 1574 1:CAS:528:DC%2BD1cXmvFOhtrg%3D 10.1161/CIRCRESAHA.108.171504 18515749
43. LD Adams RL Geary B McManus SM Schwartz 2000 A comparison of aorta and vena cava medial message expression by cDNA array analysis identifies a set of 68 consistently differentially expressed genes, all in aortic media Circ Res 87 623 631 1:CAS:528:DC%2BD3cXnt1yjsro%3D 11009569
44. C Bondjers M Kalen M Hellstrom, et al. 2003 Transcription profiling of platelet-derived growth factor-B-deficient mouse embryos identifies RGS5 as a novel marker for pericytes and vascular smooth muscle cells Am J Pathol 162 721 729 1:CAS:528:DC%2BD3sXit1Gks74%3D 12598306
45. TS Mitchell J Bradley GS Robinson, et al. 2008 RGS5 expression is a quantitative measure of pericyte coverage of blood vessels Angiogenesis 11 141 151 1:CAS:528:DC%2BD1cXmvVCgurs%3D 10.1007/s10456-007-9085-x 18038251
46. J Hamzah M Jugold F Kiessling, et al. 2008 Vascular normalization in Rgs5-deficient tumours promotes immune destruction Nature 453 410 414 1:CAS:528:DC%2BD1cXlvV2qtL4%3D 10.1038/nature06868 18418378 (Pubitemid 351693122)
47. S Hollinger JR Hepler 2002 Cellular regulation of RGS proteins: modulators and integrators of G protein signaling Pharmacol Rev 54 527 559 1:CAS:528:DC%2BD38XotVSmsro%3D 10.1124/pr.54.3.527 12223533
48. MH Nisancioglu WM Mahoney Jr DD Kimmel, et al. 2008 Generation and characterization of rgs5 mutant mice Mol Cell Biol 28 2324 2331 1:CAS:528:DC%2BD1cXjvFemtb4%3D 10.1128/MCB.01252-07 18212066 (Pubitemid 351429978)
49. H Cho C Park IY Hwang, et al. 2008 Rgs5 targeting leads to chronic low blood pressure and a lean body habitus Mol Cell Biol 28 2590 2597 1:CAS:528:DC%2BD1cXksFWqsbc%3D 10.1128/MCB.01889-07 18268011 (Pubitemid 351542360)
50. M Trojanowska 2008 Role of PDGF in fibrotic diseases and systemic sclerosis Rheumatology (Oxford) 47 Suppl 5 v2 v4 1:CAS:528:DC%2BD1MXpvFynu7k%3D 10.1093/rheumatology/ken265
51. A Akhmetshina P Venalis C Dees, et al. 2009 Treatment with imatinib prevents fibrosis in different preclinical models of systemic sclerosis and induces regression of established fibrosis Arthritis Rheum 60 219 224 1:CAS:528:DC%2BD1MXhvFCjsr4%3D 10.1002/art.24186 19116940
52. SS Baroni M Santillo F Bevilacqua, et al. 2006 Stimulatory autoantibodies to the PDGF receptor in systemic sclerosis N Engl J Med 354 2667 2676 1:CAS:528:DC%2BD28XmtFSgtLg%3D 10.1056/NEJMoa052955 16790699
53. G Tellides JS Pober 2007 Interferon-gamma axis in graft arteriosclerosis Circ Res 100 622 632 1:CAS:528:DC%2BD2sXisFyntLw%3D 10.1161/01.RES.0000258861. 72279.29 17363708 (Pubitemid 46594876)
54. Z Li ZG Wang C Bian, et al. 2009 Interferon regulatory factor-1 exerts inhibitory effect on neointimal formation after vascular injury Chin Med Sci J 24 91 96 10.1016/S1001-9294(09)60068-7 19618605
55. H Shen M Zhang GY Minuk Y Gong 2002 Different effects of rat interferon alpha, beta and gamma on rat hepatic stellate cell proliferation and activation BMC Cell Biol 3 9 10.1186/1471-2121-3-9 11940252 (Pubitemid 38597732)
56. SH Schirmer JO Fledderus PT Bot, et al. 2008 Interferon-beta signaling is enhanced in patients with insufficient coronary collateral artery development and inhibits arteriogenesis in mice Circ Res 102 1286 1294 1:CAS:528: DC%2BD1cXlslGltrc%3D 10.1161/CIRCRESAHA.108.171827 18420941
57. AJ Stout I Gresser WD Thompson 1993 Inhibition of wound healing in mice by local interferon alpha/beta injection Int J Exp Pathol 74 79 85 1:CAS:528:DyaK2cXmtVejt7w%3D 7682435
58. ML Eloranta K Franck-Larsson T Lovgren, et al. 2010 Type I interferon system activation and association with disease manifestations in systemic sclerosis Ann Rheum Dis 69 1396 1402 1:CAS:528:DC%2BC3cXhtVSlur7F 10.1136/ard.2009.121400 20472592