Development of a sarcoidosis murine lung granuloma model using Mycobacterium superoxide dismutase A peptide

American Journal of Respiratory Cell and Molecular Biology

Volumn 44, Issue 2, 2011, Pages 166-174

  Swaisgood, Carmen M ^a   Oswald Richter, Kyra ^b   Moeller, Stephen D ^a   Klemenc, Jennifer M ^a   Ruple, Lisa M ^a   Farver, Carol F ^a   Drake, John M ^b   Culver, Daniel A ^a   Drake, Wonder P ^b  

^a LERNER RESEARCH INSTITUTE   (United States)

^b VANDERBILT UNIVERSITY   (United States)

Author keywords

Granuloma; Lung; Mouse; Mycobacterium soda; Sarcoidosis

Indexed keywords

ALANYLALANYLALANYLISOLEUCYLALANYLGLYCYLALANYLPHENYLALANYLGLYCYLSERYLPHENYLALANYLASPARTYLLYSYLPHENYLALANYLARGININE; FREUND ADJUVANT; GAMMA INTERFERON; INTERLEUKIN 2; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; MYCOBACTERIUM ANTIGEN; PARASITE ANTIGEN; SCHISTOSOME EGG ANTIGEN; SUPEROXIDE DISMUTASE; SUPEROXIDE DISMUTASE A PEPTIDE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CD4+ T LYMPHOCYTE; CELLULAR IMMUNITY; CONTROLLED STUDY; CYTOKINE RELEASE; FEMALE; GRANULOMATOUS INFLAMMATION; LUNG GRANULOMA; LUNG LAVAGE; LUNG SARCOIDOSIS; LYMPHADENOPATHY; MOUSE; MYCOBACTERIUM; NEUTROPHIL CHEMOTAXIS; NONHUMAN; NUCLEOTIDE SEQUENCE; SCHISTOSOMA MANSONI; SENSITIZATION; TH1 CELL;

AMINO ACID SEQUENCE; ANIMALS; ANTIGENS, BACTERIAL; BACTERIAL PROTEINS; BRONCHOALVEOLAR LAVAGE FLUID; DISEASE MODELS, ANIMAL; FEMALE; GRANULOMA; HUMANS; MICE; MICE, INBRED C57BL; MYCOBACTERIUM; PEPTIDE FRAGMENTS; SARCOIDOSIS, PULMONARY; SUPEROXIDE DISMUTASE; TH1 CELLS;

ANIMALIA; MURINAE; MUS; MYCOBACTERIUM; SCHISTOSOMA; SCHISTOSOMA MANSONI;

EID: 79551517696     PISSN: 10441549     EISSN: None     Source Type: Journal    
DOI: 10.1165/rcmb.2009-0350OC     Document Type: Article

References (30)

1. Ichikawa H, Kataoka M, Hiramatsu J, Ohmori M, Tanimoto Y, Kanehiro A, Nakata Y, Tanimoto M. Quantitative analysis of propionibacterial dna in bronchoalveolar lavage cells from patients with sarcoidosis. Sarcoidosis Vasc Diffuse Lung Dis 2008;25:15-20.
2. Drake WP, Pei ZH, Pride DT, Collins RD, Cover TL, Blaser MJ. Molecular analysis of sarcoidosis tissues for Mycobacterium species DNA. Emerg Infect Dis 2002;8:1334-1341.
3. Song ZM, Marzilli L, Greenlee BM, Chen ES, Silver RE, Askin FB, Teirstein AS, Zhang Y, Cotter RJ, Moller DR. Mycobacterial catalase-peroxidase is a tissue antigen and target of the adaptive immune response in systemic sarcoidosis. J Exp Med 2005;201:755-767.
4. Dubaniewicz A, Dubaniewicz-Wybieralska M, Sternau A, Zwolska Z, Izycka-Swieszewska E, Augustynowicz-Kopec E, Skokowski J, Singh M, Zimnoch L. Mycobacterium tuberculosis complex and mycobacterial heat shock proteins in lymph node tissue from patients with pulmonary sarcoidosis. J Clin Microbiol 2006;44:3448-3451.
5. Rossman MD, Thompson B, Frederick M, Maliarik M, Iannuzzi MC, Rybicki BA, Pandey JP, Newman LS, Magira E, Beznik-Cizman B, et al. HLA-DRB1*1101: a significant risk factor for sarcoidosis in blacks and whites. Am J Hum Genet 2003;73:720-735.
6. Dubaniewicz A, Dubaniewicz A, Dubaniewicz A, Moszkowska G. DQA1*03011 allele: protective or an adverse effect on the development of sarcoidosis: preliminary study. Respir Med 2007;101:2213-2216.
7. Drake WP, Dhason MS, Nadaf M, Shepherd BE, Vadivelu S, Hajizadeh R, Newman LS, Kalams SA. Cellular recognition of Mycobacterium tuberculosis ESAT-6 and katG peptides in systemic sarcoidosis. Infect Immun 2007;75:527-530.
8. Chen ES, Wahlstrom J, Song ZM, Willett MH, Wiken M, Yung RC, West EE, Mcdyer JF, Zhang Y, Eklund A, et al. T cell responses to mycobacterial catalase-peroxidase profile a pathogenic antigen in systemic sarcoidosis. J Immunol 2008;181:8784-8796.
9. Hajizadeh R, Sato H, Carlisle J, Nadaf MT, Evans W, Shepherd BE, Miller RF, Kalams SA, Drake WP. Mycobacterium tuberculosis antigen 85A induces Th-1 immune responses in systemic sarcoidosis. J Clin Immunol 2007;27:445-454.
10. Oswald-Richter KA, Culver DA, Hawkins C, Hajizadeh R, Abraham S, Shepherd BE, Jenkins CA, Judson MA, Drake WP. Cellular responses to mycobacterial antigens are present in bronchoalveolar lavage fluid used in the diagnosis of sarcoidosis. Infect Immun 2009;77: 3740-3748.
11. Allen SS, Evans W, Carlisle J, Hajizadeh R, Nadaf M, Shepherd BE, Pride DT, Johnson JE, Drake WP. Superoxide dismutase A antigens derived from molecular analysis of sarcoidosis granulomas elicit systemic Th-1 immune responses. Respir Res 2008;9:36.
12. Swaisgood CM, Richter K, Moeller S, Klemenc J, Drake WP. Development of a sarcoidosis murine model using mycobacterial antigens ESAT-6 and SodA. Am J Respir Crit Care Med 2009; 179:A3996.
13. Chensue SW, Warmington K, Ruth J, Lincoln P, Kuo MC, Kunkel SL. Cytokine responses during mycobacterial and schistosomal antigen-induced pulmonary granuloma-formation: production of Th1 and Th2 cytokines and relative contribution of tumor-necrosis-factor. Am J Pathol 1994;145:1105-1113.
14. Swaisgood CM, French EL, Noga C, Simon RH, Ploplis VA. The development of bleomycin-induced pulmonary fibrosis in mice deficient for components of the fibrinolytic system. Am J Pathol 2000; 157:177-187.
15. Oswald-Richter K, Sato H, Hajizadeh R, Shepherd BE, Sette A, Sidney J, Newman LS, Drake WP. Mycobacterial ESAT-6 and katG are recognized by sarcoidosis CD4+ T cells when presented by the American sarcoidosis susceptibility allele, DRB1*1101. J Clin Immunol 2010;30:157-166.
16. Chensue SW, Warmington KS, Ruth JH, Lincoln P, Kunkel SL. Cytokine function during mycobacterial and schistosomal antigen-induced pulmonary granuloma-formation: local and regional participation of IFN-gamma, IL-10, and TNF. J Immunol 1995;154: 5969-5976.
17. Chensue SW, Warmington K, Ruth JH, Lukacs N, Kunkel SL. Mycobacterial and schistosomal antigen-elicited granuloma formation in IFN-gamma and IL-4 knockout mice: analysis of local and regional cytokine and chemokine networks. J Immunol 1997;159: 3565-3573.
18. Chiu BC, Freeman CM, Stolberg VR, Komuniecki E, Lincoln PM, Kunkel SL, Chensue SW. Cytokine-chemokine networks in experimental mycobacterial and schistosomal pulmonary granuloma formation. Am J Respir Cell Mol Biol 2003;29:106-116.
19. Minami J, Eishi Y, Ishige Y, Kobayashi I, Ishige I, Kobayashi D, Ando N, Uchida K, Ikeda S, Sorimachi N, et al. Pulmonary granulomas caused experimentally in mice by a recombinant trigger-factor protein of Propionibacterium acnes. J Med Dent Sci 2003;50:265-274.
20. Nishiwaki T, Yoneyama H, Eishi Y, Matsuo N, Tatsumi K, Kimura H, Kuriyama T, Matsushima K. Indigenous pulmonary Propionibacterium acnes primes the host in the development of sarcoid-like pulmonary granulomatosis in mice. Am J Pathol 2004;165:631-639.
21. McCaskill JG, Chason KD, Hua XY, Neuringer IP, Ghio AJ, Funkhouser WK, Tilley SL. Pulmonary immune responses to Propionibacterium acnes in C57BL/6 and BALB/c mice. Am J Respir Cell Mol Biol 2006;35:347-356.
22. Kunkel SL, Lukacs NW, Strieter RM, Chensue SW. Th1 and Th2 responses regulate experimental lung granuloma development. Sarcoidosis Vasc Diffuse Lung Dis 1996;13:120-128.
23. Moller DR, Forman JD, Liu MC, Noble PW, Greenlee BM, Vyas P, Holden DA, Forrester JM, Lazarus A, Wysocka M, et al. Enhanced expression of IL-12 associated with Th1 cytokine profiles in active pulmonary sarcoidosis. J Immunol 1996;156:4952-4960.
24. Gudmundsson G, Hunninghake GW. Interferon-gamma is necessary for the expression of hypersensitivity pneumonitis. J Clin Invest 1997;99: 2386-2390. (Pubitemid 27227715)
25. Wang J, Wakeham J, Harkness R, Xing Z. Macrophages are a significant source of Type 1 cytokines during mycobacterial infection. J Clin Invest 1999;103:1023-1029.
26. Kunkel SL, Chensue SW, Strieter RM, Lynch JP, Remick DG. Cellular and molecular aspects of granulomatous inflammation. Am J Respir Cell Mol Biol 1989;1:439-447.
27. Grunewald J, Eklund A. Lofgren's syndrome human leukocyte antigen strongly influences the disease course. Am J Respir Crit Care Med 2009;179:307-312.
28. Saltini C, Pallante M, Puxeddu E, Contini S, Voorter CE, Drent M, Amicosante MM. M. avium binding to HLA-DR expressed alleles in silicon: a model of phenotypic susceptibility to sarcoidosis. Sarcoidosis Vasc Diffuse Lung Dis 2008;25:100-116.
29. Kunkel SL, Lukacs NW, Strieter RM, Chensue SW. Animal models of granulomatous inflammation. Semin Respir Infect 1998;13:221-228.
30. Chensue SW, Terebuh PD, Warmington KS, Hershey SD, Evanoff HL, Kunkel SL, Higashi GI. Role of IL-4 and IFN-gamma in Schistosomamansoni egg-induced hypersensitivity granuloma-formation: orchestration, relative contribution, and relationship to macrophage function. J Immunol 1992;148:900-906.