Effects of endocannabinoid 1 and 2 (CB1; CB2) receptor agonists on luteal weight, circulating progesterone, luteal mRNA for luteinizing hormone (LH) receptors, and luteal unoccupied and occupied receptors for LH in vivo in ewes

Prostaglandins and Other Lipid Mediators

Volumn 94, Issue 1-2, 2011, Pages 17-24

  Tsutahara, Nicole M ^a   Weems, Yoshie S ^a   Arreguin Arevalo, J Alejandro ^b   Nett, Torrance M ^b   Laporte, Magen E ^a   Uchida, Janelle ^a   Pang, Janelle ^a   McBride, Tonya ^a   Randel, Ronald D ^c   Weems, Charles W ^a  

^a UNIVERSITY OF HAWAII   (United States)

^b Department of Environmental and Radiological Health Sciences   (United States)

^c TEXAS A AND M UNIVERSITY   (United States)

Author keywords

Corpus luteum; Endocannabinoids; LH receptors; mRNA LH; Progesterone; Sheep

Indexed keywords

CANNABINOID 1 RECEPTOR; CANNABINOID 1 RECEPTOR AGONIST; CANNABINOID 2 RECEPTOR; CANNABINOID 2 RECEPTOR AGONIST; LIQUID NITROGEN; LUTEINIZING HORMONE RECEPTOR; MESSENGER RNA; METHANANDAMIDE; PROGESTERONE;

ANIMAL EXPERIMENT; ARTICLE; CORPUS LUTEUM; ESTRUS CYCLE; EWE; FEMALE; INTERSTITIUM; NONHUMAN; RADIOIMMUNOASSAY; VASCULAR PEDICLE;

ANIMALS; ARACHIDONIC ACIDS; CATTLE; CORPUS LUTEUM; ESTROUS CYCLE; FEMALE; INDOLEACETIC ACIDS; LUTEAL CELLS; LUTEINIZING HORMONE; MORPHOLINES; ORGAN SIZE; PROGESTERONE; RECEPTOR, CANNABINOID, CB1; RECEPTOR, CANNABINOID, CB2; RECEPTORS, LH; RNA, MESSENGER;

EID: 79551507599     PISSN: 10988823     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.prostaglandins.2010.11.002     Document Type: Article

References (134)

1. L.A. Matsuda, S.J. Lolait, M.J. Brownstein, A.C. Young, and T.I. Bonner Structure of a cannabinoid receptor and functional expression of the cloned cDNA Nature 346 1990 561 564
2. S. Munro, K.L. Thomas, and M. Abu-sharr Molecular characterization of a peripheral receptor for cannabinoids Nature 365 1993 61 65
3. A.C. Howlett, F. Barth, and T.I. Bonner International Union of Pharmacology. XXVII. Classification of cannabinoid receptors Pharmacol Rev 54 2002 161 202
4. R.G. Pertwee, and R.A. Ross Cannabinoid receptors and their ligands Prostaglandins Leukot Essent Fatty Acids 66 2002 101 121
5. O. Piomelli The molecular logic of endocannabinoid signaling Nat Rev Neurosci 4 2003 873 884
6. O.M. Habayeb, S.C. Bell, and J.C. Konje Endogenous cannabinoids: metabolism and their role in reproduction Life Sci 70 2002 1963 1977
7. T. Sugiura, Y. Kobayashi, S. Oka, and K. Waku Biosynthesis and degradation of anandamide and 2-arachidonoylglycerol and their possible physiological significance Prostaglandins Leukot Essent Fatty Acids 66 2002 173 192
8. M.L. Yates, and E.L. Barker Inactivation and biotransformation of the endogenous cannabinoids anandamide and 2-arachidonylglycerol Mol Pharmacol 76 2009 11 17
9. M. Boubaboula, C. Poinot-Chazel, and B. Bouxrie Activation of mitogen-activated protein kinase by stimulation of the central cannabinoid receptor CB1 Biochem J 312 1995 637 641
10. W.A. Devane, L. Hanus, and A. Breuer Isolation and structure of a brain constituent that binds to the cannabinoid receptor Science 1992 1946 1949
11. M.D. Jhaveri, D. Richardson, and V. Chapman Endocannabinoid metabolism and uptake: novel targets for neuropathic and inflammatory pain Br J Pharmacol 152 2007 624 632
12. S.D. McAllister, and M. Glass CB1 and CB2 receptor-mediated signalling: a focus on endocannabinoids Prostaglandins Leukot Essent Fatty Acids 66 2002 161 171
13. Y. Waksman, J.M. Olson, S.J. Carlisle, and G.A. Cabral The central cannabinoid receptor (CB1) mediates inhibition of nitric oxide production by rat microglial cells J Pharmacol Exp Ther 288 1999 1357 1366
14. M. Cella, G.F. Leguizamon, and M.S. Sordelli Dual effect of anandamide on rat placenta nitric oxide synthesis Placenta 29 2008 699 707
15. C.A. Vercelli, J. Aisemberg, S. Billi, M.L. Wolfson, and A.M. Franchi Endocannabinoid system and nitric oxide are involved in the deleterious effects of lipopolysaccharide on murine decidua Placenta 30 2009 579 584
16. C.A. Vercelli, J. Aisemberg, and S. Billi Anandamide regulates lipopolysaccharide-induced nitric oxide synthesis and tissue damage in the murine uterus Reprod Biomed Online 18 2009 824 831
17. U. Pagotto, G. Marsicano, D. Cota, B. Lutz, and R. Pasquali The emerging role of the endocannabinoid system in endocrine regulation and energy balance Endocr Rev 27 2006 73 100
18. C. Borner, M. Smida, V. Hollt, B. Schraven, and J. Kraus Cannabinoid receptor type 1- and 2-mediated increase in cyclic AMP inhibits T cell receptor-triggered signaling J Biol Chem 284 2009 35450 35460
19. M. Maccarrone, K. Falciglia, M. Di Rienzo, and A. Finazzi-Agro Endocannabinoids, hormone-cytokine networks and human fertility Prostaglandins Leukot Essent Fatty Acids 66 2002 309 317
20. M. Maccarrone, H. Valensise, M. Bari, N. Lazzacin, C. Romanini, and A. Finazzi-Agro Progesterone up-regulates anandamine hydrolase in human lymphocytes: role of cytokines and implications for fertility J Immunol 166 2001 7183 7189
21. M. Guida, A. Ligresti, and S. De Filippis The levels of the endocannabinoid receptor CB2 and its ligand 2-arachidonoylglycerol are elevated in endometrial carcinoma Endocrinology 151 2010 921 928
22. T. Marczylo, P.M.W. Lam, A. Amoako, and J. Konje Anandamide levels in human female reproductive tissues: solid-phase extraction and measurement by ultraperformance liquid chromatography tandem mass spectrometry Anal Biochem 400 2010 155 162
23. M. Maccarrone Endocannabinoids: friends and foes of reproduction Prog Lipid Res 48 2009 344 364
24. A.H. Taylor, C. Ang, S.C. Bell, and J. Konje The role of the endocannabinoid system in gametogenesis, implantation, and early pregnancy Hum Reprod Update 13 2007 501 513
25. E. Fride, N. Gobshtis, H. Dahan, A. Weller, A. Giuffrida, and S. Ben-Shabat The endocannabinoid system during development: emphasis on perinatal events and delayed effects Vitam Horm 81 2009 139 158
26. S.E. Lewis, and Maccarrone Endocannabinoids, sperm biology and human fertility Pharmacol Res 60 2009 126 131
27. B.M. Fonseca, G. Corria-da-Silva, and N.A. Teixeira Anandamide-induced cell death: dual effects in primary rat decidual cell cultures Placenta 30 2009 686 692
28. O.M.H. Habayeb, A.H. Taylor, S.C. Bell, D.J. Taylor, and J.C. Konje Expression of the endocannabinoid system in human first trimester placenta and its role in trophoblast proliferation Endocrinology 149 2008 5052 5060
29. E. Trabucco, G. Acone, and A. Marenna Endocannabinoid system in first trimester placenta: low FAAH and high CB1 expression characterize spontaneous miscarriage Placenta 30 2009 516 522
30. P.J. Brighton, J. McDonald, and A.H. Taylor Characterization of anandamide-stimulated cannabinoid receptor signaling in human ULTR myometrial smooth muscle cells Mol Endocrinol 23 2009 1415 1427
31. N. Battisa, N. Pasquariello, M. Di Thomaso, and M. Maccarrone Interplay between endocannabinoids, steroids and cytokines in the control of human reproduction J Neuroendocrinol 20 Suppl. 1 2008 82 89
32. E. Fried Multiple roles for the endocannabinoid system during the earliest stages of life: pre- and postnatal development J Neuroendocrinol 20 Suppl. 1 2008 75 81
33. O.M. Habayeb, A.H. Taylor, M. Finney, M.D. Evans, and J.C. Konje Plasma anandamide concentration and pregnancy outcome in women with threatened miscarriage JAMA 299 2008 1135 1136
34. N. Battista, M. Bari, C. Rapino, F. Trasatti, A. D'Agostino, and M. Maccarrone Regulation of female fertility by the endocannabinoid system Hum Fertil 10 2007 207 216
35. M. Maccarrone CB2 receptors in reproduction Br J Pharmacol 153 2008 189 198
36. H. Wang, H. Xie, and X. Sun Differential regulation of endocannabinoid synthesis and degradation in the uterus during embryo implantation Prostaglandins Other Lipid Mediat 83 2007 62 74
37. C. Davitian, M. Uzan, A. Tigaizin, G. Ducarme, H. Dauphin, and C. Poncelet Consommation maternelle de cannabis et retard de croissance intra-uterin Gynecol Obstet Fertil 34 2006 632 637
38. H. Wang, H. Xie, and Y. Guo Fatty acid amide hydrolase deficiency limits early pregnancy events J Clin Invest 116 2006 2123 2131
39. G. Acone, E. Trabucco, and N. Colacurci Low type I cannabinoid receptor levels characterize placental villous in laboruring delivery Placenta 30 2009 203 205
40. L.W. Chamley, A. Bhalla, and P.R. Stone Nuclear localization of the endocannabinoid metabolizing enzyme fatty acid amide hydrolase (FAAH) in invasive trophoblasts and an association with recurrent miscarriage Placenta 29 2008 970 975
41. M.Y. Turco, K. Matsukawa, and M. Czernik High levels of anandamide, an endogenous cannabinoid, block the growth of sheep preimplantation embryos by inducing apoptosis and reversible arrest of cell proliferation Hum Reprod 23 2008 2331 2338
42. M.G. Gervasi, M. Rapanelli, and M.L. Ribeiro The endocannabinoid system in bull sperm and bovine oviductal epithelium: role of anandamide in sperm-oviduct interaction Reproduction 137 2009 403 414
43. M. Maccarrone, B. Barboni, and A. Paradisi Characterization of the endocannabinoid system in boar spermatozoa and implications for sperm capacitation and acrosome reaction J Cell Sci 118 2005 4393 4404
44. H. Schuel, and L.J. Burkman A tale of two cells: endocannabinoid- signaling regulates functions of neurons and sperm Biol Reprod 73 2005 1078 1086
45. S. Aquila, C. Guido, and A. Santoro Rimonabant (SR141716) induces metabolism and acquisition of fertilizing ability in human sperm Br J Pharmacol 159 2010 831 841
46. O.M.H. Habayeb, A.H. Taylor, and M.D. Evans Plasma levels of endocannabinoid anandamide in women: a potential role in pregnancy maintenance and labor? J Clin Endocrinol Metab 89 2004 5482 5487
47. M.R. El-Talatini, A.H. Taylor, and J.C. Konje Fluctuation in anandamide levels from ovulation to early pregnancy in in vitro fertilization-embryo transfer women, and its hormonal regulation Hum Reprod 24 2009 1989 1998
48. M. Maccarrone, T. Bisogno, and H. Valensise Low fatty acid amide hydrolase and high anandamide levels are associated with failure to achieve an ongoing pregnancy after IVF and embryo transfer Mol Hum Reprod 8 2002 188 195
49. G. Ioannidis, G. Sacks, and N. Reddy Day 14 maternal serum progesterone levels predict pregnancy outcome in IVF/ICSI treatment cycle: a prospective study Hum Reprod 20 2005 741 746
50. M. Maccarrone Endocannabinoids and reproductive endocrinology Curr Opin Investig Drugs 10 2009 305 310
51. B. Park, J.M. McPartland, and M. Glass Cannabis, cannabinoids and reproduction Prostaglandins Leukot Essent Fatty Acids 70 2004 189 197
52. H. Wang, H. Xie, and S.K. Dey Endocannabinoid signaling directs periimplantation events AAPS J 8 2006 E425 432
53. N. Battista, C. Rapino, M. Di Thommaso, M. Bari, N. Pasquariello, and M. Maccarrone Regulation of male fertility by the endocannabinoid system Mol Cell Endocrinol 286 2008 S17 S23
54. F. Francavilla, N. Battista, and A. Barbonetti Characterization of the endocannabinoid system in human spermatozoa and involvement of transient receptor potential vanilloid 1 receptor in their fertilizing ability Endocrinology 150 2009 4692 4700
55. M. Schneider Cannabis use in pregnancy and early life and its consequences: animal model Eur Arch Psychiatry Clin Neurosci 259 2009 383 393
56. P. Grimaldi, G. Rossi, G. Catanzaro, and M. Maccarrone Modulation of the endocannabinoid-degrading enzyme fatty acid amide hydrolase by follicle-stimulating hormone Vitam Horm 81 2009 231 261
57. B.M. Fonseca, G. Correia-da-Silva, A.H. Taylor, J.C. Konje, S.C. Bell, and N.A. Teixeira Spatio-temporal expression patterns of anandamide-binding receptors in rat implantation sites: evidence for a role of the endocannabinoid system during the period of placental development Reprod Biol Endocrinol 7 2009 121 132
58. R.J.A. Helliwell, L.W. Chamley, and K. Blake-Palmer Characterization of the endocannabinoid system in early human pregnancy J Clin Endocrinol Metab 89 2004 5168 5174
59. H. Wang, H. Matsumoto, Y. Guo, B.C. Paria, R.L. Roberts, and S.K. Dey Differential G protein coupled cannabinoid receptor signaling by anandamide directs blastocyst activation for implantation Proc Natl Acad Sci USA 100 2003 14914 14919
60. H. Wang, S.K. Dey, and M. Maccarrone Jekyll and Hyde: two faces of cannabinoid signaling in male and female fertility Endocr Rev 27 2006 427 428
61. O.M.H. Habayeb, A.H. Taylor, and M.D. Evans Plasma levels of the endocannabinoid anandamide in women - a potential role in pregnancy maintenance and labor? J Clin Endocrinol Metab 89 2004 5482 5487
62. H. Schuel Tuning the oviduct to the anandamide tone J Clin Invest 116 2006 2087 2089
63. S.K. Das, B.C. Paria, I. Chakraborty, and S.K. Dey Cannabinoid ligand-receptor signaling in the mouse uterus Proc Natl Acad Sci USA 92 1995 4332 4336
64. B.C. Paria, S.K. Das, and S.K. Dey The preimplantation mouse embryo is a target for cannabinoid ligand-receptor signaling Proc Natl Acad Sci USA 92 1995 9460 9464
65. P.C. Schmid, B.C. Paria, R.J. Krebsbach, H. Schmid, O. H, and S.K. Dey Changes in anandamide levels in mouse uterus are associated with uterine receptivity for embryo implantation Proc Natl Acad Sci USA 94 1997 4188 4192
66. H. Wang, Y. Guo, and D. Wang Aberrant cannabinoid signaling impairs oviductal transport of embryos Nat Med 10 2004 1074 1080
67. R. Shao Understanding the mechanisms of human tubal ectopic pregnancies: new evidence from knockout mouse models Hum Reprod 25 2010 584 587
68. A.W. Horne, J.A. Phillips, and N. Kane CB1 expression is attenuated in fallopian tube and decidua of women with ectopic pregnancy PLoS One 3 2008 1 6
69. M.R. El-Talatini, A.H. Taylor, J.C. Elson, L. Brown, A.C. Davidson, and J.C. Konje Localisation and function of the endocannabinoid system in the human ovary PLoS One 4 2009 e45794583
70. B. Paria, H. Song, and X. Wang Dysregulated cannabinoid signaling disrupts uterine receptivity for embryo implantation J Biol Chem 276 2001 20523 20528
71. H. Wang, H. Xie, and S.K. Dey Loss of cannabinoid receptor CB1 induces preterm birth PLoS One 3 2008 e33203324
72. M. Liu, E.K. Duan, and Y.J. Cao Effects of anandamide on embryo implantation in the mouse Life Sci 71 2002 1623 1632
73. X. Sun, and S.K. Dey Aspects of endocannabinoid signaling in periimplantation biology Mol Cell Endocrinol 286 2008 S3 11
74. C.W. Weems, Y.S. Weems, and R.D. Randel Prostaglandins and reproduction in female farm animals Vet J 172 2006 206 228
75. 2, adenosine, estradiol-17β, histone-H2A and progesterone of conceptus, uterine or ovarian origin during early and midpregnancy in the ewe Reprod Fertil Dev 4 1992 289 295
76. C.W. Weems, Y.S. Weems, and Vincent DL Maternal recognition of pregnancy and maintenance of gestation in sheep G. Enne, G.F. Greppi, A. Lauria, Reproduction and animal breeding: advances and strategies. Proceedings XXX international Simposia Societa Italiana Zootechnica Milan, Italy 1995 Elsevier Press Amsterdam, Holland 277 293
77. C.W. Weems, M. Huie, G.L. Hoyer, R.R. Magness, and G.L. Whysong Maternal recognition of pregnancy in ruminants W.C. Davis, J.N. Shelton, C.W. Weems, Characterization of the bovine immune system and the genes regulating expression of immunity with particular reference to their role in disease resistance 1985 Washington State University Press Pullman, Washington 193 210
78. G.D. Niswender, J.L. Juengel, P.J. Silva, M.K. Rollyson, and E.W. McIntush Mechanisms controlling the function and life span of the corpus luteum Physiol Rev 80 2000 1 29
79. G.D. Niswender Molecular control of luteal secretion of progesterone Reproduction 123 2002 333 339
80. G.D. Niswender, J.L. Juengel, W.J. McGuire, C.J. Belfiore, and M.C. Wiltbank Luteal function: the estrous cycle and early pregnancy Biol Reprod 50 1994 239 247
81. G.D. Niswender, C.E. Farin, F. Gamboni, H.R. Sawyer, and T.M. Nett Role of luteinizing hormone in regulating luteal function in ruminants J Anim Sci 2 62 (Suppl.) 1986 1 13
82. G.D. Niswender, R.H. Schwall, T.A. Fitz, C.E. Farin, and H.R. Sawyer Regulation of luteal function in domestic ruminants: new concepts Recent Prog Horm Res 41 1985 101 151
83. G.D. Niswender, T.L. Davis, and R.J. Griffith Judge, jury, and executioner: the auto-regulation of luteal function J.L. Juengel, J.F. Murray, M.F. Smith, Reproduction in domestic ruminants VI. EDS 2007 Nottingham University Press 191 206
84. Y.P. Cheon, Q. Li, X. Xu, F.J. Demayo, I.C. Bachi, and M.K. Bachi A genomic approach to identify novel progesterone regulated pathways in the uterus during implantation Mol Endocrinol 16 2002 2853 2871
85. H. Lim, H. Song, B.C. Paria, J. Reese, S.K. Das, and S.K. Dey Molecules in blastocyst implantation: uterine and embryonic perspectives Vitam Horm 64 2002 43 57
86. 2 on rate of decidualization in rats Prostaglandins 46 1993 243 250
87. 2, trichosanthin and pregnancy specific protein B (PSPB) on secretion of progesterone in vitro by the corpus luteum (CL) from nonpregnant and pregnant cows Prostaglandins 55 28-43 1998 29
88. Y.S. Weems, R.D. Randel, S. Tatman, A. Lewis, D.A. Neuendorff, and C.W. Weems Effects of estrous synchronization on response to nitric oxide donors and endothelin-1 in vitro Prostaglandins Other Lipid Mediat 74 2004 45 59
89. Y.S. Weems, R.D. Randel, S. Tatman, A.W. Lewis, D.A. Neuendorff, and C.W. Weems Effects of estrous synchronization on response to nitric oxide donors and endothelin-1 in vitro Prostaglandins Other Lipid Mediat 74 2004 45 59
90. 2α in vitro by corpora lutea (CL) from nonpregnant and pregnant cows Prostaglandins 55 1998 359 376
91. 2α, and progesterone by bovine corpora lutea of mid-pregnancy in vitro Chin J Physiol 45 4 2002 163 168
92. Y.S. Weems, R.D. Randel, A. Tatman, A.W. Lewis, D.A. Neuendorff, and C.W. Weems In vivo progestin treatments inhibit nitric oxide and endothelin-1-induced bovine endometrial prostaglandin (PG) E (PGE) secretion in vitro Prostaglandins Other Lipid Mediat 78 2005 276 290
93. Y.S. Weems, A.W. Lewis, D.A. Neuendorff, R.D. Randel, and C.W. Weems Endocannabinoid (ECN) receptor agonists affect cow luteal function Prostaglandins Other Lipid Mediat 90 2009 89 93
94. Y.S. Weems, E. Lennon, and T. Uchima Is nitric oxide luteolytic or antiluteolytic? Prostaglandins Other Lipid Mediat 78 2005 141 150
95. Y.S. Weems, D. Johnson, and T. Uchima Is endothelin-1 luteolytic or antiluteolytic in vivo in ewes Prostaglandins Other Lipid Mediat 90 2009 63 68
96. Y.S. Weems, T. Uchima, and E. Lennon Mechanisn whereby nitric oxide (NO) is antiluteolytic rather than being luteolytic Prostaglandins Other Lipid Mediat 85 2008 33 41
97. α) on sources of progesterone in hysterectomized, intact, or ovariectomized 90-100 day pregnant ewes Prostaglandins 43 1992 203 222
98. M.K. Guy, J.L. Juengel, T.R. Tandeki, and G.D. Niswender Steady-state concentrations of mRNA encoding the receptor for luteinizing hormone during the estrous cycle and following prostaglandin treatment Endocrine 3 1995 585 589
99. R.L. Ashley, J.A. Arreguin-Arevalo, and T.M. Nett Binding characteristics of the ovine membrane progesterone receptor alpha and expression of the receptor during the estrous cycle Reprod Biol Endocrinol 7 2009 42 49
100. J.A. Whelan, N.B. Russell, and M.A. Whelan A method for the absolute quantification of cDNA using real-time PCR J Immunol Methods 278 2003 261 269
101. 2α-induced loss of corpus luteum gonadotropin receptors Prostaglandins 7 1974 449 453
102. 2α Endocrinology 98 1976 146 152
103. B. Jaffe, and H.R. Behrman Methods of hormone radioimmunoassay 1979 Academic Press NY
104. 2) on luteal function and binding of luteinizing hormone in nonpregnant ewes Prostaglandins 29 1985 161 173
105. 2) alters luteal and endometrial luteinizing hormone (LH) occupied and unoccupied receptors and mRNA for LH receptors in ovine luteal tissue to prevent luteolysis Prostaglandins Other Lipid Mediat 91 2010 42 50
106. Y.S. Weems, T.M. Nett, and T.L. Davis Effects of prostaglandin E and F receptor agonists in vivo on luteal function in ewes Prostaglandins Other Lipid Mediat 92 2010 67 72
107. R.G.D. Steel, and J.H. Torrie Principles and procedures of statistics 1960 McGraw-Hill Book Co., Inc. NY
108. J.L. Gill, and H.D. Hafs Analysis of repeated measurements of animals J Anim Sci 33 1971 331 336
109. Statistical Analysis Systems (SAS). Cary, North Carolina; 1987.
110. M.W. Pfaffl, G.W. Horgan, and L. Dempfle Relative Expression Software Tool (REST) for group-wise comparison and statistical analysis of relative expression results in real-time PCR Nucleic Acids Res 30 9 2002 E36
111. Pfaffl M. Relative Expression Software Tool 2008 (REST 2008) Munichl. Available form: http://www.gene-quantification.de/pfaffl-nar-2001.pdf ; 2008.
112. 2α during early pregnancy Acta Vet Scand 77 Suppl. 1981 117 130
113. T.M. Nett, M.C. McClellan, and G.D. Niswender Effects of prostaglandins on the ovine corpus luteum: blood flow, secretion of progesterone and morphology Biol Reprod 15 1976 66 78
114. M. Wiltbank, M. Diskin, and G.D. Niswender Differential actions of second messenger systems in the corpus luteum J Reprod Fertil 43 Suppl. 1991 65 75
115. M.C. Wiltbank, C.J. Belfiore, and G.D. Niswender Steroidogenic enzyme activity after acute activation of protein kinase (PK) A and PKC in ovine small and large luteal cells Mol Cell Endocrinol 97 1993 1 7
116. L. Penny Monocyte chemoattractant protein 1 in luteolysis Rev Reprod 5 2000 63 579
117. 2α-induced luteolysis Biol Reprod 50 1994 10 15
118. S.J. Tsai, J.L. Juengel, and M.C. Wiltbank Hormonal regulation of monocyte chemoattractant protein-1 messenger ribonucleic acid expression in corpora lutea Endocrinology 138 1997 4517 4520
119. 2α by the ovine corpus luteum in vivo Biol Reprod 51 1994 800 806
120. M.C. Wiltbank, P.B. Guthrie, M.P. Mattson, S.B. Kater, and G.D. Niswender Hormonal regulation of free intracellular calcium concentrations in small and large ovine luteal cells Biol Reprod 41 1989 771 778
121. K.R. Kozak, B.C. Crews, and J.A. Morrow Metabolism of the endocannabinoids, 20 arachidonylglycerol and anandamide, into prostaglandin, thromboxane, and prostacyclin esters and ethanolamides J Biol Chem 277 2002 44877 44895
122. K.R. Kozak, and L.J. Marnett Oxidative metabolism of endocannabinoids Prostaglandins Leukot Essent Fatty Acids 66 2002 211 220
123. C.A. Rouzer, and L.J. Marnett Non-redundant functions of cyclooxygenases: oxygenation of endocannabinoids J Biol Chem 283 2009 8065 8072
124. K.R. Kozak, B.C. Crews, J.L. Ray, H. Tai, J.D. Morrow, and L.J. Marnett Metabolism of prostaglandin glycerolesters and prostaglandin ethanolamides in vitro and in vivo J Biol Chem 276 2001 36993 36998
125. K.R. Kozak, S.W. Rowlinson, and L.J. Marnett Oxygenation of the endocannabinoidm 20arachidonylglycerol to glyceryl prostaglandins by cyclooxygenase-2 J Biol Chem 275 2000 33744 33749
126. C.J. Hillard Biochemistry and pharmacology of the endocannabinoids arachidonylethanolamide and 2-arachidonylglycerol Prostaglandins Other Lipid Mediat 61 2000 3 18
127. K.R. Kozak, J.J. Prusakiewicz, and L.J. Marnett Oxidatice metabolism of endocannabinoids by COX-2 Curr Pharm Des 10 2004 659 667
128. K.R. Kozak, J.J. Prusakiewicz, S.W. Rowlinson, D.R. Prudhomme, and L.J. Marnett Amino acid determinants in cyclooxygenase-2 oxygenation of the endocannabinoid anandamide Biochemistry 42 2003 9041 9049
129. D.G. Deutsch, and S.A. Chin Enzymatic synthesis and degradation of anandamide, a cannabinoid receptor agonist Biochem Pharmacol 46 1993 791 796
130. N. Ueda, and S. Yamamoto Anandamide amidohydrolase (fatty acid amide hydrolase) Prostaglandins Other Lipid Mediat 61 2000 19 28
131. J. Kotwica, D.J. Skarzynski, M. Bogacki, P. Melin, and B. Starostka The use of an oxytocin antagonist to study the function of ovarian oxytocin during luteolysis in cattle Theriogenology 48 1997 1287 1299
132. 2α; and removal of corpora lutea J Anim Sci 46 389-398 1978 1718 1723
133. 2α-induced luteolysis in ewes? Biol Reprod 83 2010 ABSTR.221
134. 2) on luteal function and binding of luteinizing hormone in nonpregnant ewes Prostaglandins 29 1985 161 173