Radiosensitization of oropharyngeal squamous cell carcinoma cells by human papillomavirus 16 oncoprotein E6I

International Journal of Radiation Oncology Biology Physics

Volumn 79, Issue 3, 2011, Pages 860-865

  Pang, Ervinna ^a,b   Delic, Naomi C ^a,b   Hong, Angela ^a   Zhang, Mei ^a   Rose, Barbara R ^a,b   Lyons, J Guy ^a,b  

^a ROYAL PRINCE ALFRED HOSPITAL   (Australia)

^b UNIVERSITY OF SYDNEY   (Australia)

Author keywords

Human papillomavirus; Keratinocyte; Oncogene; Oropharyngeal squamous cell carcinoma; Radiotherapy

Indexed keywords

APOPTOSIS; CELL CYCLE; CELL FRACTION; CELL LINES; CONTROL-CELL; FLOW-CYTOMETRIC ANALYSIS; HUMAN PAPILLOMAVIRUS; ISOFORMS; KERATINOCYTES; ONCOGENE; ONCOPROTEINS; OPEN READING FRAME; OROPHARYNGEAL; PROGRAMMED CELL DEATHS; RADIATION RESISTANCE; RADIATION-INDUCED; RADIO-SENSITIZATION; REPORTER GENE; SQUAMOUS CELL CARCINOMA; TRANSACTIVATORS; TUMOR SUPPRESSORS;

CELL CULTURE; CELL DEATH; FLOW CYTOMETRY;

RADIOTHERAPY;

PROTEIN E6; PROTEIN P53;

APOPTOSIS; ARTICLE; CELL CYCLE; CELL FRACTIONATION; HUMAN; HUMAN PAPILLOMAVIRUS TYPE 16; NONHUMAN; OPEN READING FRAME; OROPHARYNX CARCINOMA; PRIORITY JOURNAL; RADIOSENSITIVITY; RADIOSENSITIZATION; SQUAMOUS CELL CARCINOMA; TRANSACTIVATION;

APOPTOSIS; CARCINOMA, SQUAMOUS CELL; CELL LINE, TUMOR; FLOW CYTOMETRY; G1 PHASE; G2 PHASE; HUMAN PAPILLOMAVIRUS 16; HUMANS; KERATINOCYTES; ONCOGENE PROTEINS, VIRAL; OPEN READING FRAMES; OROPHARYNGEAL NEOPLASMS; PROTEIN ISOFORMS; RADIATION TOLERANCE; REPRESSOR PROTEINS; TRANSCRIPTIONAL ACTIVATION; TUMOR SUPPRESSOR PROTEIN P53;

EID: 79551505067     PISSN: 03603016     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijrobp.2010.06.028     Document Type: Article

References (35)

1. H. zur Hausen Papillomaviruses and cancer: From basic studies to clinical application Nat Rev Cancer 2 2002 342 350
2. K. Munger, and P.M. Howley Human papillomavirus immortalization and transformation functions Virus Res 89 2002 213 228
3. T. Yamada, T. Yamashita, and T. Nishikawa Biologic activity of human papillomavirus type 16 E6/E7 cDNA clones isolated from SiHa cervical carcinoma cell line Virus Genes 10 1995 15 25
4. S. Song, A. Liem, and J.A. Miller Human papillomavirus types 16 E6 and E7 contribute differently to carcinogenesis Virology 267 2000 141 150
5. S. Song, G.A. Gulliver, and P.F. Lambert Human papillomavirus type 16 E6 and E7 oncogenes abrogate radiation-induced DNA damage responses in vivo through p53-dependent and p53-independent pathways Proc Natl Acad Sci USA 95 1998 2290 2295
6. T. Andl, T. Kahn, and A. Pfuhl Etiological involvement of oncogenic human papillomavirus in tonsillar squamous cell carcinomas lacking retinoblastoma cell cycle control Cancer Res 58 1998 5 13
7. B.M. Brinkman, and D.T. Wong Disease mechanism and biomarkers of oral squamous cell carcinoma Curr Opin Oncol 18 2006 228 233
8. M.L. Gillison, W.M. Koch, and R.B. Capone Evidence for a causal association between human papillomavirus and a subset of head and neck cancers J Natl Cancer Inst 92 2000 709 720
9. K. Lindel, K.T. Beer, and J. Laissue Human papillomavirus positive squamous cell carcinoma of the oropharynx: A radiosensitive subgroup of head and neck carcinoma Cancer 92 2001 805 813
10. R. Herrero, X. Castellsague, and M. Pawlita Human papillomavirus and oral cancer: the International Agency for Research on Cancer multicenter study J Natl Cancer Inst 95 2003 1772 1783
11. W.H. Westra, J.M. Taube, and M.L. Poeta Inverse relationship between human papillomavirus-16 infection and disruptive p53 gene mutations in squamous cell carcinoma of the head and neck Clin Cancer Res 14 2008 366 369
12. S.M. Schwartz, J.R. Daling, and D.R. Doody Oral cancer risk in relation to sexual history and evidence of human papillomavirus infection J Natl Cancer Inst 90 1998 1626 1636
13. C. Fakhry, W.H. Westra, and S. Li Improved survival of patients with human papillomavirus-positive head and neck squamous cell carcinoma in a prospective clinical trial J Natl Cancer Inst 100 2008 261 269
14. W. Li, C.H. Thompson, and C.J. OBrien Human papillomavirus positivity predicts favourable outcome for squamous carcinoma of the tonsil Int J Cancer 106 2003 553 558
15. C.S. Kong, B. Narasimhan, and H. Cao The relationship between human papillomavirus status and other molecular prognostic markers in head and neck squamous cell carcinomas Int J Radiat Oncol Biol Phys 74 2009 553 561
16. B. Cummings, T. Keane, and M. Pintilie Five year results of a randomized trial comparing hyperfractionated to conventional radiotherapy over four weeks in locally advanced head and neck cancer Radiother Oncol 85 2007 7 16
17. A.K. Gupta, J.H. Lee, and W.W. Wilke Radiation response in two HPV-infected head-and-neck cancer cell lines in comparison to a non-HPV-infected cell line and relationship to signaling through AKT Int J Radiat Oncol Biol Phys 74 2009 928 933
18. C. Fallai, F. Perrone, and L. Licitra Oropharyngeal squamous cell carcinoma treated with radiotherapy or radiochemotherapy: Prognostic role of TP53 and HPV status Int J Radiat Oncol Biol Phys 52 2009 1345 1351
19. D.G. Brachman, M. Beckett, and D. Graves p53 mutation does not correlate with radiosensitivity in 24 head and neck cancer cell lines Cancer Res 53 1993 3667 3669
20. V. Patel, J.F. Ensley, and J.S. Gutkind Induction of apoptosis in head-and-neck squamous carcinoma cells by gamma-irradiation and bleomycin is p53-independent Int J Cancer 88 2000 737 743
21. R. Grenman, T.E. Carey, and K.D. McClatchey In vitro radiation resistance among cell lines established from patients with squamous cell carcinoma of the head and neck Cancer 67 1991 2741 2747
22. M. Cardinali, H. Pietraszkiewicz, and J.F. Ensley Tyrosine phosphorylation as a marker for aberrantly regulated growth-promoting pathways in cell lines derived from head and neck malignancies Int J Cancer 61 1995 98 103
23. J.G. Lyons, V. Patel, and N. Roue Snail up-regulates proinflammatory mediators and inhibits differentiation in oral keratinocytes Cancer Res 68 2008 4525 4530
24. W.S. el-Deiry, T. Tokino, and V.E. Velculescu WAF1, a potential mediator of p53 tumor suppression Cell 75 1993 817 825
25. M. Zhang, M. Boyer, and L. Rivory Radiosensitization of vinorelbine and gemcitabine in NCI-H460 non-small-cell lung cancer cells Int J Radiat Oncol Biol Phys 58 2004 353 360
26. Z.G. Liu, L.N. Zhao, and Y.W. Liu Activation of Cdc2 contributes to apoptosis in HPV E6 expressing human keratinocytes in response to therapeutic agents J Mol Biol 374 2007 334 345
27. H. Huang, C.Y. Li, and J.B. Little Abrogation of P53 function by transfection of HPV16 E6 gene does not enhance resistance of human tumour cells to ionizing radiation Int J Radiat Biol 70 1996 151 160
28. L. Hampson, E.S. El Hady, and J.V. Moore The HPV16 E6 and E7 proteins and the radiation resistance of cervical carcinoma FASEB J 15 2001 1445 1447
29. T.L. DeWeese, J.C. Walsh, and L.E. Dillehay Human papillomavirus E6 and E7 oncoproteins alter cell cycle progression but not radiosensitivity of carcinoma cells treated with low-dose-rate radiation Int J Radiat Oncol Biol Phys 37 1997 145 154
30. A. Shai, M.L. Nguyen, and J. Wagstaff HPV16 E6 confers p53-dependent and p53-independent phenotypes in the epidermis of mice deficient for E6AP Oncogene 26 2007 3321 3328
31. W.C. Dewey, C.C. Ling, and R.E. Meyn Radiation-induced apoptosis: Relevance to radiotherapy Int J Radiat Oncol Biol Phys 33 1995 781 796
32. M. Abend Reasons to reconsider the significance of apoptosis for cancer therapy Int J Radiat Biol 79 2003 927 941
33. E.C. de Bruin, and J.P. Medema Apoptosis and non-apoptotic deaths in cancer development and treatment response Cancer Treat Rev 34 2008 737 749
34. M. Filippova, M.M. Johnson, and M. Bautista The large and small isoforms of human papillomavirus type 16 E6 bind to and differentially affect procaspase 8 stability and activity J Virol 81 2007 4116 4129
35. B. Ramser, A. Kokot, and D. Metze Hydroxychloroquine modulates metabolic activity and proliferation and induces autophagic cell death of human dermal fibroblasts J Invest Dermatol 2009 advance online publication