Melatonin inhibits tachykinin NK 2 receptor-triggered 5-HT release from guinea pig isolated colonic mucosa

British Journal of Pharmacology

Volumn 162, Issue 5, 2011, Pages 1179-1185

  Kojima, Shu Ichi ^a   Tohei, Atsushi ^a   Ikeda, Masashi ^a  

^a DOKKYO MEDICAL UNIVERSITY   (Japan)

Author keywords

5 HT release; colon; melatonin; MT 3 melatonin receptor; NK 2 receptors; serotonin release; tachykinin

Indexed keywords

5 HYDROXYINDOLEACETIC ACID; 5 METHOXYCARBONYLAMINO N ACETYLTRYPTAMINE; HORMONE RECEPTOR BLOCKING AGENT; HORMONE RECEPTOR STIMULATING AGENT; LUZINDOLE; MELATONIN; MELATONIN 1 RECEPTOR; MELATONIN 2 RECEPTOR; MELATONIN 3 RECEPTOR; MELATONIN RECEPTOR; N PENTANOYL 2 BENZYLTRYPTAMINE; NEUROKININ 2 RECEPTOR; NEUROKININ A [4-10][8 BETA ALANINE]; PRAZOSIN; SEROTONIN; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; COLON MOTILITY; COLON MUCOSA; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG MECHANISM; GUINEA PIG; MALE; NONHUMAN; PRIORITY JOURNAL; SEROTONIN RELEASE;

ANIMALS; COLON; GUINEA PIGS; HYDROXYINDOLEACETIC ACID; INTESTINAL MUCOSA; MELATONIN; NEUROKININ A; PEPTIDE FRAGMENTS; PRAZOSIN; RECEPTORS, MELATONIN; RECEPTORS, NEUROKININ-2; SEROTONIN; TRYPTAMINES;

EID: 79551500591     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/j.1476-5381.2010.01122.x     Document Type: Article

References (26)

1. Bertrand PP, Bertrand RL, Camello PJ, Pozo MJ, (2010). Simultaneous measurement of serotonin and melatonin from the intestine of old mice: the effects of daily melatonin supplementation. J Pineal Res 49: 23-34.
2. Bubenik GA, (2008). Thirty four years since the discovery of gastrointestinal melatonin. J Physiol Pharmacol 59: 33-51.
3. Camilleri M, (2002). Serotonergic modulation of visceral sensation: lower gut. Gut 51 (Suppl. 1): i81-i86.
4. Coates MD, Mahoney CR, Linden DR, Sampson JE, Chen J, Blaszyk H, et al. (2004). Molecular defects in mucosal serotonin content and decreased serotonin reuptake transporter in ulcerative colitis and irritable bowel syndrome. Gastroenterology 126: 1657-1664.
5. Dubocovich ML, (1988). Luzindole (N-0774): a novel melatonin receptor antagonist. J Pharmacol Exp Ther 246: 902-910.
6. Dubocovich ML, Rivera-Bermudez MA, Gerdin MJ, Masana MI, (2003). Molecular pharmacology, regulation and function of mammalian melatonin receptors. Front Biosci 8: d1093-d1108.
7. Gershon MD, Tack J, (2007). The serotonin signaling system: from basic understanding to drug development for functional GI disorders. Gastroenterology 132: 397-414.
8. Jockers R, Maurice P, Boutin JA, Delagrange P, (2008). Melatonin receptors, heterodimerization, signal transduction and binding sites: what's new? Br J Pharmacol 154: 1182-1195.
9. 3 receptors. Br J Pharmacol 141: 385-390.
10. 2-receptor-triggered serotonin release from guinea-pig colonic mucosa. J Pharamcol Sci 98: 175-180.
11. 2 receptor-triggered serotonin release from guinea-pig proximal colon. J Pharmacol Sci 110: 122-126.
12. Lu WZ, Gwee KA, Moochhalla S, Ho KY, (2005). Melatonin improves bowel symptoms in female patients with irritable bowel syndrome: a double-blind placebo-controlled study. Aliment Pharmacol Ther 22: 927-934.
13. Lu WZ, Song GH, Gwee KA, Ho KY, (2009). The effects of melatonin on colonic transit time in normal control and IBS patients. Dig Dis Sci 54: 1087-1093.
14. 4 and melatonin receptors. Br J Pharmacol 121: 1775-1781.
15. Miwa J, Echizen H, Matsueda K, Umeda N, (2001). Patients with constipation-predominant irritable bowel syndrome (IBS) may have elevated serotonin concentrations in colonic mucosa as compared with diarrhea-predominant patients and subjects with normal bowel habits. Digestion 63: 188-194.
16. 2- and sodium nitroprusside-induced ion secretion in rat distal colon. Eur J Pharmacol 581: 164-170.
17. 125I]iodomelatonin binding sites in syrian hamster peripheral organs. J Pharmacol Exp Ther 290: 334-340.
18. Pintor J, Pelaez T, Hoyle CHV, Peral A, (2003). Ocular hypotensive effects of melatonin receptor agonists in the rabbit: further evidence for an MT3 receptor. Br J Pharmacol 138: 831-836.
19. Portbury AL, Furness JB, Southwell BR, Wong H, Walsh JH, Bunnett NW, (1996). Distribution of neurokinin-2 receptors in the guinea-pig gastrointestinal tract. Cell Tissue Res 286: 281-292.
20. Racke K, Schworer H, (1991). Regulation of serotonin release from the intestinal mucosa. Pharmacol Res 23: 13-25.
21. Santagostino-Barbone MG, Masoero E, Spelta V, Lucchelli A, (2000). 2-Phenylmelatonin: a partial agonist at enteric melatonin receptors. Pharmacol Toxicol 87: 156-160.
22. Song GH, Leng PH, Gwee KA, Moochhala SM, Ho KY, (2005). Melatonin improves abdominal pain in irritable bowel syndrome patients who have sleep disturbances-a randomized double blind placebo controlled study. Gut 54: 1402-1407.
23. Stebelova K, Anttila K, Manttari S, Saarela S, Zeman M, (2010). Immunohistochemical definition of MT(2) receptors and melatonin in the gastrointestinal tissues of rat. Acta Histochem 112: 26-33.
24. Ting KN, Blaylock NA, Sugden D, Delagrange P, Scalbert E, Wilson VG, (1999). Molecular and phaemacological evidence for MT1 melatonin receptor subtype in the tail artery of juvenile wistar rats. Br J Pharmacol 127: 987-995.
25. Van Rossum JM, (1963). Cumulative dose-reponse curves. II. Technique for the making of dose-response curves in isolated organs and the evaluation of drug parameters. Arch Int Pharmacodyn 143: 299-330.
26. Wardell CF, Bornstein JC, Furness JB, (1994). Projection of 5-hydroxytryptamine-immunoreactive neurons in guinea-pig distal colon. Cell Tissue Res 278: 379-387.