Detrimental effects of thyroid hormone analog DITPA in the mouse heart: Increased mortality with in vivo acute myocardial ischemia-reperfusion

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 300, Issue 2, 2011, Pages

  Hassan Talukder, M A ^a   Yang, Fuchun ^a,d   Nishijima, Yoshinori ^a   Chen, Chun An ^a   Xie, Lin ^a   Mahamud, Shouvik D ^a   Kalyanasundaram, Anuradha ^b   Bonagura, John D ^c   Periasamy, Muthu ^b   Zweier, Jay L ^a,b  

^a OHIO STATE UNIVERSITY   (United States)

^b THE OHIO STATE UNIVERSITY COLLEGE OF MEDICINE   (United States)

^c OHIO STATE UNIVERSITY   (United States)

^d GUANGXI MEDICAL UNIVERSITY   (China)

Author keywords

Cardiac function; Fatal cardiac rhythm; Postischemic recovery

Indexed keywords

3,5 DIIODOTHYROPROPIONIC ACID; HEAT SHOCK PROTEIN; PHOSPHOLAMBAN; SARCOPLASMIC RETICULUM CALCIUM TRANSPORTING ADENOSINE TRIPHOSPHATASE; THYROID HORMONE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BODY TEMPERATURE; BODY WEIGHT; CARDIOVASCULAR FUNCTION; CONTROLLED STUDY; DOSE RESPONSE; DRUG DOSE INCREASE; DRUG EFFECT; EX VIVO STUDY; HEART MUSCLE CONTRACTILITY; HEART MUSCLE ISCHEMIA; HEART RATE; HEART RHYTHM; HYPERTENSION; IN VIVO STUDY; ISOLATED HEART; MORTALITY; MOUSE; NONHUMAN; PRIORITY JOURNAL; REPERFUSION INJURY; STATISTICAL SIGNIFICANCE;

ANIMALS; ARRHYTHMIAS, CARDIAC; BLOOD PRESSURE; BLOTTING, WESTERN; CARDIOTONIC AGENTS; DATA INTERPRETATION, STATISTICAL; DIIODOTHYRONINES; DOSE-RESPONSE RELATIONSHIP, DRUG; ECHOCARDIOGRAPHY; ELECTROCARDIOGRAPHY; HEART; MALE; MICE; MICE, INBRED C57BL; MYOCARDIAL INFARCTION; MYOCARDIAL REPERFUSION INJURY; PROPIONIC ACIDS; SYMPATHOMIMETICS; THYROXINE; TRIIODOTHYRONINE; VENTRICULAR FUNCTION, LEFT;

EID: 79551497054     PISSN: 03636135     EISSN: 15221539     Source Type: Journal    
DOI: 10.1152/ajpheart.00514.2010     Document Type: Article

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