C-reactive protein: Just a biomarker of inflammation or a pathophysiological player in myocardial function and morphology?

Hypertension

Volumn 57, Issue 2, 2011, Pages 151-153

  Schulz, Rainer ^a   Heusch, Gerd ^b  

^a JUSTUS LIEBIG UNIVERSITY   (Germany)

^b UNIVERSITY HOSPITAL ESSEN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

APOLIPOPROTEIN E; C REACTIVE PROTEIN; LOW DENSITY LIPOPROTEIN RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE; NITRIC OXIDE SYNTHASE;

ARTERIAL WALL THICKNESS; ARTIFICIAL EMBOLISM; ATHEROSCLEROSIS; ATHEROSCLEROTIC PLAQUE; CARDIOVASCULAR DISEASE; DNA POLYMORPHISM; ENDOTHELIAL DYSFUNCTION; GENOTYPE; HEART FUNCTION; HEART INFARCTION; HUMAN; INFLAMMATION; MICROCIRCULATION; MONOCYTE; MORTALITY; NON ST SEGMENT ELEVATION MYOCARDIAL INFARCTION; NONHUMAN; NOTE; PATHOPHYSIOLOGY; PERIPHERAL OCCLUSIVE ARTERY DISEASE; PREDICTION; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; STROKE; SUDDEN DEATH; THROMBOCYTE AGGREGATION; VASODILATATION;

ANIMALS; C-REACTIVE PROTEIN; GENE EXPRESSION; GLUTATHIONE PEROXIDASE; HEART; HUMANS; IMMUNOBLOTTING; INFLAMMATION; INTERLEUKIN-6; MICE; MICE, TRANSGENIC; MODELS, BIOLOGICAL; MYOCARDIUM; NADPH OXIDASE; REACTIVE OXYGEN SPECIES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TUMOR NECROSIS FACTOR-ALPHA; VENTRICULAR REMODELING;

EID: 79551496263     PISSN: 0194911X     EISSN: None     Source Type: Journal    
DOI: 10.1161/HYPERTENSIONAHA.110.165837     Document Type: Note

References (10)

1. Zacho J, Tybjaerg-Hansen A, Nordestgaard BG. C-reactive protein and all-cause mortality - the Copenhagen City Heart Study. Eur Heart J. 2010;31:1624-1632.
2. Kaptoge S, Di AE, Lowe G, Pepys MB, Thompson SG, Collins R, Danesh J. C-reactive protein concentration and risk of coronary heart disease, stroke, and mortality: an individual participant meta-analysis. Lancet. 2010;375:132-140.
3. Heusch G, Kleinbongard P, Bose D, Levkau B, Haude M, Schulz R, Erbel R. Coronary microembolization: from bedside to bench and back to bedside. Circulation. 2009;120:1822-1836.
4. Bahrmann P, Werner GS, Heusch G, Ferrari M, Poerner TC, Voss A, Figulla HR. Detection of coronary microembolization by Doppler ultrasound in patients with stable angina pectoris undergoing elective percutaneous coronary interventions. Circulation. 2007;115:600-608.
5. Nagai T, Anzai T, Kaneko H, Mano Y, Anzai A, Maekawa Y, Takahashi T, Meguro T, Yoshikawa T, Fukuda K. C-reactive protein overexpression exacerbates pressure overload-induced cardiac remodeling through enhanced inflammatory response. Hypertension. 2011;57:208-215.
6. Zhang R, Zhang YY, Huang XR, Wu Y, Chung AC, Wu EX, Szalai AJ, Wong BC, Lau CP, Lan HY. C-reactive protein promotes cardiac fibrosis and inflammation in angiotensin II-induced hypertensive cardiac disease. Hypertension. 2010;55:953-960.
7. Takahashi T, Anzai T, Kaneko H, Mano Y, Anzai A, Nagai T, Kohno T, Maekawa Y, Yoshikawa T, Fukuda K, Ogawa S. Increased C-reactive protein expression exacerbates left ventricular dysfunction and remodeling after myocardial infarction. Am J Physiol Heart Circ Physiol. 2010; 299:H1795-H1804.
8. Heusch P, Canton M, Aker S, van de SA, Konietzka I, Rassaf T, Menazza S, Brodde OE, Di LF, Heusch G, Schulz R. The contribution of reactive oxygen species and p38 mitogen-activated protein kinase to myofilament oxidation and progression of heart failure in rabbits. Br J Pharmacol. 2010;160:1408-1416.
9. Heusch P, Aker S, Boengler K, Deindl E, van de SA, Klein K, Rassaf T, Konietzka I, Sewell A, Menazza S, Canton M, Heusch G, Di LF, Schulz R. Increased inducible nitric oxide synthase and arginase II expression in heart failure: no net nitrite/nitrate production and protein S-nitrosylation. Am J Physiol Heart Circ Physiol. 2010;299:H446-H453.
10. Yun KH, Jeong MH, Oh SK, Rhee SJ, Park EM, Lee EM, Yoo NJ, Kim NH, Ahn YK, Jeong JW. Response of high-sensitivity C-reactive protein to percutaneous coronary intervention in patients with acute coronary syndrome. Heart Vessels. 2009;24:175-180.