Feasibility Study of an Intensity-Modulated Radiation Model for the Study of Erectile Dysfunction

Journal of Sexual Medicine

Volumn 8, Issue 2, 2011, Pages 411-418

  Koontz, Bridget F ^a   Yan, Hui ^a   Kimura, Masaki ^a   Vujaskovic, Zeljko ^a   Donatucci, Craig ^a   Yin, Fang Fang ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Animal Model; Erectile Dysfunction; Intensity Modulated Radiation Therapy; Prostate Cancer; Radiation Associated Erectile Dysfunction; Stereotactic

Indexed keywords

ANIMAL EXPERIMENT; ANIMAL MODEL; AREA UNDER THE CURVE; ARTICLE; COLLIMATOR; CONTROLLED STUDY; DIAGNOSTIC IMAGING; ERECTILE DYSFUNCTION; FEASIBILITY STUDY; INTENSITY MODULATED RADIATION THERAPY; IRRADIATION; MALE; MEAN ARTERIAL PRESSURE; NERVE STIMULATION; NONHUMAN; ORGAN SIZE; PRIORITY JOURNAL; QUALITY CONTROL; RADIATION DOSE FRACTIONATION; RAT; SPRAGUE DAWLEY RAT; STEREOTACTIC RADIOSURGERY; TREATMENT PLANNING;

EID: 79551494708     PISSN: 17436095     EISSN: 17436109     Source Type: Journal    
DOI: 10.1111/j.1743-6109.2010.02125.x     Document Type: Article

References (25)

1. Meltzer D, Egleston B, Abdalla I. Patterns of prostate cancer treatment by clinical stage and age. Am J Public Health 2001;91:126-8.
2. Incrocci L. Sexual function after external-beam radiotherapy for prostate cancer: What do we know? Crit Rev Oncol Hematol 2006;57:165-73.
3. Teloken PE, Parker M, Mohideen N, Mulhall JP. Predictors of response to sildenafil citrate following radiation therapy for prostate cancer. J Sex Med 2009;6:1135-40.
4. Goldstein I, Feldman MI, Deckers PJ, Babayan RK, Krane RJ. Radiation-associated impotence. A clinical study of its mechanism. JAMA 1984;251:903-10.
5. Mulhall J, Ahmed A, Parker M, Mohideen N. The hemodynamics of erectile dysfunction following external beam radiation for prostate cancer. J Sex Med 2005;2:432-7.
6. Zelefsky MJ, Eid JF. Elucidating the etiology of erectile dysfunction after definitive therapy for prostatic cancer. Int J Radiat Oncol Biol Phys 1998;40:129-33.
7. Incrocci L. Radiation therapy for prostate cancer and erectile (dys)function: The role of imaging. Acta Oncol 2005;44:673-8.
8. van der Wielen GJ, Mulhall JP, Incrocci L. Erectile dysfunction after radiotherapy for prostate cancer and radiation dose to the penile structures: A critical review. Radiother Oncol 2007;84:107-13.
9. Sadovsky R, Basson R, Krychman M, Morales AM, Schover L, Wang R, Incrocci L. Cancer and sexual problems. The J Sexual Medicine 2010;7:349-73.
10. Azadzoi KM, Goldstein I. Erectile dysfunction due to atherosclerotic vascular disease: The development of an animal model. J Urol 1992;147:1675-81.
11. Canguven O, Burnett A. Cavernous nerve injury using rodent animal models. J Sex Med 2008;5:1776-85.
12. Gur S, Kadowitz PJ, Hellstrom WJ. A critical appraisal of erectile function in animal models of diabetes mellitus. Int J Androl 2008.
13. Kovanecz I, Ferrini MG, Vernet D, Nolazco G, Rajfer J, Gonzalez-Cadavid NF. Ageing-related corpora veno-occlusive dysfunction in the rat is ameliorated by pioglitazone. BJU Int 2007;100:867-74.
14. Carrier S, Hricak H, Lee SS, Baba K, Morgan DM, Nunes L, Ross GY, Phillips TL, Lue TF. Radiation-induced decrease in nitric oxide synthase-Containing nerves in the rat penis. Radiology 1995;195:95-9.
15. Merlin SL, Brock GB, Begin LR, Hiou Tim FF, Macramalla AN, Seyam RM, Shenouda G, Dion SB. New insights into the role of endothelin-1 in radiation-associated impotence. Int J Impot Res 2001;13:104-9.
16. van der Wielen GJ, Vermeij M, de Jong BW, Schuit M, Marijnissen J, Kok DJ, van Weerden WM, Incrocci L. Changes in the penile arteries of the rat after fractionated irradiation of the prostate: A pilot study. J Sex Med 2009;6:1908-13.
17. Nelson JW, Yoo DS, Sampson JH, Isaacs RE, Larrier NA, Marks LB, Yin FF, Wu QJ, Wang Z, Kirkpatrick JP. Stereotactic body radiotherapy for lesions of the spine and paraspinal regions. Int J Radiat Oncol Biol Phys 2009;73:1369-75.
18. Timmerman RD, Kavanagh BD, Cho LC, Papiez L, Xing L. Stereotactic body radiation therapy in multiple organ sites. J Clin Oncol 2007;25:947-52.
19. Chang Z, Wang Z, Wu QJ, Yan H, Bowsher J, Zhang J, Yin FF. Dosimetric characteristics of novalis Tx system with high definition multileaf collimator. Med Phys 2008;35:4460-3.
20. Wu QJ, Yoo S, Kirkpatrick JP, Thongphiew D, Yin FF. Volumetric arc intensity-modulated therapy for spine body radiotherapy: Comparison with static intensity-modulated treatment. Int J Radiat Oncol Biol Phys 2009;75:1596-604.
21. Yin FF, Ryu S, Ajlouni M, Yan H, Jin JY, Lee SW, Kim J, Rock J, Rosenblum M, Kim JH. Image-guided procedures for intensity-modulated spinal radiosurgery. Technical note. J Neurosurg 2004;101(3 suppl):419-24.
22. Ju SG, Han Y, Kum O, Cheong KH, Shin EH, Shin JS, Kim JS, Ahn YC. Comparison of film dosimetry techniques used for quality assurance of intensity modulated radiation therapy. Med Phys 2010;37:2925-33.
23. Low DA, Harms WB, Mutic S, Purdy JA. A technique for the quantitative evaluation of dose distributions. Med Phys 1998;25:656-61.
24. Carneiro FS, Nunes KP, Giachini FR, Lima VV, Carneiro ZN, Nogueira EF, Leite R, Ergul A, Rainey WE, Clinton Webb R, Tostes RC. Activation of the ET-1/ETA pathway contributes to erectile dysfunction associated with mineralocorticoid hypertension. J Sex Med 2008;5:2793-807.
25. Proietti M, Aversa A, Letizia C, Rossi C, Menghi G, Bruzziches R, Merla A, Spera G, Salsano F. Erectile dysfunction in systemic sclerosis: Effects of longterm inhibition of phosphodiesterase type-5 on erectile function and plasma endothelin-1 levels. J Rheumatol 2007;34:1712-7.