Blood gene expression reveal pathway differences between diet-sensitive and resistant obese subjects prior to caloric restriction

Obesity

Volumn 19, Issue 2, 2011, Pages 457-463

  Ghosh, Sujoy ^a   Dent, Robert ^b   Harper, Mary E ^c   Stuart, Joan ^d   McPherson, Ruth ^e  

^a NORTH CAROLINA CENTRAL UNIVERSITY   (United States)

^b UNIVERSITY OF OTTAWA   (Canada)

^c UNIVERSITY OF OTTAWA   (Canada)

^d GLAXOSMITHKLINE   (United States)

^e UNIVERSITY OF OTTAWA HEART INSTITUTE   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEASOME; PROTON;

ADULT; ARTICLE; BLOOD ANALYSIS; CALORIC RESTRICTION; CLINICAL ARTICLE; COHORT ANALYSIS; CONTROLLED STUDY; DIET; DIET THERAPY; FEMALE; GENE; GENE EXPRESSION PROFILING; GENETICS; HUMAN; MALE; METABOLISM; MIDDLE AGED; OBESITY; OXIDATIVE PHOSPHORYLATION; OXPHOS GENE; SIGNAL TRANSDUCTION; SKELETAL MUSCLE; TREATMENT FAILURE; UPREGULATION; WEIGHT REDUCTION;

CALORIC RESTRICTION; COHORT STUDIES; FEMALE; GENE EXPRESSION PROFILING; HUMANS; MALE; MIDDLE AGED; OBESITY; OXIDATIVE PHOSPHORYLATION; PROTONS; TREATMENT FAILURE; WEIGHT LOSS;

EID: 79551492462     PISSN: 19307381     EISSN: 1930739X     Source Type: Journal    
DOI: 10.1038/oby.2010.209     Document Type: Article

References (16)

1. Dent R, McPherson R, Harper ME. Variability in weight loss in highly compliant women on a controlled dietary regimen. Obes Res 1999;7(Suppl 1).
2. Harper ME, Dent R, Monemdjou S et al. Decreased mitochondrial proton leak and reduced expression of uncoupling protein 3 in skeletal muscle of obese diet-resistant women. Diabetes 2002;51:2459-2466.
3. Dent RM, Penwarden RM, Harris N, Hotz SB. Development and evaluation of patient-centered software for a weight-management clinic. Obes Res 2002;10:651-656.
4. Batliwalla FM, Baechler EC, Xiao X et al. Peripheral blood gene expression profiling in rheumatoid arthritis. Genes Immun 2005;6:388-397.
5. Glatt SJ, Everall I P, Kremen WS et al. Comparative gene expression analysis of blood and brain provides concurrent validation of SELENBP1 up-regulation in schizophrenia. Proc Natl Acad Sci USA 2005;102:15533-15538.
6. Vernon SD, Unger ER, Dimulescu IM, Rajeevan M, Reeves WC. Utility of the blood for gene expression profiling and biomarker discovery in chronic fatigue syndrome. Dis Markers 2002;18:193-199.
7. Irizarry RA, Wu Z, Jaffee HA. Comparison of Affymetrix GeneChip expression measures. Bioinformatics 2006;22:789-794.
8. Baldi P, Long AD. A Bayesian framework for the analysis of microarray expression data: regularized t -test and statistical inferences of gene changes. Bioinformatics 2001;17:509-519.
9. Mootha VK, Lindgren CM, Eriksson KF et al. PGC-1alpha-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes. Nat Genet 2003;34:267-273.
10. Dennis G Jr, Sherman BT, Hosack DA et al. DAVID: Database for Annotation, Visualization, and Integrated Discovery. Genome Biol 2003;4:P3.
11. Hosack DA, Dennis G Jr, Sherman BT, Lane HC, Lempicki RA. Identifying biological themes within lists of genes with EASE. Genome Biol 2003;4:R70.
12. Rikke BA, Battaglia ME, Allison DB, Johnson TE. Murine weight loss exhibits significant genetic variation during dietary restriction. Physiol Genomics 2006;27:122-130.
13. Chang TL, Chang CJ, Lee WY et al. The roles of ubiquitin and 26S proteasome in human obesity. Metab Clin Exp 2009;58:1643-1648.
14. Sakamoto K, Sato Y, Shinka T et al. Proteasome subunits mRNA expressions correlate with male BMI: implications for a role in obesity. Obesity (Silver Spring) 2009;17:1044-1049.
15. Larrouy D, Barbe P, Valle C et al. Gene expression profiling of human skeletal muscle in response to stabilized weight loss. Am J Clin Nutr 2008;88:125-132.
16. Farley D, Tejero ME, Comuzzie AG et al. Feto-placental adaptations to maternal obesity in the baboon. Placenta 2009;30:752-760.