-
1
-
-
12244301581
-
In vivo antitumor activity of SU11248, a novel tyrosine kinase inhibitor targeting vascular endothelial growth factor and platelet-derived growth receptors: Determination of a pharmacokinetic/pharmacodynamic relationship
-
Mendel DB, Laird AD, Xin X, Louie SG, Christensen JG, Li G, Schreck RE, Abrams TJ, Ngai TJ, Lee LB, Murray LJ, Carver J, Chan E, Moss KG, Haznedar JO, Sukbuntherng J, Blake RA, Sun L, Tang C, Miller T, Shirazian S, McMahon G, Cherrington JM: In vivo antitumor activity of SU11248, a novel tyrosine kinase inhibitor targeting vascular endothelial growth factor and platelet-derived growth receptors: determination of a pharmacokinetic/pharmacodynamic relationship. Clin Cancer Res, 9: 327-337, 2003.
-
(2003)
Clin Cancer Res
, vol.9
, pp. 327-337
-
-
Mendel, D.B.1
Laird, A.D.2
Xin, X.3
Louie, S.G.4
Christensen, J.G.5
Li, G.6
Schreck, R.E.7
Abrams, T.J.8
Ngai, T.J.9
Lee, L.B.10
Murray, L.J.11
Carver, J.12
Chan, E.13
Moss, K.G.14
Haznedar, J.O.15
Sukbuntherng, J.16
Blake, R.A.17
Sun, L.18
Tang, C.19
Miller, T.20
Shirazian, S.21
McMahon, G.22
Cherrington, J.M.23
more..
-
2
-
-
78650874372
-
SU11248 inhibits KIT and platelet-derived growth factor receptor beta in preclinical models of human small cell lung cancer
-
Abrams TJ, Lee LB, Murray LJ, Pryer NK, Cherrington JM: SU11248 inhibits KIT and platelet-derived growth factor receptor beta in preclinical models of human small cell lung cancer. Mol Cancer Ther, 2: 471-478, 2003.
-
(2003)
Mol Cancer Ther
, vol.2
, pp. 471-478
-
-
Abrams, T.J.1
Lee, L.B.2
Murray, L.J.3
Pryer, N.K.4
Cherrington, J.M.5
-
3
-
-
9144274970
-
SU 11248 inhibits tumor growth and CSF-1R-dependent osteolysis in a experimental breast cancer bone metastasis model
-
Murray LJ, Abrams TJ, Long KR, Ngai TJ, Olson LM, Hong W, Keast PK, Brassard JA, O'Farrell AM, Cherrington JM, Pryer NK: SU 11248 inhibits tumor growth and CSF-1R-dependent osteolysis in a experimental breast cancer bone metastasis model. Clin Exp Metastasis, 20: 757-766, 2003.
-
(2003)
Clin Exp Metastasis
, vol.20
, pp. 757-766
-
-
Murray, L.J.1
Abrams, T.J.2
Long, K.R.3
Ngai, T.J.4
Olson, L.M.5
Hong, W.6
Keast, P.K.7
Brassard, J.A.8
O'Farrell, A.M.9
Cherrington, J.M.10
Pryer, N.K.11
-
4
-
-
0038204144
-
SU11248 is a novel FLT3 tyrosine kinase inhibitor with potent activity in vitro and in vivo
-
O'Farrell AM, Abrams TJ, Yuen HA, Ngai TJ, Louie SG, Yee KW, Wong LM, Hong W, Lee LB, Town A, Smolich BD, Manning WC, Murray LJ, Heinrich MC, Cherrington JM: SU11248 is a novel FLT3 tyrosine kinase inhibitor with potent activity in vitro and in vivo. Blood, 101: 3597-3605, 2003.
-
(2003)
Blood
, vol.101
, pp. 3597-3605
-
-
O'Farrell, A.M.1
Abrams, T.J.2
Yuen, H.A.3
Ngai, T.J.4
Louie, S.G.5
Yee, K.W.6
Wong, L.M.7
Hong, W.8
Lee, L.B.9
Town, A.10
Smolich, B.D.11
Manning, W.C.12
Murray, L.J.13
Heinrich, M.C.14
Cherrington, J.M.15
-
5
-
-
33644847440
-
Safety, pharmacokinetic, and antitumor activity of SU11248, a novel oral multitarget tyrosine kinase inhibitor, in patients with cancer
-
Faivre S, Delbaldo C, Vera K, Robert C, Lozahic S, Lassau N, Bello C, Deprimo S, Brega N, Massimini G, Armand JP, Scigalla P, Raymond E: Safety, pharmacokinetic, and antitumor activity of SU11248, a novel oral multitarget tyrosine kinase inhibitor, in patients with cancer. J Clin Oncol, 24: 25-35, 2006.
-
(2006)
J Clin Oncol
, vol.24
, pp. 25-35
-
-
Faivre, S.1
Delbaldo, C.2
Vera, K.3
Robert, C.4
Lozahic, S.5
Lassau, N.6
Bello, C.7
Deprimo, S.8
Brega, N.9
Massimini, G.10
Armand, J.P.11
Scigalla, P.12
Raymond, E.13
-
6
-
-
49149114782
-
Activity of sunitinib in patients with advanced neuroendocrine tumors
-
Kulke MH, Lenz HJ, Meropol NJ, Posey J, Ryan DP, Picus J, Bergsland E, Stuart K, Tye L, Huang X, Li JZ, Baum CM, Fuchs C: Activity of sunitinib in patients with advanced neuroendocrine tumors. J Clin Oncol, 26: 3403-3410, 2006.
-
(2006)
J Clin Oncol
, vol.26
, pp. 3403-3410
-
-
Kulke, M.H.1
Lenz, H.J.2
Meropol, N.J.3
Posey, J.4
Ryan, D.P.5
Picus, J.6
Bergsland, E.7
Stuart, K.8
Tye, L.9
Huang, X.10
Li, J.Z.11
Baum, C.M.12
Fuchs, C.13
-
7
-
-
0034594628
-
New guidelines to evaluate the response to treatment in solid tumors
-
Therasse P, Arbuck SG, Eisenhauer EA, Wanders J, Kaplan RS, Rubinstein L, Verweij J, Van Glabbeke M, van Oosterom AT, Christian MC, Gwyther SG: New guidelines to evaluate the response to treatment in solid tumors. J Natl Cancer Inst, 92: 205-216, 2000.
-
(2000)
J Natl Cancer Inst
, vol.92
, pp. 205-216
-
-
Therasse, P.1
Arbuck, S.G.2
Eisenhauer, E.A.3
Wanders, J.4
Kaplan, R.S.5
Rubinstein, L.6
Verweij, J.7
Van Glabbeke, M.8
Van Oosterom, A.T.9
Christian, M.C.10
Gwyther, S.G.11
-
8
-
-
0036118172
-
How many pathways to pheochromocytomas?
-
Neumann HPH, Hoegerle S, Manz T, Brenner K, Iliopoulos O: How many pathways to pheochromocytomas? Semin Nephrol, 22: 88-99, 2002.
-
(2002)
Semin Nephrol
, vol.22
, pp. 88-99
-
-
Neumann, H.P.H.1
Hoegerle, S.2
Manz, T.3
Brenner, K.4
Iliopoulos, O.5
-
10
-
-
0031752341
-
Benign and malignant pheochromocytoma: Diagnosis, treatment and follow-up
-
Kebebew E, Duh QY: Benign and malignant pheochromocytoma: diagnosis, treatment and follow-up. Surg Oncol Clin N Am, 7: 765-789, 1998.
-
(1998)
Surg Oncol Clin N Am
, vol.7
, pp. 765-789
-
-
Kebebew, E.1
Duh, Q.Y.2
-
11
-
-
0028198770
-
Evolving concepts in the pathophysiology, diagnosis and treatment of pheochromocytoma
-
Bravo EL: Evolving concepts in the pathophysiology, diagnosis and treatment of pheochromocytoma. Endocr Rev, 15: 356-368, 1994.
-
(1994)
Endocr Rev
, vol.15
, pp. 356-368
-
-
Bravo, E.L.1
-
12
-
-
0021357206
-
Phaeochromocytoma and acute cardiovascular death (with special reference tomyocardial infarction)
-
Cohen CD, Dent DM: Phaeochromocytoma and acute cardiovascular death (with special reference tomyocardial infarction). Postgrad Med, 60: 111-115, 1984.
-
(1984)
Postgrad Med
, vol.60
, pp. 111-115
-
-
Cohen, C.D.1
Dent, D.M.2
-
13
-
-
0014006877
-
The neurologist's experience with pheochromocytoma: A review of 100 cases
-
Thomas JE, Rooke ED, Kvale WF: The neurologist's experience with pheochromocytoma: a review of 100 cases. JAMA, 197: 754-758, 1966.
-
(1966)
JAMA
, vol.197
, pp. 754-758
-
-
Thomas, J.E.1
Rooke, E.D.2
Kvale, W.F.3
-
14
-
-
0041388525
-
Adrenal medulla and pathology
-
Besser GM, Thorner MO (eds), 3rd ed, Elsevier Science, Philadelphia
-
Grossman AB, Kaltsas G: Adrenal medulla and pathology. In: Comprehensive clinical endocrinology, Besser GM, Thorner MO (eds), pp 223-237, 3rd ed, Elsevier Science, Philadelphia, 2002.
-
(2002)
Comprehensive Clinical Endocrinology
, pp. 223-237
-
-
Grossman, A.B.1
Kaltsas, G.2
-
15
-
-
55749091604
-
Treatment of malignant pheochromocytoma/ paraganglioma with cyclophosphamide, vincristine, and dacarbazine: Recommendation from a 22-year follow-up of 18 patients
-
Huang H, Abraham J, Hung E, Averbuch S, Merino M, Steinberg SM, Pacak K, Fojo T:Treatment of malignant pheochromocytoma/ paraganglioma with cyclophosphamide, vincristine, and dacarbazine: recommendation from a 22-year follow-up of 18 patients. Cancer, 113: 2020-2028, 2008.
-
(2008)
Cancer
, vol.113
, pp. 2020-2028
-
-
Huang, H.1
Abraham, J.2
Hung, E.3
Averbuch, S.4
Merino, M.5
Steinberg, S.M.6
Pacak, K.7
Fojo, T.8
-
16
-
-
33644846851
-
Phase II study of temozolomide and thalidomide in patients with metastatic neuroendocrine tumors
-
Kulke MH, Stuart K, Enzinger PC, Ryan DP, Clark JW, Mazikansky A, Vincitore M, Michelini A, Fuchs CS: Phase II study of temozolomide and thalidomide in patients with metastatic neuroendocrine tumors. J Clin Oncol, 24: 401-406, 2006.
-
(2006)
J Clin Oncol
, vol.24
, pp. 401-406
-
-
Kulke, M.H.1
Stuart, K.2
Enzinger, P.C.3
Ryan, D.P.4
Clark, J.W.5
Mazikansky, A.6
Vincitore, M.7
Michelini, A.8
Fuchs, C.S.9
-
17
-
-
0025028868
-
Detection of somatostatin receptors in surgical and percutaneous needle biopsy samples of carcinoids and islet cell carcinomas
-
Reubi JC, Kvols LK, Waser B, Nagorney DM, Heitz PU, Charboneau JW, Reading CC, Moertel C: Detection of somatostatin receptors in surgical and percutaneous needle biopsy samples of carcinoids and islet cell carcinomas. Cancer Res, 50: 5969-5977, 1990.
-
(1990)
Cancer Res
, vol.50
, pp. 5969-5977
-
-
Reubi, J.C.1
Kvols, L.K.2
Waser, B.3
Nagorney, D.M.4
Heitz, P.U.5
Charboneau, J.W.6
Reading, C.C.7
Moertel, C.8
-
18
-
-
3442884868
-
Consensus report on the use of somatostatin analogs for the management of neuroendocrine tumors of the gastroenteropancreatic system
-
Oberg K, Kvols L, Caplin M: Consensus report on the use of somatostatin analogs for the management of neuroendocrine tumors of the gastroenteropancreatic system. Ann Oncol, 15: 966-973, 2004.
-
(2004)
Ann Oncol
, vol.15
, pp. 966-973
-
-
Oberg, K.1
Kvols, L.2
Caplin, M.3
-
19
-
-
0027198659
-
Octreotide as an antineoplastic agent in the treatment of functional and nonfunctional neuroendocrine tumors
-
Saltz L, Trochanowski B, Buckley M, Heffernan B, Niedzwiecki D, Tao Y, Kelsen D: Octreotide as an antineoplastic agent in the treatment of functional and nonfunctional neuroendocrine tumors. Cancer, 72: 244-248, 1993.
-
(1993)
Cancer
, vol.72
, pp. 244-248
-
-
Saltz, L.1
Trochanowski, B.2
Buckley, M.3
Heffernan, B.4
Niedzwiecki, D.5
Tao, Y.6
Kelsen, D.7
-
20
-
-
70350442637
-
Placebo-controlled, double-blind, prospective, randomized study of the effect of octreotide LAR in the control of tumor growth in patients with metastatic neuroendocrine midgut tumors: A report from the PROMID study group
-
abstr 4508
-
Arnold R, Müller H, Schade-Brittinger C, Rinke A, Barth P, Wied M, Mayer C, Aminossadati B: Placebo-controlled, double-blind, prospective, randomized study of the effect of octreotide LAR in the control of tumor growth in patients with metastatic neuroendocrine midgut tumors: a report from the PROMID study group. J Clin Oncol, 27:15s (suppl; abstr 4508), 2009.
-
(2009)
J Clin Oncol
, vol.27
, Issue.SUPPL.
-
-
Arnold, R.1
Müller, H.2
Schade-Brittinger, C.3
Rinke, A.4
Barth, P.5
Wied, M.6
Mayer, C.7
Aminossadati, B.8
-
21
-
-
70350354684
-
Novel and evolving therapies in the treatment of malignant phaeochromocytoma: Experience with the mTOR inhibitor everolimus (RAD001)
-
Druce MR, Kaltsas GA, Fraenkel M, Gross DJ, Grossman AB: Novel and evolving therapies in the treatment of malignant phaeochromocytoma: experience with the mTOR inhibitor everolimus (RAD001). Horm Metab Res, 41: 697-702, 2009.
-
(2009)
Horm Metab Res
, vol.41
, pp. 697-702
-
-
Druce, M.R.1
Kaltsas, G.A.2
Fraenkel, M.3
Gross, D.J.4
Grossman, A.B.5
-
22
-
-
0142217202
-
Angiogenesis in endocrine tumors
-
Turner HE, Harris AL, Melmed S, Wass JA: Angiogenesis in endocrine tumors. Endocr Rev, 24: 600-632, 2003.
-
(2003)
Endocr Rev
, vol.24
, pp. 600-632
-
-
Turner, H.E.1
Harris, A.L.2
Melmed, S.3
Wass, J.A.4
-
23
-
-
0037258782
-
Localization of vascular endothelial growth factor and its receptors in digestive endocrine tumors: Correlation with microvessel density and clinicopathologic features
-
La Rosa S, Uccella S, Finzi G, Albarello L, Sessa F, Capella C: Localization of vascular endothelial growth factor and its receptors in digestive endocrine tumors: correlation with microvessel density and clinicopathologic features. Hum Pathol, 34: 18-27, 2003.
-
(2003)
Hum Pathol
, vol.34
, pp. 18-27
-
-
La Rosa, S.1
Uccella, S.2
Finzi, G.3
Albarello, L.4
Sessa, F.5
Capella, C.6
-
24
-
-
33644833910
-
Activity of SU11248, a multitargeted inhibitor or vascular endothelial growth factor receptor and platelet-derived growth factor receptor, in patients with metastatic renal cell carcinoma
-
Motzer RJ, Dror Michaelson M, Redman BG, Hudes GR, Wilding G, Figlin RA, Ginsberg MS, Kim ST, Baum CM, De-Primo SE, Li JZ, Bello CL, Theuer CP, George DJ, Rini BI: Activity of SU11248, a multitargeted inhibitor or vascular endothelial growth factor receptor and platelet-derived growth factor receptor, in patients with metastatic renal cell carcinoma. J Clin Oncol, 24: 16-24, 2006.
-
(2006)
J Clin Oncol
, vol.24
, pp. 16-24
-
-
Motzer, R.J.1
Dror Michaelson, M.2
Redman, B.G.3
Hudes, G.R.4
Wilding, G.5
Figlin, R.A.6
Ginsberg, M.S.7
Kim, S.T.8
Baum, C.M.9
De-Primo, S.E.10
Li, J.Z.11
Bello, C.L.12
Theuer, C.P.13
George, D.J.14
Rini, B.I.15
-
25
-
-
35548970733
-
Optimisation of sunitinib therapy in metastatic renal cell carcinoma: Adverse-event management
-
Négrier S, Ravaud A: Optimisation of sunitinib therapy in metastatic renal cell carcinoma: adverse-event management. Eur J Cancer, 5: 12-19, 2007.
-
(2007)
Eur J Cancer
, vol.5
, pp. 12-19
-
-
Négrier, S.1
Ravaud, A.2
-
26
-
-
37249072373
-
A phase I and pharmacokinetic study of sunitinib administered daily for 2 weeks, followed by a 1-week off period
-
Britten CD, Kabbinavar F, Hecht JR, Bello CL, Li J, Baum C, Slamon D: A phase I and pharmacokinetic study of sunitinib administered daily for 2 weeks, followed by a 1-week off period. Cancer Chemother Pharmacol, 61: 515-524, 2008.
-
(2008)
Cancer Chemother Pharmacol
, vol.61
, pp. 515-524
-
-
Britten, C.D.1
Kabbinavar, F.2
Hecht, J.R.3
Bello, C.L.4
Li, J.5
Baum, C.6
Slamon, D.7
-
27
-
-
33846978108
-
Hypothyroidism in patients with metastatic renal cell carcinoma treated with sunitinib
-
Rini BI, Tamaskar I, Shaheen P, Salas R, Garcia J, Wood L, Reddy S, Dreicer R, Bukowski RM: Hypothyroidism in patients with metastatic renal cell carcinoma treated with sunitinib. J Natl Cancer Inst, 99: 81-83, 2007.
-
(2007)
J Natl Cancer Inst
, vol.99
, pp. 81-83
-
-
Rini, B.I.1
Tamaskar, I.2
Shaheen, P.3
Salas, R.4
Garcia, J.5
Wood, L.6
Reddy, S.7
Dreicer, R.8
Bukowski, R.M.9
-
28
-
-
0035525207
-
Angiogenesis inhibition in solid tumors
-
Rosen LS: Angiogenesis inhibition in solid tumors. Cancer J, 7: S120-128, 2001.
-
(2001)
Cancer J
, vol.7
-
-
Rosen, L.S.1
-
29
-
-
33645209476
-
International criteria for tumour assessment
-
Ollivier L: International criteria for tumour assessment. Cancer Imaging, 1: 32-34, 2000.
-
(2000)
Cancer Imaging
, vol.1
, pp. 32-34
-
-
Ollivier, L.1
-
30
-
-
23344454965
-
Critical issues in response evaluation on computed tomography: Lessons from the gastrointestinal stromal tumor model
-
Choi H: Critical issues in response evaluation on computed tomography: lessons from the gastrointestinal stromal tumor model. Curr Oncol Rep, 7: 307-311, 2005.
-
(2005)
Curr Oncol Rep
, vol.7
, pp. 307-311
-
-
Choi, H.1
-
31
-
-
0027076295
-
Southwest Oncology Group standard response criteria, endpoint definitions and toxicity criteria
-
Green S, Weiss GR: Southwest Oncology Group standard response criteria, endpoint definitions and toxicity criteria. Invest New Drugs, 10: 239-253, 1992.
-
(1992)
Invest New Drugs
, vol.10
, pp. 239-253
-
-
Green, S.1
Weiss, G.R.2
-
32
-
-
46849120190
-
Response assessment in solid tumours: A comparison of WHO, SWOG and Recist guidelines
-
Julka PK, Doval DC, Gupta S, Rath GK: Response assessment in solid tumours: a comparison of WHO, SWOG and Recist guidelines. Br J Radiol, 81: 444-449, 2008.
-
(2008)
Br J Radiol
, vol.81
, pp. 444-449
-
-
Julka, P.K.1
Doval, D.C.2
Gupta, S.3
Rath, G.K.4
-
33
-
-
0032757213
-
Measurement of clinical and subclinical tumour response using [18F]-fluorodeoxyglucose and positron emission tomography: Review and 1999 EORTC recommendations
-
European Organization for Research and Treatment of Cancer (EORTC) PET Study Group
-
Young H, Baum R, Cremerius U, Herholz K, Hoekstra O, Lammertsma AA, Pruim J, Price P: Measurement of clinical and subclinical tumour response using [18F]-fluorodeoxyglucose and positron emission tomography: review and 1999 EORTC recommendations. European Organization for Research and Treatment of Cancer (EORTC) PET Study Group. Eur J Cancer, 35: 1773-1782, 1999.
-
(1999)
Eur J Cancer
, vol.35
, pp. 1773-1782
-
-
Young, H.1
Baum, R.2
Cremerius, U.3
Herholz, K.4
Hoekstra, O.5
Lammertsma, A.A.6
Pruim, J.7
Price, P.8
-
34
-
-
67849097067
-
11C-acetate PET for early prediction of sunitinib response in metastatic renal cell carcinoma
-
11C-acetate PET for early prediction of sunitinib response in metastatic renal cell carcinoma. Tumori, 95: 382-384, 2009.
-
(2009)
Tumori
, vol.95
, pp. 382-384
-
-
Maleddu, A.1
Pantaleo, M.A.2
Castellucci3
Astorino, M.4
Nanni, C.5
Nannini, M.6
Busato, F.7
Di Battista, M.8
Farsad, M.9
Lodi, F.10
Boschi, S.11
Fanti, S.12
-
35
-
-
16644389881
-
CT evaluation of the response of gastrointestinal stromal tumors after imatinib mesylate treatment: A quantitative analysis correlated with FDG PET findings
-
Choi H, Charnsangavej C, de Castro Faria S, Tamm EP, Benjamin RS, Johnson MM, Macapinlac HA, Podoloff DA: CT evaluation of the response of gastrointestinal stromal tumors after imatinib mesylate treatment: a quantitative analysis correlated with FDG PET findings. Am J Roentgenol, 183: 1619-1628, 2004.
-
(2004)
Am J Roentgenol
, vol.183
, pp. 1619-1628
-
-
Choi, H.1
Charnsangavej, C.2
De Castro Faria, S.3
Tamm, E.P.4
Benjamin, R.S.5
Johnson, M.M.6
Macapinlac, H.A.7
Podoloff, D.A.8
-
36
-
-
72449167070
-
Phase III, randomized, double-blind trial of sunitinib versus placebo in patients with progressive, well-differentiated pancreatic islet cell tumours
-
abstr O-0013
-
th World Congress on Gastrointestinal Cancer, 24-27 June, 2009, Barcelona, Spain: abstr O-0013, 2009.
-
(2009)
th World Congress on Gastrointestinal Cancer, 24-27 June, 2009, Barcelona, Spain
-
-
Raymond, E.1
Raoul, J.2
Niccoli, P.3
Bang, Y.4
Borbath, I.5
Lombard-Bohas, C.6
Metrakos, P.7
Lu, D.8
Blanckmeister, C.9
Vinik, A.10
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