In situ Raman spectroscopy to monitor the hydrolysis of acetal in microreactors

Microfluidics and Nanofluidics

Volumn 10, Issue 1, 2011, Pages 145-153

  Rinke, Guenter ^a   Ewinger, Angela ^a   Kerschbaum, Sigrid ^a   Rinke, Monika ^a  

^a KARLSRUHE INSTITUTE OF TECHNOLOGY   (Germany)

Author keywords

Acid catalyzed hydrolysis; Microchannel; Micromixer; Microreactor; Online analysis; Raman spectroscopy

Indexed keywords

ACID-CATALYZED HYDROLYSIS; ARGON-ION LASER; CHANNEL DEPTH; CHANNEL WIDTHS; CHEMICAL INFORMATION; CHEMICAL PROCESS; CONCENTRATION PROFILES; CONTINUOUS WAVES; EXCITATION SOURCES; HYDROGEN IONS; IN-SITU MONITORING; IN-SITU RAMAN SPECTROSCOPY; LASER RAMAN SPECTROSCOPY; MICRO MIXERS; MICRO-REACTOR; MICROSCOPE OBJECTIVE; ON-LINE ANALYSIS; OPTICAL ABERRATION; QUANTITATIVE ANALYSIS; QUARTZ PLATES; SPATIAL RESOLUTION;

ACETONE; ARGON; ARGON LASERS; CATALYSIS; CHEMICAL COMPOUNDS; CHEMICAL REACTORS; HYDROLYSIS; LASER EXCITATION; METHANOL; MICROCHANNELS; MIXERS (MACHINERY); QUARTZ; RAMAN SCATTERING; RAMAN SPECTROSCOPY; SPECTRUM ANALYSIS;

CHEMICAL ANALYSIS;

EID: 79551478320     PISSN: 16134982     EISSN: 16134990     Source Type: Journal    
DOI: 10.1007/s10404-010-0654-8     Document Type: Article

References (36)

1. Abramowitz M, Stegun IA (1972) Handbook of mathematical functions with formulas, graphs, and mathematical tables. NBS, New York, Dover
2. J Antes D Boskovic H Krause S Löbbecke N Lutz T Türcke W Schweikert 2003 Analysis and improvement of strong exothermic nitrations in microreactors Trans Inst Chem Eng 81 Part A 760 765 10.1205/026387603322302931
3. J Baldyga JR Bourne B Walker 1998 Non-isothermal micromixing in turbulent liquids: theory and experiment Can J Chem Eng 76 641 649 10.1002/cjce. 5450760336
4. Bohn L, Braune S, Kotthaus M, Kraut M, Pöchlauer P, Vorbach M, Wenka A, Schubert K (2006) Large-scale application of microreaction technology within commercial chemical production of DSM. In: 9th International conference on microreaction technology, 6-8 September 2006, Potsdam
5. D Bothe C Stemich HJ Warnecke 2006 Fluid mixing in a T-shaped micro-mixer Chem Eng Sci 61 9 2950 2958 10.1016/j.ces.2005.10.060
6. KLA Chan S Gulati JB Edel AJ de Mello SG Kazarian 2009 Chemical imaging of microfluidic flows using ATR-FTIR spectroscopy Lab Chip 9 2909 2913 10.1039/b909573j
7. DB Dennison GA Gettys DG Kubler D Shepard 1976 Kinetic salt effects on the hydrolysis of benzaldehyde dimethyl acetal J Org Chem 41 13 2344 2348 10.1021/jo00875a028
8. PD Fletcher SJ Haswell 2003 Monitoring of chemical reactions within microreactors using an inverted Raman microscopic spectrometer Electrophoresis 24 3239 3245 10.1002/elps.200305532
9. TM Floyd MA Schmidt KF Jensen 2005 Silicon micromixers with infrared detection for studies of liquid-phase reactions Ind Eng Chem Res 44 2351 2358 10.1021/ie049348j
10. Hessel V, Hardt S, Löwe H (2004) Chemical micro process engineering: fundamentals, modelling and reactions. Wiley, Weinheim
11. V Hessel H Löwe F Schönfeld 2005 Micromixers: a review on passive and active mixing principles Chem Eng Sci 60 8-9 2479 2501
12. Hessel V, Renken A, Schouten JC, Yoshida J (2009) Micro process engineering: a comprehensive handbook. Wiley, Weinheim
13. P Hinsmann J Frank P Svasek M Harasek B Lendl 2001 Design, simulation and application of a new micromixing device for time resolved infrared spectroscopy of chemical reactions in solution Lab Chip 1 16 21 10.1039/b104391a
14. M Hoffmann M Schlüter N Räbiger 2006 Experimental investigation of liquid-liquid mixing in T-shaped micro-mixers using μ-LIF and μ-PIV Chem Eng Sci 61 2968 2976 10.1016/j.ces.2005.11.029
15. BK Johnson RK Prud'homme 2003 Chemical processing and micromixing in confined impinging jets AIChE J 49 9 2264 2282 10.1002/aic.690490905
16. AE Kamholz BH Weigl BA Finlayson P Yager 1999 Quantitative analysis of molecular interaction in a microfluidic channel: the T-sensor Anal Chem 71 23 5340 5346 10.1021/ac990504j
17. SG Kazarian KLA Chan 2006 Applications of ATR-FTIR spectroscopic imaging to biomedical samples Biochim Biophys Acta 1758 858 867 10.1016/j.bbamem.2006. 02.011
18. R Keoschkerjan M Richter D Boskovic F Schnürer S Löbbecke 2004 Novel multifunctional microreaction unit for chemical engineering Chem Eng J 101 469 475 10.1016/j.cej.2004.01.012
19. C Lindenberg J Schöll L Vicum M Mazzotti J Brozio 2008 Experimental characterization and multi-scale modeling of mixing in static mixers Chem Eng Sci 63 4135 4149 10.1016/j.ces.2008.05.026
20. S Löbbecke W Ferstl S Panic T Türcke 2005 Concepts for modularization and automation of microreaction technology Chem Eng Technol 28 4 484 493 10.1002/ceat.200500005
21. A Müller V Cominos V Hessel B Horn J Schürer A Ziogas K Jähnisch V Hillmann V Groer KA Jam A Bazzanella G Rinke M Kraut 2005 Fluidic bus system for chemical process engineering in the laboratory and for small-scale production Chem Eng J 107 205 214 10.1016/j.cej.2004.12.030
22. NT Nguyen Z Wu 2005 Micromixers-a review J Micromech Microeng 15 R1 R16 10.1088/0960-1317/15/2/R01
23. T Park M Lee J Choo YS Kim EK Lee DJ Kim SH Lee 2004 Analysis of passive mixing behavior in a Poly(dimethylsiloxane) microfluidic channel using confocal fluorescence and Raman microscopy Appl Spectrosc 58 1172 1179 10.1366/0003702042336019
24. Rinke G, Kraut M, Grosser V, Hillmann V, Müller A, Horn B, Jähnisch K, Bazzanella A (2003) Modular micro process engineering and applications. In: 7th International Conference on Microreaction technology (IMRET 7), Lausanne, CH, 7-10 September 2003, Frankfurt, Proceedings, DECHEMA, 2003, 339-341
25. Rinke G, Kerschbaum S, Wenka A, Holpe H (2006) Micro process engineering for industrial production of biodiesel. In: 9th International conference on microreaction technology, 6-8 September 2006, Potsdam
26. JB Salmon A Ajdari P Tabeling L Servant D Talaga M Joanicot 2005 In situ Raman imaging of interdiffusion in a microchannel Appl Phys Lett 86 094106 10.1063/1.1873050
27. Santos RG, Figueiredo JR (2007) Laminar elliptic flow in the entrance region of tubes. J Braz Soc Mech Sci Eng 29(3):233-239, Rio de Janeiro July/Sept. 2007
28. K Schubert J Brandner M Fichtner G Linder U Schygulla A Wenka 2001 Microstructure devices for applications in thermal and chemical process engineering Microscale Thermophys Eng 5 17 39 10.1080/108939501300005358
29. N Steinfeldt U Bentrup K Jähnisch 2010 Reaction mechanism and in situ ATR spectroscopic studies of the 1-Decene ozonolysis in micro- and semibatch reactors Ind Eng Chem Res 49 72 80 10.1021/ie900726s
30. KR Strehle D Cialla P Rösch T Henkel M Köhler J Popp 2007 A reproducible surface-enhanced raman spectroscopy approch. Online SERS measurements in a segmented microfluidic system Anal Chem 79 4 1542 1547 10.1021/ac0615246
31. RA Taylor WR Penney HX Vo 2005 Scale-up methods for fast competitive chemical reactions in pipeline mixers Ind Eng Chem Res 44 6095 6102 10.1021/ie040237u
32. 2: phase behaviour monitoring and activity profiling Analyst 133 1352 1354 10.1039/b808984c
33. T Vilkner D Janasek A Manz 2004 Micro total analysis systems. Recent developments Anal Chem 76 3373 3386 10.1021/ac040063q
34. Walker BM (1996) Einfluss der Temperatur auf die Selektivität rasch ablaufender Reaktionen. PhD Thesis, ETH Zürich (in German)
35. P Watts C Wiles 2007 Recent advances in synthetic micro reaction technology Chem Commun 5 443 467 10.1039/b609428g
36. Wirth T (2008) Microreactors in organic synthesis and catalysis. Wiley, Weinheim