Infantile haemangioma: New aspects on the pathogenesis of the most common skin tumour in children

British Journal of Dermatology

Volumn 164, Issue 2, 2011, Pages 234-235

  Hoeger, P H ^a  

^a Catholic Children's Hospital Wilhelmstift   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIGEN; CD15 ANTIGEN; CHEMOKINE RECEPTOR CCR6; GLUCOSE TRANSPORTER 1; HYPOXIA INDUCIBLE FACTOR 1ALPHA; INDOLEAMINE 2,3 DIOXYGENASE; LEWIS Y ANTIGEN; MEROSIN; UNCLASSIFIED DRUG; VASCULOTROPIN RECEPTOR 1; VASCULOTROPIN RECEPTOR 2;

ANGIOGENESIS; BIRTH WEIGHT; CAPILLARY HEMANGIOMA; CAUCASIAN; CHILDHOOD DISEASE; DISEASE COURSE; DYSPLASIA; EMBOLISM; ENDOTHELIAL PROGENITOR CELL; ENDOTHELIUM CELL; ENZYME ACTIVITY; GENETIC TRANSCRIPTION; GLYCOLYSIS; HUMAN; HYPOXEMIA; INVOLUTION; MICROCHIMERISM; MONOCYTE; NOTE; PATHOGENESIS; PLACENTA; PLACENTA CIRCULATION; PREMATURITY; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECURRENCE RISK; SEX DIFFERENCE;

CELL HYPOXIA; CHILD; CHILD, PRESCHOOL; FEMALE; GLUCOSE TRANSPORTER TYPE 1; HEMANGIOMA; HUMANS; MALE; RECEPTORS, VASCULAR ENDOTHELIAL GROWTH FACTOR; SKIN NEOPLASMS; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 79551474880     PISSN: 00070963     EISSN: 13652133     Source Type: Journal    
DOI: 10.1111/j.1365-2133.2011.10204.x     Document Type: Note

References (17)

1. Holland KE, Drolet BA,. Infantile hemangioma. Pediatr Clin North Am 2010; 57: 1069-83.
2. North PE, Waner M, Mizeracki A, et al. A unique microvascular phenotype shared by juvenile hemangiomas and human placenta. Arch Dermatol 2001; 137: 559-70.
3. Pittman KM, Losken HW, Kleinman ME, et al. No evidence of maternal-fetal microchimerism in infantile hemangioma: a molecular genetic investigation. J Invest Dermatol 2006; 126: 2533-8.
4. Hoeger PH, Maerker JM, Kienast AK, et al. Neonatal haemangiomatosis associated with placental chorioangiomas: report of three cases and review of the literature. Clin Exp Dermatol 2009; 34: e78-80.
5. Jinnin M, Medici D, Park L, et al. Suppressed NFAT-dependent VEGFR1 expression and constitutive VEGFR2 signaling in infantile hemangioma. Nat Med 2008; 14: 1236-46.
6. Boscolo E, Bischoff J,. Vasculogenesis in infantile hemangioma. Angiogenesis 2009; 12: 197-207.
7. Drolet B, Frieden IJ,. Characteristics of infantile hemangiomas as clues to pathogenesis. Does hypoxia connect the dots? Arch Dermatol 2010; 146: 1295-9.
8. Gutierrez JCL, Avila LF, Sosa G, Patron M,. Placental anomalies in children with infantile hemangioma. Pediatr Dermatol 2007; 24: 353-5.
9. Colonna V, Resta L, Napoli A, Bonifazi E,. Placental hypoxia and neonatal haemangioma: clinical and histological observations. Br J Dermatol 2010; 162: 208-9.
10. Drolet BA, Swanson EA, Frieden IJ,; Hemangioma Investigator Group. Infantile hemangiomas: an emerging health issue linked to an increased rate of low birth weight infants. J Pediatr 2008; 153: 712-15.
11. Praveen V, Vidavalur R, Rosenkrantz TS, Hussain N,. Infantile hemangiomas and retinopathy of prematurity: possible association. Pediatrics 2009; 123: e484-9.
12. Ahrens WA, Ridenour RV, Caron BL, et al. GLUT-1 expression in mesenchymal tumors: an immunohistochemical study of 247 soft tissue and bone neoplasms. Hum Pathol 2008; 39: 1519-26.
13. Herbert A, Ng H, Jessup W, et al. Hypoxia regulates the production and activity of glucose transporter-1 and indoleamine 2,3-deoxygenase in monocyte-derived endothelial-like cells: possible relevance to infantile haemangioma pathogenesis. Br J Dermatol 2011; 164: 308-15.
14. Kleinman ME, Greives MR, Churgin S, et al. Hypoxia-induced mediators of stem/progenitor cell trafficking are increased in children with hemangioma. Arterioscler Thromb Vasc Biol 2007; 27: 2664-70.
15. Ingemarsson I,. Gender aspects of preterm birth. BJOG 2003; 110 (Suppl. 20): 34-8.
16. Greenberger S, Boscolo E, Adini I, et al. Corticosteroid suppression of VEGF-A in infantile hemangioma-derived stem cells. N Engl J Med 2010; 362: 1005-13.
17. Haggstrom AN, Lammer EJ, Schneider RA, et al. Patterns of infantile hemangiomas: new clues to hemangioma pathogenesis and embryonic facial development. Pediatrics 2006; 117: 698-703.