Infantile Hemangioma

Pediatric Clinics of North America

Volumn 57, Issue 5, 2010, Pages 1069-1083

  Holland, Kristen E ^a   Drolet, Beth A ^a  

^a Department of Dermatology Children's Hospital of Wisconsin Medical College of Wisconsin ^*  (United States)

Author keywords

Complications; Infantile hemangioma; Treatment

Indexed keywords

ANTIBIOTIC AGENT; BACITRACIN; BECAPLERMIN; CORTICOSTEROID; COTRIMOXAZOLE; GLUCOSE TRANSPORTER 1; METRONIDAZOLE; POLYMYXIN; PROPRANOLOL; PSEUDOMONIC ACID; RECOMBINANT ALPHA INTERFERON; TRIAMCINOLONE; VINCRISTINE;

ABDOMINAL COMPARTMENT SYNDROME; ABDOMINAL CRAMP; ADRENAL DISEASE; AIRWAY OBSTRUCTION; AMBLYOPIA; BONE DEMINERALIZATION; BRADYCARDIA; BRONCHOSPASM; CALCIFICATION; CARDIOMYOPATHY; CENTRAL RETINA ARTERY OCCLUSION; CHROMOSOME 5Q; CLINICAL FEATURE; CONGENITAL BLOOD VESSEL MALFORMATION; CONGESTIVE HEART FAILURE; CONSTIPATION; DECOMPENSATED LIVER CIRRHOSIS; DEPRESSION; DRUG FEVER; FLU LIKE SYNDROME; GASTROINTESTINAL SYMPTOM; GROWTH RETARDATION; HEART MUSCLE CONTRACTILITY; HEART RATE; HEMANGIOMA; HIGH OUTPUT HEART FAILURE; HUMAN; HYPERTENSION; HYPERTROPHIC OBSTRUCTIVE CARDIOMYOPATHY; HYPOGLYCEMIA; HYPOTENSION; HYPOTHYROIDISM; IMMUNE DEFICIENCY; INCIDENCE; INFANTILE HEMANGIOMA; IRRITABILITY; LACRIMAL DUCT OCCLUSION; LIVER HEMANGIOMA; MALAISE; MOON FACE; MULTIPLE PREGNANCY; NAUSEA; NEUROMUSCULAR DISEASE; NEUTROPENIA; NIGHTMARE; PATHOGENESIS; PERIOCULAR HEMANGIOMA; PERONEUS NERVE PARALYSIS; PNEUMOCYSTIS PNEUMONIA; PULSED DYE LASER; REFRACTION ERROR; REVIEW; SECONDARY INFECTION; SIDE EFFECT; SKIN ATROPHY; SKIN HEMANGIOMA; SKIN NECROSIS; SLEEP DISORDER; SPASTIC PARESIS; SPINAL CORD MALFORMATION; ULCER; VOMITING; WOUND CARE; CLASSIFICATION; DECISION MAKING; DISEASE COURSE; EVIDENCE BASED MEDICINE; INFANT; INFANT WELFARE; INFANT, NEWBORN, DISEASES; NEWBORN; RISK ASSESSMENT; SKIN NEOPLASMS; SOFT TISSUE NEOPLASMS; STATISTICS AND NUMERICAL DATA;

DECISION MAKING; DISEASE PROGRESSION; EVIDENCE-BASED MEDICINE; HEMANGIOMA; HUMANS; INFANT; INFANT WELFARE; INFANT, NEWBORN; INFANT, NEWBORN, DISEASES; RISK ASSESSMENT; SKIN NEOPLASMS; SOFT TISSUE NEOPLASMS;

EID: 77957285726     PISSN: 00313955     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.pcl.2010.07.008     Document Type: Review

References (47)

1. Kilcline C., Frieden I.J. Infantile hemangiomas: how common are they? A systematic review of the medical literature. Pediatr Dermatol 2008, 25(2):168-173.
2. Haggstrom A.N., Drolet B.A., et al. Prospective study of infantile hemangiomas: demographic, prenatal, and perinatal characteristics. J Pediatr 2007, 150(3):291-294. Group Hemangioma Investigator.
3. Drolet B.A., Swanson E.A., Frieden I.J., et al. Infantile hemangiomas: an emerging health issue linked to an increased rate of low birth weight infants. J Pediatr 2008, 153(5):712. No-715.
4. Walter J.W., Blei F., Anderson J.L., et al. Genetic mapping of a novel familial form of infantile hemangioma. Am J Med Genet 1999, 82(1):77-83.
5. North P.E., Waner M., Mizeracki A., et al. GLUT1: a newly discovered immunohistochemical marker for juvenile hemangiomas. Hum Pathol 2000, 31(1):11-22.
6. Barnes C.M., Huang S., Kaipainen A., et al. Evidence by molecular profiling for a placental origin of infantile hemangioma. Proc Natl Acad Sci U S A 2005, 102(52):19097-19102.
7. Kleinman M.E., Greives M.R., Churgin S.S., et al. Hypoxia-induced mediators of stem/progenitor cell trafficking are increased in children with hemangioma. Arterioscler Thromb Vasc Biol 2007, 27(12):2664-2670.
8. Dadras S.S., North P.E., Bertoncini J., et al. Infantile hemangiomas are arrested in an early developmental vascular differentiation state. Mod Pathol 2004, 17(9):1068-1079.
9. Yu Y., Flint A.F., Mulliken J.B., et al. Endothelial progenitor cells in infantile hemangioma. Blood 2004, 103(4):1373-1375.
10. Jinnin M., Medici D., Park L., et al. Suppressed NFAT-dependent VEGFR1 expression and constitutive VEGFR2 signaling in infantile hemangioma. Nat Med 2008, 14(11):1236-1246.
11. Drolet B.A., Esterly N.B., Frieden I.J. Hemangiomas in children. N Engl J Med 1999, 341(3):173-181.
12. Haggstrom A.N., Lammer E.J., Schneider R.A., et al. Patterns of infantile hemangiomas: new clues to hemangioma pathogenesis and embryonic facial development. Pediatrics 2006, 117(3):698-703.
13. Chiller K.G., Passaro D., Frieden I.J. Hemangiomas of infancy: clinical characteristics, morphologic subtypes, and their relationship to race, ethnicity, and sex. Arch Dermatol 2002, 138(12):1567-1576.
14. Chang L.C., Haggstrom A.N., Drolet B.A., et al. Growth characteristics of infantile hemangiomas: implications for management. Pediatrics 2008, 122(2):360-367.
15. Brandling-Bennett H.A., Metry D.W., Baselga E., et al. Infantile hemangiomas with unusually prolonged growth phase: a case series. Arch Dermatol 2008, 144(12):1632-1637.
16. Waner M., North P.E., Scherer K.A., et al. The nonrandom distribution of facial hemangiomas. Arch Dermatol 2003, 139(7):869-875.
17. Haggstrom A.N., Drolet B.A., Baselga E., et al. Prospective study of infantile hemangiomas: clinical characteristics predicting complications and treatment. Pediatrics 2006, 118(3):882-887.
18. Chamlin S.L., Haggstrom A.N., Drolet B.A., et al. Multicenter prospective study of ulcerated hemangiomas. J Pediatr 2007, 151(6):684.
19. Shin H.T., Orlow S.J., Chang M.W. Ulcerated haemangioma of infancy: a retrospective review of 47 patients. Br J Dermatol 2007, 156(5):1050-1052.
20. Bilyk J.R., Adamis A.P., Mulliken J.B. Treatment options for periorbital hemangioma of infancy. Int Ophthalmol Clin 1992, 32(3):95-109.
21. Golitz L.E., Rudikoff J., O'Meara O.P. Diffuse neonatal hemangiomatosis. Pediatr Dermatol 1986, 3(2):145-152.
22. Dickie B., Dasgupta R., Nair R., et al. Spectrum of hepatic hemangiomas: management and outcome. J Pediatr Surg 2009, 44(1):125-133.
23. Horii KA, Drolet BA, Frieden IJ, et al. Prospective study of the frequency of hepatic hemangiomas in infants with multiple cutaneous infantile hemangiomas. Pediatrics, in press.
24. Orlow S.J., Isakoff M.S., Blei F. Increased risk of symptomatic hemangiomas of the airway in association with cutaneous hemangiomas in a beard distribution. J Pediatr 1997, 131(4):643-646.
25. O T.M., Alexander R.E., Lando T., et al. Segmental hemangiomas of the upper airway. Laryngoscope 2009, 119(11):2242-2247.
26. Perkins J.A., Duke W., Chen E., et al. Emerging concepts in airway infantile hemangioma assessment and management. Otolaryngol Head Neck Surg 2009, 141(2):207-212.
27. Girard C., Bigorre M., Guillot B., et al. PELVIS syndrome. Arch Dermatol 2006, 142(7):884-888.
28. Stockman A., Boralevi F., Taieb A., et al. SACRAL syndrome: spinal dysraphism, anogenital, cutaneous, renal and urologic anomalies, associated with an angioma of lumbosacral localization. Dermatology 2007, 214(1):40-45.
29. Drolet BA, Garzon MC, Adams D, et al. A prospective study of spinal anomalies in children with infantile hemangiomas of the lumbosacral skin. J Pediatr, in press.
30. Frieden I.J., Reese V., Cohen D. PHACE syndrome. The association of posterior fossa brain malformations, hemangiomas, arterial anomalies, coarctation of the aorta and cardiac defects, and eye abnormalities. Arch Dermatol 1996, 132(3):307-311.
31. Metry D., Heyer G., Hess C., et al. Consensus statement on diagnostic criteria for PHACE syndrome. Pediatrics 2009, 124(5):1447-1456.
32. Metry D.W., Haggstrom A.N., Drolet B.A., et al. A prospective study of PHACE syndrome in infantile hemangiomas: demographic features, clinical findings, and complications. Am J Med Genet A 2006, 140(9):975-986.
33. Haggstrom A.N., Garzon M.C., Baselga E., et al. Risk for PHACE syndrome in infants with large facial hemangiomas. Arch Dermatol 2010, 126(2). e418-26.
34. Metz B.J., Rubenstein M.C., Levy M.L., et al. Response of ulcerated perineal hemangiomas of infancy to becaplermin gel, a recombinant human platelet-derived growth factor. Arch Dermatol 2004, 140(7):867-870.
35. Enjolras O., Riche M.C., Merland J.J., et al. Management of alarming hemangiomas in infancy: a review of 25 cases. Pediatrics 1990, 85(4):491-498.
36. Barrio V.R., Drolet B.A. Treatment of hemangiomas of infancy. Dermatol Ther 2005, 18(2):151-159.
37. Kelly M.E., Juern A.M., Grossman W.J., et al. Immunosuppressive effects in infants treated with corticosteroids for infantile hemangiomas. Arch Dermatol 2010, 146(7):767-774.
38. Maronn M.L., Corden T., Drolet B.A. Pneumocystis carinii pneumonia in infant treated with oral steroids for hemangioma. Arch Dermatol 2007, 143(9):1224-1225.
39. Enjolras O., Breviere G.M., Roger G., et al. Arch Pediatr 2004, 11:99-107.
40. Fawcett S.L., Grant I., Hall P.N., et al. Vincristine as a treatment for a large haemangioma threatening vital functions. Br J Plast Surg 2004, 57(2):168-171.
41. Boehm D.K., Kobrinsky N.L. Treatment of cavernous hemangioma with vincristine. Ann Pharmacother 1993, 27(7-8):981.
42. Leaute-Labreze C., Dumas de la Roque E., Hubiche T., et al. Propranolol for severe hemangiomas of infancy. N Engl J Med 2008, 358(24):2649-2651.
43. Sans V., Dumas de la Roque E., Berge J., et al. Propranolol for severe infantile hemangiomas: follow-up report. Pediatrics 2009.
44. Holland K.E., Frieden I.J., Frommelt P.C., et al. Hypoglycemia in children taking propranolol for the treatment of infantile hemangioma. Arch Dermatol 2010, 146(7):775-778.
45. Witman P.M., Wagner A.M., Scherer K., et al. Complications following pulsed dye laser treatment of superficial hemangiomas. Lasers Surg Med 2006, 38(2):116-123.
46. Morelli J.G., Tan O.T., Yohn J.J., et al. Treatment of ulcerated hemangiomas of infancy. Arch Pediatr Adolesc Med 1994, 148(10):1104-1105.
47. David L.R., Malek M.M., Argenta L.C. Efficacy of pulse dye laser therapy for the treatment of ulcerated haemangiomas: a review of 78 patients. Br J Plast Surg 2003, 56(4):317-327.