Morphometric analysis of neuronal and glial cell pathology in the caudate nucleus in late-life depression

American Journal of Geriatric Psychiatry

Volumn 19, Issue 2, 2011, Pages 132-141

  Khundakar, Ahmad ^a   Morris, Christopher ^a   Oakley, Arthur ^a   Thomas, Alan J ^a  

^a NEWCASTLE UNIVERSITY   (United Kingdom)

Author keywords

caudate nucleus; disector; Late life depression; morphometric

Indexed keywords

AGED; ARTICLE; CAUDATE NUCLEUS; CLINICAL ARTICLE; CONTROLLED STUDY; DEPRESSION; FEMALE; GLIA CELL; HISTOPATHOLOGY; HUMAN; HUMAN CELL; HUMAN TISSUE; MALE; NERVE CELL; NEUROIMAGING; PREFRONTAL CORTEX; UNITED KINGDOM;

EID: 79551473590     PISSN: 10647481     EISSN: 15457214     Source Type: Journal    
DOI: 10.1097/JGP.0b013e3181df4642     Document Type: Article

References (53)

1. Beekman AT, Copeland JR, Prince MJ: Review of community prevalence of depression in later life. Br J Psychiatry 1999; 174: 307-311
2. Luijendijk HJ, van den Berg JF, Dekker MJ, et al: Incidence and recurrence of late-life depression. Arch Gen Psychiatry 2008; 65:1394-1401
3. Baldwin RC, O'Brien J: Vascular basis of late-onset depressive disorder. Br J Psychiatry 2002; 180:157-160
4. Alexopoulos GS, Meyers BS, Young RC, et al: Clinically defined vascular depression. Am J Psychiatry 1997; 154:562-565
5. Salloway S, Malloy P, Kohn R, et al: MRI and neuropsychological differences in early-and late-life-onset geriatric depression. Neurology 1996; 46:1567-1574
6. Bonelli RM, Cummings JL: Frontal-subcortical circuitry and behavior. Dialogues Clin Neurosci 2007; 9:141-151
7. Levy R, Friedman HR, Davachi L, et al: Differential activation of the caudate nucleus in primates performing spatial and nonspatial working memory tasks. J Neurosci 1997; 17:3870-3882
8. Middleton FA, Strick PL: Basal ganglia output and cognition: evidence from anatomical, behavioral, and clinical studies. Brain Cogn 2000; 42:183-200
9. Kim MJ, Hamilton JP, Gotlib IH: Reduced caudate gray matter volume in women with major depressive disorder. Psychiatry Res 2008; 164:114-122
10. Krishnan KR, McDonald WM, Escalona PR, et al: Magnetic resonance imaging of the caudate nuclei in depression. Preliminary observations. Arch Gen Psychiatry 1992; 49:553-557
11. Parashos IA, Tupler LA, Blitchington T, et al: Magnetic-resonance morphometry in patients with major depression. Psychiatry Res 1998; 84:7-15
12. Butters MA, Aizenstein HJ, Hayashi KM, et al: Three-dimensional surface mapping of the caudate nucleus in late-life depression. Am J Geriatr Psychiatry 2009; 17:4-12
13. Baumann B, Bielau H, Krell D, et al: Circumscribed numerical deficit of dorsal raphe neurons in mood disorders. Psychol Med 2002; 32:93-103
14. Bielau H, Trubner K, Krell D, et al: Volume deficits of subcor-tical nuclei in mood disorders. A postmortem study. Eur Arch Psychiatry Clin Neurosci 2005; 255:401-412
15. Buchsbaum MS, Wu J, DeLisi LE, et al: Frontal cortex and basal ganglia metabolic rates assessed by positron emission tomography with [18F]2-deoxyglucose in affective illness. J Affect Disord 1986; 10:137-152
16. Baxter LR Jr, Phelps ME, Mazziotta JC, et al: Cerebral metabolic rates for glucose in mood disorders. Studies with positron emission tomography and fluorodeoxyglucose F 18. Arch Gen Psychiatry 1985; 42:441-447
17. Hannestad J, Taylor WD, McQuoid DR, et al: White matter lesion volumes and caudate volumes in late-life depression. Int J Geriatr Psychiatry 2006; 21:1193-1198
18. Steffens DC, Helms MJ, Krishnan KR, et al: Cerebrovascular disease and depression symptoms in the cardiovascular health study. Stroke 1999; 30:2159-2166
19. Miguel-Hidalgo JJ, Baucom C, Dilley G, et al: Glial fibrillary acidic protein immunoreactivity in the prefrontal cortex distinguishes younger from older adults in major depressive disorder. Biol Psychiatry 2000; 48:861-873
20. Rajkowska G, Miguel-Hidalgo JJ, Wei J, et al: Morphometric evidence for neuronal and glial prefrontal cell pathology in major depression. Biol Psychiatry 1999; 45:1085-1098
21. Khundakar A, Morris C, Oakley A, et al: Morphometric analysis of neuronal and glial cell pathology in the dorsolateral pre-frontal cortex in late-life depression. Br J Psychiatry 2009; 195: 163-169
22. Rajkowska G, Miguel-Hidalgo JJ, Dubey P, et al: Prominent reduction in pyramidal neurons density in the orbitofrontal cortex of elderly depressed patients. Biol Psychiatry 2005; 58:297-306
23. Davis S, Thomas A, Perry R, et al: Glial fibrillary acidic protein in late life major depressive disorder: an immunocytochemical study. J Neurol Neurosurg Psychiatry 2002; 73:556-560
24. Thomas AJ, Ferrier IN, Kalaria RN, et al: Cell adhesion molecule expression in the dorsolateral prefrontal cortex and anterior cin-gulate cortex in major depression in the elderly. Br J Psychiatry 2002; 181:129-134
25. Thomas AJ, Ferrier IN, Kalaria RN, et al: Elevation in late-life depression of intercellular adhesion molecule-1 expression in the dorsolateral prefrontal cortex. Am J Psychiatry 2000; 157: 1682-1684
26. American Psychiatric Association: The Diagnostic and Statistical Manual of Mental Disorders.4th ed. Washington, DC, American Psychiatric Association, 1994.
27. Mai JK, Assheuer J, Paxinos G: Atlas of the Human Brain. San Diego, Academic Press, 1997
28. Gundersen HJ, Bagger P, Bendtsen TF, et al: The new stereo-logical tools: disector, fractionator, nucleator and point sampled intercepts and their use in pathological research and diagnosis. APMIS 1988; 96:857-881
29. Sterio DC: The unbiased estimation of number and sizes of arbitrary particles using the disector. J Microsc 1984; 134:127-136
30. Gundersen HJ: The nucleator. J Microsc 1988; 151:3-21
31. Dorph-Petersen KA, Nyengaard JR, Gundersen HJ: Tissue shrinkage and unbiased stereological estimation of particle number and size. J Microsc 2001; 204:232-246
32. Gundersen HJ, Jensen EB: The efficiency of systematic sampling in stereology and its prediction. J Microsc 1987; 147:229-263
33. Cruz-Orive L-M: Best linear unbiased estimators for stereology. Biometrics 1980; 36:595-605
34. Dorph-Petersen KA, Delevich KM, Marcsisin MJ, et al: Pyramidal neuron number in layer 3 of primary auditory cortex of subjects with schizophrenia. Brain Res 2009; 1285:42-57
35. Howard CV, Reed MG: Unbiased Stereology: Three-Dimensional Measurement in Microscopy. Oxford, Bios Scientific Publishers, 1998
36. Thomas AJ, Ferrier IN, Kalaria RN, et al: A neuropathological study of vascular factors in late-life depression. J Neurol Neurosurg Psychiatry 2001; 70:83-87
37. Cotter D, Landau S, Beasley C, et al: The density and spatial distribution of GABAergic neurons, labelled using calcium binding proteins, in the anterior cingulate cortex in major depressive disorder, bipolar disorder, and schizophrenia. Biol Psychiatry 2002; 51:377-386
38. Ongur D, Drevets WC, Price JL: Glial reduction in the subgenual prefrontal cortex in mood disorders. Proc Natl Acad Sci USA 1998; 95:13290-13295
39. Thomas AJ, O'Brien JT, Davis S, et al: Ischemic basis for deep white matter hyperintensities in major depression: a neuropatho-logical study. Arch Gen Psychiatry 2002; 59:785-792
40. Cotter D, Mackay D, Landau S, et al: Reduced glial cell density and neuronal size in the anterior cingulate cortex in major depressive disorder. Arch Gen Psychiatry 2001; 58:545-553
41. Cotter D, Hudson L, Landau S: Evidence for orbitofrontal pathology in bipolar disorder and major depression, but not in schizophrenia. Bipolar Disord 2005; 7:358-369
42. Hickie IB, Naismith SL, Ward PB, et al: Serotonin transporter gene status predicts caudate nucleus but not amygdala or hippocampal volumes in older persons with major depression. J Affect Disord 2007; 98:137-142
43. Khundakar AA, Zetterstrom TS: Biphasic change in BDNF gene expression following antidepressant drug treatment explained by differential transcript regulation. Brain Res 2006; 1106:12-20
44. Zafra F, Hengerer B, Leibrock J, et al: Activity dependent regulation of BDNF and NGF mRNAs in the rat hippocampus is mediated by non-NMDA glutamate receptors. EMBO J 1990; 9:3545-3550
45. Matsumoto T, Numakawa T, Yokomaku D, et al: Brain-derived neurotrophic factor-induced potentiation of glutamate and GABA release: different dependency on signaling pathways and neu-ronal activity. Mol Cell Neurosci 2006; 31:70-84
46. D'Sa C, Duman RS: Antidepressants and neuroplasticity. Bipolar Disord 2002; 4:183-194
47. Nair A, Vaidya VA: Cyclic AMP response element binding protein and brain-derived neurotrophic factor: molecules that modulate our mood? J Biosci 2006; 31:423-434
48. Nibuya M, Nestler EJ, Duman RS: Chronic antidepressant administration increases the expression of cAMP response element binding protein (CREB) in rat hippocampus. J Neurosci 1996; 16:2365-2372
49. Chen B, Dowlatshahi D, MacQueen GM, et al: Increased hip-pocampal BDNF immunoreactivity in subjects treated with an-tidepressant medication. Biol Psychiatry 2001; 50:260-265
50. O'Brien JT, Ames D, Schweitzer I, et al: Clinical and magnetic resonance imaging correlates of hypothalamic-pituitary-adrenal axis function in depression and Alzheimer's disease. Br J Psychiatry 1996; 168:679-687
51. Sapolsky RM, Romero LM, Munck AU: How do glucocorticoids influence stress responses? Integrating permissive, suppressive, stimulatory, and preparative actions. Endocr Rev 2000; 21:55-89
52. Guehl D, Benazzouz A, Aouizerate B, et al: Neuronal correlates of obsessions in the caudate nucleus. Biol Psychiatry 2008; 63: 557-562
53. Tekin S, Cummings JL: Frontal-subcortical neuronal circuits and clinical neuropsychiatry: an update. J Psychosom Res 2002; 53:647-654