Associations between APOE variants and metabolic traits and the impact of psychological stress

PLoS ONE

Volumn 6, Issue 1, 2011, Pages

  Iqbal Kring, Sofia I ^a,b   Barefoot, John ^c   Brummett, Beverly H ^c   Boyle, Stephen H ^c   Siegler, Ilene C ^c   Toubro, Søren ^d   Hansen, Torben ^e,f   Astrup, Arne ^g   Pedersen, Oluf ^e,h,i   Williams, Redford B ^c   Sørensen, Thorkild I A ^a  

^a The Capital Region   (Denmark)

^b UNIVERSITY OF COPENHAGEN   (Denmark)

^c DUKE UNIVERSITY MEDICAL CENTER   (United States)

^d HVIDOVRE HOSPITAL   (Denmark)

^e HAGEDORN RESEARCH INSTITUTE   (Denmark)

^f UNIVERSITY OF SOUTHERN DENMARK   (Denmark)

^g UNIVERSITY OF COPENHAGEN   (Denmark)

^h UNIVERSITY OF COPENHAGEN   (Denmark)

ⁱ AARHUS UNIVERSITY   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

APOLIPOPROTEIN E; GLUCOSE; HIGH DENSITY LIPOPROTEIN; INSULIN; LIPID; TRIACYLGLYCEROL;

ADULT; ARTICLE; CONTROLLED STUDY; DENMARK; FEEDBACK SYSTEM; GENETIC ASSOCIATION; GENETIC TRAIT; GENETIC VARIABILITY; GENOTYPE; GLUCOSE BLOOD LEVEL; HUMAN; INSULIN BLOOD LEVEL; INSULIN RESPONSE; INSULIN SENSITIVITY; LIPID BLOOD LEVEL; LIPOPROTEIN BLOOD LEVEL; MALE; MENTAL STRESS; METABOLIC REGULATION; NUCLEOTIDE SEQUENCE; OBESITY; PHENOTYPIC VARIATION; QUESTIONNAIRE; RISK ASSESSMENT; TRIACYLGLYCEROL BLOOD LEVEL; WAIST CIRCUMFERENCE; BLOOD; CASE CONTROL STUDY; GENETICS; INSULIN RESISTANCE; METABOLISM; METHODOLOGY; MIDDLE AGED; MORPHOMETRICS; SINGLE NUCLEOTIDE POLYMORPHISM;

APOLIPOPROTEINS E; BLOOD GLUCOSE; BODY WEIGHTS AND MEASURES; CASE-CONTROL STUDIES; DENMARK; GENOME-WIDE ASSOCIATION STUDY; GENOTYPE; HUMANS; INSULIN RESISTANCE; MALE; METABOLISM; MIDDLE AGED; OBESITY; POLYMORPHISM, SINGLE NUCLEOTIDE; QUESTIONNAIRES; STRESS, PSYCHOLOGICAL; TRIGLYCERIDES;

EID: 79251635683     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0015745     Document Type: Article

References (26)

1. Kahn SE (2003) The relative contributions of insulin resistance and beta-cell dysfunction to the pathophysiology of Type 2 diabetes. Diabetologia 46/1: 3-19.
2. Martyn JA, Kaneki M, Yasuhara S (2008) Obesity-induced insulin resistance and hyperglycemia: etiologic factors and molecular mechanisms. Anesthesiology 109/1: 137-148.
3. Despres JP (2001) Health consequences of visceral obesity. Ann Med 33/8: 534-541.
4. Kahn SE, Hull RL, Utzschneider KM (2006) Mechanisms linking obesity to insulin resistance and type 2 diabetes. Nature 444/7121: 840-846.
5. Song Y, Stampfer MJ, Liu S (2004) Meta-analysis: apolipoprotein E genotypes and risk for coronary heart disease. Ann Intern Med 141/2: 137-147.
6. Breslow JL (2000) Genetics of lipoprotein abnormalities associated with coronary artery disease susceptibility. Annu Rev Genet 34: 233-254.
7. Eichner JE, Dunn ST, Perveen G, Thompson DM, Stewart KE, et al. (2002) Apolipoprotein E Polymorphism and Cardiovascular Disease: A HuGE Review. Am J Epidemiol 155/6: 487-495.
8. Fumeron F, Rigaud D, Bertiere MC, Bardon S, Dely C, et al. (1988) Association of apolipoprotein epsilon 4 allele with hypertriglyceridemia in obesity. Clin Genet 34/4: 258-264.
9. Elosua R, Demissie S, Cupples LA, Meigs JB, Wilson PW, et al. (2003) Obesity modulates the association among APOE genotype, insulin, and glucose in men. Obes Res 11/12: 1502-1508.
10. Jemaa R, Elasmi M, Naouali C, Feki M, Kallel A, et al. (2006) Apolipoprotein E polymorphism in the Tunisian population: frequency and effect on lipid parameters. Clin Biochem 39/8: 816-820.
11. Kring SI, Brummett BH, Barefoot J, Garrett ME, Ashley-Koch AE, et al. (2010) Impact of psychological stress on the associations between apolipoprotein E variants and metabolic traits: findings in an American sample of caregivers and controls. Psychosom Med 72/5: 427-433.
12. Black E, Holst C, Astrup A, Toubro S, Echwald S, et al. (2005) Long-term influences of body-weight changes, independent of the attained weight, on risk of impaired glucose tolerance and Type 2 diabetes. Diabet Med 22/9: 1199-1205.
13. Kring SII, Larsen LH, Holst C, Toubro S, Hansen T, et al. (2008) Genotypephenotype associations in obesity dependent on definition of the obesity phenotype. Obesity Facts 1: 138-145.
14. Sonne-Holm S, Sørensen TIA, Jensen G, Schnohr P (1989) Independent effects of weight change and attained body weight on prevalence of arterial hypertension in obese and non-obese men. BMJ 299/6702: 767-770.
15. World Health Organization (2003) Physical status: The Use and Interpretation of Anthropometry Report of a WHO Expert Committee. Geneva, Switzerland: WHO.
16. Stumvoll M, Mitrakou A, Pimenta W, Jenssen T, Yki-Jarvinen H, et al. (2000) Use of the oral glucose tolerance test to assess insulin release and insulin sensitivity. Diabetes Care 23/3: 295-301.
17. Hansen T, Drivsholm T, Urhammer SA, Palacios RT, Volund A, et al. (2007) The BIGTT test: a novel test for simultaneous measurement of pancreatic betacell function, insulin sensitivity, and glucose tolerance. Diabetes Care 30/2: 257-262.
18. Schnohr P, Jensen G, Lange P, Scharling H, Appleyard M (2001) The Copenhagen City Heart Study. Tables with data from the third examination 1991-1994. Journal of the European Society of Cardiology 3, Supplement H.
19. Buemann B, Sørensen TIA, Pedersen O, Black E, Holst C, et al. (2005) Lowerbody fat mass as an independent marker of insulin sensitivity - the role of adiponectin. Int J Obes Relat Metab Disord 29/6: 624-631.
20. Prescott E, Holst C, Gronbaek M, Schnohr P, Jensen G, et al. (2003) Vital exhaustion as a risk factor for ischaemic heart disease and all-cause mortality in a community sample. A prospective study of 4084 men and 5479 women in the Copenhagen City Heart Study. Int J Epidemiol 32/6: 990-997.
21. Aulchenko YS, Ripatti S, Lindqvist I, Boomsma D, Heid IM, et al. (2009) Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts. Nat Genet 41/1: 47-55.
22. Brummett BH, Babyak MA, Siegler IC, Vitaliano PP, Ballard EL, et al. (2006) Associations among perceptions of social support, negative affect, and quality of sleep in caregivers and noncaregivers. Health Psychol 25/2: 220-225.
23. Brummett BH, Krystal AD, Ashley-Koch A, Kuhn CM, Zuchner S, et al. (2007) Sleep quality varies as a function of 5-HTTLPR genotype and stress. Psychosom Med 69/7: 621-624.
24. Brummett BH, Krystal AD, Siegler IC, Kuhn C, Surwit RS, et al. (2007) Associations of a regulatory polymorphism of monoamine oxidase-A gene promoter (MAOA-uVNTR) with symptoms of depression and sleep quality. Psychosom Med 69/5: 396-401.
25. Cordell HJ, Clayton DG (2005) Genetic association studies. Lancet 366/9491: 1121-1131.
26. Benyamin B, Sørensen TIA, Schousboe K, Fenger M, Visscher PM, et al. (2007) Are there common genetic and environmental factors behind the endophenotypes associated with the metabolic syndrome? Diabetologia 50/9: 1880-1888.