Oxidized low-density lipoprotein promotes osteoblast differentiation in primary cultures of vascular smooth muscle cells by up-regulating Osterix expression in an Msx2-dependent manner

Journal of Cellular Biochemistry

Volumn 112, Issue 2, 2011, Pages 581-588

  Taylor, Jesse ^a   Butcher, Martin ^a   Zeadin, Melec ^a   Politano, Amanda ^a   Shaughnessy, Stephen G ^a  

^a MCMASTER UNIVERSITY   (Canada)

Author keywords

Msx2; osteoblast differentiation; Osterix; oxidized low density lipoprotein; smooth muscle cells

Indexed keywords

ALKALINE PHOSPHATASE; GLYCEROL 2 PHOSPHATE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; OXIDIZED LOW DENSITY LIPOPROTEIN; TRANSCRIPTION FACTOR MSX2; TRANSCRIPTION FACTOR OSTERIX; TRANSCRIPTION FACTOR RUNX2;

ANIMAL CELL; ANIMAL TISSUE; AORTA MEDIA; ARTICLE; ATHEROSCLEROTIC PLAQUE; BLOOD VESSEL CALCIFICATION; BONE DEVELOPMENT; CELL DIFFERENTIATION; ENZYME ACTIVITY; NONHUMAN; OSTEOBLAST; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; SMOOTH MUSCLE FIBER;

ANIMALS; CATTLE; CELL DIFFERENTIATION; CELLS, CULTURED; GLYCEROPHOSPHATES; HOMEODOMAIN PROTEINS; HUMANS; LIPOPROTEINS, LDL; MUSCLE, SMOOTH, VASCULAR; MYOCYTES, SMOOTH MUSCLE; OSTEOBLASTS; TRANSCRIPTION FACTORS;

BOVINAE;

EID: 79251630740     PISSN: 07302312     EISSN: 10974644     Source Type: Journal    
DOI: 10.1002/jcb.22948     Document Type: Article

References (33)

1. Afzal F, Pratap J, Ito K, Ito Y, Stein JL, Van Wijnen AJ, Stein G, Lian JB, Javed A,. 2005. Smad function and intranuclear targeting share a Runx2 motif required for osteogenic lineage induction and BMP2 responsive transcription. J Cell Physiol 204: 63-72.
2. Aubin J, Lian J, Stein G,. 2006. Primer on the metabolic bone diseases and disorders of mineral metabolism (Chapter 4)., Favus MJ, editor. American Society for Bone and Mineral Research. 6th edition. Lippincott Williams and Wilkins: Philadelphia, PA, USA.
3. Bear M, Butcher M, Shaughnessy S,. 2008. Oxidized low-density lipoprotein acts synergistically with β-glycerophosphate to induce osteoblast differentiation in primary cultures of vascular smooth muscle cells. J Cell Biochem 105: 108-193.
4. Bellows CG, Aubin JE, Heersche JN,. 1991. Initiation and progression of mineralization of bone nodules formed in vitro: The role of alkaline phosphatase and organic phosphate. Bone Miner 14 (1): 27-40.
5. Bostrom K, Watson KE, Horn S, Wortham C, Herman IM, Demer LL,. 1993. Bone morphogenetic protein expression in human atherosclerotic lesions. J Clin Invest 91: 1800-1809.
6. Celil AB, Campbell PG,. 2005. BMP-2 and insulin-like growth factor-1 mediate osterix (Osx) expression in human mesenchymal stem cells via the MAPK and protein kinase D signalling pathways. J Biol Chem 280: 31353-31359.
7. Celil AB, Hollinger JO, Campbell PG,. 2005. Osx transcriptional regulation is mediated by additional pathways to BMP2/Smad signalling. J Cell Biochem 95: 518-528.
8. Chen NX, Duan D, O'Neill KD, Wolisi GO, Koczman JJ, LaClair R, Moe SM,. 2006. The mechanism of uremic serum-induced expression of bone matrix proteins in bovine vascular smooth muscle cells. Kidney Int 70: 1046-1053.
9. Cheng S, Shao J, Charlton-Kachigaian N, Lowey A, Towler D,. 2003. Msx2 promotes osteogenesis and suppresses adipogenic differentiation of multipotent mesencymal progenitors. J Biol Chem 278: 45969-45977.
10. Doherty TM, Fitzpatrick LA, Inoue D, Qiao JH, Fishbein MC, Detrano RC, Shah PK, Rajavashisth TB,. 2004. Molecular, endocrine, and genetic mechanism of arterial calcification. Endocr Rev 25: 629-672.
11. Fujii M, Takeda K, Imamura T, Aoki H, Sampath TK, Enomoto S, Kawabata M, Kato M, Ichijo H, Miyazono K,. 1999. Roles of bone morphogenetic protein type 1 receptors and Smad proteins in osteoblast and chondroblast differentiation. Mol Biol Cell 10: 3801-3813.
12. Hanai J, Chen LF, Kanno T, Ohtani-Fujita N, Kim WY, Guo WH, Imamura T, Ishidou Y, Fukuchi M, Shi MJ, Stavnezer J, Kawabata M, Miyazono K, Ito Y,. 1999. Interaction and functional cooperation of PEBP2/CBF with Smads. J Biol Chem 274: 31577-31582.
13. Ichida F, Nishimura R, Hata K, Matsubara T, Ikeda F, Hisada K, Yatani H, Cao X, Komori T, Yamaguchi A, Yoneda T,. 2004. Reciprocal roles of Msx2 in regulation of osteoblast and adipocyte differentiation. J Biol Chem 279: 34015-34022.
14. Kim YJ, Lee MH, Wozney JM, Cho JY, Ryoo HM,. 2004. BMP-2 induced ALP expression is stimulated by Dlx5 and repressed by Msx2. J Biol Chem 279: 50073-50080.
15. Komori T,. 2006. Regulation of osteoblast differentiation by transcription factors. J Cell Biochem 99 (5): 1233-1239.
16. Komori T, Yagi H, Nomura S, Yamaguchi A, Sasaki K, Deguchi K, Shimizu Y, Bronson RT, Gao YH, Inada M, Sato M, Okamoto R, Kitamura Y, Yoshiki S, Kishimoto T,. 1997. Targeted disruption of Cbfa1 results in complete lack of bone formation owing to maturational arrest of osteoblasts. Cell 89 (5): 755-764.
17. Lee M, Kwon T, Park H, Wozney J, Ryoo H,. 2003. BMP-2-induced Osterix expression is mediated by Dlx5 but is independent of Runx2. Biochem Biophys Res Commun 309: 689-694.
18. Manolagas S, Buron D, Deftos L,. 1981. 1,25-Dihydroxyvitamin D3 stimulates the alkaline phosphatase activity of osteoblast-like cells. J Biol Chem 256: 7115-7117.
19. Matsubara T, Kida K, Yamaguchi A, Hata K, Ichida F, Meguro H, Aburatani H, Nishimura R, Yoneda T,. 2008. BMP2 regulates Osterix through Msx2 and Runx2 during osteoblast differentiation. J Biol Chem 283: 29119-29125.
20. Nakashima K, Zhou X, Kunkel G, Zhang Z, Deng J, Behringer R, de Crombrugghe B,. 2002. The novel zinc finger-containing transcription factor osterix is required for osteoblast differentiation and bone formation. Cell 108: 17-29.
21. Nishio Y, Dong Y, Paris M, O'Keefe RJ, Schwarz EM, Drissi H,. 2006. Runx2-mediated regulation of the zinc finger Osterix/Sp7 gene. Gene 10: 62-70.
22. Otto F, Thornell AP, Crompton T, Denzel A, Gilmour KC, Rosewell IR, Stamp GWH, Beddington RSP, Mundlos S, Olsen BR, Selby PB, Owen MJ,. 1997. Cbfa1, a candidate gene for cleidocranial dysplasia syndrome, is essential for osteoblast differentiation and bone development. Cell 89: 765-771.
23. Phimphilai M, Zhao Z, Boules H, Roca H, Franceschi RT,. 2006. BMP Signaling is required for RunX2-dependent induction of the osteoblast phenotype. J Bone Miner Res 21: 637-646.
24. Schroeder T, Jensen E, Westendorf J,. 2005. Runx2: A master organizer of gene transcription in developing and maturing osteoblasts. Birth Defects Res 75: 213-225.
25. Shanahan CM, Weissberg PL,. 1999. Smooth muscle cell phenotypes in atherosclerotic lesions. Curr Opin Lipidol 10: 507-513.
26. Tenenbaum HC, Limeback H, McCulloch CA, Mamujee H, Sukhu B, Torontali M,. 1992. Osteogenic phase-specific co-regulation of collagen synthesis and mineralization by beta-glycerophosphate in chick periosteal cultures. Bone 13 (5): 129-138.
27. Tyson KL, Reynolds JL, McNair R, Zhang Q, Weissberg PL, Shanahan CM,. 2003. Osteo/chondrocytic transcription factors and their target genes exhibit distinct patterns of expression in human arterial calcification. Arterioscler Thromb Vasc Biol 23: 489-494.
28. Vattikuti R, Towler DA,. 2004. Osteogenic regulation of vascular calcification: An early prospective. Am J Physiol Endocrinol Metab 286: E686-E696.
29. Velarde VA, Jenkins J, Christopher T, Lyons A, Jaffa A,. 2001. Activation of MAPK by modified low-density lipoproteins in vascular smooth muscle cells. J Appl Physiol 91: 412-420.
30. Watson KE, Bostrom K, Ravindranath R, Lam T, Norton B, Demer LL,. 1994. TGF-β1 and 25-hydroxycholesterol stimulate osteoblast-like vascular cells to calcify. J Clin Invest 93: 2106-2113.
31. Yang L, Butcher M, Simon R, Osip S, Shaughnessy S,. 2005. The effect of heparin on osteoblast differentiation and activity in primary cultures of bovine aortic smooth muscle cells. Atherosclerosis 179: 79-86.
32. Zeadin M, Butcher M, Werstuck G, Khan M, Yee CY, Shaughnessy SG,. 2009. The effect of leptin on vascular calcification in Apolipoprotein E-deficient mice. Arterioscler Thromb Vasc Biol 29: 2069-2075.
33. Zhang Y, Natsuo Y, Ito K, Huang G, Fujii M, Hanai J, Nogami H, Ochi T, Miyazono Z, Ito Y,. 2000. A RUNX2/PEBP2αA/CBFA1 mutation displaying impaired transactivation and Smad interaction in cleidocranial dysplasia. PNAS 97: 10549-10554.