Molecular and functional characterization of cynomolgus monkey IgG subclasses

Journal of Immunology

Volumn 186, Issue 1, 2011, Pages 341-349

  Jacobsen, Frederick W ^a   Padaki, Rupa ^a   Morris, Arvia E ^b   Aldrich, Teri L ^b,c   Armitage, Richard J ^b   Allen, Martin J ^b,d   Lavallee, Jennifer C ^a   Arora, Taruna ^a  

^a AMGEN INC   (United States)

^b AMGEN INC   (United States)

^c ZYMOGENETICS INC   (United States)

^d PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FC RECEPTOR; IMMUNOGLOBULIN G; IMMUNOGLOBULIN G1; IMMUNOGLOBULIN G2; IMMUNOGLOBULIN G3; IMMUNOGLOBULIN G4;

ARTICLE; CLINICAL STUDY; CONTROLLED STUDY; CYNOMOLGUS MONKEY; GENE SEQUENCE; GENETIC ASSOCIATION; HUMAN; HUMAN CELL; IMMUNE RESPONSE; IMMUNOMODULATION; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIMATE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN BINDING; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; RHESUS MONKEY;

AMINO ACID SEQUENCE; ANIMALS; CELL LINE, TRANSFORMED; CONSERVED SEQUENCE; HUMANS; IMMUNOGLOBULIN CONSTANT REGIONS; IMMUNOGLOBULIN G; IMMUNOGLOBULIN LIGHT CHAINS; MACACA FASCICULARIS; MACACA MULATTA; MOLECULAR SEQUENCE DATA; PROTEIN ENGINEERING; SEQUENCE ANALYSIS, DNA; SEQUENCE HOMOLOGY, AMINO ACID;

EID: 79251585222     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1001685     Document Type: Article

References (37)

1. Ferrant, J. L., C. D. Benjamin, A. H. Cutler, S. L. Kalled, Y. M. Hsu, E. A. Garber, D. M. Hess, R. I. Shapiro, N. S. Kenyon, D. M. Harlan, et al. 2004. The contribution of Fc effector mechanisms in the efficacy of anti-CD154 immunotherapy depends on the nature of the immune challenge. Int. Immunol. 16: 1583-1594.
2. Tabrizi, M. A., and L. K. Roskos. 2007. Preclinical and clinical safety of monoclonal antibodies. Drug Discov. Today 12: 540-547.
3. Ravetch, J. V., and J. P. Kinet. 1991. Fc receptors. Annu. Rev. Immunol. 9: 457-492.
4. Gessner, J. E., H. Heiken, A. Tamm, and R. E. Schmidt. 1998. The IgG Fc receptor family. Ann. Hematol. 76: 231-248.
5. Jefferis, R., and J. Lund. 2002. Interaction sites on human IgG-Fc for FcγR: current models. Immunol. Lett. 82: 57-65.
6. Nimmerjahn, F., and J. V. Ravetch. 2006. Fcγ receptors: old friends and new family members. Immunity 24: 19-28.
7. Canfield, S. M., and S. L. Morrison. 1991. The binding affinity of human IgG for its high affinity Fc receptor is determined by multiple amino acids in the CH2 domain and is modulated by the hinge region. J. Exp. Med. 173: 1483-1491.
8. H3 domains on in vivo effector function. J. Immunol. 161: 3862-3869.
9. Calvas, P., P. Apoil, F. Fortenfant, F. Roubinet, J. Andris, D. Capra, and A. Blancher. 1999. Characterization of the three immunoglobulin G subclasses of macaques. Scand. J. Immunol. 49: 595-610.
10. Hayasaka, K., K. Fujii, and S. Horai. 1996. Molecular phylogeny of macaques: implications of nucleotide sequences from an 896-base pair region of mitochondrial DNA. Mol. Biol. Evol. 13: 1044-1053.
11. Lewis, A. P., K. A. Barber, H. J. Cooper, M. J. Sims, J. Worden, and J. S. Crowe. 1993. Cloning and sequence analysis of k and g cynomolgus monkey immunoglobulin cDNAs. Dev. Comp. Immunol. 17: 549-560.
12. Scinicariello, F., C. N. Engleman, L. Jayashankar, H. M. McClure, and R. Attanasio. 2004. Rhesus macaque antibody molecules: sequences and heterogeneity of α and γ constant regions. Immunology 111: 66-74.
13. Ettehadieh, E., S. Wong-Madden, T. Aldrich, K. Lane, and A. E. Morris. 2002. Over-expression of protein kinase Bα enhances recombinant protein expression in transient systems. Cytotechnology 38: 11-14.
14. Shirakata, M., and K. Hirai. 1998. Identification of minimal oriP of Epstein-Barr virus required for DNA replication. J. Biochem. 123: 175-181. (Pubitemid 28068582)
15. Shields, R. L., A. K. Namenuk, K. Hong, Y. G. Meng, J. Rae, J. Briggs, D. Xie, J. Lai, A. Stadlen, B. Li, et al. 2001. High resolution mapping of the binding site on human IgG1 for FcγRI, FcγRII, FcγRIII, and FcRn and design of IgG1 variants with improved binding to the FcγR. J. Biol. Chem. 276: 6591-6604.
16. Tao, M. H., and S. L. Morrison. 1989. Studies of aglycosylated chimeric mouse-human IgG: role of carbohydrate in the structure and effector functions mediated by the human IgG constant region. J. Immunol. 143: 2595-2601.
17. Chappel, M. S., D. E. Isenman, M. Everett, Y. Y. Xu, K. J. Dorrington, and M. H. Klein. 1991. Identification of the Fcγ receptor class I binding site in human IgG through the use of recombinant IgG1/IgG2 hybrid and point-mutated antibodies. Proc. Natl. Acad. Sci. USA 88: 9036-9040.
18. Jefferis, R., J. Lund, and J. Pound. 1990. Molecular definition of interaction sites on human IgG for Fc receptors (huFcγR). Mol. Immunol. 27: 1237-1240.
19. Schuurman, J., G. J. Perdok, A. D. Gorter, and R. C. Aalberse. 2001. The interheavy chain disulfide bonds of IgG4 are in equilibrium with intra-chain disulfide bonds. Mol. Immunol. 38: 1-8.
20. Grubb, R. 1995. Advances in human immunoglobulin allotypes. Exp. Clin. Immunogenet. 12: 191-197.
21. Bruhns, P., B. Iannascoli, P. England, D. A. Mancardi, N. Fernandez, S. Jorieux, and M. Daëron. 2009. Specificity and affinity of human Fcγ receptors and their polymorphic variants for human IgG subclasses. Blood 113: 3716-3725.
22. Bhogal, N., and R. Combes. 2006. TGN1412: time to change the paradigm for the testing of new pharmaceuticals. Altern. Lab. Anim. 34: 225-239.
23. Clynes, R. 2006. Antitumor antibodies in the treatment of cancer: Fc receptors link opsonic antibody with cellular immunity. Hematol. Oncol. Clin. North Am. 20: 585-612.
24. Koene, H. R., M. Kleijer, J. Algra, D. Roos, A. E. von dem Borne, and M. de Haas. 1997. FcγRIIIa-158V/F polymorphism influences the binding of IgG by natural killer cell FcγRIIIa, independently of the FcγRIIIa-48L/ R/H phenotype. Blood 90: 1109-1114.
25. Ravetch, J. V., and B. Perussia. 1989. Alternative membrane forms of FcγRIII (CD16) on human natural killer cells and neutrophils: cell type-specific expression of two genes that differ in single nucleotide substitutions. J. Exp. Med. 170: 481-497.
26. van der Pol, W., and J. G. van de Winkel. 1998. IgG receptor polymorphisms: risk factors for disease. Immunogenetics 48: 222-232. (Pubitemid 28352188)
27. Cartron, G., L. Dacheux, G. Salles, P. Solal-Celigny, P. Bardos, P. Colombat, and H. Watier. 2002. Therapeutic activity of humanized anti-CD20 monoclonal antibody and polymorphism in IgG Fc receptor FcγRIIIa gene. Blood 99: 754-758.
28. Wu, J., J. C. Edberg, P. B. Redecha, V. Bansal, P. M. Guyre, K. Coleman, J. E. Salmon, and R. P. Kimberly. 1997. A novel polymorphism of FcγRIIIa (CD16) alters receptor function and predisposes to autoimmune disease. J. Clin. Invest. 100: 1059-1070.
29. Rogers, K. A., F. Scinicariello, and R. Attanasio. 2006. IgG Fc receptor III homologues in nonhuman primate species: genetic characterization and ligand interactions. J. Immunol. 177: 3848-3856.
30. Salmon, J. E., J. C. Edberg, N. L. Brogle, and R. P. Kimberly. 1992. Allelic polymorphisms of human Fcγ receptor IIA and Fcγ receptor IIIB: independent mechanisms for differences in human phagocyte function. J. Clin. Invest. 89: 1274-1281.
31. Roux, K. H., L. Strelets, and T. E. Michaelsen. 1997. Flexibility of human IgG subclasses. J. Immunol. 159: 3372-3382.
32. Dillon, T. M., M. S. Ricci, C. Vezina, G. C. Flynn, Y. D. Liu, D. S. Rehder, M. Plant, B. Henkle, Y. Li, S. Deechongkit, et al. 2008. Structural and functional characterization of disulfide isoforms of the human IgG2 subclass. J. Biol. Chem. 283: 16206-16215.
33. Lund, J., T. Tanaka, N. Takahashi, G. Sarmay, Y. Arata, and R. Jefferis. 1990. A protein structural change in aglycosylated IgG3 correlates with loss of huFcγR1 and huFcγR111 binding and/or activation. Mol. Immunol. 27: 1145-1153.
34. Wypych, J., M. Li, A. Guo, Z. Zhang, T. Martinez, M. J. Allen, S. Fodor, D. N. Kelner, G. C. Flynn, Y. D. Liu, et al. 2008. Human IgG2 antibodies display disulfide-mediated structural isoforms. J. Biol. Chem. 283: 16194-16205.
35. van der Neut Kolfschoten, M., J. Schuurman, M. Losen, W. K. Bleeker, P. Martínez-Martínez, E. Vermeulen, T. H. den Bleker, L. Wiegman, T. Vink, L. A. Aarden, et al. 2007. Anti-inflammatory activity of human IgG4 antibodies by dynamic Fab arm exchange. Science 317: 1554-1557.
36. Duncan, A. R., J. M. Woof, L. J. Partridge, D. R. Burton, and G. Winter. 1988. Localization of the binding site for the human high-affinity Fc receptor on IgG. Nature 332: 563-564.
37. Lund, J., N. Takahashi, J. D. Pound, M. Goodall, H. Nakagawa, and R. Jefferis. 1995. Oligosaccharide-protein interactions in IgG can modulate recognition by Fcγ receptors. FASEB J. 9: 115-119.