HTS, chemical hybridization, and drug design identify a chemically unique antituberculosis agent-coupling serendipity and rational approaches to drug discovery

ChemMedChem

Volumn 2, Issue 6, 2007, Pages 811-813

  Mao, Jialin ^a   Wan, Baojie ^a   Wang, Yuehong ^a   Franzblau, Scott G ^a   Kozikowski, Alan P ^a  

^a UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

Author keywords

Isoxazole; Mefloquine; MIC; Nitrile oxide cycloaddition; Tuberculosis

Indexed keywords

DRUG DERIVATIVE; ISOXAZOLE DERIVATIVE; LEUCINAMIDE; LEUCINE; MEFLOQUINE; TUBERCULOSTATIC AGENT; UNCLASSIFIED DRUG;

ANIMAL; ARTICLE; CELL LINE; CERCOPITHECUS; CHEMISTRY; DRUG DELIVERY SYSTEM; DRUG DESIGN; DRUG EFFECT; MICROBIOLOGICAL EXAMINATION; MOLECULAR LIBRARY; MOUSE; MYCOBACTERIUM TUBERCULOSIS; SYNTHESIS; VERO CELL;

ANIMALS; ANTITUBERCULAR AGENTS; CELL LINE; CERCOPITHECUS AETHIOPS; DRUG DELIVERY SYSTEMS; DRUG DESIGN; ISOXAZOLES; LEUCINE; MEFLOQUINE; MICE; MICROBIAL SENSITIVITY TESTS; MYCOBACTERIUM TUBERCULOSIS; SMALL MOLECULE LIBRARIES; VERO CELLS;

EID: 51049100017     PISSN: 18607179     EISSN: 18607187     Source Type: Journal    
DOI: 10.1002/cmdc.200700048     Document Type: Article

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