Acquisition of humoral transplantation tolerance upon de novo emergence of B lymphocytes

Journal of Immunology

Volumn 186, Issue 1, 2011, Pages 614-620

  Parsons, Ronald F ^a   Vivek, Kumar ^a   Rostami, Susan Y ^a   Zekavat, Ghazal ^a   Ziaie, Seyed M ^a   Luo, Yanping ^a,b   Koeberlein, Brigitte ^a   Redfield, Robert R ^a   Cancro, Michael P ^a   Naji, Ali ^a   Noorchashm, Hooman ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b INSTITUTE OF HYDROBIOLOGY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ALLOANTIBODY; ALLOANTIGEN;

ALLOIMMUNITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; B LYMPHOCYTE; CARDIAC GRAFT REJECTION; CONTROLLED STUDY; DONOR; GRAFT REJECTION; HEART TRANSPLANTATION; HUMAN; HUMORAL IMMUNITY; IMMUNOLOGICAL TOLERANCE; LYMPHOID CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; SKIN TRANSPLANTATION; STEADY STATE; T LYMPHOCYTE;

ADOPTIVE TRANSFER; ANIMALS; ANTIBODY SPECIFICITY; B-LYMPHOCYTE SUBSETS; BONE MARROW TRANSPLANTATION; CELL DIFFERENTIATION; CLONE CELLS; HEART TRANSPLANTATION; HEMATOPOIETIC STEM CELL TRANSPLANTATION; ISOANTIBODIES; ISOANTIGENS; LYMPHOCYTE DEPLETION; LYMPHOCYTE TRANSFUSION; LYMPHOPENIA; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MICE, KNOCKOUT; MICE, SCID; MICE, TRANSGENIC; SKIN TRANSPLANTATION; T-LYMPHOCYTE SUBSETS; TRANSPLANTATION TOLERANCE;

EID: 79251561881     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1002873     Document Type: Article

References (38)

1. Kwun, J., and S. J. Knechtle. 2009. Overcoming chronic rejection-can it B? Transplantation 88: 955-961.
2. Terasaki, P. I., and J. Cai. 2008. Human leukocyte antigen antibodies and chronic rejection: from association to causation. Transplantation 86: 377-383.
3. Noorchashm, H., A. J. Reed, S. Y. Rostami, R. Mozaffari, G. Zekavat, B. Koeberlein, A. J. Caton, and A. Naji. 2006. B cell-mediated antigen presentation is required for the pathogenesis of acute cardiac allograft rejection. J. Immunol. 177: 7715-7722.
4. Kirk, A. D., W. M. Baldwin, M. I. Cascalho, A. S. Chong, M. Sykes, and L. J. West. 2007. American society of transplantation symposium on B cells in transplantation: harnessing humoral immunity from rodent models to clinical practice. Am. J. Transplant. 7: 1464-1470.
5. Norvell, A., L. Mandik, and J. G. Monroe. 1995. Engagement of the antigen-receptor on immature murine B lymphocytes results in death by apoptosis. J. Immunol. 154: 4404-4413.
6. Nossal, G. J., and B. L. Pike. 1975. Evidence for the clonal abortion theory of B-lymphocyte tolerance. J. Exp. Med. 141: 904-917.
7. Nemazee, D. A., and K. Bürki. 1989. Clonal deletion of B lymphocytes in a transgenic mouse bearing anti-MHC class I antibody genes. Nature 337: 562-566.
8. Cancro, M. P. 2009. Signalling crosstalk in B cells: managing worth and need. Nat. Rev. Immunol. 9: 657-661.
9. Sandel, P. C., and J. G. Monroe. 1999. Negative selection of immature B cells by receptor editing or deletion is determined by site of antigen encounter. Immunity 10: 289-299.
10. Miller, J. P., J. E. Stadanlick, and M. P. Cancro. 2006. Space, selection, and surveillance: setting boundaries with BLyS. J. Immunol. 176: 6405-6410.
11. Parsons, R. F., K. Vivek, R. R. Redfield, T. S. Migone, M. Cancro, A. Naji, and H. Noorchashm. 2009. B-cell tolerance in transplantation: is repertoire remodeling the answer? Expert Rev. Clin. Immunol. 5: 703-723.
12. Allman, D. M., S. E. Ferguson, and M. P. Cancro. 1992. Peripheral B cell maturation. I. Immature peripheral B cells in adults are heat-stable antigenhi and exhibit unique signaling characteristics. J. Immunol. 149: 2533-2540.
13. Allman, D. M., S. E. Ferguson, V. M. Lentz, and M. P. Cancro. 1993. Peripheral B cell maturation. II. Heat-stable antigen(hi) splenic B cells are an immature developmental intermediate in the production of long-lived marrow-derived B cells. J. Immunol. 151: 4431-4444.
14. Schwickert, T. A., R. L. Lindquist, G. Shakhar, G. Livshits, D. Skokos, M. H. Kosco-Vilbois, M. L. Dustin, and M. C. Nussenzweig. 2007. In vivo imaging of germinal centres reveals a dynamic open structure. Nature 446: 83-87.
15. Li, Y., L. Ma, J. Shen, and A. S. Chong. 2007. Peripheral deletion of mature alloreactive B cells induced by costimulation blockade. Proc. Natl. Acad. Sci. USA 104: 12093-12098.
16. Burns, A. M., L. Ma, Y. Li, D. Yin, J. Shen, J. Xu, and A. S. Chong. 2009. Memory alloreactive B cells and alloantibodies prevent anti-CD154-mediated allograft acceptance. J. Immunol. 182: 1314-1324.
17. Mandik-Nayak, L., A. Bui, H. Noorchashm, A. Eaton, and J. Erikson. 1997. Regulation of anti-double-stranded DNA B cells in nonautoimmune mice: localization to the T-B interface of the splenic follicle. J. Exp. Med. 186: 1257-1267.
18. Hartley, S. B., J. Crosbie, R. Brink, A. B. Kantor, A. Basten, and C. C. Goodnow. 1991. Elimination from peripheral lymphoid tissues of self-reactive B lymphocytes recognizing membrane-bound antigens. Nature 353: 765-769.
19. Goodnow, C. C., J. Crosbie, S. Adelstein, T. B. Lavoie, S. J. Smith-Gill, R. A. Brink, H. Pritchard-Briscoe, J. S. Wotherspoon, R. H. Loblay, K. Raphael, et al. 1988. Altered immunoglobulin expression and functional silencing of self-reactive B lymphocytes in transgenic mice. Nature 334: 676-682.
20. Trivedi, H. L., P. I. Terasaki, A. Feroz, A. V. Vanikar, V. B. Trivedi, S. I. Khemchandani, S. D. Dave, V. Shankar, P. R. Modi, H. Kaneku, et al. 2010. Clonal deletion with bortezomib followed by low or no maintenance immuno-suppression in renal allograft recipients. Transplantation 90: 221-222.
21. Trivedi, H. L., H. Kaneku, P. I. Terasaki, A. Feroz, A. V. Vanikar, V. B. Trivedi, S. I. Khemchandani, S. D. Dave, P. R. Modi, F. Jahr, et al. 2009. Clonal deletion using total lymphoid irradiation with no maintenance immunosuppression in renal allograft recipients. Clin. Transpl.: 265-280.
22. Marti, H. P., J. Henschkowski, G. Laux, B. Vogt, C. Seiler, G. Opelz, and F. J. Frey. 2006. Effect of donor-specific transfusions on the outcome of renal allografts in the cyclosporine era. Transpl. Int. 19: 19-26.
23. Flye, M. W., K. Burton, T. Mohanakumar, D. Brennan, C. Keller, J. A. Goss, G. A. Sicard, and C. B. Anderson. 1995. Donor-specific transfusions have long-term beneficial effects for human renal allografts. Transplantation 60: 1395-1401.
24. Wu, K., F. Xiang, J. Yuan, Z. Zeng, H. Zhou, S. Chang, and Z. K. Chen. 2008. A combination of donor specific transfusion and rapamycin prolongs cardiac allograft survival in mice. Transplant. Proc. 40: 3699-3701.
25. Salgar, S. K., R. Shapiro, F. Dodson, R. Corry, K. McCurry, A. Zeevi, S. Pham, K. Abu-Elmagd, J. Reyes, M. Jordan, et al. 1999. Infusion of donor leukocytes to induce tolerance in organ allograft recipients. J. Leukoc. Biol. 66: 310-314.
26. Sykes, M., I. Shimizu, and T. Kawahara. 2005. Mixed hematopoietic chimerism for the simultaneous induction of T and B cell tolerance. Transplantation 79(3, Suppl)S28-S29.
27. Yang, Y. G., E. deGoma, H. Ohdan, J. L. Bracy, Y. Xu, J. Iacomini, A. D. Thall, and M. Sykes. 1998. Tolerization of anti-Galalpha1-3Gal natural antibody-forming B cells by induction of mixed chimerism. J. Exp. Med. 187: 1335-1342.
28. Cosimi, A. B., and D. H. Sachs. 2004. Mixed chimerism and transplantation tolerance. Transplantation 77: 943-946.
29. Kawai, T., A. B. Cosimi, T. R. Spitzer, N. Tolkoff-Rubin, M. Suthanthiran, S. L. Saidman, J. Shaffer, F. I. Preffer, R. Ding, V. Sharma, et al. 2008. HLA-mismatched renal transplantation without maintenance immunosuppression. N. Engl. J. Med. 358: 353-361.
30. Scandling, J. D., S. Busque, S. Dejbakhsh-Jones, C. Benike, M. T. Millan, J. A. Shizuru, R. T. Hoppe, R. Lowsky, E. G. Engleman, and S. Strober. 2008. Tolerance and chimerism after renal and hematopoietic-cell transplantation. N. Engl. J. Med. 358: 362-368.
31. Russell, D. M., Z. Dembić, G. Morahan, J. F. Miller, K. Bürki, and D. Nemazee. 1991. Peripheral deletion of self-reactive B cells. Nature 354: 308-311.
32. Lang, J., M. Jackson, L. Teyton, A. Brunmark, K. Kane, and D. Nemazee. 1996. B cells are exquisitely sensitive to central tolerance and receptor editing induced by ultralow affinity, membrane-bound antigen. J. Exp. Med. 184: 1685-1697.
33. Fulcher, D. A., A. B. Lyons, S. L. Korn, M. C. Cook, C. Koleda, C. Parish, B. Fazekas de St Groth, and A. Basten. 1996. The fate of self-reactive B cells depends primarily on the degree of antigen receptor engagement and availability of T cell help. J. Exp. Med. 183: 2313-2328.
34. Cyster, J. G., S. B. Hartley, and C. C. Goodnow. 1994. Competition for follicular niches excludes self-reactive cells from the recirculating B-cell repertoire. Nature 371: 389-395.
35. Lang, J., and D. Nemazee. 2000. B cell clonal elimination induced by membrane-bound self-antigen may require repeated antigen encounter or cell competition. Eur. J. Immunol. 30: 689-696.
36. Claas, F. 2004. Chimerism as a tool to induce clinical transplantation tolerance. Curr. Opin. Immunol. 16: 578-583.
37. Liu, C., H. Noorchashm, J. A. Sutter, M. Naji, E. L. Prak, J. Boyer, T. Green, M. R. Rickels, J. E. Tomaszewski, B. Koeberlein, et al. 2007. B lymphocyte-directed immunotherapy promotes long-term islet allograft survival in nonhuman primates. Nat. Med. 13: 1295-1298.
38. Kelishadi, S. S., A. M. Azimzadeh, T. Zhang, T. Stoddard, E. Welty, C. Avon, M. Higuchi, A. Laaris, X. F. Cheng, C. McMahon, and R. N. Pierson, III. 2010. Preemptive CD20+ B cell depletion attenuates cardiac allograft vasculopathy in cyclosporine-treated monkeys. J. Clin. Invest. 120: 1275-1284.