Synthesis of 1-[(1R)-1-(6-fluoro-1,3-benzothiazol-2-yl)ethyl]-3-substituted phenyl ureas and their inhibition activity to acetylcholinesterase and butyrylcholinesterase

Journal of Heterocyclic Chemistry

Volumn 48, Issue 1, 2011, Pages 57-62

  Pejchal, Vladimír ^a   Ŝtêpánková, Ŝárka ^a   Drabina, Pavel ^a  

^a UNIVERSITY OF PARDUBICE   (Czech Republic)

Author keywords

[No Author keywords available]

Indexed keywords

1 (2,6 DIISOPROPYLPHENYL) 3 [1 (6 FLUORO 1,3 BENZOTHIAZOL 2 YL)ETHYL]UREA; 1 (3 CHLORO 4 METHYLPHENYL) 3 [1 (6 FLUORO 1,3 BENZOTHIAZOL 2 YL)ETHYL]UREA; 1 (3,5 DICHLOROPHENYL) 3 [1 (6 FLUORO 1,3 BENZOTHIAZOL 2 YL)ETHYL]UREA; 1 (3,5 DIMETHYLPHENYL) 3 [1 (6 FLUORO 1,3 BENZOTHIAZOL 2 YL)ETHYL]UREA; 1 (4 CHLOROPHENYL) 3 [1 (6 FLUORO 1,3 BENZOTHIAZOL 2 YL)ETHYL]UREA; 1 (4 CYANOPHENYL) 3 [1 (6 FLUORO 1,3 BENZOTHIAZOL 2 YL)ETHYL]UREA; 1 (4 ISOPROPYLPHENYL) 3 [1 (6 FLUORO 1,3 BENZOTHIAZOL 2 YL)ETHYL]UREA; 1 (4 NITROPHENYL) 3 [1 (6 FLUORO 1,3 BENZOTHIAZOL 2 YL)ETHYL]UREA; 1 [1 (6 FLUORO 1,3 BENZOTHIAZOL 2 YL)ETHYL] 3 PHENYLUREA; 1 BENZYL 3 [1 (6 FLUORO 1,3 BENZOTHIAZOL 2 YL)ETHYL]UREA; ACETYLCHOLINESTERASE; BENZOTHIAZOLE DERIVATIVE; CARBANILAMIDE DERIVATIVE; CHOLINESTERASE; CHOLINESTERASE INHIBITOR; ETHYLAMINE; ISOCYANIC ACID DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CHOLINESTERASE INHIBITION; DRUG STRUCTURE; DRUG SYNTHESIS; FLUORINE NUCLEAR MAGNETIC RESONANCE; IC 50; OPTICAL ROTATION; POLYMERIZATION; PROTON NUCLEAR MAGNETIC RESONANCE;

EID: 79251553781     PISSN: 0022152X     EISSN: 19435193     Source Type: Journal    
DOI: 10.1002/jhet.502     Document Type: Article

References (12)

1. Marcelo, F.,;, Silva, F. V. M.,;, Goulart, M.,;, Justino, J.,;, SinaÃ, P.,;, Blériot, Y.,;, Rauter, A. P., Bioorg Med Chem 2009, 17, 5106.
2. Massoulié, J.,;, Pezzementi, L.,;, Bon, S.,;, Krejci, E.,;, Vallette, F.-M., Prog Neurobiol 1993, 41, 31.
3. ŜtÄpánková, Ŝ.,;, Komers, K., Curr Enzyme Inhib 2008, 4, 160.
4. Grutzendler, J.,;, Morris, J. C., Drugs 2001, 61, 41.
5. Blacklock, T. J.,;, Shuman, R. F.,;, Butcher, J. W.,;, Schearin, W. E.,;, Budavari, J.,;, Grenda, V. J., J Org Chem 1988, 53, 836.
6. Hijikata, Ch,. WO Pat. 2,001,074,794, 2001
7. Hijikata, Ch, Chem Abstr 2001, 135, 288775.
8. Hijikata, Ch,. US patent 6,608,207, 2003.
9. Itoh, O.,;, Honnami, T.,;, Amano, A.,;, Murata, K.,;, Koichi, Y.,;, Sugita, T., J Org Chem 1992, 57, 7334.
10. Sussman, J. L.,;, Harel, M.,;, Frolow, F.,;, Oefner, C.,;, Goldman, A.,;, Toker, L.,;, Silman, I., Science 1991, 25, 872.
11. Vellom, D. C.,;, Radic, Z.,;, Li, Y.,;, Pickering, N. A.,;, Camp, S.,;, Taylor, P., Biochemistry 1993, 32, 12.
12. ZdraÅilová, P.,;, ŜtÄpánková, Ŝ.,;, Komers, K.,;, Ventura, K.,;, Cegan, A. Z., Naturforsch 2004, 59c, 293.