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Volumn 4, Issue 4, 2008, Pages 160-171

Cholinesterases and cholinesterase inhibitors

Author keywords

Alzheimer's disease; Cholinesterase inhibitors; Cholinesterases

Indexed keywords

ACETYLCHOLINE; ACETYLCHOLINESTERASE; CARBAMIC ACID DERIVATIVE; CHOLINESTERASE; CHOLINESTERASE INHIBITOR; DONEPEZIL; EPTASTIGMINE; GALANTAMINE; HUPERZINE A; HUPERZINE B; MEMANTINE; METRIFONATE; NAMEDA; NEUROTRANSMITTER; PHYSOSTIGMINE; PSYCHOTROPIC AGENT; RIVASTIGMINE; TACRINE; UNCLASSIFIED DRUG;

EID: 65749099856     PISSN: 15734080     EISSN: None     Source Type: Journal    
DOI: 10.2174/157340808786733631     Document Type: Review
Times cited : (27)

References (65)
  • 1
    • 25844486970 scopus 로고    scopus 로고
    • H3.M. Alzheimer's Disease and Neuronal Transplantation as Prospective Cell Therapy
    • Oliveira, A.A.; Hodges, H3.M. Alzheimer's Disease and Neuronal Transplantation as Prospective Cell Therapy. Curr. Alzheimer Res., 2005, 2, 79-95.
    • (2005) Curr. Alzheimer Res , vol.2 , pp. 79-95
    • Oliveira, A.A.1    Hodges2
  • 4
    • 0030464914 scopus 로고    scopus 로고
    • β-Amyloid deposition and other measures of neuropathology predict cognitive status in Alzheimer's disease
    • Cummings, B.J.; Pike, C.J.; Shankle, R.; Cotman, C.W. β-Amyloid deposition and other measures of neuropathology predict cognitive status in Alzheimer's disease. Neurobiol. Aging, 1996, 17, 921-933.
    • (1996) Neurobiol. Aging , vol.17 , pp. 921-933
    • Cummings, B.J.1    Pike, C.J.2    Shankle, R.3    Cotman, C.W.4
  • 5
    • 0030710114 scopus 로고    scopus 로고
    • The 'amyloid cascade hypothesis' of AD: Decoy or real McCoy?
    • Davis, J.N.; Chisholm, J.C. The 'amyloid cascade hypothesis' of AD: decoy or real McCoy?. Trends Neurosci., 1997, 20, 558-559.
    • (1997) Trends Neurosci , vol.20 , pp. 558-559
    • Davis, J.N.1    Chisholm, J.C.2
  • 6
    • 0036660258 scopus 로고    scopus 로고
    • Review of drug Development and Therapeutic Role of Cholinesterase Inhibitors in Alzheimer's Disease
    • Sramek, J.J.; Zarotsky, V.; Cutler, N.R. Review of drug Development and Therapeutic Role of Cholinesterase Inhibitors in Alzheimer's Disease. Drug Dev. Res., 2002, 56, 347-353.
    • (2002) Drug Dev. Res , vol.56 , pp. 347-353
    • Sramek, J.J.1    Zarotsky, V.2    Cutler, N.R.3
  • 8
    • 0032478778 scopus 로고    scopus 로고
    • Is there a rationale for the use of acetylcholinesterase inhibitors in the therapy of AD?
    • Benzi, G.; Moretti, A. Is there a rationale for the use of acetylcholinesterase inhibitors in the therapy of AD? Eur. J. Pharmacol., 1998, 346, 1-13.
    • (1998) Eur. J. Pharmacol , vol.346 , pp. 1-13
    • Benzi, G.1    Moretti, A.2
  • 9
    • 65749096984 scopus 로고    scopus 로고
    • American Health Assistance Foundation, Alzheimer's Disease Research program
    • www.ahaf.org (American Health Assistance Foundation, Alzheimer's Disease Research program).
  • 10
    • 37449033897 scopus 로고    scopus 로고
    • Pharmacotherapy of Alzheimer's disease
    • Wilkinson, D. Pharmacotherapy of Alzheimer's disease. Psychiatry, 2007, 7, 9-14.
    • (2007) Psychiatry , vol.7 , pp. 9-14
    • Wilkinson, D.1
  • 11
    • 0035142278 scopus 로고    scopus 로고
    • Cholinesterase Inhibitors for Alzheimer's Disease
    • Grutzendler, J.; Morris, J.C. Cholinesterase Inhibitors for Alzheimer's Disease. Drugs, 2001, 61, 41-52.
    • (2001) Drugs , vol.61 , pp. 41-52
    • Grutzendler, J.1    Morris, J.C.2
  • 12
    • 0015004604 scopus 로고
    • Comparative Aspects of the Purification and Properties of Cholinesterases
    • Augustinsson, K.-B. Comparative Aspects of the Purification and Properties of Cholinesterases. B World Health Organ., 1971, 44, 81-89.
    • (1971) B World Health Organ , vol.44 , pp. 81-89
    • Augustinsson, K.-B.1
  • 14
    • 65749084998 scopus 로고    scopus 로고
    • Tougu, V. Acetylcholinesterase: Mechanism of Catalysis and Inhibition. Curr. Med. Chem. - Central Nervous System Agents, 2001, 1, 155-170.
    • Tougu, V. Acetylcholinesterase: Mechanism of Catalysis and Inhibition. Curr. Med. Chem. - Central Nervous System Agents, 2001, 1, 155-170.
  • 15
    • 28744438871 scopus 로고    scopus 로고
    • Lessons from functional analysis of AChE covalent and noncovalent inhibitors for design of AD therapeutic agents
    • Barak, D.; Ordentlich, A.; Kaplan, D.; Kronman, C.H.; Velan, B.; Shafferman, A. Lessons from functional analysis of AChE covalent and noncovalent inhibitors for design of AD therapeutic agents. Chem. Biol. Interact., 2005, 157-158, 219-226.
    • (2005) Chem. Biol. Interact , vol.157-158 , pp. 219-226
    • Barak, D.1    Ordentlich, A.2    Kaplan, D.3    Kronman, C.H.4    Velan, B.5    Shafferman, A.6
  • 16
    • 27144449182 scopus 로고    scopus 로고
    • Butyrylcholinesterase: Structure and Physiological Importance
    • Çokuǧraş, A. N. Butyrylcholinesterase: Structure and Physiological Importance. Turk. J. Biochem., 2003, 28, 54-61.
    • (2003) Turk. J. Biochem , vol.28 , pp. 54-61
    • Çokuǧraş, A.N.1
  • 17
    • 0035727527 scopus 로고    scopus 로고
    • A Valid Alternative for Therapy of Alzheimer's Disease?
    • Giacobini, E. A Valid Alternative for Therapy of Alzheimer's Disease? Drug Aging, 2001, 18, 891-898.
    • (2001) Drug Aging , vol.18 , pp. 891-898
    • Giacobini, E.1
  • 18
    • 0035847069 scopus 로고    scopus 로고
    • Effects of mutations of active site residues and amino acids interacting with Ω loop on substrate activation of butyrylcholinesterase
    • Masson, P.; Xie, W.; Froment, M.T.; Lockridge, O. Effects of mutations of active site residues and amino acids interacting with Ω loop on substrate activation of butyrylcholinesterase. Biochim. Biophys. Acta, 2001, 1544, 166-176.
    • (2001) Biochim. Biophys. Acta , vol.1544 , pp. 166-176
    • Masson, P.1    Xie, W.2    Froment, M.T.3    Lockridge, O.4
  • 19
    • 0034058991 scopus 로고    scopus 로고
    • Tissue cholinesterases. A comparative study of their kinetic properties
    • Dave, K.R.; Syal, A.R.; Katyare, S.S. Tissue cholinesterases. A comparative study of their kinetic properties. Z. Naturforsch, 2000, 55c, 100-108.
    • (2000) Z. Naturforsch , vol.55 c , pp. 100-108
    • Dave, K.R.1    Syal, A.R.2    Katyare, S.S.3
  • 20
    • 0019317512 scopus 로고
    • Effective charge on acetylcholinesterase active sites determined from the ionic strenght dependence of association rate constants with cationic ligands
    • Nolte, H.J.; Rosenberry, T.L.; Neumann, E. Effective charge on acetylcholinesterase active sites determined from the ionic strenght dependence of association rate constants with cationic ligands. Biochemistry, 1980, 19, 3705-3711.
    • (1980) Biochemistry , vol.19 , pp. 3705-3711
    • Nolte, H.J.1    Rosenberry, T.L.2    Neumann, E.3
  • 21
    • 0025778840 scopus 로고
    • Atomic structure of acetylcholinesterase from Torpedo Californica: A prototypic binding protein
    • Sussman, J.L.; Harel, M.; Frolow, F.; Oefner, C.; Goldman, A.; Toker, L.; Silman I. Atomic structure of acetylcholinesterase from Torpedo Californica: A prototypic binding protein. Science, 1991, 253, 872-879.
    • (1991) Science , vol.253 , pp. 872-879
    • Sussman, J.L.1    Harel, M.2    Frolow, F.3    Oefner, C.4    Goldman, A.5    Toker, L.6    Silman, I.7
  • 22
    • 0027459560 scopus 로고
    • Amino acid residues controlling acetylcholinesterase and butyrylcholinesterase specifity
    • Vellom, D.C.; Radić, Z.; Li, Y.; Pickering, N.A.; Camp, S.; Taylor, P. Amino acid residues controlling acetylcholinesterase and butyrylcholinesterase specifity. Biochemistry, 1993, 32, 12-17.
    • (1993) Biochemistry , vol.32 , pp. 12-17
    • Vellom, D.C.1    Radić, Z.2    Li, Y.3    Pickering, N.A.4    Camp, S.5    Taylor, P.6
  • 23
    • 0033379073 scopus 로고    scopus 로고
    • Molecular Recognition by Acetylcholinesterase at the Peripheral Anioni Site: Structure-Activity Relationships for Inhibitions by Aryl Carbamates
    • Lin, G.; Lai, Ch-Y.; Liao, W-Ch. Molecular Recognition by Acetylcholinesterase at the Peripheral Anioni Site: Structure-Activity Relationships for Inhibitions by Aryl Carbamates. Bioorgan. Med. Chem., 1999, 7, 2683-2689.
    • (1999) Bioorgan. Med. Chem , vol.7 , pp. 2683-2689
    • Lin, G.1    Lai, C.-Y.2    Liao, W.-C.3
  • 24
    • 0036349129 scopus 로고    scopus 로고
    • Clinical Pharmacokinetics and Pharmacodynamics of Cholinesterase Inhibitors
    • Jann, M.W.; Shirley, K.L.; Small, G.W. Clinical Pharmacokinetics and Pharmacodynamics of Cholinesterase Inhibitors. Clin. Pharmacokinet., 2002, 41, 719-739.
    • (2002) Clin. Pharmacokinet , vol.41 , pp. 719-739
    • Jann, M.W.1    Shirley, K.L.2    Small, G.W.3
  • 28
    • 0036482371 scopus 로고    scopus 로고
    • Cholinergic Drugs in Pharamcotherapy of Alzheimer's Disease
    • Camps, P.; Muños-Torrero, D. Cholinergic Drugs in Pharamcotherapy of Alzheimer's Disease. Mini-Rev. Med. Chem., 2002, 2, 11-25.
    • (2002) Mini-Rev. Med. Chem , vol.2 , pp. 11-25
    • Camps, P.1    Muños-Torrero, D.2
  • 29
    • 8844226702 scopus 로고    scopus 로고
    • Biologically active components of Physostigma venenosum
    • Zhao, B.; Moochhala, S.M.; Tham, S.-Y. Biologically active components of Physostigma venenosum. J. Chromatogr. B, 2004, 812, 183-192.
    • (2004) J. Chromatogr. B , vol.812 , pp. 183-192
    • Zhao, B.1    Moochhala, S.M.2    Tham, S.-Y.3
  • 30
    • 0037216854 scopus 로고    scopus 로고
    • Medicinal Chemistry Approaches for the Treatment and Prevention of Alzheimer's Disease
    • Bachurin, S. O. Medicinal Chemistry Approaches for the Treatment and Prevention of Alzheimer's Disease. Med. Res. Rev., 2003, 23, 48-88.
    • (2003) Med. Res. Rev , vol.23 , pp. 48-88
    • Bachurin, S.O.1
  • 31
    • 0020633185 scopus 로고
    • Oral physostigmine and lecithin improve memory in Alzheimer disease
    • Thal, L.; Fuld, P.A.; Masur, D.M.; Sharpless, N.S. Oral physostigmine and lecithin improve memory in Alzheimer disease. Ann. Neurol., 1983, 13, 491-496.
    • (1983) Ann. Neurol , vol.13 , pp. 491-496
    • Thal, L.1    Fuld, P.A.2    Masur, D.M.3    Sharpless, N.S.4
  • 32
    • 0019949485 scopus 로고
    • Enhancement of memory processes in Alzheimer's disease with multiple-dose intravenous physostigmine
    • Davis, K.L.; Mohs, R.S. Enhancement of memory processes in Alzheimer's disease with multiple-dose intravenous physostigmine. Am. J. Psychiatry., 1982, 139, 1421-1424.
    • (1982) Am. J. Psychiatry , vol.139 , pp. 1421-1424
    • Davis, K.L.1    Mohs, R.S.2
  • 33
    • 0032078728 scopus 로고    scopus 로고
    • Cholinesterase inhibitors for Alzheimer's disease therapy: From tacrine to future applications
    • Giacobini, E. Cholinesterase inhibitors for Alzheimer's disease therapy: from tacrine to future applications. Neurochem. Int., 1998, 32, 413-419.
    • (1998) Neurochem. Int , vol.32 , pp. 413-419
    • Giacobini, E.1
  • 34
    • 0035695827 scopus 로고    scopus 로고
    • Cholinergic Adverse Effects of Cholinesterase Inhibitors in Alzheimer's Disease
    • Gauthier, S. Cholinergic Adverse Effects of Cholinesterase Inhibitors in Alzheimer's Disease. Drug Aging, 2001, 18, 853-862.
    • (2001) Drug Aging , vol.18 , pp. 853-862
    • Gauthier, S.1
  • 35
    • 0034130555 scopus 로고    scopus 로고
    • Metrifonate: A review of its use in Alzheimer's disease
    • Ormrod, D.; Spencer, C. Metrifonate: A review of its use in Alzheimer's disease. CNS Drugs, 2000, 13, 443-467.
    • (2000) CNS Drugs , vol.13 , pp. 443-467
    • Ormrod, D.1    Spencer, C.2
  • 36
    • 17444446525 scopus 로고    scopus 로고
    • Synthesis of a New Reactivator of Tabun-Inhibited Acetylcholinesterase
    • Kuča, K.; Bielavský, J.; Cabal, J.; Kassa, J. Synthesis of a New Reactivator of Tabun-Inhibited Acetylcholinesterase. Bioorg. Med. Chem. Lett., 2003, 13, 3545-3547.
    • (2003) Bioorg. Med. Chem. Lett , vol.13 , pp. 3545-3547
    • Kuča, K.1    Bielavský, J.2    Cabal, J.3    Kassa, J.4
  • 37
    • 26044459638 scopus 로고    scopus 로고
    • Diagnostic aspects of organophosphate poisoning
    • Worek, F.; Koller, M.; Thiermann, H.; Szincz, L. Diagnostic aspects of organophosphate poisoning. Toxicology, 2005, 214, 182-189.
    • (2005) Toxicology , vol.214 , pp. 182-189
    • Worek, F.1    Koller, M.2    Thiermann, H.3    Szincz, L.4
  • 38
    • 0034816672 scopus 로고    scopus 로고
    • Treatment of cognitive dysfunction associated with Alzheimer's disease with cholinergic precursors. Ineffective treatments or inappropriate approaches?
    • Amenta, F.; Parnetti, L.; Gallai, V.; Wallin A. Treatment of cognitive dysfunction associated with Alzheimer's disease with cholinergic precursors. Ineffective treatments or inappropriate approaches? Mech. Ageing Dev., 2001, 122, 2025-2040.
    • (2001) Mech. Ageing Dev , vol.122 , pp. 2025-2040
    • Amenta, F.1    Parnetti, L.2    Gallai, V.3    Wallin, A.4
  • 39
    • 0021705403 scopus 로고    scopus 로고
    • Kerkut, G.A. Acetylcholinestrase (ACHE) (EC 3.1.1.7). Gen. Pharmacol., 1984, 15, 375-378.
    • Kerkut, G.A. Acetylcholinestrase (ACHE) (EC 3.1.1.7). Gen. Pharmacol., 1984, 15, 375-378.
  • 40
    • 0028316959 scopus 로고
    • Hepatotoxic effects of tacrine administration in patients with Alzheimer's disease
    • Watkins, P.B.; Zimmerman, H.J.; Knapp, M.J.; Gracon, S.I.; Lewis, K.W. Hepatotoxic effects of tacrine administration in patients with Alzheimer's disease. JAMA, 1994, 271, 992-998.
    • (1994) JAMA , vol.271 , pp. 992-998
    • Watkins, P.B.1    Zimmerman, H.J.2    Knapp, M.J.3    Gracon, S.I.4    Lewis, K.W.5
  • 41
    • 0033980910 scopus 로고    scopus 로고
    • A New Class of Psychotropic Compounds
    • Cummings, J.L. A New Class of Psychotropic Compounds. Am. J. Psychiatry., 2000, 157, 4-15.
    • (2000) Am. J. Psychiatry , vol.157 , pp. 4-15
    • Cummings, J.L.1
  • 42
    • 0024818025 scopus 로고    scopus 로고
    • Nielsen, J. A.; Mena, E.E.; Williams, I.H.; Nocerini, M.R.; Liston, D. Correlation of brain levels of 9-amino-1,2,3,4-tetra-aminoacridine (THA) with neurochemical and behavioural changes. Eur. J. Pharmacol., 1989, 173, 53-64.
    • Nielsen, J. A.; Mena, E.E.; Williams, I.H.; Nocerini, M.R.; Liston, D. Correlation of brain levels of 9-amino-1,2,3,4-tetra-aminoacridine (THA) with neurochemical and behavioural changes. Eur. J. Pharmacol., 1989, 173, 53-64.
  • 43
    • 0025907011 scopus 로고
    • Tacrine: A pharmacological review
    • Freeman, S.E.; Dawson, R.M. Tacrine: A pharmacological review. Prog. Neurobiol., 1991, 36, 257-277.
    • (1991) Prog. Neurobiol , vol.36 , pp. 257-277
    • Freeman, S.E.1    Dawson, R.M.2
  • 44
    • 0031014153 scopus 로고    scopus 로고
    • Donepezil approved for treatment of Alzheimer's disease
    • Nightingale, S.L. Donepezil approved for treatment of Alzheimer's disease. JAMA, 1997, 277, 10.
    • (1997) JAMA , vol.277 , pp. 10
    • Nightingale, S.L.1
  • 45
    • 0032424680 scopus 로고    scopus 로고
    • Pharmacokinetic and pharmacodynamic profile of donepezil HCl following single oral doses
    • Rogers, S.L.; Friedhoff, L.T. Pharmacokinetic and pharmacodynamic profile of donepezil HCl following single oral doses. Br. J. Clin. Pharmacol., 1998, 46 (Suppl. 1), 1-6.
    • (1998) Br. J. Clin. Pharmacol , vol.46 , Issue.SUPPL. 1 , pp. 1-6
    • Rogers, S.L.1    Friedhoff, L.T.2
  • 46
    • 0028823072 scopus 로고
    • Synthesis and structure-activity relationships of acetylcholinesterase inhibitors: 1-benzyl-4-[(5,6-dimethoxy-1-oxoindan-2-yl)methyl]piperidine hydrochloride and related compounds
    • Sugimuto, H.; Iimura, Y.; Yamanishi, Y.; Yamatsu K. Synthesis and structure-activity relationships of acetylcholinesterase inhibitors: 1-benzyl-4-[(5,6-dimethoxy-1-oxoindan-2-yl)methyl]piperidine hydrochloride and related compounds. J. Med. Chem., 1995, 38, 4821-4829.
    • (1995) J. Med. Chem , vol.38 , pp. 4821-4829
    • Sugimuto, H.1    Iimura, Y.2    Yamanishi, Y.3    Yamatsu, K.4
  • 47
    • 0033010553 scopus 로고    scopus 로고
    • Cognitive enhancer donepezil
    • In Czech
    • Švestka, J. Cognitive enhancer donepezil. Psychiatry, 1999, 1, 36-42. In Czech.
    • (1999) Psychiatry , vol.1 , pp. 36-42
    • Švestka, J.1
  • 49
    • 0027429837 scopus 로고
    • Brain selective inhibition of acetylcholinesterase. A novel approach to therapy for Alzheimer's disease
    • Enz, A.; Amstutz, R.; Boddeke, H.; Gmelin, G.; Malanowski, J. Brain selective inhibition of acetylcholinesterase. A novel approach to therapy for Alzheimer's disease. Prog. Brain Res., 1993, 98, 431-438.
    • (1993) Prog. Brain Res , vol.98 , pp. 431-438
    • Enz, A.1    Amstutz, R.2    Boddeke, H.3    Gmelin, G.4    Malanowski, J.5
  • 51
    • 0034919194 scopus 로고    scopus 로고
    • New Treatments for Alzheimer's Disease
    • Zurad, E.G. New Treatments for Alzheimer's Disease. Drug Benefit Trends, 2001, 13, 27-40.
    • (2001) Drug Benefit Trends , vol.13 , pp. 27-40
    • Zurad, E.G.1
  • 52
    • 0034732104 scopus 로고    scopus 로고
    • Allosteric modulation of nicotinic acetylcholine receptors as a treatment strategy for Alzheimer's disease
    • Maelicke, A.; Albuquerque, X. Allosteric modulation of nicotinic acetylcholine receptors as a treatment strategy for Alzheimer's disease. Eur. J. Pharmacol., 2000, 393, 165-170.
    • (2000) Eur. J. Pharmacol , vol.393 , pp. 165-170
    • Maelicke, A.1    Albuquerque, X.2
  • 53
    • 0035251762 scopus 로고    scopus 로고
    • Galanthamine, a Cholinesterase Inhibitor that Allosterically Modulates Nicotinic Receptors: Effects on the Course of Alzheimer's disease
    • Coyle, J.; Kershaw, P. Galanthamine, a Cholinesterase Inhibitor that Allosterically Modulates Nicotinic Receptors: Effects on the Course of Alzheimer's disease. Biol. Psychiatry., 2001, 49, 289-299.
    • (2001) Biol. Psychiatry , vol.49 , pp. 289-299
    • Coyle, J.1    Kershaw, P.2
  • 54
    • 0026086023 scopus 로고
    • In vitro effects of various cholinesterase inhibitors on acetyl- and butyrylcholinesterase of healthy volunteers
    • Thomsen, T.; Zendeh, B.; Fischer, J.P.; Kewitz, H. In vitro effects of various cholinesterase inhibitors on acetyl- and butyrylcholinesterase of healthy volunteers. Biochem. Pharmacol., 1991, 41, 139-141.
    • (1991) Biochem. Pharmacol , vol.41 , pp. 139-141
    • Thomsen, T.1    Zendeh, B.2    Fischer, J.P.3    Kewitz, H.4
  • 57
    • 0028890937 scopus 로고
    • A multi-dose safety trial of eptastigmine in Alzheimer's disease, with pharmacodynamic observations of red blood cell cholinesterase
    • Sramek, J.J.; Block, G.A.; Reines, S.A.; Sawin, S.F.; Barchowsky, A.; Cutler, N.R. A multi-dose safety trial of eptastigmine in Alzheimer's disease, with pharmacodynamic observations of red blood cell cholinesterase. Life Sci., 1995, 56, 319-326.
    • (1995) Life Sci , vol.56 , pp. 319-326
    • Sramek, J.J.1    Block, G.A.2    Reines, S.A.3    Sawin, S.F.4    Barchowsky, A.5    Cutler, N.R.6
  • 58
    • 0033541027 scopus 로고    scopus 로고
    • Efficacy and safety of eptastigmine for the treatment of patients with Alzheimer's disease
    • Imbimbo, B.P.; Martelli, P.; Troetel, W. M.; Lucchelli, F.; Lucca, U.; Thal, L. J. Efficacy and safety of eptastigmine for the treatment of patients with Alzheimer's disease. Neurology, 1999, 52, 700-708.
    • (1999) Neurology , vol.52 , pp. 700-708
    • Imbimbo, B.P.1    Martelli, P.2    Troetel, W.M.3    Lucchelli, F.4    Lucca, U.5    Thal, L.J.6
  • 59
    • 10244259208 scopus 로고    scopus 로고
    • Roger, S.L.; Friedhoff, T. The efficacy and safety of Donepezil in patients with Alzheimer's disease: Results of U.S. multicentre, randomized, double-blind, placebo-controlled trial. Dementia, 1996, 7, 293-300.
    • Roger, S.L.; Friedhoff, T. The efficacy and safety of Donepezil in patients with Alzheimer's disease: Results of U.S. multicentre, randomized, double-blind, placebo-controlled trial. Dementia, 1996, 7, 293-300.
  • 60
    • 0034808155 scopus 로고    scopus 로고
    • Cholinesterase inhibitors. Comparing the options for mild-to-moderate dementia
    • Conn, D.K. Cholinesterase inhibitors. Comparing the options for mild-to-moderate dementia. Geriatrics, 2001, 56, 56-57.
    • (2001) Geriatrics , vol.56 , pp. 56-57
    • Conn, D.K.1


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