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ChemMedChem

Volumn 6, Issue 2, 2011, Pages 321-328

Synthesis and Evaluation of Indatraline-Based Inhibitors for Trypanothione Reductase

(6) Walton, Jeffrey G A a Jones, Deuan C b Kiuru, Paula a Durie, Alastair J a Westwood, Nicholas J a Fairlamb, Alan H b

a UNIVERSITY OF ST ANDREWS (United Kingdom)

b UNIVERSITY OF DUNDEE (United Kingdom)

Author keywords

Antiprotozoal agents; Drug discovery; Indatraline; Nazarov reaction; Trypanothione reductase

Indexed keywords

4 [3 (3,4 DICHLOROPHENYL)INDAN 1 YL]MORPHOLINE; [3 (3,4 DIBROMOPHENYL) 6 METHOXYINDAN 1 YL](3-METHYLBUTYL)AMINE; [3 (3,4 DICHLOROPHENYL) 6 METHOXYINDAN 1 YL](3-METHYLBUTYL)AMINE; [3 (3,4 DICHLOROPHENYL)INDAN 1 YL](3 METHYLBUTYL)AMINE; [3 (3,4 DICHLOROPHENYL)INDAN 1 YL](3,4 DICHLOROBENZYL)AMINE; [3 (3,4 DICHLOROPHENYL)INDAN 1 YL](4 AMINOBENZYL)AMINE; [3 (3,4 DICHLOROPHENYL)INDAN 1 YL](4 CHLOROBENZYL)AMINE; [3 (3,4 DICHLOROPHENYL)INDAN 1 YL](4 DIMETHYLAMINOBENZYL); [3 (3,4 DICHLOROPHENYL)INDAN 1 YL](4 METHOXYBENZYL)AMINE; [3 (3,4 DICHLOROPHENYL)INDAN 1 YL](4 METHYLBENZYL)AMINE; [3 (3,4 DICHLOROPHENYL)INDAN 1 YL]OCTYLAMINE; [3 (4 CHLOROPHENYL) 6 METHOXYINDAN 1 YL](3-METHYLBUTYL)AMINE; [3 (4 METHOXYPHENYL) 6 METHOXYINDAN 1 YL](3 METHYLBUTYL)AMINE; [3 (4 METHYLPHENYL) 6 METHOXYINDAN 1 YL] (3 METHYLBUTYL)AMINE; AMINE; AROMATIC COMPOUND; BENZYL[3 (3,4 DICHLOROPHENYL) 6 METHOXYINDAN 1 YL]AMINE; INDATRALINE; N [3 (3,4 DICHLOROPHENYL)INDAN 1 YL] 4 METHYLBENZENESULFONAMIDE; N [3 (3,4 DICHLOROPHENYL)INDAN 1 YL]ACETAMIDE; OXIDOREDUCTASE INHIBITOR; PENTAMIDINE; TRYPANOTHIONE REDUCTASE; TRYPANOTHIONE REDUCTASE INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DRUG MECHANISM; DRUG POTENCY; DRUG SCREENING; DRUG SYNTHESIS; ENZYME INHIBITION; HIGH THROUGHPUT SCREENING; NONHUMAN; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION; TRYPANOSOMA BRUCEI;

CHROMATOGRAPHY, HIGH PRESSURE LIQUID; ENZYME INHIBITORS; INDANS; MAGNETIC RESONANCE SPECTROSCOPY; MASS SPECTROMETRY; METHYLAMINES; NADH, NADPH OXIDOREDUCTASES; STEREOISOMERISM;

EID: 79251542373 PISSN: 18607179 EISSN: 18607187 Source Type: Journal
DOI: 10.1002/cmdc.201000442 Document Type: Article

Times cited : (22)

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