Subtype specific genetic associations for juvenile idiopathic arthritis: ERAP1 with the enthesitis related arthritis subtype and IL23R with juvenile psoriatic arthritis

Arthritis Research and Therapy

Volumn 13, Issue 1, 2011, Pages

  Hinks, Anne ^a,c   Martin, Paul ^a   Flynn, Edward ^a   Eyre, Steve ^a   Packham, Jon ^b   Barton, Anne ^a   Worthington, Jane ^a   Thomson, Wendy ^a  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

^b HAYWOOD HOSPITAL   (United Kingdom)

^c UNIVERSITY OF MANCHESTER   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AMINOPEPTIDASE; ENDOPLASMIC RETICULUM AMINOPEPTIDASE 1; INTERLEUKIN 23 RECEPTOR; UNCLASSIFIED DRUG; ERAP1 PROTEIN, HUMAN; IL23R PROTEIN, HUMAN; INTERLEUKIN RECEPTOR;

ANKYLOSING SPONDYLITIS; ARTICLE; CONTROLLED STUDY; ENTHESITIS; FEMALE; GENETIC ASSOCIATION; GENETIC SUSCEPTIBILITY; GENOTYPE; HUMAN; JUVENILE RHEUMATOID ARTHRITIS; MAJOR CLINICAL STUDY; MALE; PSORIATIC ARTHRITIS; SINGLE NUCLEOTIDE POLYMORPHISM; GENETIC PREDISPOSITION; GENETICS; PATHOLOGY;

AMINOPEPTIDASES; ARTHRITIS, JUVENILE RHEUMATOID; ARTHRITIS, PSORIATIC; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HUMANS; MALE; POLYMORPHISM, SINGLE NUCLEOTIDE; RECEPTORS, INTERLEUKIN;

EID: 79251542052     PISSN: 14786354     EISSN: 14786362     Source Type: Journal    
DOI: 10.1186/ar3235     Document Type: Article

References (19)

1. Lettre G, Rioux JD. Autoimmune diseases: insights from genome-wide association studies. Hum Mol Genet 2008, 17:R116-R121. 10.1093/hmg/ddn246, 2782355, 18852199.
2. Burton PR, Clayton DG, Cardon LR, Craddock N, Deloukas P, Duncanson A, Kwiatkowski DP, McCarthy MI, Ouwehand WH, Samani NJ, Todd JA, Donnelly P, Barrett JC, Davison D, Easton D, Evans DM, Leung HT, Marchini JL, Morris AP, Spencer CC, Tobin MD, Attwood AP, Boorman JP, Cant B, Everson U, Hussey JM, Jolley JD, Knight AS, Koch K, Meech E, et al. Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants. Nat Genet 2007, 39:1329-1337. 10.1038/ng.2007.17, 2680141, 17952073.
3. Strange A, Capon F, Spencer CC, Knight J, Weale ME, Allen MH, Barton A, Band G, Bellenguez C, Bergboer JG, Blackwell JM, Bramon E, Bumpstead SJ, Casas JP, Cork MJ, Corvin A, Deloukas P, Dilthey A, Duncanson A, Edkins S, Estivill X, Fitzgerald O, Freeman C, Giardina E, Gray E, Hofer A, Huffmeier U, Hunt SE, Irvine AD, Jankowski J, et al. A genome-wide association study identifies new psoriasis susceptibility loci and an interaction between HLA-C and ERAP1. Nat Genet 2010, 42:985-990. 10.1038/ng.694, 20953190.
4. Cargill M, Schrodi SJ, Chang M, Garcia VE, Brandon R, Callis KP, Matsunami N, Ardlie KG, Civello D, Catanese JJ, Leong DU, Panko JM, McAllister LB, Hansen CB, Papenfuss J, Prescott SM, White TJ, Leppert MF, Krueger GG, Begovich AB. A large-scale genetic association study confirms IL12B and leads to the identification of IL23R as psoriasis-risk genes. Am J Hum Genet 2007, 80:273-290. 10.1086/511051, 1785338, 17236132.
5. Filer C, Ho P, Smith RL, Griffiths C, Young HS, Worthington J, Bruce IN, Barton A. Investigation of association of the IL12B and IL23R genes with psoriatic arthritis. Arthritis Rheum 2008, 58:3705-3709. 10.1002/art.24128, 3001112, 19035472.
6. Petty RE, Southwood TR, Manners P, Baum J, Glass DN, Goldenberg J, He X, Maldonado-Cocco J, Orozco-Alcala J, Prieur AM, Suarez-Almazor ME, Woo P. International League of Associations for Rheumatology classification of juvenile idiopathic arthritis: second revision, Edmonton, 2001. J Rheumatol 2004, 31:390-392.
7. Hinks A, Eyre S, Ke X, Barton A, Martin P, Flynn E, Packham J, Worthington J, Thomson W. Childhood Arthritis Prospective Study (CAPS); UKRAG Consortium; BSPAR Study Group Overlap of disease susceptibility loci for rheumatoid arthritis (RA) and juvenile idiopathic arthritis (JIA). Ann Rheum Dis 2010, 69:1049-1053. 10.1136/ard.2009.110650, 2935325, 19674979, Childhood Arthritis Prospective Study (CAPS); UKRAG Consortium; BSPAR Study Group.
8. The European Genome-phenome Archive. , http://www.ebi.ac.uk/ega/page.php
9. Sequenom. , http://www.sequenom.com/
10. QUANTO. , http://hydra.usc.edu/gxe/
11. Harvey D, Pointon JJ, Evans DM, Karaderi T, Farrar C, Appleton LH, Sturrock RD, Stone MA, Oppermann U, Brown MA, Wordsworth BP. Investigating the genetic association between ERAP1 and ankylosing spondylitis. Hum Mol Genet 2009, 18:4204-4212. 10.1093/hmg/ddp371, 2758148, 19692350.
12. Purcell S, Neale B, Todd-Brown K, Thomas L, Ferreira MA, Bender D, Maller J, Sklar P, De Bakker PI, Daly MJ, Sham PC. PLINK: a tool set for whole-genome association and population-based linkage analyses. Am J Hum Genet 2007, 81:559-575. 10.1086/519795, 1950838, 17701901.
13. Fung EY, Smyth DJ, Howson JM, Cooper JD, Walker NM, Stevens H, Wicker LS, Todd JA. Analysis of 17 autoimmune disease-associated variants in type 1 diabetes identifies 6q23/TNFAIP3 as a susceptibility locus. Genes Immun 2009, 10:188-191. 10.1038/gene.2008.99, 19110536.
14. Haroon N, Inman RD. Endoplasmic reticulum aminopeptidases: Biology and pathogenic potential. Nat Rev Rheumatol 2010, 6:461-467. 10.1038/nrrheum.2010.85, 20531381.
15. Duerr RH, Taylor KD, Brant SR, Rioux JD, Silverberg MS, Daly MJ, Steinhart AH, Abraham C, Regueiro M, Griffiths A, Dassopoulos T, Bitton A, Yang H, Targan S, Datta LW, Kistner EO, Schumm LP, Lee AT, Gregersen PK, Barmada MM, Rotter JI, Nicolae DL, Cho JH. A genome-wide association study identifies IL23R as an inflammatory bowel disease gene. Science 2006, 314:1461-1463. 10.1126/science.1135245, 17068223.
16. Dubinsky MC, Wang D, Picornell Y, Wrobel I, Katzir L, Quiros A, Dutridge D, Wahbeh G, Silber G, Bahar R, Mengesha E, Targan SR, Taylor KD, Rotter JI. IL-23 receptor (IL-23R) gene protects against pediatric Crohn's disease. Inflamm Bowel Dis 2007, 13:511-515. 10.1002/ibd.20126, 2169293, 17309073.
17. Brown MA. Progress in spondylarthritis. Progress in studies of the genetics of ankylosing spondylitis. Arthritis Res Ther 2009, 11:254. 10.1186/ar2692, 2787301, 19886979.
18. Colbert RA. Classification of juvenile spondyloarthritis: Enthesitis-related arthritis and beyond. Nat Rev Rheumatol 2010, 6:477-485. 10.1038/nrrheum.2010.103, 2994189, 20606622.
19. Wellcome Trust Case Control Consortium. , http://www.wtccc.org.uk