AVE4454B - A novel sodium-hydrogen exchanger isoform-1 inhibitor - Compared less effective than cariporide for resuscitation from cardiac arrest

Translational Research

Volumn 157, Issue 2, 2011, Pages 71-80

  Radhakrishnan, Jeejabai ^a   Kolarova, Julieta D ^a   Ayoub, Iyad M ^a   Gazmuri, Raúl J ^a  

^a ROSALIND FRANKLIN UNIVERSITY OF MEDICINE AND SCIENCE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AVE4454B; CARDIOVASCULAR AGENT; CARIPORIDE; CYTOCHROME C; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; AORTA PRESSURE; ARTICLE; CONTROLLED STUDY; CORONARY ARTERY PRESSURE; DRUG EFFICACY; ELECTRIC SHOCK; HEART ARREST; HEART LEFT VENTRICLE ENDDIASTOLIC PRESSURE; HEART LEFT VENTRICLE FUNCTION; HEART LEFT VENTRICLE PRESSURE; HEART VENTRICLE FIBRILLATION; MALE; NONHUMAN; PERFUSION PRESSURE; PLASMA; PRIORITY JOURNAL; RAT; RESUSCITATION; STATISTICAL SIGNIFICANCE; SURVIVAL;

EID: 79251530773     PISSN: 19315244     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.trsl.2010.11.004     Document Type: Article

References (42)

1. M. von Planta, M.H. Weil, R.J. Gazmuri, J. Bisera, and E.C. Rackow Myocardial acidosis associated with CO2 production during cardiac arrest and resuscitation Circulation 80 1989 684 692
2. F. Kette, M.H. Weil, R.J. Gazmuri, J. Bisera, and E.C. Rackow Intramyocardial hypercarbic acidosis during cardiac arrest and resuscitation Crit Care Med 21 1993 901 906 (Pubitemid 23173030)
3. M. Noc, M.H. Weil, R.J. Gazmuri, S. Sun, J. Bisera, and W. Tang Ventricular fibrillation voltage as a monitor of the effectiveness of cardiopulmonary resuscitation J Lab Clin Med 124 1994 421 426
4. M. Karmazyn, M. Sawyer, and L. Fliegel The na(+)/h(+) exchanger: a target for cardiac therapeutic intervention Curr Drug Targets Cardiovasc Haematol Disord 5 2005 323 335
5. S. Wang, J. Radhakrishnan, I.M. Ayoub, J.D. Kolarova, D.M. Taglieri, and R.J. Gazmuri Limiting sarcolemmal Na+ entry during resuscitation from VF prevents excess mitochondrial Ca2+ accumulation and attenuates myocardial injury J Appl Physiol 103 2007 55 65
6. K. Imahashi, H. Kusuoka, K. Hashimoto, J. Yoshioka, H. Yamaguchi, and T. Nishimura Intracellular sodium accumulation during ischemia as the substrate for reperfusion injury Circ Res 84 1999 1401 1406
7. R.J. Gazmuri, E. Hoffner, and J. Kalcheim Myocardial protection during ventricular fibrillation by reduction of proton-driven sarcolemmal sodium influx J Lab Clin Med 137 2001 43 55
8. M. Avkiran, C. Ibuki, Y. Shimada, and P.S. Haddock Effects of acidic reperfusion on arrhythmias and Na(+)-K(+)-ATPase activity in regionally ischemic rat hearts Am J Physiol 270 1996 H957 H964
9. J. An, S.G. Varadarajan, and A. Camara Blocking Na(+)/H(+) exchange reduces [Na(+)](i) and [Ca(2+)](i) load after ischemia and improves function in intact hearts Am J Physiol 281 2001 H2398 H2409
10. S. Yamamoto, K. Matsui, and N. Ohashi Protective effect of Na+ /H+ exchange inhibitor, SM-20550, on impaired mitochondrial respiratory function and mitochondrial Ca2+ overload in ischemic/reperfused rat hearts J Cardiovasc Pharmacol 39 2002 569 575
11. V. Borutaite, and G.C. Brown Mitochondria in apoptosis of ischemic heart FEBS Lett 541 2003 1 5
12. I.M. Ayoub, J. Radhakrishnan, and R.J. Gazmuri Targeting mitochondria for resuscitation from cardiac arrest Crit Care Med 36 2008 S440 S446
13. R.J. Gazmuri, I.M. Ayoub, E. Hoffner, and J.D. Kolarova Successful ventricular defibrillation by the selective sodium-hydrogen exchanger isoform-1 inhibitor cariporide Circulation 104 2001 234 239
14. R.J. Gazmuri, I.M. Ayoub, J.D. Kolarova, and M. Karmazyn Myocardial protection during ventricular fibrillation by inhibition of the sodium-hydrogen exchanger isoform-1 Crit Care Med 30 2002 S166 S171
15. I.M. Ayoub, J.D. Kolarova, and Z. Yi Sodium-hydrogen exchange inhibition during ventricular fibrillation: Beneficial effects on ischemic contracture, action potential duration, reperfusion arrhythmias, myocardial function, and resuscitability Circulation 107 2003 1804 1809
16. I.M. Ayoub, J. Kolarova, R.L. Kantola, R. Sanders, and R.J. Gazmuri Cariporide minimizes adverse myocardial effects of epinephrine during resuscitation from ventricular fibrillation Crit Care Med 33 2005 2599 2605
17. J. Kolarova, Z. Yi, I.M. Ayoub, and R.J. Gazmuri Cariporide potentiates the effects of epinephrine and vasopressin by nonvascular mechanisms during closed-chest resuscitation Chest 127 2005 1327 1334
18. J.D. Kolarova, I.M. Ayoub, and R.J. Gazmuri Cariporide enables hemodynamically more effective chest compression by leftward shift of its flow-depth relationship Am J Physiol Heart Circ Physiol 288 2005 H2904 H2911
19. R.J. Gazmuri, and I.M. Ayoub The case for sodium-hydrogen exchanger isoform-1 inhibition during cardiac resuscitation remains strong Crit Care Med 34 2006 1580 1582
20. I.M. Ayoub, J. Kolarova, R. Kantola, J. Radhakrishnan, and R.J. Gazmuri Zoniporide preserves left ventricular compliance during ventricular fibrillation and minimizes post-resuscitation myocardial dysfunction through benefits on energy metabolism Crit Care Med 35 2007 2329 2336
21. I.M. Ayoub, J. Kolarova, and R.J. Gazmuri Cariporide given during resuscitation promotes return of electrically stable and mechanically competent cardiac activity Resuscitation 81 2009 106 110
22. J. Radhakrishnan, I.M. Ayoub, and R.J. Gazmuri Activation of caspase-3 may not contribute to postresuscitation myocardial dysfunction Am J Physiol Heart Circ Physiol 296 2009 H1164 H1174
23. R.M. Mentzer Jr., C. Bartels, and R. Bolli Sodium-hydrogen exchange inhibition by cariporide to reduce the risk of ischemic cardiac events in patients undergoing coronary artery bypass grafting: results of the EXPEDITION study Ann Thorac Surg 85 2008 1261 1270
24. J. Radhakrishnan, S. Wang, I.M. Ayoub, J.D. Kolarova, R.F. Levine, and R.J. Gazmuri Circulating levels of cytochrome c after resuscitation from cardiac arrest: a marker of mitochondrial injury and predictor of survival Am J Physiol Heart Circ Physiol 292 2007 H767 H775
25. I. von Planta, M.H. Weil, and M. von Planta Cardiopulmonary resuscitation in the rat J Appl Physiol 65 1988 2641 2647
26. K. Klouche, M.H. Weil, and S. Sun Evolution of the stone heart after prolonged cardiac arrest Chest 122 2002 1006 1011
27. M. Takino, and Y. Okada Firm myocardium in cardiopulmonary resuscitation Resuscitation 33 1996 101 106
28. A.B. Sanders, M. Atlas, G.A. Ewy, K.B. Kern, and S. Bragg Expired PCO2 as an index of coronary perfusion pressure Am J Emerg Med 3 1985 147 149
29. C.V. Gudipati, M.H. Weil, J. Bisera, H.G. Deshmukh, and E.C. Rackow Expired carbon dioxide: a noninvasive monitor of cardiopulmonary resuscitation Circulation 77 1988 234 239
30. D. Singh, J.D. Kolarova, S. Wang, I.M. Ayoub, and R.J. Gazmuri Myocardial protection by erythropoietin during resuscitation from ventricular fibrillation Am J Ther 14 2007 361 368
31. S. Grmec, M. Strnad, D. Kupnik, A. Sinkovic, and R.J. Gazmuri Erythropoietin facilitates the return of spontaneous circulation and survival in victims of out-of-hospital cardiac arrest Resuscitation 80 2009 631 637
32. R.J. Gazmuri, M.H. Weil, J. Bisera, W. Tang, M. Fukui, and D. McKee Myocardial dysfunction after successful resuscitation from cardiac arrest Crit Care Med 24 1996 992 1000
33. K.B. Kern, R.W. Hilwig, K.H. Rhee, and R.A. Berg Myocardial dysfunction after resuscitation from cardiac arrest: an example of global myocardial stunning J Am Coll Cardiol 28 1996 232 240
34. I. Laurent, M. Monchi, and J.D. Chiche Reversible myocardial dysfunction in survivors of out-of-hospital cardiac arrest J Am Coll Cardiol 40 2002 2110 2116
35. M. Ruiz-Bailen, d.H. Aguayo, and S. Ruiz-Navarro Reversible myocardial dysfunction after cardiopulmonary resuscitation Resuscitation 66 2005 175 181
36. T. Xu, W. Tang, G. Ristagno, H. Wang, S. Sun, and M.H. Weil Postresuscitation myocardial diastolic dysfunction following prolonged ventricular fibrillation and cardiopulmonary resuscitation Crit Care Med 36 2008 188 192
37. J.W. Phillis, A.Y. Estevez, L.L. Guyot, and M.H. O'Regan 5-(N-Ethyl-N-isopropyl)-amiloride, an Na(+)-H(+) exchange inhibitor, protects gerbil hippocampal neurons from ischemic injury Brain Res 839 1999 199 202
38. S.F. Pedersen The Na+/H+ exchanger NHE1 in stress-induced signal transduction: implications for cell proliferation and cell death Pflugers Arch 452 2006 249 259
39. J.R. Schelling, and B.G. bu Jawdeh Regulation of cell survival by Na+/H+ exchanger-1 Am J Physiol Renal Physiol 295 2008 F625 F632
40. M. Redlin, J. Werner, H. Habazettl, W. Griethe, H. Kuppe, and A.R. Pries Cariporide (HOE 642) attenuates leukocyte activation in ischemia and reperfusion Anesth Analg 93 2001 1472 1479
41. H. Palandoken, K. By, M. Hegde, W.R. Harley, F.A. Gorin, and M.H. Nantz Amiloride peptide conjugates: prodrugs for sodium-proton exchange inhibition J Pharmacol Exp Ther 312 2005 961 967
42. W. Scholz, U. Albus, and L. Counillon Protective effects of HOE642, a selective sodium-hydrogen exchange subtype 1 inhibitor, on cardiac ischaemia and reperfusion Cardiovasc Res 29 1995 260 268