A randomized double-blind crossover trial to investigate the efficacy of screening for adult hypothyroidism

Journal of Medical Screening

Volumn 17, Issue 4, 2010, Pages 164-169

  Abu Helalah, M ^a,b   Law, M R ^b   Bestwick, J P ^b   Monson, J P ^b   Wald, N J ^b  

^a King Hussein Cancer Centre   (Jordan)

^b QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

THYROTROPIN; THYROXINE;

AGED; ARTICLE; BLOOD; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; FEMALE; HUMAN; HYPOTHYROIDISM; MALE; MIDDLE AGED; RANDOMIZED CONTROLLED TRIAL;

AGED; DOUBLE-BLIND METHOD; FEMALE; HUMANS; HYPOTHYROIDISM; MALE; MIDDLE AGED; THYROTROPIN; THYROXINE;

EID: 79251529885     PISSN: 09691413     EISSN: 14755793     Source Type: Journal    
DOI: 10.1258/jms.2010.010057     Document Type: Article

References (32)

1. Petersen K, Lindstedt G, Lundberg P-A, Bengtsson C, Lapidus L, Nyström E. Thyroid disease in middle-aged and elderly Swedish women: thyroid-related hormones, thyroid dysfunction and goitre in relation to age and smoking. J Intern Med 1991;229:407-14.
2. Association for Clinical Biochemisty, British Thyroid Association, British Thyroid Foundation. UK Guidelines for the Use of Thyroid Function Tests. See http://www.acb.org.uk/docs/TFTguidelinefinal.pdf (last checked 14 December 2010).
3. Surks MI, Ortiz E, Daniels GH, et al. Subclinical thyroid disease: scientific review and guidelines for diagnosis and management. JAMA 2004;291:228-38.
4. Gharib H, Tuttle RM, Baskin HJ, Fish LH, Singer PA, McDermott MT. Consensus statement: subclinical thyroid dysfunction: a joint statement on management from the American Association of Clinical Endocrinologists, the American Thyroid Association, and the Endocrine Society. J Clin Endocrinol Metab 2005;90:581-5. (Pubitemid 40116712)
5. US Preventive Services Task Force. Screening for thyroid disease: recommendation statement. Ann Intern Med 2004;140:125-7.
6. Canaris GJ, Manowitz NR, Mayor G, Ridgway EC. The Colorado thyroid disease prevalence study. Arch Int Med 2000;160:526-34.
7. Nyström E, Caidahl K, Fager G, Wikkelsö C, Lundberg P-A, Lindstedt G. A double-blind crossover 12-month study of L-thyroxine treatment of women with'subclinical' hypothyroidism. Clin Endocrinol 1988;29:63-76.
8. Cooper DS, Halpern R, Wood LC, Levin AA, Ridgway EC. L-thyroxine therapy in subclinical hypothyroidism: a double-blind, placebo-controlled trial. Ann Intern Med 1984;101:18-24.
9. Meier C, Staub J-J, Roth C-B, et al. TSH-controlled L-thyroxine therapy reduces cholesterol levels and clinical symptoms in subclinical hypothyroidism: a double-blind, placebo-controlled trial (Basel Thyroid Study). J Clin Endocrinol Metab 2001;86:4860-6.
10. Jorde R, Waterloo K, Storhaug H, Nyrnes A, Sundsfjord J, Jenssen TG. Neuropsychological function and symptoms in subjects with subclinical hypothyroidism and the effect of thyroxine treatment. J Clin Endocrinol Metab 2006;91:145-53.
11. Jaeschke R, Guyatt G, Gerstein H, et al. Does treatment with L-thyroxine influence health status in middle-aged and older adults with subclinical hypothyroidism? J Gen Intern Med 1996;11:744-9.
12. Kong WM, Sheikh MH, Lumb PJ, et al. A 6-month randomized trial of thyroxine treatment in women with mild subclinical hypothyroidism. Am J Med 2002;112:348-54.
13. Razvi S, Ingoe L, Keeka G, Oates C, McMillan C, Weaver JU. The beneficial effect of L-thyroxine on cardiovascular risk factors, endothelial function, and quality of life in subclinical hypothyroidism: randomized, crossover trial. J Clin Endocrinol Metab 2007;92:1715-23.
14. Villar HCCE, Saconato H, Valente O, Atallah AN. Thyroid hormone replacement for subclinical hypothyroidism. Cochrane Database of Systematic Reviews 2007, Issue 3. Art. No.: CD003419. DOI: 10.1002/14651858.CD003419.pub2. (Pubitemid 351805671)
15. Manji N, Carr-Smith JD, Boelaert K, et al. Influences of age, gender, smoking, and family history on autoimmune thyroid disease phenotype. J Clin Endocrinol Metab 2006;91:4873-80.
16. Surks MI, Sievert R. Drugs and thyroid function. N Engl J Med 1995;333:1688-94.
17. Wartofsky L, Dickey RA. The evidence for a narrower thyrotropin reference range is compelling. J Clin Endocrinol Metab 2005;90:5483-8.
18. Vanderpump MPJ, Tunbridge WMG, French JM, et al. The incidence of thyroid disorders in the community: a twenty-year follow-up of the Whickham Survey. Clin Endocrinol 1995;43:55-68.
19. Brunton LL, Lazo JS, Parker KL. Goodman & Gilman's the Pharmacological Basis of Therapeutics. 11th edn. New York: McGraw-Hill, 2006.
20. Woeber KA. Thyrotoxicosis and the heart. N Eng J Med 1992; 327:94-8.
21. Sawin CT, Geller A, Wolf PA, et al. Low serum thyrotropin concentrations as a risk factor for atrial fibrillation in older persons. N Engl J Med 1994;331:1249-52.
22. Bowling A. Measuring Health: A Review of Quality of Life Measurement Scales. 3rd edn. Maidenhead, Berkshire, England: Open University Press, 2005.
23. Ware JE, Kosinski M, Keller SD. SF-36 Physical and Mental Health Summary Scales: A User's Manual. Boston, MA: The Health Institute, New England Medical Center, 1994.
24. Jenkinson C, Stewart-Brown S, Petersen S, Paice C. Assessment of the SF-36 version 2 in the United Kingdom. J Epidemiol Community Health 1999;53:46-50.
25. Goldberg D, Williams P. A User's Guide to the General Health Questionnaire. Windsor, UK: NFER-Nelson Publishing Company Ltd, 1988.
26. Huppert FA, Walters DE, Day NE, Elliott BJ. The factor structure of the General Health Questionnaire (GHQ-30): a reliability study on 6317 community residents. Br J Psychiatry 1989;155:178-85.
27. Zulewski H, Müller B, Exer P, Miserez AR, Staub JJ. Estimation of tissue hypothyroidism by a new clinical score: evaluation of patients with various grades of hypothyroidism and controls. J Clin Endocrinol Metab 1997;82:771-6.
28. Billewicz WZ, Chapman RS, Crooks J, et al. Statistical methods applied to the diagnosis of hypothyroidism. Q J Med 1969;38:255-66.
29. StataCorp. Stat Statistical Software: Release 10. College Station, TX: 2007.
30. Breslow NE, Day NE. The analysis of case-control studies. In: Davies W, ed. Statistical Methods in Cancer Research. IARC Scientific publication no 32. Lyon: IARC, 1980:162-89.
31. Collette HJA, Day NE, Rombach JJ, De F. Evaluation of screening for breast cancer in a non-randomised study (the DOM project) by means of a case-control study. Lancet 1984;1:1224-6.
32. Vaidya B, Anthony S, Bilous M, et al. Detection of thyroid dysfunction in early pregnancy: universal screening or targeted high-risk case finding?. J Clin Endocrinol Metab 2007;92:203-7.