Toxicological drivers issues in "legal highs" use

Romanian Journal of Legal Medicine

Volumn 18, Issue 4, 2010, Pages 271-278

  Gorun, Gabriel ^a   Dermengiu, Dan ^a   Curca, George Cristian ^a   Hostiuc, Sorin ^a   Ioan, Beatrice ^b   Luta, Veronica ^c  

^a NATIONAL INSTITUTE OF LEGAL MEDICINE MINA MINOVICI   (Romania)

^b GRIGORE T POPA UNIVERSITY OF MEDICINE AND PHARMACY   (Romania)

^c Disciplina de Medicin Legal   (Romania)

Author keywords

Hallucinogenic plants; Legal highs; Psychoactive substances; Spice

Indexed keywords

3,4 METHYLENEDIOXYMETHAMPHETAMINE; 4' METHYLMETHCATHINONE; ALPHA 1 ADRENERGIC RECEPTOR STIMULATING AGENT; CANNABINOID; DEXANABINOL; DRONABINOL; MONOAMINE OXIDASE A INHIBITOR; PSYCHEDELIC AGENT; PSYCHOTROPIC AGENT; SEROTONIN 2A AGONIST;

ABDOMINAL PAIN; ALTHAEA OFICINALIS; ARTICLE; BOTANY; BRUXISM; CANAVALIA; CLINICAL FEATURE; DEREGULATION; DIAPHORESIS; DIZZINESS; DRUG INDUSTRY; DRUG RESEARCH; EPISTAXIS; HEADACHE; HERBAL MEDICINE; HUMAN; INTOXICATION; LAW; LEONOTIS LEONURUS; LEONURUS SIBIRICUS; MEDICAL RESEARCH; MEDICINAL PLANT; NAUSEA; NELUMBO NUCIFERA; NUCLEAR MAGNETIC RESONANCE; NYMPHAEA ALBA; PEDICULARIS DENSIFLORA; PROTEIN SYNTHESIS; ROSA CANINA; SCUTELLARIA NANA; TANDEM MASS SPECTROMETRY; TREMOR; TRISMUS; VOMITING;

EID: 79251521845     PISSN: 12218618     EISSN: 18448585     Source Type: Journal    
DOI: 10.4323/rjlm.2010.271     Document Type: Article

References (21)

1. www.emcdda.europa.eu/about/press/news-releases. In; 2010
2. Gorun GS, Tofoleanu IT, Cimpineanu B, Buda O. Retrospective study of forensic medicine's management of drug related deaths in Romania: 2001-2007. Romanian Journal of Legal Medicine 2008;16:217-225
3. Kubota S, Nakashima S. The study of leonurus sibiricus, L. I. Chemical study of the alkaloid "leonurin" isolated from leonurus sibiricus L. Yakugaku Zasshi 1930;11 153-158
4. Sridhar KR, Seena S. Nutritional and antinutritional significance of four unconventional legumes of the genus Canavalia - A comparative study. Food Chemistry 2006;99:267-288
5. Assreuy AMS, Fontenele SR, Pires AD, et al. Vasodilator effects of Diocleinae lectins from the Canavalia genus. Naunyn-Schmiedebergs Archives of Pharmacology 2009;380:509-521
6. Kuchta K, Volk R, Rauwald H. Quantitative determination of stachydrine via HPTLC in cardioactive Leonurus and Leonotis drugs. Planta Medica 2010;76:1330-1330
7. Bagul M, Srinivasa H, Padh H, Rajani M. A rapid densitometric method for simultaneous quantification of gallic acid and ellagic acid in herbal raw materials using HPTLC. Journal of Separation Science 2005;28:581-584
8. Titretir S, Sakar MK. Determination of some metals in medicinal plants by flame atomic absorption spectrometry after different digestion procedures. Fresenius Environmental Bulletin 2007;16:216-222
9. Gorun GS. Cinematography - pull factor in drug addiction. Romanian Journal of Legal Medicine 2007;15:55-62
10. Costache E, Stoian M.G. Connections made by forensic investigation between judiciary toxicology and forensic medicine. Romanian Journal of Legal Medicine 2007;15:219-228
11. Vlase L, Popa DS, Zaharia D, Loghin F. High-throughput toxicological analysis of Delta 9-THC and 11-nor-9-carboxy-Delta 9-THC by LC/MS/MS. Romanian Journal of Legal Medicine 2010;18:133-140
12. Huffman J, Duncan S. Synthesis and pharmacology of the 1',2'-dimethylheptyl- Δ8-THC isomers: exceptionally potent cannabinoids. Bioorganic and Medicinal Chemistry Letters 1997;7:2799-2804
13. Shulgin A, Shulgin A, Joy D. Pihkal: a chemical love story. California: Transform Press; 1991
14. Uchiyama N, Kikura-Hanajiri R, Kawahara N, Haishima Y, Goda Y. Identification of a cannabinoid analog as a new type of designer drug in a herbal product. Chemical and Pharmaceutical Bulletin 2009;57:439-441
15. Piggee C. Investigating a not-so-natural high. Analytical Chemistry 2009;81:3205-3207
16. Corkery J. UK mephedrone and MDPV deaths update. In. Lisbon: EMCDDA DRD expert meeting; 2010, Nov. 11-12
17. Auwärter V, Dresen S, Weinmann W, et al. Spice and other herbal blends: harmless incense or cannabinoid designer drugs? Journal of Mass Spectrometry 2009;44:832-837
18. http://www.emcdda.europa.eu/online/annual-report/2010/new-drugs-and-trends/2. 2010
19. Vlase L, Popa DS, Loghin F, Leucuta SE. High-throughput toxicological analysis of Methamphetamine, MDA and MDMA from human plasma by LC-MS/MS. Romanian Journal of Legal Medicine 2009;17:213-220
20. Sargent T, Shulgin A, Kusubov N. Quantitative measurement of demethylation of 14C-methoxy labeled DMPEA and TMA-2 in rats. Psychopharmacology Community 1976;2:199-206
21. European Monitorind Centre for Drugs and drug Addiction Report on the risk assessment of 4-MTA in the framework of the joint action on new synthetic drugs Luxembourg, office for Official Publications of the European Communities. In; 2004