High-throughput toxicological analysis of Δ9-THC and 11-nor-9-carboxy-Δ9-THC by LC/MS/MS

Romanian Journal of Legal Medicine

Volumn 18, Issue 2, 2010, Pages 133-140

  Vlase, Laurian ^a   Popa, Daniela Saveta ^a   Zaharia, Daniela ^b   Loghin, Felicia ^a  

^a IULIU HATIEGANU UNIVERSITY OF MEDICINE AND PHARMACY   (Romania)

^b Forensic Institute   (Romania)

Author keywords

9 tetrahydrocannabinol; 11 nor 9 carboxy 9 tetrahydrocannabinol; Forensic analyses; High throughput assay; LC MS MS

Indexed keywords

ACETONITRILE; AMMONIUM FORMATE; DRONABINOL; METHANOL; PHOSPHORIC ACID; TETRAHYDROCANNABINOLIC ACID; WATER;

ACCURACY; ARTICLE; CANNABIS ADDICTION; CONTROLLED STUDY; FLOW RATE; FORENSIC TOXICOLOGY; HIGH THROUGHPUT SCREENING; HUMAN; LIQUID CHROMATOGRAPHY; QUANTITATIVE ANALYSIS; SENSITIVITY AND SPECIFICITY; TANDEM MASS SPECTROMETRY; URINALYSIS;

EID: 77954945226     PISSN: 12218618     EISSN: 18448585     Source Type: Journal    
DOI: 10.4323/rjlm.2010.133     Document Type: Article

References (19)

1. Fischedick J, Van Der Kooy F, Verpoorte R, Cannabinoid receptor 1 binding activity and quantitative analysis of Cannabis sativa L. smoke and vapor, Chem Pharm Bull (Tokyo). 2010; 58(2):201-207.
2. Moffat AC, Osselton MD, Widdop B, Galichet LY, Clarke's Analysis of Drugs and Poisons, Third Edition, London: Pharmaceutical Press; 2004. p.740-743.
3. 9-tetrahydrocannabinol-9-carboxylic acid in urine, J Chromatogr B. 2009; 877:2153-2157. DOI:10.1016/j.jchromb.2009.04.047.
4. Huq S, Dixon A, Kelly K, Kallury KM, Novel solid-phase extraction protocol for 11-nor-9-carboxy-delta9- tetrahydrocannabinol from urine samples employing a polymeric mixed-mode cation-exchange resin, Strata-X-C, suitable for gas chromatography-mass spectrometry or liquid chromatography-mass spectrometry analysis, J Chromatogr A. 2005; 1073(1-2):355-361. DOI:10.1016/j.chroma.2004.10.052.
5. Del Mar Ramirez Fernandez M, De Boeck G, Wood M, Lopez-Rivadulla M, Samyn N, Simultaneous analysis of THC and its metabolites in blood using liquid chromatography-tandem mass spectrometry, J Chromatogr B Analyt Technol Biomed Life Sci. 2008; 875(2):465-470. DOI:10.1016/j.jchromb.2008.09.032.
6. Jagerdeo E, Shaff JE, 2005; Montgomery MA, LeBeau MA, A semi-automated solid-phase extraction liquid chromatography/tandem mass spectrometry method for the analysis of tetrahydrocannabinol and metabolites in whole blood, Rapid Commun Mass Spectrom. 2009; 23:2697-2705. DOI: 10.1002/rcm.4174.
7. Grauwiler SB, Scholer A, Drewe J, Development of a LC/MS/MS method for the analysis of cannabinoids in human EDTA-plasma and urine after small doses of Cannabis sativa extracts, J Chromatogr B Analyt Technol Biomed Life Sci. 2007; 850(1-2):515-522. DOI:10.1016/j.jchromb.2006.12.045.
8. Jung J, Kempf J, Mahler H, Weinmann W, Detection of Delta9-tetrahydrocannabinolic acid A in human urine and blood serum by LC-MS/MS, J Mass Spectrom. 2007; 42(3):354-360.
9. Maralikova B, Weinmann W, Simultaneous determination of Delta9-tetrahydrocannabinol, 11-hydroxy-Delta9- tetrahydrocannabinol and 11-nor-9-carboxy- Delta9-tetrahydrocannabinol in human plasma by high-performance liquid chromatography/tandem mass spectrometry, J Mass Spectrom. 2004; 39(5):526-531.
10. Laloup M, Ramirez Fernandez Mdel M, Wood M, De Boeck G, Henquet C, Maes V, Samyn N, Quantitative analysis of delta9-tetrahydrocannabinol in preserved oral fluid by liquid chromatography-tandem mass spectrometry, J Chromatogr A. 2005; 1082(1):15-24. DOI:10.1016/j.chroma.2005.03.031.
11. Teixeira H, Proença P, Verstraete A, Corte-Real F, Vieira DN, Analysis of Delta9-tetrahydrocannabinol in oral fluid samples using solid-phase extraction and high-performance liquid chromatography-electrospray ionization mass spectrometry, Forensic Sci Int. 2005; 150(2-3):205-211. DOI:10.1016/j.forsciint.2004.11.026.
12. Weinmann W, Goerner M, Vogt S, Goerke R, Pollak S, Fast confirmation of 11-nor-9-carboxy-Delta(9)- tetrahydrocannabinol (THC-COOH) in urine by LC/MS/MS using negative atmospheric-pressure chemical ionisation (APCI), Forensic Sci Int. 2001; 121(1-2):103-107.
13. Weinmann W, Vogt S, Goerke R, Müller C, Bromberger A, Simultaneous determination of THC-COOH and THC- COOH-glucuronide in urine samples by LC/MS/MS, Forensic Sci Int. 2000; 113(1-3):381-387.
14. Annesley TM, Ion Suppression in Mass Spectrometry, Clinical Chemistry. 2003; 49(7):1041-1044
15. Gao S, Zhang ZP, Karnes HT, Sensitivity enhancement in liquid chromatography/atmospheric pressure ionization mass spectrometry using derivatization and mobile phase additives, J Chromatogr B. 2005; 825:98-110. DOI:10.1016/j.jchromb.2005.04.021.
16. Kostiainen R, Kauppila TJ, Effect of eluent on the ionization process in liquid chromatography-mass spectrometry, J Chromatogr A. 2009; 1216:685-699. DOI:10.1016/j.chroma.2008.08.095.
17. Guidance for Industry, Bioanalytical Method Validation. U.S. Department of Health and Human Services, Food and Drug Administration. Federal Register. 2001; 66.
18. Guidance on the Investigation of Bioavailability and Bioequivalence. The European Agency for the Evaluation of Medicinal Products, Committee for Proprietary Medicinal Products. 2001; CPMP/EWP/QWP/1401/98.
19. Imre S, Vlase L, Muntean DL, Bioanalytical method validation, Revista Romana de Medicina de Laborator. 2008; 10(1):13-21.