Autocrine effects of interleukin-6 mediate acute-phase proinflammatory and tissue-reparative transcriptional responses of canine bladder mucosa

Infection and Immunity

Volumn 79, Issue 2, 2011, Pages 708-715

  Wood, Michael W ^a   Breitschwerdt, Edward B ^a   Gookin, Jody L ^a  

^a NORTH CAROLINA STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BONE MORPHOGENETIC PROTEIN 5; CHEMOKINE RECEPTOR CCR3; DESMIN; ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1; EPIREGULIN; GELATINASE A; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; GLYCOSAMINOGLYCAN; HEPARAN SULFATE DEXTRO GLUCOSAMINYL 3 O SULFOTRANSFERASE 3A1; HYALURONAN SYNTHASE 2; HYPOXANTHINE PHOPHORIBOSYLTRANSFERASE; INTERLEUKIN 1BETA; INTERLEUKIN 6 RECEPTOR; INTERSTITIAL COLLAGENASE; MYOSIN BINDING PROTEIN C; PROTEIN; RECOMBINANT INTERLEUKIN 6; STAT3 PROTEIN; STROMELYSIN; SUPPRESSOR OF CYTOKINE SIGNALING 3; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; AUTOCRINE EFFECT; BLADDER MUCOSA; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; ENZYME LINKED IMMUNOSORBENT ASSAY; ESCHERICHIA COLI; ESCHERICHIA COLI INFECTION; EX VIVO STUDY; GENE EXPRESSION REGULATION; GENE TARGETING; HUMAN; IMMUNITY; MICROARRAY ANALYSIS; NONHUMAN; NUCLEOTIDE SEQUENCE; OUTCOME ASSESSMENT; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; TISSUE INJURY; URINARY TRACT INFECTION; UROTHELIUM; WESTERN BLOTTING; WOUND HEALING;

ACUTE-PHASE REACTION; ANIMALS; DOGS; HUMANS; INTERLEUKIN-6; MUCOUS MEMBRANE; SIGNAL TRANSDUCTION; TISSUE CULTURE TECHNIQUES; URINARY BLADDER; UROPATHOGENIC ESCHERICHIA COLI; UROTHELIUM;

EID: 79251513584     PISSN: 00199567     EISSN: 10985522     Source Type: Journal    
DOI: 10.1128/IAI.01102-10     Document Type: Article

References (46)

1. Aderka, D., J. M. Le, and J. Vilcek. 1989. IL-6 inhibits lipopolysaccharide-induced tumor necrosis factor production in cultured human-monocytes, U937 cells, and in mice. J. Immunol. 143:3517-3523.
2. Agace, W., et al. 1993. Selective cytokine production by epithelial cells following exposure to Escherichia coli. Infect. Immun. 61:602-609.
3. Bartges, J. W. 2004. Diagnosis of urinary tract infections. Vet. Clin. North Am. Small Anim. Pract. 34:923-933.
4. Chin, A. C., W. Y. Lee, A. Nusrat, N. Vergnolle, and C. A. Parkos. 2008. Neutrophil-mediated activation of epithelial protease-activated receptors-1 and -2 regulates barrier function and transepithelial migration. J. Immunol. 181:5702-5710.
5. Dinarello, C. A. 2003. Interleukin=1 family [IL=1∓1, F2], p. 643-668. In A. W. Thompson and M. T. Lotze (ed.), The cytokine handbook, 4th ed., vol. 2. Academic Press, Boston, MA.
6. Foxman, B., R. Barlow, H. D'Arcy, B. Gillespie, and J. D. Sobel. 2000. Urinary tract infection: self-reported incidence and associated costs. Ann. Epidemiol. 10:509-515.
7. Foxman, B., and R. R. Frerichs. 1985. Epidemiology of urinary-tract infection. 2. Diet, clothing, and urination habits. Am. J. Public Health 75:1314-1317.
8. Funfstuck, R., et al. 2001. Secretion of cytokines by uroepithelial cells stimulated by Escherichia coli and Citrobacter spp. Int. J. Antimicrob. Agents 17:253-258.
9. Gabay, C. 2006. Interleukin-6 and chronic inflammation. Arthritis Res. Ther. 8(Suppl. 2):S3.
10. Gill, S. E., and W. C. Parks. 2008. Metalloproteinases and their inhibitors: regulators of wound healing. Int. J. Biochem. Cell Biol. 40:1334-1347.
11. Gotte, M. 2003. Syndecans in inflammation. FASEB J. 17:575-591.
12. Hang, L., B. Wullt, Z. X. Shen, D. Karpman, and C. Svanborg. 1998. Cytokine repertoire of epithelial cells lining the human urinary tract. J. Urol. 159:2185-2192.
13. Hauser, P. J., et al. 2009. Restoring barrier function to acid damaged bladder by intravesical chondroitin sulfate. J. Urol. 182:2477-2482.
14. Hedges, S., et al. 1994. Uroepithelial cells are part of a mucosal cytokine network. Infect. Immun. 62:2315-2321.
15. Hedges, S., P. Anderson, G. Lidin-Janson, P. de Man, and C. Svanborg. 1991. Interleukin-6 response to deliberate colonization of the human urinary tract with Gram-negative bacteria. Infect. Immun. 59:421-427.
16. Hedges, S., et al. 1992. Comparison of urine and serum concentrations of interleukin-6 in women with acute pyelonephritis or asymptomatic bacteriuria. J. Infect. Dis. 166:653-656.
17. Hedges, S., M. Svensson, and C. Svanborg. 1992. Interleukin-6 response of epithelial cell lines to bacterial stimulation in vitro. Infect. Immun. 60:1295-1301.
18. Hicks, R. M., B. Ketterer, and R. C. Warren. 1974. Ultrastructure and chemistry of the luminal plasma membrane of mammalian urinary bladder: a structure with low permeability to water and ions. Philos. Trans. R. Soc. Lond. B Biol. Sci. 268:23-38.
19. Hiro, D., A. Ito, K. Matsuta, and Y. Mori. 1986. Hyaluronic acid is an endogenous inducer of interleukin-1 production by human monocytes and rabbit macrophages. Biochem. Biophys. Res. Commun. 140:715-722.
20. Hooton, T. M., and W. E. Stamm. 1997. Diagnosis and treatment of uncomplicated urinary tract infection. Infect. Dis. Clin. North Am. 11:551-581.
21. Hu, P., et al. 2002. Role of membrane proteins in permeability barrier function: uroplakin ablation elevates urothelial permeability. Am. J. Physiol. Renal Physiol. 283:F1200-F1207.
22. Hull, R. A., R. E. Gill, P. Hsu, B. H. Minshew, and S. Falkow. 1981. Construction and expression of recombinant plasmids encoding type 1 or Dmannose-resistant pili from a urinary tract infection Escherichia coli isolate. Infect. Immun. 33:933-938.
23. Jantausch, B. A., R. O'Donnell, and B. L. Wiedermann. 2000. Urinary interleukin-6 and interleukin-8 in children with urinary tract infection. Pediatr. Nephrol. 15:236-240.
24. Jones, M. R., et al. 2006. Roles of interleukin-6 in activation of STAT proteins and recruitment of neutrophils during Escherichia coli pneumonia. J. Infect. Dis. 193:360-369.
25. Leemans, J. C., M. Vervoordeldonk, S. Florquin, K. P. van Kessel, and T. van der Poll. 2002. Differential role of interleukin-6 in lung inflammation induced by lipoteichoic acid and peptidoglycan from Staphylococcus aureus. Am. J. Respir. Crit. Care Med. 165:1445-1450.
26. Lewis, S. A. 2000. Everything you wanted to know about the bladder epithelium but were afraid to ask. Am. J. Physiol. Renal Physiol. 278:F867-F874.
27. Lewis, S. A., D. C. Eaton, and J. M. Diamond. 1976. The mechanism of Na+ transport by rabbit urinary bladder. J. Membr. Biol. 28:41-70.
28. Mehrad, B., and T. J. Standiford. 1999. Role of cytokines in pulmonary antimicrobial host defense. Immunol. Res. 20:15-27.
29. Naugler, W. E., and M. Karin. 2008. The wolf in sheep's clothing: the role of interieukin-6 in immunity, inflammation and cancer. Trends Mol. Med. 14: 109-119.
30. Negrete, H. O., J. P. Lavelle, J. Berg, S. A. Lewis, and M. L. Zeidel. 1996. Permeability properties of the intact mammalian bladder epithelium. Am. J. Physiol. 271:F886-F894.
31. Ohsugi, Y. 2007. Recent advances in immunopathophysiology of interleukin-6: an innovative therapeutic drug, tocilizumab (recombinant humanized anti-human interieukin-6 receptor antibody), unveils the mysterious etiology of immune-mediated inflammatory diseases. Biol. Pharm. Bull. 30:2001-2006.
32. Otto, G., J. Braconier, A. Andreasson, and C. Svanborg. 1999. Interleukin-6 and disease severity in patients with bacteremic and nonbacteremic febrile urinary tract infection. J. Infect. Dis. 179:172-179.
33. Parsons, C. L. 2007. The role of the urinary epithelium in the pathogenesis of interstitial cystitis/prostatitis/urethritis. Urology 69:9-16.
34. Parsons, C. L., D. Boychuk, S. Jones, R. Hurst, and H. Callahan. 1990. Bladder surface glycosaminoglycans: an epithelial permeability barrier. J. Urol. 143:139-142.
35. Parsons, C. L., and S. G. Mulholland. 1978. Bladder surface mucin - its antibacterial effect against various bacterial species. Am. J. Pathol. 93:423-432.
36. Parsons, C. L., C. W. Stauffer, and J. D. Schmidt. 1988. Reversible inactivation of bladder surface glycosaminoglycan antibacterial activity by protamine sulfate. Infect. Immun. 56:1341-1343.
37. Quinton, L. J., et al. 2008. Alveolar epithelial STAT3, IL-6 family cytokines, and host defense during Escherichia coli pneumonia. Am. J. Respir. Cell Mol. Biol. 38:699-706.
38. Rose-John, S., G. H. Waetzig, J. Scheller, J. Grotzinger, and D. Seegert. 2007. The IL-6/sIL-6R complex as a novel target for therapeutic approaches. Expert Opin. Ther. Targets 11:613-624.
39. Schindler, R., et al. 1990. Correlations and interactions in the production of interleukin-6 (IL-6), IL-1, and tumor necrosis factor (TNF) in human blood mononuclear cells: IL-6 suppresses IL-1 and TNF. Blood 75:40-47. (Pubitemid 20031487)
40. Senior, D. F. 2007. Management of urinary tract infections, p. 282-289. In J. Elliott and G. Grauer (ed.), BSAVA manual of canine and feline nephrology and urology, 2nd ed. British Small Animal Veterinary Association, Gloucester, United Kingdom.
41. Svanborg, C., G. Godaly, and M. Hedlund. 1999. Cytokine responses during mucosal infections: role in disease pathogenesis and host defence. Curr. Opin. Microbiol. 2:99-105.
42. Tilg, H., E. Trehu, M. B. Atkins, C. A. Dinarello, and J. W. Mier. 1994. Interleukin-6 (IL-6) as an anti-inflammatory cytokine: induction of circulating IL-1 receptor antagonist and soluble tumor necrosis factor receptor P55. Blood 83:113-118.
43. Umegaki, H., et al. 1996. Protective effect of interleukin-6 against the death of PC12 cells caused by serum deprivation or by the addition of a calcium ionophore. Biochem. Pharmacol. 52:911-916.
44. Wang, X. P., et al. 2004. The interleukin-6 cytokine system regulates epidermal permeability barrier homeostasis. J. Invest. Dermatol. 123:124-131.
45. Wolters, P. J., et al. 2009. Neutrophil-derived IL-6 limits alveolar barrier disruption in experimental ventilator-induced lung injury. J. Immunol. 182: 8056-8062.
46. Xing, Z., et al. 1998. IL-6 is an antiinflammatory cytokine required for controlling local or systemic acute inflammatory responses. J. Clin. Invest. 101:311-320.