XB130, a novel adaptor protein, promotes thyroid tumor growth

American Journal of Pathology

Volumn 178, Issue 1, 2011, Pages 391-401

  Shiozaki, Atsushi ^a   Lodyga, Monika ^a   Bai, Xiao Hui ^a   Nadesalingam, Jeya ^a   Oyaizu, Takeshi ^a   Winer, Daniel ^b   Asa, Sylvia L ^b   Keshavjee, Shaf ^a,c   Liu, Mingyao ^a,c  

^a UNIVERSITY HEALTH NETWORK   (Canada)

^b UNIVERSITY HEALTH NETWORK   (Canada)

^c UNIVERSITY OF TORONTO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

A KINASE ANCHOR PROTEIN 12; ADAPTOR PROTEIN; BASIC HELIX LOOP HELIX TRANSCRIPTION FACTOR; BASIC HELIX LOOP HELIX TRANSCRIPTION FACTOR B; CYCLIC AMP DEPENDENT PROTEIN KINASE ANCHORING PROTEIN; DICER; DICER 1; ENDOTHELIN RECEPTOR; ENDOTHELIN RECEPTOR TYPE A; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153; HEAT SHOCK PROTEIN; HEAT SHOCK PROTEIN A1A; MYC PROTEIN; PEROXIREDOXIN 2; PHOSPHATIDYLINOSITOL 3 KINASE; PROSTAGLANDIN E SYNTHASE; PROTEIN DNAJ; PROTEIN DNAJB1; PROTEIN DNAJB4; PROTEIN P85; PROTEIN P85 ALPHA; PROTEIN PATCHED; PROTEIN RET; RGS2 PROTEIN; SHORT HAIRPIN RNA; SMALL INTERFERING RNA; STEM CELL FACTOR; TISSUE PLASMINOGEN ACTIVATOR; UNCLASSIFIED DRUG; UNINDEXED DRUG; XB 130;

ANIMAL MODEL; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CARCINOGENESIS; CELL CYCLE; CELL CYCLE G1 PHASE; CELL CYCLE S PHASE; CELL DEATH; CELL FUNCTION; CELL GROWTH; CELL PROLIFERATION; CELL SURVIVAL; CONTROLLED STUDY; FEMALE; GENE EXPRESSION; GENE EXPRESSION PROFILING; GENE SILENCING; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; SIGNAL TRANSDUCTION; THYROID CANCER; THYROID CARCINOMA; THYROID GLAND; TISSUE MICROARRAY; TRANSCRIPTION REGULATION; TUMOR GROWTH;

EID: 79251510554     PISSN: 00029440     EISSN: 15252191     Source Type: Journal    
DOI: 10.1016/j.ajpath.2010.11.024     Document Type: Article

References (40)

1. Flynn DC: Adaptor proteins. Oncogene 2001, 20:6270-6272
2. Csiszar A: Structural and functional diversity of adaptor proteins involved in tyrosine kinase signaling. Bioessays 2006, 28:465-479
3. Dorfleutner A, Stehlik C, Zhang J, Gallick GE, Flynn DC: AFAP-110 is required for actin stress fiber formation and cell adhesion in MDAMB-231 breast cancer cells. J Cell Physiol 2007, 213:740-749
4. Zhang J, Park SI, Artime MC, Summy JM, Shah AN, Bomser JA, Dorfleutner A, Flynn DC, Gallick GE: AFAP-110 is overexpressed in prostate cancer and contributes to tumorigenic growth by regulating focal contacts. J Clin Invest 2007, 117:2962-2973
5. Seals DF, Azucena EF Jr, Pass I, Tesfay L, Gordon R, Woodrow M, Resau JH, Courtneidge SA: The adaptor protein Tks5/Fish is required for podosome formation and function, and for the protease-driven invasion of cancer cells. Cancer Cell 2005, 7:155-165
6. Blouw B, Seals DF, Pass I, Diaz B, Courtneidge SA: A role for the podosome/invadopodia scaffold protein Tks5 in tumor growth in vivo. Eur J Cell Biol 2008, 87:555-567
7. Lodyga M, Bai XH, Mourgeon E, Han B, Keshavjee S, Liu M: Molecular cloning of actin filament-associated protein: a putative adaptor in stretch-induced Src activation. Am J Physiol Lung Cell Mol Physiol 2002, 283:L265-274
8. Han B, Bai XH, Lodyga M, Xu J, Yang BB, Keshavjee S, Post M, Liu M: Conversion of mechanical force into biochemical signaling. J Biol Chem 2004, 279:54793-54801
9. Xu J, Bai XH, Lodyga M, Han B, Xiao H, Keshavjee S, Hu J, Zhang H, Yang BB, Liu M: XB130, a novel adaptor protein for signal transduction. J Biol Chem 2007, 282:16401-16412
10. Lodyga M, De Falco V, Bai XH, Kapus A, Melillo RM, Santoro M, Liu M: XB130, a tissue-specific adaptor protein that couples the RET/PTC oncogenic kinase to PI 3-kinase pathway. Oncogene 2009, 28:937-949
11. Grieco M, Santoro M, Berlingieri MT, Melillo RM, Donghi R, Bongarzone I, Pierotti MA, Della Porta G, Fusco A, Vecchio G: PTC is a novel rearranged form of the ret proto-oncogene and is frequently detected in vivo in human thyroid papillary carcinomas. Cell 1990, 60:557-563
12. Kondo T, Ezzat S, Asa SL: Pathogenetic mechanisms in thyroid follicular-cell neoplasia. Nat Rev Cancer 2006, 6:292-306
13. Lodyga M, Bai XH, Kapus A, Liu M: Novel adaptor protein XB130 is a Rac-controlled component of lamellipodia, which regulates cell motility and invasion. J Cell Sci 2010, In press
14. Mura M, Han B, Andrade CF, Seth R, Hwang D, Waddell TK, Keshavjee S, Liu M: The early responses of VEGF and its receptors during acute lung injury: implication of VEGF in alveolar epithelial cell survival. Crit Care 2006, 10:R130
15. Noguchi PD, Johnson JB, Browne W: Measurement of DNA synthesis by flow cytometry. Cytometry 1981, 1:390-393
16. Takei Y, Kadomatsu K, Yuzawa Y, Matsuo S, Muramatsu T: A small interfering RNA targeting vascular endothelial growth factor as cancer therapeutics. Cancer Res 2004, 64:3365-3370 (Pubitemid 38657905)
17. Nozawa H, Tadakuma T, Ono T, Sato M, Hiroi S, Masumoto K, Sato Y: Small interfering RNA targeting epidermal growth factor receptor enhances chemosensitivity to cisplatin, 5-fluorouracil and docetaxel in head and neck squamous cell carcinoma. Cancer Sci 2006, 97:1115-1124 (Pubitemid 44322563)
18. Briese J, Cheng S, Ezzat S, Liu W, Winer D, Wagener C, Bamberger AM, Asa SL: Osteopontin (OPN) expression in thyroid carcinoma. Anticancer Res 30:1681-1688
19. Liu W, Wei W, Winer D, Bamberger AM, Bamberger C, Wagener C, Ezzat S, Asa SL: CEACAM1 impedes thyroid cancer growth but promotes invasiveness: a putative mechanism for early metastases. Oncogene 2007, 26:2747-2758 (Pubitemid 46663832)
20. Mura M, Andrade CF, Han B, Seth R, Zhang Y, Bai XH, Waddell TK, Hwang D, Keshavjee S, Liu M: Intestinal ischemia-reperfusion-induced acute lung injury and oncotic cell death in multiple organs. Shock 2007, 28:227-238
21. Tusher VG, Tibshirani R, Chu G: Significance analysis of microarrays applied to the ionizing radiation response. Proc Natl Acad Sci USA 2001, 98:5116-5121
22. Kaneda H, Waddell TK, de Perrot M, Bai XH, Gutierrez C, Arenovich T, Chaparro C, Liu M, Keshavjee S: Pre-implantation multiple cytokine mRNA expression analysis of donor lung grafts predicts survival after lung transplantation in humans. Am J Transplant 2006, 6:544-551
23. Tang PS, Mura M, Seth R, Liu M: Acute lung injury and cell death: how many ways can cells die? Am J Physiol Lung Cell Mol Physiol 2008, 294:L632-641
24. Liu W, Asa SL, Ezzat S: 1alpha,25-Dihydroxyvitamin D3 targets PTEN-dependent fibronectin expression to restore thyroid cancer cell adhesiveness. Mol Endocrinol 2005, 19:2349-2357
25. Liu W, Cheng S, Asa SL, Ezzat S: The melanoma-associated antigen A3 mediates fibronectin-controlled cancer progression and metastasis. Cancer Res 2008, 68:8104-8112
26. dos Santos CC, Han B, Andrade CF, Bai X, Uhlig S, Hubmayr R, Tsang M, Lodyga M, Keshavjee S, Slutsky AS, Liu M: DNA microarray analysis of gene expression in alveolar epithelial cells in response to TNFalpha, LPS, and cyclic stretch. Physiol Genomics 2004, 19:331-342
27. dos Santos CC, Okutani D, Hu P, Han B, Crimi E, He X, Keshavjee S, Greenwood C, Slutsky AS, Zhang H, Liu M: Differential gene profiling in acute lung injury identifies injury-specific gene expression. Crit Care Med 2008, 36:855-865
28. Mazzaferri EL, Jhiang SM: Long-term impact of initial surgical and medical therapy on papillary and follicular thyroid cancer. Am J Med 1994, 97:418-428
29. Sherman SI, Brierley JD, Sperling M, Ain KB, Bigos ST, Cooper DS, Haugen BR, Ho M, Klein I, Ladenson PW, Robbins J, Ross DS, Specker B, Taylor T, Maxon HR 3rd: Prospective multicenter study of thyroid carcinoma treatment: initial analysis of staging and outcome. National Thyroid Cancer Treatment Cooperative Study Registry Group. Cancer 1998, 83:1012-1021
30. Cooper DS, Doherty GM, Haugen BR, Kloos RT, Lee SL, Mandel SJ, Mazzaferri EL, McIver B, Sherman SI, Tuttle RM: Management guidelines for patients with thyroid nodules and differentiated thyroid cancer. Thyroid 2006, 16:109-142
31. Durante C, Haddy N, Baudin E, Leboulleux S, Hartl D, Travagli JP, Caillou B, Ricard M, Lumbroso JD, De Vathaire F, Schlumberger M: Long-term outcome of 444 patients with distant metastases from papillary and follicular thyroid carcinoma: benefits and limits of radioiodine therapy. J Clin Endocrinol Metab 2006, 91:2892-2899
32. Emaduddin M, Edelmann MJ, Kessler BM, Feller SM: Odin (ANKS1A) is a Src family kinase target in colorectal cancer cells. Cell Commun Signal 2008, 6:7
33. Cunha IW, Carvalho KC, Martins WK, Marques SM, Muto NH, Falzoni R, Rocha RM, Aguiar S, Simoes AC, Fahham L, Neves EJ, Soares FA, Reis LF: Identification of genes associated with local aggressiveness and metastatic behavior in soft tissue tumors. Transl Oncol 3:23-32
34. Behlke MA: Progress towards in vivo use of siRNAs. Mol Ther 2006, 13:644-670
35. Akhtar S, Benter IF: Nonviral delivery of synthetic siRNAs in vivo. J Clin Invest 2007, 117:3623-3632
36. Takata T, Ishikawa F: Human Sir2-related protein SIRT1 associates with the bHLH repressors HES1 and HEY2 and is involved in HES1- and HEY2-mediated transcriptional repression. Biochem Biophys Res Commun 2003, 301:250-257
37. Matsuda S, Kawamura-Tsuzuku J, Ohsugi M, Yoshida M, Emi M, Nakamura Y, Onda M, Yoshida Y, Nishiyama A, Yamamoto T: Tob, a novel protein that interacts with p185erbB2, is associated with antiproliferative activity. Oncogene 1996, 12:705-713
38. Ubeda M, Vallejo M, Habener JF: CHOP enhancement of gene transcription by interactions with Jun/Fos AP-1 complex proteins. Mol Cell Biol 1999, 19:7589-7599
39. Alitalo K, Schwab M, Lin CC, Varmus HE, Bishop JM: Homogeneously staining chromosomal regions contain amplified copies of an abundantly expressed cellular oncogene (c-myc) in malignant neuroendocrine cells from a human colon carcinoma. Proc Natl Acad Sci USA 1983, 80:1707-1711
40. Nau MM, Brooks BJ, Battey J, Sausville E, Gazdar AF, Kirsch IR, McBride OW, Bertness V, Hollis GF, Minna JD: L-myc, a new mycrelated gene amplified and expressed in human small cell lung cancer. Nature 1985, 318:69-73 (Pubitemid 16230338)