-
1
-
-
17944366735
-
Interindividual variability in sensitivity to warfarin-nature or nuture?
-
Loebstein R, Yonath H, Peleg D, et al. Interindividual variability in sensitivity to warfarin-nature or nuture? Clin Pharmacol Ther 2001;70:159-64
-
(2001)
Clin Pharmacol Ther
, vol.70
, pp. 159-64
-
-
Loebstein, R.1
Yonath, H.2
Peleg, D.3
-
2
-
-
0033608466
-
Association of polymorphisms in the cytochrome P450 CYP2C9 with warfarin dose requirement and risk of bleeding complications
-
Aithal GP, Day CP, Kesteven PJ, Daly AK. Association of polymorphisms in the cytochrome P450 CYP2C9 with warfarin dose requirement and risk of bleeding complications. Lancet 1999;353:717-19
-
(1999)
Lancet
, vol.353
, pp. 717-19
-
-
Aithal, G.P.1
Day, C.P.2
Kesteven, P.J.3
Daly, A.K.4
-
3
-
-
0037012465
-
Association between CYP2C9 genetic variants and anticoagulation-related outcomes during warfarin therapy
-
Higashi MK, Veenstra DL, Kondo LM, et al. Association between CYP2C9 genetic variants and anticoagulation-related outcomes during warfarin therapy. JAMA 2002;287:1690-8
-
(2002)
JAMA
, vol.287
, pp. 1690-8
-
-
Higashi, M.K.1
Veenstra, D.L.2
Kondo, L.M.3
-
4
-
-
0034283762
-
Influence of cytochrome P-450 CYP2C9 polymorphisms on warfarin sensitivity and risk of over-anticoagulation in patients on long-term treatment
-
Taube J, Halsall D, Baglin T. Influence of cytochrome P-450 CYP2C9 polymorphisms on warfarin sensitivity and risk of over-anticoagulation in patients on long-term treatment. Blood 2000;96:1816-19
-
(2000)
Blood
, vol.96
, pp. 1816-19
-
-
Taube, J.1
Halsall, D.2
Baglin, T.3
-
5
-
-
11244332058
-
A polymorphism in the VKORC1 gene is associated with inter-individual variability in the dose-anticoagulant effect of warfarin
-
D'Andrea G, D'Ambrosio RL, Di Perna P, et al. A polymorphism in the VKORC1 gene is associated with inter-individual variability in the dose-anticoagulant effect of warfarin. Blood 2005;105:645-9
-
(2005)
Blood
, vol.105
, pp. 645-9
-
-
D'Andrea, G.1
D'Ambrosio, R.L.2
Di Perna, P.3
-
6
-
-
23644437525
-
Common VKORC1 and GGCX polymorphisms associated with warfarin dose
-
Wadelius M, Chen LY, Downes K, et al. Common VKORC1 and GGCX polymorphisms associated with warfarin dose. Pharmacogenomics J 2005;5:262-70
-
(2005)
Pharmacogenomics J
, vol.5
, pp. 262-70
-
-
Wadelius, M.1
Chen, L.Y.2
Downes, K.3
-
7
-
-
21144448879
-
Effect of VKORC1 haplotypes on transcriptional regulation and warfarin dose
-
Rieder MJ, Reiner AP, Gage BF, et al. Effect of VKORC1 haplotypes on transcriptional regulation and warfarin dose. N Engl J Med 2005;352:2285-93
-
(2005)
N Engl J Med
, vol.352
, pp. 2285-93
-
-
Rieder, M.J.1
Reiner, A.P.2
Gage, B.F.3
-
8
-
-
65549085682
-
CYP4F2 genetic variant (rs2108622) significantly contributes to warfarin dosing variability in the Italian population
-
Borgiani P, Ciccacci C, Forte V, et al. CYP4F2 genetic variant (rs2108622) significantly contributes to warfarin dosing variability in the Italian population. Pharmacogenomics 2009;10:261-6
-
(2009)
Pharmacogenomics
, vol.10
, pp. 261-6
-
-
Borgiani, P.1
Ciccacci, C.2
Forte, V.3
-
9
-
-
77949874684
-
A polymorphism in the VKORC1 regulator calumenin predicts higher warfarin dose requirement in African Americans
-
Voora D, Koboldt DC, King CR, et al. A polymorphism in the VKORC1 regulator calumenin predicts higher warfarin dose requirement in African Americans. Clin Pharmacol Ther 2010;87:445-51
-
(2010)
Clin Pharmacol Ther
, vol.87
, pp. 445-51
-
-
Voora, D.1
Koboldt, D.C.2
King, C.R.3
-
10
-
-
23044440450
-
The impact of CYP2C9 and VKORC1 genetic polymorphism and patient characteristics upon warfarin dose requirements: Proposal for a new dosing regimen
-
Sconce EA, Khan TI, Wynne HA, et al. The impact of CYP2C9 and VKORC1 genetic polymorphism and patient characteristics upon warfarin dose requirements: proposal for a new dosing regimen. Blood 2005;106:2329-33
-
(2005)
Blood
, vol.106
, pp. 2329-33
-
-
Sconce, E.A.1
Khan, T.I.2
Wynne, H.A.3
-
11
-
-
34347403221
-
Estimation of warfarin maintenance dose based on VKORC1 (-1639 G > A) and CYP 2C9 genotypes
-
Zhu Y, Shennan M, Reynolds KK, et al. Estimation of warfarin maintenance dose based on VKORC1 (-1639 G > A) and CYP 2C9 genotypes. Clin Chem 2007;53:1199-205
-
(2007)
Clin Chem
, vol.53
, pp. 1199-205
-
-
Zhu, Y.1
Shennan, M.2
Reynolds, K.K.3
-
12
-
-
65449125050
-
Relative contribution of CYP 2C9 and VKORC1 genotypes and early INR response to the prediction of warfarin sensitivity during initiation of therapy
-
Li C, Schwarz UI, Ritchie MD, et al. Relative contribution of CYP 2C9 and VKORC1 genotypes and early INR response to the prediction of warfarin sensitivity during initiation of therapy. Blood 2009;113:3925-30
-
(2009)
Blood
, vol.113
, pp. 3925-30
-
-
Li, C.1
Schwarz, U.I.2
Ritchie, M.D.3
-
13
-
-
33845260086
-
Genotypes of the cytochrome p450 isoform, CYP2C9 and the vitamine K epoxide reductase complex subunit 1 conjointly determine stable warfarin dose: A prospective study
-
Carlquist JF, Horne BD, Muhlestein JB, et al. Genotypes of the cytochrome p450 isoform, CYP2C9 and the vitamine K epoxide reductase complex subunit 1 conjointly determine stable warfarin dose: a prospective study. J Thromb Thrombolysis 2006;22:191-7
-
(2006)
J Thromb Thrombolysis
, vol.22
, pp. 191-7
-
-
Carlquist, J.F.1
Horne, B.D.2
Muhlestein, J.B.3
-
14
-
-
59649117935
-
The largest prospective warfarin-treated cohort supports genetic forecasting
-
Wadelius M, Chen LY, Lindh JD, et al. The largest prospective warfarin-treated cohort supports genetic forecasting. Blood 2009;113:784-92
-
(2009)
Blood
, vol.113
, pp. 784-92
-
-
Wadelius, M.1
Chen, L.Y.2
Lindh, J.D.3
-
15
-
-
60849097257
-
Estimation of the warfarin dose with clinical and pharmacogenetic data
-
The International Warfarin Pharmacogenetics Consortium
-
The International Warfarin Pharmacogenetics Consortium. Estimation of the warfarin dose with clinical and pharmacogenetic data. N Engl J Med 2009;360:753-64
-
(2009)
N Engl J Med
, vol.360
, pp. 753-64
-
-
-
16
-
-
42449136621
-
Dosing algorithm for warfarin using CYP2C9 and VKORC1 genotyping from a multi-ethnic population: Comparison with other equations
-
Wu AHB, Wang P, Smith A, et al. Dosing algorithm for warfarin using CYP2C9 and VKORC1 genotyping from a multi-ethnic population: comparison with other equations. Pharmacogenomics 2008;9:169-78
-
(2008)
Pharmacogenomics
, vol.9
, pp. 169-78
-
-
Ahb, W.1
Wang, P.2
Smith, A.3
-
17
-
-
36148985283
-
Contribution of age, body weight, and CYP2C9 and VKORC1 genotype to the anticoagulant response to warfarin: Proposal for a new dosing regimen in Chinese patients
-
Miao L, Yang J. Contribution of age, body weight, and CYP2C9 and VKORC1 genotype to the anticoagulant response to warfarin: proposal for a new dosing regimen in Chinese patients. Eur J Clin Pharmacol 2007;63:1135-41
-
(2007)
Eur J Clin Pharmacol
, vol.63
, pp. 1135-41
-
-
Miao, L.1
Yang, J.2
-
18
-
-
62349134303
-
Validation of VKORC1 and CYP2C9 genotypes on interindividual warfarin maintenance dose: A prospective study in Chinese patients
-
Huang SW, Chen HS, Wang XQ, et al. Validation of VKORC1 and CYP2C9 genotypes on interindividual warfarin maintenance dose: a prospective study in Chinese patients. Pharmacogenet Genomics 2009;19:226-34
-
(2009)
Pharmacogenet Genomics
, vol.19
, pp. 226-34
-
-
Huang, S.W.1
Chen, H.S.2
Wang, X.Q.3
-
19
-
-
42549147841
-
Prospective study of warfarin dosage requirements based on CYP2C9 and VKORC1 genotypes
-
Wen SM, Lee MTM, Chen JJ, et al. Prospective study of warfarin dosage requirements based on CYP2C9 and VKORC1 genotypes. Clin Pharmacol Ther 2008;84:83-9
-
(2008)
Clin Pharmacol Ther
, vol.84
, pp. 83-9
-
-
Wen, S.M.1
Mtm, L.2
Chen, J.J.3
-
20
-
-
78651495631
-
Warfarin dosing algorithm using clinical, demographic and pharmacogenetic data from Chinese patients
-
published online 29 June 2010, doi:10.1007/s11239-010-0497-x
-
You JHS, Wong RSM, Waye MMY, et al. Warfarin dosing algorithm using clinical, demographic and pharmacogenetic data from Chinese patients. J Thromb Thrombolysis 2010: published online 29 June 2010, doi:10.1007/s11239-010-0497-x
-
(2010)
J Thromb Thrombolysis
-
-
Jhs, Y.1
Rsm, W.2
Mmy, W.3
-
21
-
-
49849105411
-
Laboratory and clinical outcomes of pharmacogenetics vs. clinical protocols for warfarin initiation in orthopedic patients
-
Lenzini PA, Grice CG, Milligan PE, et al. Laboratory and clinical outcomes of pharmacogenetics vs. clinical protocols for warfarin initiation in orthopedic patients. J Thromb Haemost 2008;6:1655-62
-
(2008)
J Thromb Haemost
, vol.6
, pp. 1655-62
-
-
Lenzini, P.A.1
Grice, C.G.2
Milligan, P.E.3
-
22
-
-
77957295385
-
Worldwide allele frequency distribution of four polymorphisms associated with warfarin dose requirements
-
published online 17 June 2010, doi:10.1038/jhg.2010.73
-
Ross KA, Bigham AW, Edwards M, et al. Worldwide allele frequency distribution of four polymorphisms associated with warfarin dose requirements. J Hum Genet 2010: published online 17 June 2010, doi:10.1038/jhg.2010.73
-
(2010)
J Hum Genet
-
-
Ross, K.A.1
Bigham, A.W.2
Edwards, M.3
-
23
-
-
25144502325
-
Association of vitamin K epoxide reductase complex 1 (VKORC1) variants with warfarin dose in a Hong Kong Chinese patient population
-
Veenstra DL, You JHS, Rieder MJ, et al. Association of vitamin K epoxide reductase complex 1 (VKORC1) variants with warfarin dose in a Hong Kong Chinese patient population. Pharmacogenet Genomics 2005;15:687-91
-
(2005)
Pharmacogenet Genomics
, vol.15
, pp. 687-91
-
-
Veenstra, D.L.1
Jhs, Y.2
Rieder, M.J.3
-
24
-
-
77952927473
-
Combined CYP2C9, VKORC1 and CYP4F2 frequencies among racial and ethnic groups
-
Scott SA, Khasawneh R, Peter I, et al. Combined CYP2C9, VKORC1 and CYP4F2 frequencies among racial and ethnic groups. Pharmacogenomics 2010;11:781-91
-
(2010)
Pharmacogenomics
, vol.11
, pp. 781-91
-
-
Scott, S.A.1
Khasawneh, R.2
Peter, I.3
-
25
-
-
27744485315
-
A prospective, randomized pilot trial of model-based warfarin dose initiation using CYP2C9 genotype and clinical data
-
Hillman MA, Wilke RA, Yale SH, et al. A prospective, randomized pilot trial of model-based warfarin dose initiation using CYP2C9 genotype and clinical data. Clin Med Res 2005;3:137-45
-
(2005)
Clin Med Res
, vol.3
, pp. 137-45
-
-
Hillman, M.A.1
Wilke, R.A.2
Yale, S.H.3
-
26
-
-
36549030324
-
Randomized trial of genotype-guided versus standard warfarin dosing in patients initiating oral anticoagulation
-
Couma-Gen Investigators
-
Anderson JL, Horne BD, Stevens SM, et al. Couma-Gen Investigators. Randomized trial of genotype-guided versus standard warfarin dosing in patients initiating oral anticoagulation. Circulation 2007;116:2563-70
-
(2007)
Circulation
, vol.116
, pp. 2563-70
-
-
Anderson, J.L.1
Horne, B.D.2
Stevens, S.M.3
-
27
-
-
39449086981
-
CYP2C9 genotype-guided warfarin prescribing enhances the efficacy and safety of anticoagulation: A prospective, randomized, controlled study
-
Caraco Y, Blotnick S, Muzkat M. CYP2C9 genotype-guided warfarin prescribing enhances the efficacy and safety of anticoagulation: a prospective, randomized, controlled study. Clin Pharmacol Ther 2008;83:460-70
-
(2008)
Clin Pharmacol Ther
, vol.83
, pp. 460-70
-
-
Caraco, Y.1
Blotnick, S.2
Muzkat, M.3
-
28
-
-
67349185332
-
Genetic testing before anticoagulation? A systematic review of harmacogenetics dosing of warfarin
-
Kangelaris KN, Bent S, Nussbaum RL, et al. Genetic testing before anticoagulation? A systematic review of harmacogenetics dosing of warfarin. J Gen Intern Med 2009;24:656-64
-
(2009)
J Gen Intern Med
, vol.24
, pp. 656-64
-
-
Kangelaris, K.N.1
Bent, S.2
Nussbaum, R.L.3
-
29
-
-
58849142451
-
A regulatory science perspective on warfarin therapy: A pharmacogenetic opportunity
-
Kim MJ, Huang SM, Meyer UA, et al. A regulatory science perspective on warfarin therapy: a pharmacogenetic opportunity. J Clin Pharmacol 2009;49:138-46
-
(2009)
J Clin Pharmacol
, vol.49
, pp. 138-46
-
-
Kim, M.J.1
Huang, S.M.2
Meyer, U.A.3
-
30
-
-
64149084499
-
Use of pharmacogenetics in guiding treatment with warfarin
-
Wadelius M. Use of pharmacogenetics in guiding treatment with warfarin. Clin Chem 2009;55:709-11
-
(2009)
Clin Chem
, vol.55
, pp. 709-11
-
-
Wadelius, M.1
-
31
-
-
69149098714
-
Should we be applying warfarin pharmacogenetics to clinical practice? No, not now
-
Rosove MH, Grody WW. Should we be applying warfarin pharmacogenetics to clinical practice? No, not now. Ann Intern Med 2009;151:270-3
-
(2009)
Ann Intern Med
, vol.151
, pp. 270-3
-
-
Rosove, M.H.1
Grody, W.W.2
-
32
-
-
64149087950
-
Pharmacogenetics-based initial dosing of warfarin: Not ready for prime time
-
Eby CS. Pharmacogenetics-based initial dosing of warfarin: not ready for prime time. Clin Chem 2009;55:712-14
-
(2009)
Clin Chem
, vol.55
, pp. 712-14
-
-
Eby, C.S.1
-
34
-
-
70649084116
-
Genotype-guided dosing of coumarin derivatives: The European pharmacogenetics of anticoagulant therapy (EU-PACT) trial design
-
van Schie RMF, Wadelius M, Kamali F, et al. Genotype-guided dosing of coumarin derivatives: the European pharmacogenetics of anticoagulant therapy (EU-PACT) trial design. Pharmacogenomics 2009;10:1687-95
-
(2009)
Pharmacogenomics
, vol.10
, pp. 1687-95
-
-
Van Schie Rmf1
Wadelius, M.2
Kamali, F.3
-
35
-
-
4544361864
-
The potential clinical and economic outcomes of pharmacogenetics-oriented management of warfarin therapy - A decision analysis
-
You JHS, Chan FWH, Wong RSM, Cheng G. The potential clinical and economic outcomes of pharmacogenetics-oriented management of warfarin therapy-a decision analysis. Thromb Haemost 2004;92:590-7
-
(2004)
Thromb Haemost
, vol.92
, pp. 590-7
-
-
You, J.H.S.1
Chan, F.W.H.2
Wong, R.S.M.3
Cheng, G.4
-
36
-
-
33744550480
-
CYP2C9 genotyping in acenocoumarol treatment: Is it a cost-effective addition to international normalized ratio monitoring?
-
Schalekamp T, Boink GJ, Visser LE, et al. CYP2C9 genotyping in acenocoumarol treatment: is it a cost-effective addition to international normalized ratio monitoring? Clin Pharmacol Ther 2006;79:511-20
-
(2006)
Clin Pharmacol Ther
, vol.79
, pp. 511-20
-
-
Schalekamp, T.1
Boink, G.J.2
Visser, L.E.3
-
37
-
-
44949151100
-
Healthcare impact of personalized medicine using genetic testing: An exploratory analysis for warfarin
-
McWilliam A, Lutter R, Nardinelli C. Healthcare impact of personalized medicine using genetic testing: an exploratory analysis for warfarin. Pers Med 2008;5:279-84
-
(2008)
Pers Med
, vol.5
, pp. 279-84
-
-
McWilliam, A.1
Lutter, R.2
Nardinelli, C.3
-
38
-
-
58749095297
-
Cost-effectiveness of using pharmacogenetic information in warfarin dosing for patients with non-valvular atrial fibrillation
-
Eckman MH, Rosand R, Greenberg SM, Gage BF. Cost-effectiveness of using pharmacogenetic information in warfarin dosing for patients with non-valvular atrial fibrillation. Ann Intern Med 2009;150:73-83
-
(2009)
Ann Intern Med
, vol.150
, pp. 73-83
-
-
Eckman, M.H.1
Rosand, R.2
Greenberg, S.M.3
Gage, B.F.4
-
39
-
-
70350221662
-
Potential clinical and economic outcomes of CYP2C9 and VKORC1 genotype-guided dosing in patients initiating warfarin therapy
-
You JHS, Tsui KKN, Wong RSM, Cheng G. Potential clinical and economic outcomes of CYP2C9 and VKORC1 genotype-guided dosing in patients initiating warfarin therapy. Clin Pharmacol Ther 2009;86:540-7
-
(2009)
Clin Pharmacol Ther
, vol.86
, pp. 540-7
-
-
Jhs, Y.1
Kkn, T.2
Rsm, W.3
Cheng, G.4
-
40
-
-
71649099370
-
Cost-effectiveness of genotype-guided warfarin dosing for patients with atrial fibrillation
-
published online 21 July 2009, doi:10.1161/circoutcomes.108.808592
-
Patrick AR, Avorn J, Choudhry NK. Cost-effectiveness of genotype-guided warfarin dosing for patients with atrial fibrillation. Circ Cardiovasc Qual Outcomes 2009: published online 21 July 2009, doi:10.1161/circoutcomes.108. 808592
-
(2009)
Circ Cardiovasc Qual Outcomes
-
-
Patrick, A.R.1
Avorn, J.2
Choudhry, N.K.3
-
41
-
-
73349093096
-
A policy model to evaluate the benefits, risks and costs of warfarin pharmacogenomic testing
-
Meckley LM, Gudgeon JM, Anderson JL, et al. A policy model to evaluate the benefits, risks and costs of warfarin pharmacogenomic testing. Pharmacoeconomics 2010;28:61-74
-
(2010)
Pharmacoeconomics
, vol.28
, pp. 61-74
-
-
Meckley, L.M.1
Gudgeon, J.M.2
Anderson, J.L.3
-
42
-
-
77952546324
-
Comparison of assay systems for warfarin-related CYP2C9 and VKORC1 genotyping
-
Maurice CB, Barua PK, Simses D, et al. Comparison of assay systems for warfarin-related CYP2C9 and VKORC1 genotyping. Clin Chim Acta 2010;411:947-54
-
(2010)
Clin Chim Acta
, vol.411
, pp. 947-54
-
-
Maurice, C.B.1
Barua, P.K.2
Simses, D.3
|