Altered amino acid homeostasis and the development of fatigue by breast cancer radiotherapy patients: A pilot study

Clinical Biochemistry

Volumn 44, Issue 2-3, 2011, Pages 208-215

  Hugh Dunstan, R ^a   Sparkes, Diane L ^a   Macdonald, Margaret M ^a   Roberts, Tim K ^a   Wratten, Christopher ^b   Kumar, Mahesh B ^b   Baines, Surinder ^c   Denham, J W ^b   Gallagher, Sarah A ^b   Rothkirch, Tony ^a  

^a UNIVERSITY OF NEWCASTLE   (Australia)

^b NEWCASTLE MATER HOSPITAL   (Australia)

^c UNIVERSITY OF NEWCASTLE   (Australia)

Author keywords

Amino acids; Breast cancer; Fatigue; Radiotherapy

Indexed keywords

ALANINE; AMINO ACID; ASPARAGINE; GLUTAMINE; HISTIDINE; METHIONINE; SERINE; THREONINE;

ADULT; AMINO ACID BLOOD LEVEL; AMINO ACID URINE LEVEL; ARTICLE; BLOOD CHEMISTRY; BREAST CANCER; CANCER ADJUVANT THERAPY; CANCER PATIENT; CANCER RADIOTHERAPY; CLINICAL ARTICLE; COHORT ANALYSIS; CONTROLLED STUDY; FATIGUE; FEMALE; FUNCTIONAL ASSESSMENT; HOMEOSTASIS; HUMAN; PILOT STUDY; PRIORITY JOURNAL; URINE LEVEL; BLOOD; BREAST TUMOR;

AMINO ACIDS; BREAST NEOPLASMS; FATIGUE; HOMEOSTASIS; HUMANS; PILOT PROJECTS;

EID: 79151485988     PISSN: 00099120     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.clinbiochem.2010.10.002     Document Type: Article

References (67)

1. National Comprehensive Cancer Network NCCN Clinical Practice Guidelines in Oncology™ V.1.2008: cancer-related fatigue http://www.nccn.org/professionals/physician_gls/PDF/fatigue.pdf.
2. Morrow G.R., Shelke A.R., Roscoe J.A., Hickok J.T., Mustian K. Management of cancer-related fatigue. Cancer Invest 2005, 23:229-239.
3. Bower J.E., Ganz P.A., Desmond K.A., Bernaards C., Rowland J.H., Meyerowitz B.E., et al. Fatigue in long-term breast carcinoma survivors: a longitudinal investigation. Cancer 2006, 106:751-758.
4. Ryan J.L., Carroll J.K., Ryan E.P., Mustian K.M., Fiscella K., Morrow G.R. Mechanisms of cancer-related fatigue. Oncologist 2007, 12:22-34.
5. Gutstein H.B. The biologic basis of fatigue. Cancer 2001, 92:1678-1683.
6. Bower J.E., Ganz P.A., Dickerson S.S., Petersen L., Aziz N., Fahey J.L. Diurnal cortisol rhythm and fatigue in breast cancer survivors. Psychoneuroendocrinology 2005, 30:92-100.
7. Morrow G.R., Hickok J.T., Roscoe J.A., Raubertas R.F., Andrews P.L., Flynn P.J., et al. Differential effects of paroxetine on fatigue and depression: a randomized, double-blind trial from the University of Rochester cancer center community clinical oncology program. J Clin Oncol 2003, 21:4635-4641.
8. Bower J.E., Ganz P.A., Aziz N., Fahey J.L. Fatigue and proinflammatory cytokine activity in breast cancer survivors. Psychosom Med 2002, 64:604-611.
9. Schubert C., Hong S., Natarajan L., Mills P.J., Dimsdale J.E. The association between fatigue and inflammatory marker levels in cancer patients: a quantitative review. Brain Behav Immun 2007, 21:413-427.
10. Collado-Hidalgo A., Bower J.E., Ganz P.A., Cole S.W., Irwin M.R. Inflammatory biomarkers for persistent fatigue in breast cancer survivors. Clin Cancer Res 2006, 12:2759-2766.
11. Vadhan-Raj S., Mirtsching B., Charu V., Terry D., Rossi G., Tomita D., et al. Assessment of hematologic effects and fatigue in cancer patients with chemotherapy-induced anemia given darbepoetin alfa every two weeks. J Support Oncol 2003, 1:131-138.
12. Nieboer P., Buijs C., Rodenhuis S., Seynaeve C., Beex L.V.A.M., van der Wall E., et al. Fatigue and relating factors in high-risk breast cancer patients treated with adjuvant standard or high-dose chemotherapy: a longitudinal study. J Clin Oncol 2005, 23:8296-8304.
13. Akechi T., Kugaya A., Okamura H., Yamawaki S., Uchitomi Y. Fatigue and its associated factors in ambulatory cancer patients: a preliminary study. J Pain Symptom Manage 1999, 17:42-48.
14. Geinitz H., Zimmermann F.B., Thamm R., Keller M., Busch R., Molls M. Fatigue in patients with adjuvant radiation therapy for breast cancer: long-term follow-up. J Cancer Res Clin Oncol 2004, 130:327-333.
15. Servaes P., Verhagen C., Bleijenberg G. Fatigue in cancer patients during and after treatment: prevalence, correlates and interventions. Eur J Cancer 2002, 38:27-43.
16. Carroll J.K., Kohli S., Mustian K.M., Roscoe J.A., Morrow G.R. Pharmacologic treatment of cancer-related fatigue. Oncologist 2007, 12(Suppl 1):43-51.
17. Ravasco P., Monteiro-Grillo I., Vidal P.M., Camilo M.E. Dietary counseling improves patient outcomes: a prospective, randomized, controlled trial in colorectal cancer patients undergoing radiotherapy. J Clin Oncol 2005, 23:1431-1438.
18. de Souza Fede A.B., Bensi C.G., Trufelli D.C., de Oliveira Campus M.P., Peceroni P.G., Ranzatti R.P., et al. Multivitamins do not improve radiation therapy-related fatigue: results of a double-blind randomized crossover trial. Am J Clin Oncol 2007, 30:432-436.
19. Jacobsen P.B., Donovan K.A., Vadaparampil S.T., Small B.J. Systematic review and meta-analysis of psychological and activity-based interventions for cancer-related fatigue. Health Psychol 2007, 26:660-667.
20. Fernando D., Rumberger B.G., Keul J. Aerobic exercise as therapy for cancer fatigue. Med Sci Sports Exerc 1998, 30:475-478.
21. Mock V., Frangakis C., Davidson N.E., Ropka M.E., Pickett M., Stewart K.J., et al. Exercise manages fatigue during breast cancer treatment: a randomized controlled trial. Psychooncology 2005, 14:464-477.
22. Porock D., Kristjanson L.J., Tinnelly K., Duke T., Blight J. An exercise intervention for advanced cancer patients experiencing fatigue: a pilot study. J Palliat Care 2000, 16:30-36.
23. Niblett S.N., King K.E., Dunstan R.H., Clifton-Bligh P., Hoskin L.A., Roberts T.K., et al. Hematologic and urinary excretion anomalies in patients with chronic fatigue syndrome. Exp Biol Med 2007, 232:1041-1049.
24. Cangiano C., Laviano A., Meguid M.M., Mulieri M., Conversano L., Preziosa I., et al. Effects of administration of oral branched-chain amino acids on anorexia and caloric intake in cancer patients. J Natl Cancer Inst 1996, 88:550-552.
25. Poon R.T.P., Yu W.C., Fan S.T., Wong J. Long-term oral branched chain amino acids in patients undergoing chemoembolization for hepatocellular carcinoma: a randomized trial. Aliment Pharmacol Ther 2004, 19:779-788.
26. Gramignano G., Lusso M.R., Madeddu C., Massa E., Serpe R., Deiana L., et al. Efficacy of l-carnitine administration on fatigue, nutritional status, oxidative stress, and related quality of life in 12 advanced cancer patients undergoing anticancer therapy. Nutrition 2006, 22:136-145.
27. Graziano F., Bisonni R., Catalano V., Silva R., Rovidati S., Mencarini E., et al. Potential role of levocarnitine supplementation for the treatment of chemotherapy-induced fatigue in non-anaemic cancer patients. Br J Cancer 2002, 86:1854-1857.
28. Burzynski S.R., Axler M.L., Lewy R.I., Janicki T., Ilkowska-Musial E., Baranowska A. Amino acid supplementation in treatment of cancer-related symptoms. J Appl Nutr 2003, 53:52-60.
29. Cruciani R.A., Dvorkin E., Homel P., Malamud S., Culliney B., Lapin J., et al. Safety, tolerability and symptom outcomes associated with l-carnitine supplementation in patients with cancer, fatigue, and carnitine deficiency: a phase I/II study. J Pain Symptom Manage 2006, 32:551-559.
30. van der Boon J. Former cancer patients show increase in life expectancy. Lancet Oncol 2001, 2:396.
31. Wratten C., Kilmurray J., Nash S., Seldon M., Hamilton C.S., O'Brien P.C., et al. Fatigue during breast radiotherapy and its relationship to biological factors. Int J Radiat Oncol Biol Phys 2004, 59:160-167.
32. Zigmond A.S., Snaith R.P. The hospital anxiety and depression scale. Acta Psychiatr Scand 1983, 67:361-370.
33. Ainsworth B.E., Sternfeld B., Richardson M.T., Jackson K. Evaluation of Kaiser Physical Activity Survey in women. Med Sci Sports Exerc 2000, 32:1327-1338.
34. Yellen S.B., Cella D.F., Webster K., Blendowski C., Kaplan E. Measuring fatigue and other anemia-related symptoms with the Functional Assessment of Cancer Therapy (FACT) measurement system. J Pain Symptom Manage 1997, 13:63-74.
35. Cella D.F., Tulsky D.S., Gray G., Sarafian B., Linn E., Bonomi A., et al. The Functional Assessment of Cancer Therapy scale: development and validation of the general measure. J Clin Oncol 1993, 11:570-579.
36. Cleeland C., Wang S. Measuring and understanding fatigue. Oncology 1999, 13:91-97.
37. Wengstrom Y., Haggmark C., Strander H., Forsberg C. Perceived symptoms and quality of life in women with breast cancer receiving radiation therapy. Eur J Oncol Nurs 2000, 4:78-88.
38. Irvine D.M., Vincent L., Graydon J.E., Bubela N. Fatigue in women with breast cancer receiving radiation therapy. Cancer Nurs 1998, 21:127-135.
39. Haghighat S., Akbari M.E., Holakouei K., Rahimi A., Montazeri A. Factors predicting fatigue in breast cancer patients. Support Care Cancer 2003, 11:533-538.
40. Okuyama T., Akechi T., Kugaya A., Okamura H., Imoto S., Nakano T., et al. Factors correlated with fatigue in disease-free breast cancer patients: application of the Cancer Fatigue Scale. Support Care Cancer 2000, 8:215-222.
41. Bruera E., Brenneis C., Michaud M., Rafter J., Magnan A., Tennant A., et al. Association between asthenia and nutritional status, lean body mass, anemia, psychological status, and tumor mass in patients with advanced breast cancer. J Pain Symptom Manage 1989, 4:59-63.
42. Morant R. Asthenia: an important symptom in cancer patients. Cancer Treat Rev 1996, 22:117-122.
43. Wade A.M., Tucker H.N. Antioxidant characteristics of l-histidine. J Nutr Biochem 1998, 9:308-315.
44. Adachi N. Cerebral ischemia and brain histamine. Brain Res Brain Res Rev 2005, 50:275-286.
45. Nair C.K.K., Parida D.K., Nomura T. Radioprotectors in radiotherapy. J Radiat Res 2001, 42:21-37.
46. Frost R.A., Lang C.H. Skeletal muscle cytokines: regulation by pathogen-associated molecules and catabolic hormones. Curr Opin Clin Nutr Metab Care 2005, 8:255-263.
47. Jeevanandam M., Young D.H., Ramias L., Schiller W.R. Aminoaciduria of severe trauma. Am J Clin Nutr 1989, 49:814-822.
48. Jones M.G., Cooper E., Amjad S., Goodwin C.S., Barron J.L., Chalmers R.A. Urinary and plasma organic and amino acids in chronic fatigue syndrome. Clin Chim Acta 2005, 361:150-158.
49. Yoshizawa F. Regulation of protein synthesis by branched-chain amino acids in vivo. Biochem Biophys Res Commun 2004, 313:417-422.
50. Highman B., Hanks A.R. Serum intestinal alkaline phosphatase in rats after 800R whole-body or regional X-irradiation. Proc Soc Exp Biol Med 1970, 133:1201-1206.
51. Stepan J., Havranek T., Jojkova K. Serum alkaline phosphatases as indicators of radiation damage in rats. Radiat Res 1977, 70:406-414.
52. Lum G. Significance of low serum alkaline phosphatase activity in a predominantly adult male population. Clin Chem 1995, 41:515-518.
53. Naber T.H.J., Baadenhuysen H., Jansen J.B.M.J., van den Hamer C.J.A., van den Broek W. Serum alkaline phosphatase activity during zinc deficiency and long-term inflammatory stress. Clin Chim Acta 1996, 249:109-127.
54. Nanji A.A. Decreased serum alkaline phosphatase activity in hypothyroidism: possible relationship to low zinc and magnesium. Clin Chem 1982, 28:1711-1712.
55. van Dommelen C.K.V., Klaassen C.H.L. Cyanocobalamin-dependent depression of the serum alkaline phosphatase level in patients with pernicious anemia. N Engl J Med 1964, 271:541-544.
56. Carmel R., Lau K.H.W., Baylink D.J., Saxena S., Singer F.R. Cobalamin and osteoblast-specific proteins. N Engl J Med 1988, 319:70-75.
57. Schwartz R. Alkaline phosphatase activity of the serum in kwashiorkor. J Clin Pathol 1956, 9:333-340.
58. Scholmerich J., Freudemann A., Kottgen E., Wietholtz H., Steiert B., Lohle E., et al. Bioavailability of zinc from zinc-histidine complexes. I. Comparison with zinc sulphate in healthy men. Am J Clin Nutr 1987, 45:1480-1486.
59. Millan J.L. Oncodevelopmental alkaline phosphatases: in search for a function. Proceedings of the sixth international congress on isozymes 1990, 453-475. Wiley-Liss. Z.-I. Ogita, C.L. Markert (Eds.).
60. Alexander S., Minton O., Andrews P.L., Stone P. A comparison of the characteristics of disease-free breast cancer survivors with or without cancer-related fatigue syndrome. Eur J Cancer 2009, 45:384-392.
61. Beers M.H., Berkow R. The Merck manual 1999, Merck Research Laboratories, New Jersey. Seventeenth ed.
62. Hutson S.M., Sweatt A.J., LaNoue K.F. Branched-chain amino acid metabolism: implications for establishing safe intakes. J Nutr 2005, 135:1557S-1564S.
63. Choudry H.A., Pan M., Karinch A.M., Souba W.W. Branched-chain amino acid-enriched nutritional support in surgical and cancer patients. J Nutr 2006, 136:314S-318S.
64. Freund H., Hoover H.C., Atamian S., Fischer J.E. Infusion of the branched chain amino acids in postoperative patients: anticatabolic properties. Ann Surg 1979, 190:18-23.
65. Muto Y., Sato S., Watanabe A., Moriwaki H., Suzuki K., Kato A., et al. Effects of oral branched-chain amino acid granules on event-free survival in patients with liver cirrhosis. (Abstract). Clin Gastroenterol Hepatol 2005, 3:705-713.
66. Tayek J.A., Bistrian B.R., Hehir D.J., Martin R., Moldawer L.L., Blackburn G.L. Improved protein kinetics and albumin synthesis by branched chain amino acid-enriched total parenteral nutrition in cancer cachexia. Cancer 1986, 58:147-157.
67. Wang X.-Y., Li N., Gu J., Li W.-Q., Li J.-S. The effects of the formula of amino acids enriched BCAA on nutritional support in traumatic patients. World J Gastroenterol 2003, 9:599-602.