Nephrotic syndrome after allogeneic hematopoietic stem cell transplantation: Etiology and pathogenesis

Blood Cells, Molecules, and Diseases

Volumn 46, Issue 2, 2011, Pages 182-187

  Luo, Xiao dan ^a   Liu, Qi fa ^a   Zhang, Yu ^a   Sun, Jing ^a   Wang, Guo bao ^a   Fan, Zhi ping ^a   Yi, Zheng shan ^a   Ling, Yi wen ^a   Wei, Yong qiang ^a   Liu, Xiao li ^a   Xu, Bing ^a  

^a SOUTHERN MEDICAL UNIVERSITY   (China)

Author keywords

Allogeneic hematopoietic stem cell transplantation; Cytokine; Nephrotic syndrome; Tregs

Indexed keywords

ALBUMIN; BASILIXIMAB; BUSULFAN; CD19 ANTIGEN; CD3 ANTIGEN; CD4 ANTIGEN; CD8 ANTIGEN; CORTICOSTEROID; CORTISONE; CYCLOPHOSPHAMIDE; CYCLOSPORIN A; CYTARABINE; GAMMA INTERFERON; HLA ANTIGEN; INTERLEUKIN 2 RECEPTOR ALPHA; METHOTREXATE; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; TACROLIMUS; THYMOCYTE ANTIBODY; TUMOR NECROSIS FACTOR ALPHA;

ACUTE LYMPHOCYTIC LEUKEMIA; ACUTE NONLYMPHOCYTIC LEUKEMIA; ADOLESCENT; ADULT; ALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANTATION; ARTICLE; CHILD; CHRONIC MYELOID LEUKEMIA; CONTROLLED STUDY; FEMALE; GRAFT REJECTION; GRAFT SURVIVAL; GRAFT VERSUS HOST REACTION; HISTOPATHOLOGY; HLA MATCHING; HUMAN; IMMUNE COMPLEX DEPOSITION; IMMUNOFLUORESCENCE TEST; KIDNEY BIOPSY; LYMPHOCYTE COUNT; MAJOR CLINICAL STUDY; MALE; NEPHROTIC SYNDROME; PATHOGENESIS; PRIORITY JOURNAL; REGULATORY T LYMPHOCYTE; SCHOOL CHILD; TH1 CELL; WHOLE BODY RADIATION;

ADULT; ANTIGENS, CD; BIOPSY; FEMALE; GRAFT VS HOST DISEASE; HEMATOLOGIC NEOPLASMS; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HUMANS; IMMUNOHISTOCHEMISTRY; INTERFERON-GAMMA; MALE; NEPHROTIC SYNDROME; T-LYMPHOCYTES, REGULATORY; TRANSPLANTATION, HOMOLOGOUS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 79151477221     PISSN: 10799796     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bcmd.2010.12.003     Document Type: Article

References (27)

1. Chan G.S.W., Lam M.F., Au W.Y., et al. Clinicopathologic analysis of renal biopsies after haematopoietic stem cell transplantation. Nephrology 2008, 13:322-330.
2. Nakashima Hitoshi Membranous nephropathy is developed under Th2 environment in chronic graft-versus-host disease. Med. Hypotheses 2007, 69:787-791.
3. Hingorani S. Chronic kidney disease in long-term survivors of hematopoietic cell transplantation: epidemiology, pathogenesis, and treatment. J. Am. Soc. Nephrol. 2006, 17:1995-2005.
4. Brukamp K., Doyle A.M., Bloom R.D., Bunin N., Tomaszewski J.E., Cizman B. Nephrotic syndrome after hematopoietic cell transplantation: do glomerrular lesions represent renal graft-versus-host disease. Clin. J. Am. Soc. Nephrol. 2006, 1:685-694.
5. Romagnani P., Lazzeri E., Mazzinghi B., et al. Nephrotic syndrome and renal failure after allogeneic stem cell transplantation: novel molecular diagnostic tools for a challenging differential diagnosis. Am. J. Kidney Dis. 2005, 46(3):550-556.
6. Kausman J.Y., Richard Kitching A. A new approach to idiopathic nephrotic syndrome. J. Am. Soc. Nephrol. 2007, 18:2621-2622.
7. Deconinck E., Kribs M., Rebibou J.M., Bulabois C.E., Ducloux D., Cahn J.Y. Cytomegalovirus infection and chronic graft-versus-host disease are significant predictors of renal failure after allogeneic hematopoietic stem cell transplantation. Haematologica 2005, 90(4):569-570.
8. Miralbell R., Sancho G., Bieri S., et al. Renal insufficiency in patients with hematologic malignancies undergoing total body irradiation and bone marrow transplantation:a prospective assessment. Int. J. Radiat. Oncol. Biol. Phys. 2004, 58:809-816.
9. Sakoda K., Shibuya A., Suzuki H., et al. ephrotic syndrome in patients after successful myeloablative allogeneic hematopoietic stem cell transplantation: clinical findings obtained from four transplanted patients. Nippon Jinzo Gakkai Shi 2007, 49(8):999-1006.
10. Chang A., Hingorani S., Kowalewska J., et al. Spectrum of renal pathology in hematopoietic cell transplantation: a series of 20 patients and review of the literature. Clin. J. Am. Soc. Nephrol. 2007, 2:1014-1023.
11. Rao P.S. Nephrotic syndrome in patients with peripheral blood stem cell transplant. Am. J. Kidney Dis. 2005, 45(4):780-785.
12. Akar H., Keven K., Celebi H., et al. Nephrotic syndrome after allogeneic peripheral blood stem cell transplantation. J. Nephrol. 2002, 15(1):79-82.
13. Shahed Ahmed M., Wong C.F. Rituximab and nephrotic syndrome: a new therapeutic hope?. Nephrol. Dial. Transplant. 2008, 23:11-17.
14. Apperley J., Carreras E., Gluckman E. The EBMT Handbook 2004 Revised Edition: Haemopoietic Stem Cell Transplantation [M] 2004, 163-176. Forum Service Editore, Genoa.
15. Ludmilla Le Berre, Bruneau S., Naulet J., Renaudin K., Buzelin F., Usal C., Smit H., Condamine T., Soulillou J.P., Dantal J. Induction of T regulatory cells attenuates idiopathic nephrotic syndrome. J. Am. Soc. Nephrol. 2009, 20:57-67.
16. Terrier B., Delmas Y., Hummel A., et al. Post-allogeneic haematopoietic stem cell transplantation membranous nephropathy: clinical presentation, outcome and pathogenic aspects. Nephrol. Dial. Transplant. 2007, 22:1369-1376.
17. Srinivasan R., Balow J.E., Sabnis S., et al. Nephrotic syndrome:an under-recognised immune-mediates complication of non-myeloablative allogeneic haematopoietic cell transplantation. Br. J. Haematol. 2005, 131(1):74-79.
18. Fujinaga S., Kaneko K., Muto T., Ohtomo Y., Murakami H., Yamashiro Y. Independent risk factors for chronic cyclosporine induced nephropathy in children with nephrotic syndrome. Arch. Dis. Child. 2006, 91:666-670.
19. Ghee J.Y., Han D.H., Song H.K., Kim W.Y., Kim S.H., Yoon H.E., Choi B.S., Kim Y.S., Kim J., Yang C.W. The role of macrophage in the pathogenesis of chronic cyclosporine-induced nephropathy. Nephrol. Dial. Transplant. 2008, 23:4061-4069.
20. Seconi J., Watt V., Ritchie D.S. Nephrotic syndrome following allogeneic stem cell transplantation associated with increased production of TNF-alpha and interferon-gamma by donor T cells. Bone Marrow Transplant. 2003, 32(4):447-450.
21. Raveh D., Shemesh O., Asgjebazu Y.J., Winkler R., Barak V. Tumor necrosis factor-alpha blocking agent as a treatment for nephrotic syndrome [J]. Pediatr. Nephrol. 2004, 19(11):1281-1284.
22. Berre L., Herve C., Buzelin F., Usal C., Soulillou J.P., Dantal J. Renal macrophage activation and Th2 polarization precedes the development of nephrotic syndrome in Buffalo/Mna rats. Kidney Int. 2005, 68(5):2079-2090.
23. + regulatory T cells in nonlymphopenic hosts. J. Leukoc. Biol. 2007, 82:1053-1061.
24. Kapur R., Ebeling S., Hagenbeek A. B-cell involvement in chronic graft-versus-host disease. Haematologica 2008, 93:1702-1711.
25. Marinic I., Gagro A., Rabatic S. Regulatory T cells. Acta Med. Croat. 2006, 60(5):447-456.
26. Soiffer R. Immune modulation and chronic graft-versus-host disease. Bone Marrow Transplant. 2008, 42:119-122.
27. Rieger K., Loddenkemper C., Maul J., et al. Mucosal FOXP3+ regulatory T cells are numerically deficient in acute and chronic GvHD. Blood 2006, 107:1717-1723.