Development of a successful antitumor therapeutic model combining in vivo dendritic cell vaccination with tumor irradiation and intratumoral GM-CSF delivery

Cancer Immunology, Immunotherapy

Volumn 60, Issue 2, 2011, Pages 273-281

  Driessens, Gregory ^a   Nuttin, Lise ^a   Gras, Alain ^a   Maetens, Julie ^a   Mievis, Stephane ^a   Schoore, Marylène ^a   Velu, Thierry ^b   Tenenbaum, Liliane ^a   Préat, Véronique ^c   Bruyns, Catherine ^a  

^a UNIVERSITÉ LIBRE DE BRUXELLES   (Belgium)

^b Centre Hospitalier interregional Edith Cavell   (Belgium)

^c UNIVERSITÉ CATHOLIQUE DE LOUVAIN   (Belgium)

Author keywords

Adeno associated virus; Cancer vaccines; Dendritic cells; GM CSF; Irradiation

Indexed keywords

DENDRITIC CELL VACCINE; PARVOVIRUS VECTOR; POLOXAMER; RECOMBINANT GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER RADIOTHERAPY; CELL TRANSFER; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; DRUG RESPONSE; HYDROGEL; IN VITRO STUDY; IN VIVO STUDY; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; TUMOR; TUMOR CELL;

ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; CANCER VACCINES; CELL LINE, TUMOR; COMBINED MODALITY THERAPY; DENDRITIC CELLS; GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR; INJECTIONS, INTRALESIONAL; MALE; NEOPLASMS, EXPERIMENTAL; RATS; RATS, INBRED F344; RECOMBINANT PROTEINS; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 79151477008     PISSN: 03407004     EISSN: 14320851     Source Type: Journal    
DOI: 10.1007/s00262-010-0941-y     Document Type: Article

References (44)

1. MH Andersen RB Sorensen D Schrama IM Svane JC Becker PT Straten 2008 Cancer treatment: the combination of vaccination with other therapies Cancer Immunol Immunother 57 1735 1743 1:CAS:528:DC%2BD1cXhtVejsbfM 10.1007/s00262-008-0480-y 18286284
2. G Driessens M Hamdane V Cool T Velu C Bruyns 2004 Highly successful therapeutic vaccinations combining dendritic cells and tumor cells secreting granulocyte macrophage colony-stimulating factor Cancer Res 64 8435 8442 1:CAS:528:DC%2BD2cXpvVGks7w%3D 10.1158/0008-5472.CAN-04-0774 15548715
3. G Driessens P Hoffmann M Pouwels A Zlotta C Schulman T Velu C Bruyns 2009 Synergy between dendritic cells and GM-CSF-secreting tumor cells for the treatment of a murine renal cell carcinoma J Immunother 32 140 144 1:CAS:528:DC%2BD1MXit1Cju70%3D 10.1097/CJI.0b013e3181920275 19238012
4. G Driessens L Gordower L Nuttin P Stordeur D Blocklet D Egrise T Velu C Bruyns 2008 Therapeutic efficacy of antitumor dendritic cell vaccinations correlates with persistent Th1 responses, high intratumor CD8+ T cell recruitment and low relative regulatory T cell infiltration Cancer Immunol Immunother 57 1745 1756 1:CAS:528:DC%2BD1cXhtFCgu7vF 10.1007/s00262-008-0500-y 18369621
5. RM Steinman J Banchereau 2007 Taking dendritic cells into medicine Nature 449 419 426 1:CAS:528:DC%2BD2sXhtV2is7%2FI 10.1038/nature06175 17898760
6. J Banchereau AK Palucka 2005 Dendritic cells as therapeutic vaccines against cancer Nat Rev Immunol 5 296 306 1:CAS:528:DC%2BD2MXivVaku7c%3D 10.1038/nri1592 15803149
7. ML Albert B Sauter N Bhardwaj 1998 Dendritic cells acquire antigen from apoptotic cells and induce class I restricted CTLs Nature 392 86 89 1:CAS:528:DyaK1cXhvVOntrw%3D 10.1038/32183 9510252
8. TK Hoffmann N Meidenbauer G Dworacki H Kanaya TL Whiteside 2000 Generation of tumor specific T lymphocytes by cross-priming with human dendritic cells ingesting apoptotic tumor cells Cancer Res 60 3542 3549 1:CAS:528:DC%2BD3cXkvFChsLY%3D 10910067
9. B Sauter ML Albert L Francisco M Larsson S Somersan N Bhardwaj 2000 Consequences of cell death: Exposure to necrotic tumor cells, but not primary tissue cells or apoptotic cells, induces the maturation of immunostimulatory dendritic cells J Exp Med 191 423 433 1:CAS:528:DC%2BD3cXhtV2isbg%3D 10.1084/jem.191.3.423 10662788
10. RM Steinman S Turley I Mellman K Inaba 2000 The induction of tolerance by dendritic cells that have captured apoptotic cells J Exp Med 191 411 416 1:CAS:528:DC%2BD3cXhtV2isbw%3D 10.1084/jem.191.3.411 10662786
11. L Milas NR Hunter KA Mason B Kurdoglu LJ Peters 1994 Enhancement of tumor radioresponse of a murine mammary-carcinoma by paclitaxel Cancer Res 54 3506 3510 1:CAS:528:DyaK2cXkslOntLo%3D 7912167
12. WC Dewey CC Ling RE Meyn 1995 Radiation-induced apoptosis-relevance to radiotherapy Int J Radiat Oncol Biol Phys 33 781 796 1:CAS:528: DyaK28XhslOlsw%3D%3D 10.1016/0360-3016(95)00214-8 7591884
13. EY Nikitina DI Gabrilovich 2001 Combination of gamma-irradiation and dendritic cell administration induces a potent antitumor response in tumor-bearing mice: Approach to treatment of advanced stage cancer Int J Cancer 94 825 833 1:CAS:528:DC%2BD3MXotFOkurc%3D 10.1002/1097-0215(20011215)94: 6<825::AID-IJC1545>3.0.CO;2-5 11745485
14. S Teitz-Tennenbaum Q Li S Rynkiewicz F Ito M Davis C McGinn AE Chang 2003 Radiotherapy potentiates the antitumor efficacy of intratumoral dendritic cell administration Cancer Res 63 8466 8475 1:CAS:528:DC%2BD3sXpvVagurw%3D 14679011
15. G Dranoff 2002 GM-CSF-based cancer vaccines Immunol Rev 188 147 154 1:CAS:528:DC%2BD38Xps1Oqs74%3D 10.1034/j.1600-065X.2002.18813.x 12445288
16. J Nemunaitis D Sterman D Jablons, et al. 2004 Granulocyte-macrophage colony-stimulating factor gene-modified autologous tumor vaccines in non-small-cell lung cancer J Natl Cancer Inst 96 326 331 1:CAS:528: DC%2BD2cXhsV2qtbw%3D 10.1093/jnci/djh028 14970281
17. AYC Huang P Golumbek M Ahmadzadeh E Jaffee D Pardoll H Levitsky 1994 Role of bone-marrow-derived cells in presenting Mhc class I-restricted tumor-antigens Science 264 961 965 1:CAS:528:DyaK2cXjt1SqtbY%3D 10.1126/science.7513904 7513904
18. RJCL Vuylsteke BG Molenkamp HA Gietema, et al. 2004 Local administration of granulocyte/macrophage colony-stimulating factor increases the number and activation state of dendritic cells in the sentinel lymph node of early-stage melanoma Cancer Res 64 8456 8460 1:CAS:528:DC%2BD2cXpvVGks7s%3D 10.1158/0008-5472.CAN-03-3251 15548718
19. MA Perales JDF Yuan S Powel, et al. 2008 Phase I/II study of GM-CSF DNA as an adjuvant for a multipeptide cancer vaccine in patients with advanced melanoma Mol Ther 16 2022 2029 1:CAS:528:DC%2BD1cXhsVSjsbnK 10.1038/mt.2008.196 18797450
20. NK Egilmez YS Jong MS Sabel JS Jacob E Mathiowitz RB Bankert 2000 In situ tumor vaccination with interleukin-12-encapsulated biodegradable microspheres: Induction of tumor regression and potent antitumor immunity Cancer Res 60 3832 3837 1:CAS:528:DC%2BD3cXlt1Gkt7Y%3D 10919657
21. PY Pan Y Li QS Li PD Gu O Martinet S Thung SH Chen 2004 In situ recruitment of antigen-presenting cells by intratumoral GM-CSF gene delivery Cancer Immunol Immunother 53 17 25 1:CAS:528:DC%2BD3sXpsVGit70%3D 10.1007/s00262-003-0417-4 12955480
22. S Daya KI Berns 2008 Gene therapy using adeno-associated virus vectors Clin Microbiol Rev 21 583 593 1:CAS:528:DC%2BD1cXhtlClurfN 10.1128/CMR.00008-08 18854481
23. A Srivastava 2008 Adeno-associated virus-mediated gene transfer J Cell Biochem 105 17 24 1:CAS:528:DC%2BD1cXhtFGns77M 10.1002/jcb.21819 18500727
24. Y Wang SL Liu CY Li F Yuan 2005 A novel method for viral gene delivery in solid tumors Cancer Res 65 7541 7545 1:CAS:528:DC%2BD2MXpslait7Y%3D 16140915
25. JJ Escobar-Chávez M López-Cervantes A Naïk, et al. 2006 Applications of thermo-reversible pluronic F-127 gels in pharmaceutical formulations J Pharm Pharm Sci 9 339 358 17207417
26. EHJG Aarntzen CG Figdor GJ Adema CJA Punt IJM de Vries 2008 Dendritic cell vaccination and immune monitoring Cancer Immunol Immunother 57 1559 1568 1:CAS:528:DC%2BD1cXovFyitrw%3D 10.1007/s00262-008-0553-y 18618110
27. MHMG den Brok RPM Sutmuller R van der Voort EJ Bennink CG Figdor TJM Ruers GJ Adema 2004 In situ tumor ablation creates an antigen source for the generation of antitumor immunity Cancer Res 64 4024 4029 10.1158/0008-5472.CAN- 03-3949
28. T Takeshima K Chamoto D Wakita T Ohkuri Y Togashi H Shirato H Kitamura T Nishimura 2010 Local radiation therapy inhibits tumor growth through the generation of tumor-specific CTL: its potentiation by combination with Th1 cell therapy Cancer Res 70 2697 2706 1:CAS:528:DC%2BC3cXktFynsbk%3D 10.1158/0008-5472.CAN-09-2982 20215523
29. KM Prise JM O'Sullivan 2009 Radiation-induced bystander signalling in cancer therapy Nat Rev Cancer 9 351 360 1:CAS:528:DC%2BD1MXks12ksbo%3D 10.1038/nrc2603 19377507
30. DS Lim JH Kim DS Lee CH Yoon YS Bae 2007 DC immunotherapy is highly effective for the inhibition of tumor metastasis or recurrence, although it is not efficient for the eradication of established solid tumors Cancer Immunol Immunother 56 1817 1829 10.1007/s00262-007-0325-0 17443323
31. P Kleindienst T Brocker 2003 Endogenous dendritic cells are required for amplification of T cell responses induced by dendritic cell vaccines in vivo J Immunol 170 2817 2823 1:CAS:528:DC%2BD3sXhslOkurY%3D 12626531
32. GG Hillman P Slos Y Wang, et al. 2004 Tumor irradiation followed by intratumoral cytokine gene therapy for murine renal adenocarcinoma Cancer Gene Ther 11 61 72 1:CAS:528:DC%2BD3sXpvVGgs7o%3D 10.1038/sj.cgt.7700656 14681727
33. DJ Xia T Moyana J Xiang 2006 Combinational adenovirus-mediated gene therapy and dendritic cell vaccine in combating well-established tumors Cell Res 16 241 259 1:CAS:528:DC%2BD28XitlKnt78%3D 10.1038/sj.cr.7310032 16541123
34. UT Hacker LA Wingenfeld DM Kofler, et al. 2005 Adeno-associated virus serotypes 1 to 5 mediated tumor cell directed gene transfer and improvement of transduction efficiency J Gene Med 7 1429 1438 1:CAS:528:DC%2BD2MXhtlWrtL7I 10.1002/jgm.782 15945124
35. PC Huszthy A Svendsen JM Wilson RM Kotin PE Lonning R Bjerkvig F Hoover 2005 Widespread dispersion of adeno-associated virus serotype 1 and adeno-associated virus serotype 6 vectors in the rat central nervous system and in human glioblastoma multiforme xenografts Hum Gene Ther 16 381 392 1:CAS:528:DC%2BD2MXivFWltrc%3D 10.1089/hum.2005.16.381 15812233
36. FS Shi S Weber J Gan AL Rakhmilevich DM Mahvi 1999 Granulocyte-macrophage colony-stimulating factor (GM-CSF) secreted by cDNA-transfected tumor cells induces a more potent antitumor response than exogenous GM-CSF Cancer Gen Ther 6 81 88 1:CAS:528:DyaK1MXhsFynsb8%3D 10.1038/sj.cgt.7700012
37. S Kurane MT Arca A Aruga RA Krinock JC Krauss AE Chang 1997 Cytokines as an adjuvant to tumor vaccines: efficacy of local methods of delivery Ann of Surg Oncol 4 579 585 1:STN:280:DyaK1c%2Fjtlyqtg%3D%3D 10.1007/BF02305540
38. MA Wallenfriedman JA Conrad L DelaBarre, et al. 1999 Effects of continuous localized infusion of granulocyte-macrophage colony-stimulating factor and inoculations of irradiated glioma cells on tumor regression J Neurosurg 90 1064 1071 1:CAS:528:DyaK1MXjvVeisLY%3D 10.3171/jns.1999.90.6.1064 10350253
39. E Daro N Pulendran K Brasel, et al. 2000 Polyethylene glycol-modified GM-CSF expands CD11b(high)CD11c(high) but not CD11b(low)CD11c(high) murine dendritic cells in vivo: a comparative analysis with Flt3 ligand J Immunol 165 49 58 1:CAS:528:DC%2BD3cXksVKlsrg%3D 10861034
40. PM Strappe DW Hampton B Cachon-Gonzalez, et al. 2005 Delivery of a lentiviral vector in a Pluronic F127 gel to cells of the central nervous system Eur J Pharm Biopharm 61 126 133 1:CAS:528:DC%2BD2MXhtFWhtrjN 10.1016/j.ejpb.2005.06.006 16154331
41. YZ Tong WR Song RG Crystal 2001 Combined intratumoral injection of bone marrow-derived dendritic cells and systemic chemotherapy to treat pre-existing murine tumors Cancer Res 61 7530 7535 1:CAS:528:DC%2BD3MXnvFShsb0%3D 11606390
42. JJ Mule 2009 Dendritic cell-based vaccines for pancreatic cancer and melanoma Ann N Y Acad Sci 1174 33 40 1:CAS:528:DC%2BD1MXhtlehs7rF 10.1111/j.1749-6632.2009.04936.x 19769734
43. K Palucka H Ueno J Fay J Banchereau 2009 Harnessing dendritic cells to generate cancer vaccines Ann N Y Acad Sci 1174 88 98 1:CAS:528: DC%2BD1MXhtlehs7vK 10.1111/j.1749-6632.2009.05000.x 19769741
44. R Gupta LA Emens 2010 GM-CSF-secreting vaccines for solid tumors: moving forward Discov Med 10 52 60 20670599