Therapeutic efficacy of antitumor dendritic cell vaccinations correlates with persistent Th1 responses, high intratumor CD8+ T cell recruitment and low relative regulatory T cell infiltration

Cancer Immunology, Immunotherapy

Volumn 57, Issue 12, 2008, Pages 1745-1756

  Driessens, Gregory ^a   Gordower, Laurence ^b   Nuttin, Lise ^a   Stordeur, Patrick ^b   Blocklet, Didier ^b   Egrise, Dominique ^b   Velu, Thierry ^a,b   Bruyns, Catherine ^a  

^a UNIVERSITÉ LIBRE DE BRUXELLES   (Belgium)

^b ERASME HOSPITAL   (Belgium)

Author keywords

T cells; Tumor immunity; Vaccination

Indexed keywords

DENDRITIC CELL VACCINE; GAMMA INTERFERON; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; TRANSCRIPTION FACTOR FOXP3;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER IMMUNIZATION; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELLULAR IMMUNITY; CONTROLLED STUDY; CYTOKINE RELEASE; DRUG CYTOTOXICITY; DRUG EFFICACY; GLIOSARCOMA; LYMPHOCYTIC INFILTRATION; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REGULATORY T LYMPHOCYTE; SPLEEN CELL; T LYMPHOCYTE ACTIVATION; TH1 CELL; THERAPY EFFECT; TUMOR CELL; TUMOR GROWTH; TUMOR REGRESSION;

ANIMALS; BRAIN NEOPLASMS; CANCER VACCINES; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; CYTOTOXICITY, IMMUNOLOGIC; DENDRITIC CELLS; GLIOSARCOMA; GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR; LYMPHOCYTES, TUMOR-INFILTRATING; MALE; RATS; RATS, INBRED F344; T-LYMPHOCYTES, REGULATORY; TH1 CELLS;

EID: 52549090017     PISSN: 03407004     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00262-008-0500-y     Document Type: Article

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