Prolonged Thrombocytopenia Following Allogeneic Hematopoietic Stem Cell Transplantation and Its Association with a Reduction in Ploidy and an Immaturation of Megakaryocytes

Biology of Blood and Marrow Transplantation

Volumn 17, Issue 2, 2011, Pages 274-280

  Zhang, Xiaohui ^a   Fu, Haixia ^a   Xu, Lanping ^a   Liu, Daihong ^a   Wang, Jianzhong ^b   Liu, Kaiyan ^a   Huang, Xiaojun ^a  

^a PEKING UNIVERSITY PEOPLE S HOSPITAL   (China)

^b PEKING UNIVERSITY FIRST HOSPITAL   (China)

Author keywords

Allogeneic hematopoietic stem cell transplantation; Megakaryocyte; Ploidy; Thrombocytopenia

Indexed keywords

BUSULFAN; CYCLOPHOSPHAMIDE; CYCLOSPORIN A; CYTARABINE; HYDROXYUREA; METHOTREXATE; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; SEMUSTINE; THROMBOPOIETIN RECEPTOR; THYMOCYTE ANTIBODY;

ADOLESCENT; ADULT; AGED; ALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANTATION; ARTICLE; CELL MATURATION; CHILD; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE ASSOCIATION; DRUG DOSE REDUCTION; FEMALE; FLOW CYTOMETRY; GRAFT VERSUS HOST REACTION; HUMAN; HUMAN CELL; LOW DRUG DOSE; MALE; MEGAKARYOCYTE; MONONUCLEAR CELL; PLOIDY; RECIPIENT; SCHOOL CHILD; THROMBOCYTOPENIA;

ADOLESCENT; ADULT; BONE MARROW CELLS; CELL DIFFERENTIATION; CHRONIC DISEASE; FEMALE; GRAFT SURVIVAL; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HUMANS; MALE; MEGAKARYOCYTE PROGENITOR CELLS; MEGAKARYOCYTES; MIDDLE AGED; PLATELET COUNT; POLYPLOIDY; RECEPTORS, THROMBOPOIETIN; THROMBOCYTOPENIA; TRANSPLANTATION, HOMOLOGOUS; YOUNG ADULT;

EID: 79151471987     PISSN: 10838791     EISSN: 15236536     Source Type: Journal    
DOI: 10.1016/j.bbmt.2010.09.007     Document Type: Article

References (28)

1. Kim D.H., Sohn S.K., Jeon S.B., et al. Prognostic significance of platelet recovery pattern after allogeneic HLA-identical sibling transplantation and its association with severe acute GVHD. Bone Marrow Transplant 2006, 37:101-108.
2. Kim D.H., Sohn S.K., Baek J.H., et al. Clinical significance of platelet count at day +60 after allogeneic peripheral blood stem cell transplantation. J Korean Med Sci 2006, 21:46-51.
3. Bolwell B., Pohlman B., Sobecks R., et al. Prognostic importance of the platelet count 100 days post allogeneic bone marrow transplant. Bone Marrow Transplant 2004, 33:419-423.
4. First L.R., Smith B.R., Lipton J., Nathan D.G., Parkman R., Rappeport J.M. Isolated thrombocytopenia after allogeneic bone marrow transplantation: existence of transient and chronic thrombocytopenic syndromes. Blood 1985, 65:368-374.
5. Bielski M., Yomtovian R., Lazarus H.M., Rosenthal N. Prolonged isolated thrombocytopenia after hematopoietic stem cell transplantation: morphologic correlation. Bone Marrow Transplant 1998, 22:1071-1076.
6. Yamazaki R., Kuwana M., Mori T., et al. Prolonged thrombocytopenia after allogeneic hematopoietic stem cell transplantation: associations with impaired platelet production and increased platelet turnover. Bone Marrow Transplant 2006, 38:377-384.
7. Ebbe S. Biology of megakaryocytes. Prog Hemost Thromb 1976, 3:211-229.
8. Gewirtz A.M. Megakaryocytopoiesis: the state of the art. Thromb Haemost 1995, 74:204-209.
9. Hoffman R. Regulation of megakaryocytopoiesis. Blood 1989, 74:1196-1212.
10. Huang X.J., Liu D.H., Liu K.Y., et al. Haploidentical hematopoietic stem cell transplantation without in vitro T-cell depletion for the treatment of hematological malignancies. Bone Marrow Transplant 2006, 38:291-297.
11. Lu D.P., Dong L., Wu T., et al. Conditioning including antithymocyte globulin followed by unmanipulated HLA-mismatched/haploidentical blood and marrow transplantation can achieve comparable outcomes with HLA-identical sibling transplantation. Blood 2006, 107:3065-3073.
12. Shulman H.M., Sullivan K.M., Weiden P.L., et al. Chronic graft-versus-host syndrome in man. A long-term clinicopathologic study of 20 Seattle patients. Am J Med 1980, 69:204-217.
13. Thomas E.D., Storb R., Clift R.A., et al. Bone-marrow transplantation (second of two parts). N Engl J Med 1975, 292:895-902.
14. Tomer A., Friese P., Conklin R., et al. Flow cytometric analysis of megakaryocytes from patients with abnormal platelet counts. Blood 1989, 74:594-601.
15. Tomer A. Human marrow megakaryocyte differentiation: multiparameter correlative analysis identifies von Willebrand factor as a sensitive and distinctive marker for early (2N and 4N) megakaryocytes. Blood 2004, 104:2722-2727.
16. Tomer A., Harker L.A. Measurements of in vivo megakaryocytopoiesis: studies in nonhuman primates and patients. Stem Cells 1996, 14(Suppl 1):18-30.
17. Levine R.F. Isolation and characterization of normal human megakaryocytes. Br J Haematol 1980, 45:487-497.
18. Nakeff A. Megakaryocytic cells. Bibl Haematol 1984, 131-209.
19. Harker L.A., Finch C.A. Thrombokinetics in man. J Clin Invest 1969, 48:963-974.
20. Vitrat N., Cohen-Solal K., Pique C., et al. Endomitosis of human megakaryocytes are due to abortive mitosis. Blood 1998, 91:3711-3723.
21. Zimmet J., Ravid K. Polyploidy: occurrence in nature, mechanisms, and significance for the megakaryocyte-platelet system. Exp Hematol 2000, 28:3-16.
22. Italiano J.E., Lecine P., Shivdasani R.A., Hartwig J.H. Blood platelets are assembled principally at the ends of proplatelet processes produced by differentiated megakaryocytes. J Cell Biol 1999, 147:1299-1312.
23. Patel S.R., Richardson J.L., Schulze H., et al. Differential roles of microtubule assembly and sliding in proplatelet formation by megakaryocytes. Blood 2005, 106:4076-4085.
24. Mattia G., Vulcano F., Milazzo L., et al. Different ploidy levels of megakaryocytes generated from peripheral or cord blood CD34+ cells are correlated with different levels of platelet release. Blood 2002, 99:888-897.
25. Bessman D. Prediction of platelet production during chemotherapy of acute leukemia. Am J Hematol 1982, 13:219-227.
26. Keever-Taylor C.A., Klein J.P., Eastwood D., et al. Factors affecting neutrophil and platelet reconstitution following T cell-depleted bone marrow transplantation: differential effects of growth factor type and role of CD34(+) cell dose. Bone Marrow Transplant 2001, 27:791-800.
27. Singhal S., Powles R., Treleaven J., et al. A low CD34+ cell dose results in higher mortality and poorer survival after blood or marrow stem cell transplantation from HLA-identical siblings: should 2 × 10(6) CD34+ cells/kg be considered the minimum threshold?. Bone Marrow Transplant 2000, 26:489-496.
28. Verdonck L.F., de Gast G.C., van Heugten H.G., Nieuwenhuis H.K., Dekker A.W. Cytomegalovirus infection causes delayed platelet recovery after bone marrow transplantation. Blood 1991, 78:844-848.