Delayed onset of hyperglycaemia in a mouse model with impaired glucagon secretion demonstrates that dysregulated glucagon secretion promotes hyperglycaemia and type 2 diabetes

Diabetologia

Volumn 54, Issue 2, 2011, Pages 415-422

  Gustavsson, N ^a   Seah, T ^a   Lao, Y ^b   Radda, G K ^a   Sudhof T C ^b   Han, W ^a,c  

^a AGENCY FOR SCIENCE   (Singapore)

^b STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

Author keywords

Exocytosis; Glucose tolerance test; Hepatic glucose production; Insulin resistance; Insulin secretion; Insulin tolerance test; Knockout mice; Pancreatic islets; Pyruvate tolerance test

Indexed keywords

GLUCAGON; INSULIN; SYNAPTOTAGMIN; SYNAPTOTAGMIN VII; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; GLUCAGON BLOOD LEVEL; GLUCAGON RELEASE; GLUCONEOGENESIS; GLUCOSE INTOLERANCE; HYPERGLYCEMIA; IMPAIRED GLUCOSE TOLERANCE; INSULIN RELEASE; INSULIN SENSITIVITY; LIPID DIET; MALE; MOUSE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; OBESITY; PATHOGENESIS; PRIORITY JOURNAL;

ANIMALS; BLOOD GLUCOSE; DIABETES MELLITUS, TYPE 2; DIETARY FATS; GLUCAGON; GLYCOGEN; HYPERGLYCEMIA; MALE; MICE; MICE, KNOCKOUT; SYNAPTOTAGMINS;

EID: 78951483894     PISSN: 0012186X     EISSN: 14320428     Source Type: Journal    
DOI: 10.1007/s00125-010-1950-2     Document Type: Article

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