Garlic flavonoids and organosulfur compounds: Impact on the hepatic pharmacokinetics of saquinavir and darunavir

Drug Metabolism and Pharmacokinetics

Volumn 25, Issue 6, 2010, Pages 521-530

  Berginc, Katja ^a   Milisav, Irina ^a   Kristl, Albin ^a  

^a UNIVERSITY OF LJUBLJANA   (Slovenia)

Author keywords

Aged garlic extract; Darunavir; Isolated rat hepatocytes; Rat liver slices; Saquinavir

Indexed keywords

CYTOCHROME P450 3A4; DARUNAVIR; FLAVONOID; ORGANOSULFUR DERIVATIVE; SAQUINAVIR;

ANIMAL TISSUE; ARTICLE; BINDING SITE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG BIOAVAILABILITY; DRUG DISTRIBUTION; DRUG EFFICACY; DRUG METABOLISM; DRUG POTENTIATION; DRUG TRANSPORT; ENZYME INHIBITION; GARLIC; HYDROLYSIS; LIVER; LIVER CELL; MALE; MICROSOME; NONHUMAN; PHYTOCHEMISTRY; RAT; TISSUE HOMOGENATE;

EID: 78951476121     PISSN: 13474367     EISSN: 18800920     Source Type: Journal    
DOI: 10.2133/dmpk.DMPK-10-RG-053     Document Type: Article

References (25)

1. Lelekis, I.: Alternative medicines update: A focus on the most common products your patients are using. PharmaNote, 23: 1-7 (2008).
2. Neustadt, J.: Herb-drug interactions: What clinicians need to know. Integr. Med., 5: 16-26 (2006).
3. Williamson, E. M.: Drug interactions between herbal and prescription medicines. Drug Saf., 26: 1075-1092 (2003).
4. Izzo, A. A., Di Carlo, G., Borrelli, F. and Ernst, E.: Cardiovascular pharmacotherapy and herbal medicines: the risk of drug interactions. Int. J. Cardiol., 98: 1-14 (2005).
5. Barnes, J., Anderson, L. A. and Phillipson, J. D.: Garlic. In Herbal medicines. 3rd ed. Pharmaceutical Press, London Chicago, 2007.
6. Nagpurkar, A., Peschell, J. and Holub, B. J.: Garlic constituents and disease prevention. In Mazza, G., Oomah, B. D. (eds.): Herbs, botanicals & teas, CRC Press, 2000.
7. Shord, S. S., Shah, K. and Lukose, A.: Drug-botanicals interactions: a review of the laboratory, animal and human data for 8 common botanicals. Integr. Cancer Ther., 8: 208-227 (2009).
8. Aszalos, A.: Role of ATP-binding cassette (ABC) transporters in interactions between natural products and drugs. Curr. Drug Metab., 9: 1010-1018 (2008).
9. Matsuura, H.: Saponins in garlic as modifiers of the risk of cardiovascular disease. J. Nutr., 131: 1000S-1005S (2001).
10. Cermak, R.: Effect of dietary flavonoids on pathways involved in drug metabolism. Expert Opin. Drug Metab. Toxicol., 4: 17-35 (2008).
11. Bansal, T., Jaggi, M., Khar, R. K. and Talegaonkar, S.: Emerging significance of flavonoids as P-glycoprotein inhibitors in cancer chemotherapy. J. Pharm. Pharmaceut. Sci., 12: 46-78 (2009).
12. Berginc, K., Žakelj, S. and Kristl, A.: In vitro interactions between aged garlic extract and drugs used for the treatment of cardiovascular and diabetic patients. Eur. J. Nutr. accepted for publication (DOI 10.1007/s00394-010-0095-x) (2010).
13. Berginc, K., Trontelj, J. and Kristl, A.: The influence of aged garlic extract on the uptake of saquinavir and darunavir into HepG2 cells and rat liver slices. Drug Metab. Pharmacokin., 25: 307-313 (2010).
14. Piscitelli, S. C., Burstein, A. H., Welden, N., Gallicano, K. D. and Falloon, J.: The effect of garlic supplements on the pharmacokinetics of saquinavir. Clin. Infect. Dis., 34: 234-238 (2002).
15. Maclean, C., Moenning, U., Reichel, A. and Fricker, G.: Closing the gaps-A full scan of the intestinal expression of Pgp, Bcrp and Mrp2 in male and female rats. Drug Metab. Dispos., 36: 1249-1254 (2008).
16. Fitzsimmons, M. E. and Collins, J. M.: Selective biotransformation of the human immunodeficiency virus protease inhibitor saquinavir by human small-intestinal cytochrome P4503A4. Drug Metab. Dispos., 25: 256-266 (1996).
17. Milisav, I., Nipič, D. and Šuput, D.: The riddle of mitochondrial caspase-3 from liver. Apoptosis, 14: 1070-1075 (2009).
18. Brand, W. et al.: Flavonoid-mediated inhibition of intestinal ABC transporters may affect the oral bioavailability of drugs, foodborne toxic compounds and bioactive ingredients. Biomed. Pharmacother., 60: 508-519 (2006).
19. de Castro, W. V., Mertens-Talcott, S., Derendorf, H. and Butterweck, V.: Effect of grapefruit juice, naringin, naringenin, and bergamottin on the intestinal carrier-mediated transport of talinolol in rats. J. Agric. Food Chem., 56: 4840-4845 (2008).
20. Gupta, A., Zhang, Y., Unadkat, J. D. and Mao, Q.: HIV protease inhibitors are inhibitors but not substrates of the human breast cancer resistance protein (BCRP/ABCG2). J. Pharmacol. Exp. Ther., 310: 334-341 (2004).
21. Coecke, S., et al.: The use of long-term hepatocyte cultures for detecting induction of drug metabolism enzymes: the current status. ATLA, 27: 579-638 (1999).
22. Vermeir, M., et al.: Absorption, metabolism, and excretion of darunavir, a new protease inhibitor, administered alone and with low-dose ritonavir in healthy subjects. Drug Metab. Dispos., 37: 809-820 (2009).
23. Hartkoorn, R. C., et al.: A. HIV protease inhibitors are substrates for OATP1A2, OATP1B1 and OATP1B3 and lopinavir plasma concentrations are influenced by SLCO1B1 polymorphisms. Pharmacogenet. Genomics, 2: 112-120 (2010).
24. Martin, C., Berridge, G., Higgins, C. F., Mistry, P., Charlton, P. and Callaghan, R.: Communication between multiple drug binding sites on P-glycoprotein. Mol. Pharmacol., 58: 624-632 (2000).
25. Amagase, H., Petesch, B. L, Matsuura, H. and Kasuga, S.: Intake of garlic and its bioactive components. J. Nutr., 131: 955S-962S (2001).