Var gene transcription and PfEMP1 expression in the rosetting and cytoadhesive Plasmodium falciparum clone FCR3S1.2

Malaria Journal

Volumn 10, Issue , 2011, Pages

  Albrecht, Letusa ^a   Moll, Kirsten ^a   Blomqvist, Karin ^a   Normark, Johan ^b   Chen, Qijun ^a,c   Wahlgren, Mats ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

^b UMEÅ UNIVERSITY   (Sweden)

^c PEKING UNION MEDICAL COLLEGE   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ERYTHROCYTE MEMBRANE PROTEIN 1; ERYTHROCYTE MEMBRANE PROTEIN 1, PLASMODIUM FALCIPARUM; PROTOZOAL PROTEIN; PROTOZOON ANTIBODY;

ANIMAL EXPERIMENT; ARTICLE; ASSAY; CLONE; CONTROLLED STUDY; CROSS REACTION; ERYTHROCYTE MEMBRANE; ESCHERICHIA COLI; GENETIC CODE; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; NONHUMAN; PHENOTYPE; PLASMODIUM FALCIPARUM; POLYMERASE CHAIN REACTION; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; RAT; ROSETTE FORMATION; ROSETTE TEST; TROPHOZOITE; AMINO ACID SEQUENCE; BIOSYNTHESIS; ERYTHROCYTE; FLUORESCENT ANTIBODY TECHNIQUE; GENE EXPRESSION PROFILING; IMMUNOLOGY; MOLECULAR GENETICS; PARASITOLOGY; PATHOGENICITY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SEQUENCE HOMOLOGY;

AMINO ACID SEQUENCE; ANTIBODIES, PROTOZOAN; ERYTHROCYTES; FLUORESCENT ANTIBODY TECHNIQUE; GENE EXPRESSION PROFILING; HUMANS; MOLECULAR SEQUENCE DATA; PLASMODIUM FALCIPARUM; PROTOZOAN PROTEINS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SEQUENCE HOMOLOGY, AMINO ACID; TRANSCRIPTION, GENETIC;

EID: 78951470863     PISSN: None     EISSN: 14752875     Source Type: Journal    
DOI: 10.1186/1475-2875-10-17     Document Type: Article

References (44)

1. WHO, World Malaria Report 2008 2008
2. WHO, World Malaria Report 2008 2008 (Pubitemid 13083696)
3. Parasite sequestration in Plasmodium falciparum malaria: spleen and antibody modulation of cytoadherence of infected erythrocytes. PH David M Hommel LH Miller IJ Udeinya LD Oligino, Proc Natl Acad Sci USA 1983 80 5075 5079 10.1073/pnas.80.16.5075 6348780 (Pubitemid 13046247)
4. Antigens induced on erythrocytes by P. falciparum: expression of diverse and conserved determinants. K Marsh RJ Howard, Science 1986 231 150 153 10.1126/science.2417315 2417315 (Pubitemid 16154704)
5. Human cerebral malaria: association with erythrocyte rosetting and lack of anti-rosetting antibodies. J Carlson H Helmby AV Hill D Brewster BM Greenwood M Wahlgren, Lancet 1990 336 1457 1460 10.1016/0140-6736(90)93174-N 1979090
6. Antibody recognition of Plasmodium falciparum erythrocyte surface antigens in Kenya: evidence for rare and prevalent variants. PC Bull BS Lowe M Kortok K Marsh, Infect Immun 1999 67 733 739 9916084 (Pubitemid 29059212)
7. Parasite antigens on the infected red cell surface are targets for naturally acquired immunity to malaria. PC Bull BS Lowe M Kortok CS Molyneux CI Newbold K Marsh, Nat Med 1998 4 358 360 10.1038/nm0398-358 9500614 (Pubitemid 28144099)
8. Malaria-induced acquisition of antibodies to Plasmodium falciparum variant surface antigens.[see comment]. MF Ofori D Dodoo T Staalsoe JA Kurtzhals K Koram TG Theander BD Akanmori L Hviid, Infect Immun 2002 70 2982 2988 10.1128/IAI.70.6.2982-2988.2002 12010988 (Pubitemid 34564157)
9. Plasmodium falciparum variant surface antigen expression varies between isolates causing severe and nonsevere malaria and is modified by acquired immunity. MA Nielsen T Staalsoe JA Kurtzhals BQ Goka D Dodoo M Alifrangis TG Theander BD Akanmori L Hviid, J Immunol 2002 168 3444 3450 11907103 (Pubitemid 34250409)
10. A family affair: var genes, PfEMP1 binding, and malaria disease. SM Kraemer JD Smith, Curr Opin Microbiol 2006 9 374 380 10.1016/j.mib.2006.06.006 16814594 (Pubitemid 44108717)
11. Autoagglutination of malaria-infected red blood cells and malaria severity. DJ Roberts A Pain O Kai M Kortok K Marsh, Lancet 2000 355 1427 1428 10.1016/S0140-6736(00)02143-7 10791528 (Pubitemid 30215967)
12. PfEMP1-DBL1alpha amino acid motifs in severe disease states of Plasmodium falciparum malaria. J Normark D Nilsson U Ribacke G Winter K Moll CE Wheelock J Bayarugaba F Kironde TG Egwang Q Chen B Andersson M Wahlgren, Proc Natl Acad Sci USA 2007 40 15835 15840 10.1073/pnas.0610485104 (Pubitemid 350035385)
13. Human cerebral malaria. A quantitative ultrastructural analysis of parasitized erythrocyte sequestration. GG MacPherson MJ Warrell NJ White S Looareesuwan DA Warrell, Am J Pathol 1985 119 385 401 3893148 (Pubitemid 15051887)
14. var genes, PfEMP1 and the human host. K Flick Q Chen, Mol Biochem Parasitol 2004 134 3 9 10.1016/j.molbiopara.2003.09.010 14747137 (Pubitemid 38121512)
15. Patterns of gene recombination shape var gene repertoires in Plasmodium falciparum: comparisons of geographically diverse isolates. SM Kraemer SA Kyes G Aggarwal AL Springer SO Nelson Z Christodoulou LM Smith W Wang E Levin CI Newbold PJ Myler JD Smith, BMC Genomics 2007 8 45 10.1186/1471-2164-8-45 17286864
16. P. falciparum rosetting mediated by a parasite-variant erythrocyte membrane protein and complement-receptor 1. JA Rowe JM Moulds CI Newbold LH Miller, Nature 1997 388 292 295 10.1038/40269 9230440 (Pubitemid 27317975)
17. The semiconserved head structure of Plasmodium falciparum erythrocyte membrane protein 1 mediates binding to multiple independent host receptors. Q Chen A Heddini A Barragan V Fernandez SF Pearce M Wahlgren, J Exp Med 2000 192 1 10 10.1084/jem.192.1.1 10880521
18. Heparan sulfate on endothelial cells mediates the binding of Plasmodium falciparum-infected erythrocytes via the DBL1alpha domain of PfEMP1. AM Vogt A Barragan Q Chen F Kironde D Spillmann M Wahlgren, Blood 2003 101 2405 2411 Epub 2002 Nov 2414 10.1182/blood-2002-07-2016 12433689 (Pubitemid 36302089)
19. Immunization with PfEMP1-DBL1alpha generates antibodies that disrupt rosettes and protect against the sequestration of Plasmodium falciparum-infected erythrocytes. Q Chen F Pettersson AM Vogt B Schmidt S Ahuja P Liljestrom M Wahlgren, Vaccine 2004 22 2701 2712 10.1016/j.vaccine.2004.02.015 15246600 (Pubitemid 38900644)
20. Whole-body imaging of sequestration of Plasmodium falciparum in the rat. F Pettersson AM Vogt C Jonsson BW Mok A Shamaei-Tousi S Bergstrom Q Chen M Wahlgren, Infect Immun 2005 73 7736 7746 10.1128/IAI.73.11.7736-7746.2005 16239578 (Pubitemid 41587680)
21. Rosette formation in Plasmodium falciparum isolates and anti-rosette activity of sera from Gambians with cerebral or uncomplicated malaria. CJ Treutiger I Hedlund H Helmby J Carlson A Jepson P Twumasi D Kwiatkowski BM Greenwood M Wahlgren, Am J Trop Med Hyg 1992 46 503 510 1599043
22. Plasmodium falciparum rosetting is associated with malaria severity in Kenya. A Rowe J Obeiro CI Newbold K Marsh, Infect Immun 1995 63 2323 2326 7768616
23. Fresh isolates from children with severe Plasmodium falciparum malaria bind to multiple receptors. A Heddini F Pettersson O Kai J Shafi J Obiero Q Chen A Barragan M Wahlgren K Marsh, Infect Immun 2001 69 5849 5856 10.1128/IAI.69.9.5849-5856.2001 11500463 (Pubitemid 32786525)
24. ABO-blood-group types and protection against severe, Plasmodium falciparum malaria. SL Pathirana HK Alles S Bandara M Phone-Kyaw MK Perera AR Wickremasinghe KN Mendis SM Handunnetti, Ann Trop Med Parasitol 2005 99 119 124 10.1179/136485905X19946 15814030 (Pubitemid 40393039)
25. An in vivo and in vitro model of Plasmodium falciparum rosetting and autoagglutination mediated by varO, a group A var gene encoding a frequent serotype. I Vigan-Womas M Guillotte C Le Scanf S Igonet S Petres A Juillerat C Badaut F Nato A Schneider A Lavergne H Contamin A Tall L Baril GA Bentley O Mercereau-Puijalon, Infect Immun 2008 76 5565 5580 10.1128/IAI.00901-08 18809668
26. Identification of Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) as the rosetting ligand of the malaria parasite P. falciparum. Q Chen A Barragan V Fernandez A Sundstrom M Schlichtherle A Sahlen J Carlson S Datta M Wahlgren, J Exp Med 1998 187 15 23 10.1084/jem.187.1.15 9419207 (Pubitemid 28044816)
27. Sub-grouping of Plasmodium falciparum 3D7 var genes based on sequence analysis of coding and non-coding regions. T Lavstsen A Salanti AT Jensen DE Arnot TG Theander, Malar J 2003 2 27 10.1186/1475-2875-2-27 14565852
28. Plasmodium falciparum variant surface antigen expression patterns during malaria. PC Bull M Berriman S Kyes MA Quail N Hall MM Kortok K Marsh CI Newbold, PLoS Pathog 2005 1 26 10.1371/journal.ppat.0010026
29. Virulence of malaria is associated with differential expression of Plasmodium falciparum var gene subgroups in a case-control study. M Kaestli IA Cockburn A Cortes K Baea JA Rowe HP Beck, J Infect Dis 2006 193 1567 1574 10.1086/503776 16652286 (Pubitemid 43794587)
30. Differential expression of var gene groups is associated with morbidity caused by Plasmodium falciparum infection in Tanzanian children. M Rottmann T Lavstsen JP Mugasa M Kaestli AT Jensen D Muller T Theander HP Beck, Infect Immun 2006 74 3904 3911 10.1128/IAI.02073-05 16790763 (Pubitemid 43993322)
31. The large diverse gene family var encodes proteins involved in cytoadherence and antigenic variation of Plasmodium falciparum-infected erythrocytes. XZ Su VM Heatwole SP Wertheimer F Guinet JA Herrfeldt DS Peterson JA Ravetch TE Wellems, Cell 1995 82 89 100 10.1016/0092-8674(95)90055-1 7606788
32. var gene transcription dynamics in Plasmodium falciparum patient isolates. K Blomqvist J Normark D Nilsson U Ribacke J Orikiriza P Trillkott J Byarugaba TG Egwang F Kironde B Andersson M Wahlgren, Mol Biochem Parasitol 2010 170 74 83 10.1016/j.molbiopara.2009.12.002 20006652
33. Multiple adhesive phenotypes linked to rosetting binding of erythrocytes in Plasmodium falciparum malaria. V Fernandez CJ Treutiger GB Nash M Wahlgren, Infect Immun 1998 66 2969 2975 9596774 (Pubitemid 28261810)
34. Methods in Malaria Research, 5th ed. MR4/ATCC Manassas, Virginia. K Moll I Ljungström P H A Scherf W M, 2008 http://www.biomalpar.org/ updatedMethods-In-Malaria-Research-5thedition.pdf
35. The MIQE guidelines: minimum information for publication of quantitative real-time PCR experiments. SA Bustin V Benes JA Garson J Hellemans J Huggett M Kubista R Mueller T Nolan MW Pfaffl GL Shipley J Vandesompele CT Wittwer, Clin Chem 2009 55 611 622 10.1373/clinchem.2008.112797 19246619
36. A novel DBL-domain of the P. falciparum 332 molecule possibly involved in erythrocyte adhesion. K Moll A Chene U Ribacke O Kaneko S Nilsson G Winter M Haeggstrom W Pan K Berzins M Wahlgren Q Chen, PLoS One 2007 2 10.1371/journal.pone.0000477 17534427
37. Common trafficking pathway for variant antigens destined for the surface of the Plasmodium falciparum-infected erythrocyte. M Haeggstrom F Kironde K Berzins Q Chen M Wahlgren V Fernandez, Mol Biochem Parasitol 2004 133 1 14 10.1016/j.molbiopara.2003.07.006 14668007 (Pubitemid 37510303)
38. Genome sequence of the human malaria parasite Plasmodium falciparum. MJ Gardner N Hall E Fung O White M Berriman RW Hyman JM Carlton A Pain KE Nelson S Bowman IT Paulsen K James JA Eisen K Rutherford SL Salzberg A Craig S Kyes MS Chan V Nene SJ Shallom B Suh J Peterson S Angiuoli M Pertea J Allen J Selengut D Haft MW Mather AB Vaidya DM Martin AH Fairlamb MJ Fraunholz DS Roos SA Ralph GI McFadden LM Cummings GM Subramanian C Mungall JC Venter DJ Carucci SL Hoffman C Newbold RW Davis CM Fraser B Barrell, Nature 2002 419 498 511 10.1038/nature01097 12368864
39. Generation of cross-protective antibodies against Plasmodium falciparum sequestration by immunization with an erythrocyte membrane protein 1-duffy binding-like 1 alpha domain. K Moll F Pettersson AM Vogt C Jonsson N Rasti S Ahuja M Spangberg O Mercereau-Puijalon DE Arnot M Wahlgren Q Chen, Infect Immun 2007 75 211 219 10.1128/IAI.00749-06 17074852 (Pubitemid 46047895)
40. Association of severe noncerebral Plasmodium falciparum malaria in Brazil with expressed PfEMP1 DBL1 alpha sequences lacking cysteine residues. K Kirchgatter HA del Portillo, Mol Med 2002 8 16 23 11984002 (Pubitemid 34451117)
41. Plasmodium falciparum var gene expression is modified by host immunity. GM Warimwe TM Keane G Fegan JN Musyoki CR Newton A Pain M Berriman K Marsh PC Bull, Proc Natl Acad Sci USA 2009 106 21801 21806 10.1073/pnas.0907590106 20018734
42. Effect of var gene disruption on switching in Plasmodium falciparum. P Horrocks R Pinches S Kyes N Kriek S Lee Z Christodoulou CI Newbold, Mol Microbiol 2002 45 1131 1141 10.1046/j.1365-2958.2002.03085.x 12180930 (Pubitemid 35007454)
43. A study of var gene transcription in vitro using universal var gene primers. HM Taylor SA Kyes D Harris N Kriek CI Newbold, Mol Biochem Parasitol 2000 105 13 23 10.1016/S0166-6851(99)00159-0 10613695
44. Release of sequestered malaria parasites upon injection of a glycosaminoglycan. AM Vogt F Pettersson K Moll C Jonsson J Normark U Ribacke TG Egwang HP Ekre D Spillmann Q Chen M Wahlgren, PLoS Pathogens 2006 2 100 10.1371/journal.ppat.0020100 (Pubitemid 44525729)