Inhibition of ADAM9 expression induces epithelial phenotypic alterations and sensitizes human prostate cancer cells to radiation and chemotherapy

Prostate

Volumn 71, Issue 3, 2011, Pages 232-240

  Josson, Sajni ^a   Anderson, Cynthia S ^b   Sung, Shian Ying ^c   Johnstone, Peter A S ^d   Kubo, Hiroyuki ^e   Hsieh, Chia Ling ^c   Arnold, Rebecca ^b   Gururajan, Murali ^a   Yates, Clayton ^f   Chung, Leland W K ^a  

^a CEDARS SINAI MEDICAL CENTER   (United States)

^b EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c CHINA MEDICAL UNIVERSITY   (Taiwan)

^d INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e KAGOSHIMA UNIVERSITY   (Japan)

^f TUSKEGEE UNIVERSITY   (United States)

Author keywords

ADAM9; E cadherin; prostate cancer; radiation

Indexed keywords

ADAM 9 PROTEIN; ADAM PROTEIN; ANTINEOPLASTIC AGENT; INTEGRIN; UNCLASSIFIED DRUG; UVOMORULIN;

APOPTOSIS; ARTICLE; BIOCHEMISTRY; CANCER CELL; CANCER CHEMOTHERAPY; CANCER GROWTH; CANCER PATIENT; CANCER RADIOTHERAPY; CELL STRUCTURE; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; ENZYME INHIBITION; HUMAN; HUMAN CELL; MALE; PRIORITY JOURNAL; PROSTATE CANCER; PROTEIN EXPRESSION; RADIOSENSITIVITY; SENSITIVITY ANALYSIS; SENSITIVITY AND SENSIBILITY;

ADAM PROTEINS; APOPTOSIS; CADHERINS; CELL LINE, TUMOR; EPITHELIUM; HUMANS; INTEGRINS; MALE; MEMBRANE PROTEINS; PHENOTYPE; PROSTATIC NEOPLASMS; RADIATION TOLERANCE; SUPEROXIDES;

EID: 78951469330     PISSN: 02704137     EISSN: 10970045     Source Type: Journal    
DOI: 10.1002/pros.21237     Document Type: Article

References (20)

1. Edwards DR, Handsley MM, Pennington CJ,. The ADAM metalloproteinases. Mol Aspects Med 2008; 29 (5): 258-289.
2. Sung SY, Kubo H, Shigemura K, Arnold RS, Logani S, Wang R, Konaka H, Nakagawa M, Mousses S, Amin M, Anderson C, Johnstone P, Petros JA, Marshall FF, Zhau HE, Chung LW,. Oxidative stress induces ADAM9 protein expression in human prostate cancer cells. Cancer Res 2006; 66 (19): 9519-9526.
3. Peduto L, Reuter VE, Shaffer DR, Scher HI, Blobel CP,. Critical function for ADAM9 in mouse prostate cancer. Cancer Res 2005; 65 (20): 9312-9319.
4. Fritzsche FR, Jung M, Tolle A, Wild P, Hartmann A, Wassermann K, Rabien A, Lein M, Dietel M, Pilarsky C, Calvano D, Grutzmann R, Jung K, Kristiansen G,. ADAM9 expression is a significant and independent prognostic marker of PSA relapse in prostate cancer. Eur Urol 2008; 54 (5): 1097-1106.
5. O'Shea C, McKie N, Buggy Y, Duggan C, Hill AD, McDermott E, O'Higgins N, Duffy MJ,. Expression of ADAM-9 mRNA and protein in human breast cancer. Int J Cancer 2003; 105 (6): 754-761.
6. Mazzocca A, Coppari R, De Franco R, Cho JY, Libermann TA, Pinzani M, Toker A,. A secreted form of ADAM9 promotes carcinoma invasion through tumor-stromal interactions. Cancer Res 2005; 65 (11): 4728-4738.
7. Shintani Y, Higashiyama S, Ohta M, Hirabayashi H, Yamamoto S, Yoshimasu T, Matsuda H, Matsuura N,. Overexpression of ADAM9 in non-small cell lung cancer correlates with brain metastasis. Cancer Res 2004; 64 (12): 4190-4196.
8. Grutzmann R, Luttges J, Sipos B, Ammerpohl O, Dobrowolski F, Alldinger I, Kersting S, Ockert D, Koch R, Kalthoff H, Schackert HK, Saeger HD, Kloppel G, Pilarsky C,. ADAM9 expression in pancreatic cancer is associated with tumour type and is a prognostic factor in ductal adenocarcinoma. Br J Cancer 2004; 90 (5): 1053-1058.
9. Izumi Y, Hirata M, Hasuwa H, Iwamoto R, Umata T, Miyado K, Tamai Y, Kurisaki T, Sehara-Fujisawa A, Ohno S, Mekada E,. A metalloprotease-disintegrin, MDC9/meltrin-gamma/ADAM9 and PKCdelta are involved in TPA-induced ectodomain shedding of membrane-anchored heparin-binding EGF-like growth factor. EMBO J 1998; 17 (24): 7260-7272.
10. Koike H, Tomioka S, Sorimachi H, Saido TC, Maruyama K, Okuyama A, Fujisawa-Sehara A, Ohno S, Suzuki K, Ishiura S,. Membrane-anchored metalloprotease MDC9 has an alpha-secretase activity responsible for processing the amyloid precursor protein. Biochem J 1999; 343 (Pt 2): 371-375.
11. Mohan S, Thompson GR, Amaar YG, Hathaway G, Tschesche H, Baylink DJ,. ADAM-9 is an insulin-like growth factor binding protein-5 protease produced and secreted by human osteoblasts. Biochemistry 2002; 41 (51): 15394-15403.
12. Cisse MA, Sunyach C, Lefranc-Jullien S, Postina R, Vincent B, Checler F,. The disintegrin ADAM9 indirectly contributes to the physiological processing of cellular prion by modulating ADAM10 activity. J Biol Chem 2005; 280 (49): 40624-40631.
13. Franzke CW, Tasanen K, Borradori L, Huotari V, Bruckner-Tuderman L,. Shedding of collagen XVII/BP180: Structural motifs influence cleavage from cell surface. J Biol Chem 2004; 279 (23): 24521-24529.
14. Shigemura K, Sung SY, Kubo H, Arnold RS, Fujisawa M, Gotoh A, Zhau HE, Chung LW,. Reactive oxygen species mediate androgen receptor- and serum starvation-elicited downstream signaling of ADAM9 expression in human prostate cancer cells. Prostate 2007; 67 (7): 722-731.
15. Nomura T, Huang WC, Zhau HE, Wu D, Xie Z, Mimata H, Zayzafoon M, Young AN, Marshall FF, Weitzmann MN, Chung LW,. Beta2-microglobulin promotes the growth of human renal cell carcinoma through the activation of the protein kinase A, cyclic AMP-responsive element-binding protein, and vascular endothelial growth factor axis. Clin Cancer Res 2006; 12 (24): 7294-7305.
16. Fischer OM, Hart S, Gschwind A, Prenzel N, Ullrich A,. Oxidative and osmotic stress signaling in tumor cells is mediated by ADAM proteases and heparin-binding epidermal growth factor. Mol Cell Biol 2004; 24 (12): 5172-5183.
17. Zutter MM, Sun H, Santoro SA,. Altered integrin expression and the malignant phenotype: The contribution of multiple integrated integrin receptors. J Mammary Gland Biol Neoplasia 1998; 3 (2): 191-200.
18. Odero-Marah VA, Wang R, Chu G, Zayzafoon M, Xu J, Shi C, Marshall FF, Zhau HE, Chung LW,. Receptor activator of NF-kappaB Ligand (RANKL) expression is associated with epithelial to mesenchymal transition in human prostate cancer cells. Cell Res 2008; 18 (8): 858-870.
19. Zhau HE, Odero-Marah V, Lue HW, Nomura T, Wang R, Chu G, Liu ZR, Zhou BP, Huang WC, Chung LW,. Epithelial to mesenchymal transition (EMT) in human prostate cancer: Lessons learned from ARCaP model. Clin Exp Metastasis 2008; 25 (6): 601-610.
20. Hirao T, Nanba D, Tanaka M, Ishiguro H, Kinugasa Y, Doki Y, Yano M, Matsuura N, Monden M, Higashiyama S,. Overexpression of ADAM9 enhances growth factor-mediated recycling of E-cadherin in human colon cancer cell line HT29 cells. Exp Cell Res 2006; 312 (3): 331-339.