Alpha- and beta-synucleins are new diagnostic tools for acute erythroid leukemia and acute megakaryoblastic leukemia

American Journal of Hematology

Volumn 86, Issue 2, 2011, Pages 230-234

  Maitta, Robert W ^a   Wolgast, Lucia R ^a   Wang, Qing ^a   Zhang, Hailing ^a   Bhattacharyya, Pritish ^b   Gong, Jerald Z ^c   Sunkara, Jaya ^a   Albanese, Joseph M ^a   Pizzolo, John G ^a   A Cannizzaro, Linda ^a   Ramesh, K H ^a   Ratech, Howard ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^b HACKENSACK UNIVERSITY MEDICAL CENTER   (United States)

^c Labcorp Research Triangle Park ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA SYNUCLEIN; BETA SYNUCLEIN; GAMMA SYNUCLEIN; TUMOR MARKER;

ACUTE ERYTHROID LEUKEMIA; ACUTE LEUKEMIA; ACUTE MEGAKARYOCYTIC LEUKEMIA; ADULT; AGED; BONE MARROW CELL; CANCER DIAGNOSIS; CASE REPORT; CHILD; DIAGNOSTIC TEST ACCURACY STUDY; ERYTHROLEUKEMIA; FEMALE; HUMAN; LETTER; LEUKEMIA CELL LINE; MALE; MYELODYSPLASTIC SYNDROME; MYELOPROLIFERATIVE DISORDER; PRESCHOOL CHILD; PRIORITY JOURNAL; PROTEIN EXPRESSION; SCHOOL CHILD;

ADULT; AGED; AGED, 80 AND OVER; ALPHA-SYNUCLEIN; BETA-SYNUCLEIN; BIOLOGICAL MARKERS; BONE MARROW; CELL LINE, TUMOR; CHILD; CHILD, PRESCHOOL; DIAGNOSIS, DIFFERENTIAL; EARLY DETECTION OF CANCER; FEMALE; GAMMA-SYNUCLEIN; HUMANS; LEUKEMIA; LEUKEMIA, ERYTHROBLASTIC, ACUTE; LEUKEMIA, MEGAKARYOBLASTIC, ACUTE; MALE; MEGAKARYOCYTE-ERYTHROID PROGENITOR CELLS; MIDDLE AGED; NEOPLASM PROTEINS;

EID: 78851471616     PISSN: 03618609     EISSN: 10968652     Source Type: Journal    
DOI: 10.1002/ajh.21932     Document Type: Letter

References (24)

1. Ueda K, Fukushima H, Masliah E, et al. Molecular cloning of cDNA encoding an unrecognized component of amyloid in Alzheimer disease. Proc Natl Acad Sci USA 1993; 90: 11282-11286.
2. Goedert M. Alpha-synuclein and neurodegenerative diseases. Nat Rev Neurosci 2001; 2: 492-501.
3. Takao M, Ghetti B, Yoshida H, et al. Early-onset dementia with Lewy bodies. Brain Pathol 2004; 14: 137-147.
4. Hashimoto M, Yoshimoto M, Sisk A, et al. NACP, a synaptic protein involved in Alzheimer's disease, is differentially regulated during megakaryocyte differentiation. Biochem Biophys Res Commun 1997; 237: 611-616.
5. George JM. The synucleins. Genome Biol 2002; 3:Reviews3002.
6. Nakai M, Fujita M, Waragai M, et al. Expression of alpha-synuclein, a presynaptic protein implicated in Parkinson's disease, in erythropoietic lineage. Biochem Biophys Res Commun 2007; 358: 104-110.
7. Barbour R, Kling K, Anderson JP, et al. Red blood cells are the major source of alpha-synuclein in blood. Neurodegener Dis 2008; 5: 55-59.
8. Fung KM, Rorke LB, Giasson B, et al. Expression of alpha-, beta-, and gamma-synuclein in glial tumors and medulloblastomas. Acta Neuropathol 2003; 106: 167-175.
9. Chen X, de Silva HA, Pettenati MJ, et al. The human NACP/alpha-synuclein gene: Chromosome assignment to 4q21.3-q22 and TaqI RFLP analysis. Genomics 1995; 26: 425-427.
10. Spillantini MG, Divane A, Goedert M. Assignment of human alpha-synuclein (SNCA) and beta-synuclein (SNCB) genes to chromosomes 4q21 and 5q35. Genomics 1995; 27: 379-381.
11. Ninkina NN, Alimova-Kost MV, Paterson JW, et al. Organization, expression and polymorphism of the human persyn gene. Hum Mol Genet 1998; 7: 1417-1424.
12. Fader CM, Sanchez DG, Mestre MB, et al. TI-VAMP/VAMP7 and VAMP3/cellubrevin: Two v-SNARE proteins involved in specific steps of the autophagy/multivesicular body pathways. Biochim Biophys Acta 2009; 1793: 1901-1916.
13. Burre J, Sharma M, Tsetsenis T, et al. Alpha-synuclein promotes SNARE-complex assembly in vivo and in vitro. Science 2010; 329: 1663-1667.
14. Thompson CJ, Schilling T, Howard MR, et al. SNARE-dependent glutamate release in megakaryocytes. Exp Hematol 2010; 38: 504-515.
15. Blair P, Flaumenhaft R. Platelet alpha-granules: Basic biology and clinical correlates. Blood Rev 2009; 23: 177-189.
16. Savica R, Grossardt BR, Carlin JM, et al. Anemia or low hemoglobin levels preceding Parkinson disease: A case-control study. Neurology 2009; 73: 1381-1387.
17. Harrison CJ, Haas O, Harbott J, et al. Detection of prognostically relevant genetic abnormalities in childhood B-cell precursor acute lymphoblastic leukaemia: Recommendations from the Biology and Diagnosis Committee of the International Berlin-Frankfurt-Munster study group. Br J Haematol 2010; 151: 132-142.
18. Qian Z, Joslin JM, Tennant TR, et al. Cytogenetic and genetic pathways in therapy-related acute myeloid leukemia. Chem Biol Interact 2010; 184: 50-57.
19. Klimchenko O, Mori M, Distefano A, et al. A common bipotent progenitor generates the erythroid and megakaryocyte lineages in embryonic stem cell-derived primitive hematopoiesis. Blood 2009; 114: 1506-1517.
20. Lu J, Guo S, Ebert BL, et al. MicroRNA-mediated control of cell fate in megakaryocyte-erythrocyte progenitors. Dev Cell 2008; 14: 843-853.
21. Michell AW, Luheshi LM, Barker RA. Skin and platelet alpha-synuclein as peripheral biomarkers of Parkinson's disease. Neurosci Lett 2005; 381: 294-298.
22. Abeliovich A, Schmitz Y, Farinas I, et al. Mice lacking alpha-synuclein display functional deficits in the nigrostriatal dopamine system. Neuron 2000; 25: 239-252.
23. Surguchov A. Molecular and cellular biology of synucleins. Int Rev Cell Mol Biol 2008; 270: 225-317.
24. Spector D, Goldman RD, Leinwald LA. Cells: A Laboratory Manual. Cold Spring Harbor Cold Spring Harbor Laboratory Press; 1998. 2136p.