Polymorphisms of the steroid sulfatase (STS) gene are associated with attention deficit hyperactivity disorder and influence brain tissue mRNA expression

American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics

Volumn 153, Issue 8, 2010, Pages 1417-1424

  Brookes, K J ^a   Hawi, Z ^b   Park, J ^a   Scott, S ^a   Gill, M ^b   Kent, L ^a  

^a UNIVERSITY OF ST ANDREWS   (United Kingdom)

^b ST JAMES S HOSPITAL   (Ireland)

Author keywords

ADHD; Association study; Human brain tissue; MRNA; Steroid sulfatase

Indexed keywords

MESSENGER RNA; STERYL SULFATASE;

ALLELE; ARTICLE; ATTENTION DEFICIT DISORDER; AUTOPSY; BRAIN TISSUE; CONTROLLED STUDY; DNA POLYMORPHISM; FRONTAL CORTEX; GENE; GENE FREQUENCY; GENE MAPPING; GENETIC ASSOCIATION; GENETIC TRANSCRIPTION; GENETIC VARIABILITY; GENOTYPE; HUMAN; HUMAN TISSUE; INTRON; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM; STS GENE;

ADOLESCENT; ADULT; AGED; ATTENTION DEFICIT DISORDER WITH HYPERACTIVITY; BASE SEQUENCE; BRAIN; CHILD; CHILD, PRESCHOOL; FEMALE; GENE EXPRESSION; GENETIC ASSOCIATION STUDIES; GENETIC MARKERS; GENOTYPE; HUMANS; MALE; MIDDLE AGED; POLYMERASE CHAIN REACTION; POLYMORPHISM, SINGLE NUCLEOTIDE; RNA, MESSENGER; SEQUENCE DELETION; STERYL-SULFATASE;

ANIMALIA;

EID: 78851469712     PISSN: 15524841     EISSN: 1552485X     Source Type: Journal    
DOI: 10.1002/ajmg.b.31120     Document Type: Article

References (25)

1. Angold A, Prendergast M, Cox A, Harrington R, Simonoff E, Rutter M. 1995. The Child and Adolescent Psychiatric Assessment (CAPA). Psychol Med 25: 739-753.
2. Asherson P. 2004. Attention-deficit hyperactivity disorder in the post-genomic era. Eur Child Adolesc Psychiatr 13(Suppl 1): I50-70.
3. Barrett JC, Fry B, Maller J, Daly MJ. 2005. Haploview: Analysis and visualization of LD and haplotype maps. Bioinformatics 21: 263-265.
4. Brookes KJ, Hawi Z, Kirley A, Barry E, Gill M, Kent L. 2008. Association of the steroid sulfatase (STS) gene with attention deficit hyperactivity disorder. Am J Med Genet Part B 147B: 1531-1535.
5. Collarini EJ, Kuhn R, Marshall CJ, Monuki ES, Lemke G, Richardson WD. 1992. Down-regulation of the POU transcription factor SCIP is an early event in oligodendrocyte differentiation in vitro. Development 116(1): 193-200.
6. Conners CK. 1998. Rating scales in attention deficit hyperactivity disorder; use in assessment, and treatment and monitoring. J Clin Psychiatr 59: 24-30.
7. Dalla Valle LD, Toffolo V, Nardi A, Fiore C, Bernante P, Di Liddo R, Parnigotto PP, Colombo L. 2006. Tissue-specific transcriptional initiation and activity of steroid sulfatase complementing dehydroepiandrosterone sulfate uptake and intracrine steroid activations in human adipose tissue. J Endocrinol 190(1): 129-139.
8. Dalla Valle L, Toffolo V, Nardi A, Fiore C, Armanini D, Belvedere P, Colombo L. 2007. The expression of the human steroid sulfatase-encoding gene is driven by alternative first exons. J Steroid Biochem Mol Biol 107: 22-29.
9. Davies W, Humby T, Isles AR, Burgoyne PS, Wilkinson LS. 2007. X-monosomy effects on visuospatial attention in mice: A candidate gene and implications for Turner syndrome and attention deficit hyperactivity disorder. Biol Psychiatr 61: 1351-1360.
10. Davies W, Humby T, Kong W, Otter T, Burgoyne PS, Wilkinson LS. 2009. Converging pharmacological and genetic evidence indicates a role for steroid sulfatase in attention. Biol Psychiatr 66: 360-367.
11. Dudbridge F. 2008. Likelihood-based association analysis for nuclear families and unrelated subjects with missing genotype data. Hum Hered 66: 87-98.
12. Frantz GD, Bohner AP, Akers RM, McConnell SK. 1994. Regulation of the POU domain gene SCIP during cerebral cortical development. J Neurosci 14: 472-485.
13. Gemel J, Jacobsen C, MacArthur CA. 1999. Fibroblast growth factor-8 expression is regulated by intronic engrailed and Pbx1-binding sites. J Biol Chem 274(9): 6020-6026.
14. Kaufman J, Birmaher B, Brent D, Rao U, Flynn C, Moreci P, Williamson D, Ryan N. 1997. Schedule for affective disorders and schizophrenia for school-age children-present and lifetime version (K-SADS-PL): Initial reliability and validity data. J Am Acad Child Adolesc Psychiatr 36(7): 980-988.
15. Kent L, Emerton J, Bhadravathi V, Weisblatt E, Pasco G, Willatt LR, McMahon R, Yates JR. 2008. X linked ichthyosis (steroid sulphatase deficiency) is associated with increased risk of attention deficit hyperactivity disorder, autism and social communication deficits. J Med Genet 45(8): 519-524.
16. Maayan R, Yoran-Hegesh R, Strous R, Nechmad A, Averbuch E, Weizman A, Spivak B. 2003. Three-month treatment course of methylphenidate increases plasma levels of dehydroepiandrosterone (DHEA) and dehydroepiandrosterone-sulfate (DHEA-S) in attention deficit hyperactivity disorder. Neuropsychobiology 48: 111-115.
17. Nardi A, Pomari E, Zambon D, Belvedere P, Colombo L, Dalla Valle L. 2009. Transcriptional control of human steroid sulfatase. J Steroid Biochem Mol Biol 115: 68-74.
18. Ozaki K, Ohnishi Y, Iida A, Sekine A, Yamada R, Tsunoda T, Sato H, Sato H, Hori M, Nakamura Y, Tanaka T. 2002. Functional SNPs in the lymphotoxin-alpha gene that are associated with susceptibility to myocardial infarction. Nat Genet 32(4): 650-654.
19. Polanczyk G, de Lima MS, Horta BL, Biederman J, Rohde LA. 2007. The worldwide prevalence of ADHD: A systematic review and metaregression analysis. Am J Psychiatr 164: 942-948.
20. Strous RD, Spivak B, Yoran-Hegesh R, Maayan R, Averbuch E, Kotler M, Mester R, Weizman A. 2001. Analysis of neurosteroid levels in attention deficit hyperactivity disorder. Int J Neuropsychopharmacol 4: 259-264.
21. Surinya KH, Cox TC, May BK. 1998. Identification and characterization of a conserved erythroid-specific enhancer located in intron 8 of the human 5-aminolevulinate synthase 2 gene. J Biol Chem 273(27): 16798-16809.
22. Swanson J, Castellanos FX, Murias M, LaHoste G, Kennedy J. 1998. Cognitive neuroscience of attention deficit hyperactivity disorder and hyperkinetic disorder. Curr Opin Neurobiol 8: 263-271.
23. Vandesompele J, De Preter K, Pattyn F, Poppe B, Van Roy N, De Paepe A, Speleman F. 2002. Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes. Genome Biol 3(7): RESEARCH0034.
24. Wegner M. 2001. Expression of transcription factors during oligodendroglial development. Microsc Res Tech 52: 746-752.
25. Zaichuk T, Ivancic D, Scholtens D, Schiller C, Khan SA. 2007. Tissue-specific transcripts of human steroid sulfatase are under control of estrogen signaling pathways in breast carcinoma. J Steroid Biochem Mol Biol 105: 76-84.