Acquisition of a plasmid-borne blaOXA-58 gene with an upstream IS1008 insertion conferring a high level of carbapenem resistance to Acinetobacter baumannii

Antimicrobial Agents and Chemotherapy

Volumn 52, Issue 7, 2008, Pages 2573-2580

  Chen, Te Li ^a   Wu, Roy Chen Chih ^a   Shaio, Men Fang ^b   Fung, Chang Phone ^a   Cho, Wen Long ^a  

^a NATIONAL YANG MING UNIVERSITY   (Taiwan)

^b HUNGKUANG UNIVERSITY   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

AMIKACIN; AZTREONAM; CARBAPENEM; CEFEPIME; CEFTAZIDIME; CEFTRIAXONE; CHLORAMPHENICOL; CIPROFLOXACIN; COTRIMOXAZOLE; GENTAMICIN; IMIPENEM; MEROPENEM; PIPERACILLIN; PIPERACILLIN PLUS TAZOBACTAM; SULTAMICILLIN; TIMENTIN; TOBRAMYCIN;

ACINETOBACTER BAUMANNII; ANTIBIOTIC RESISTANCE; ARTICLE; BACTERIAL GENE; BACTERIAL GENETICS; BACTERIUM ISOLATE; BLA OXA 58 GENE; GENE CONSTRUCT; GENE CONTROL; GENE DELETION; GENE INSERTION; GENETIC TRANSCRIPTION; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; NUCLEOTIDE SEQUENCE; OPEN READING FRAME; PLASMID; PRIORITY JOURNAL; PROMOTER REGION; SHUTTLE VECTOR;

ACINETOBACTER BAUMANNII; ACINETOBACTER INFECTIONS; BASE SEQUENCE; BETA-LACTAM RESISTANCE; BETA-LACTAMASES; CARBAPENEMS; CROSS INFECTION; DNA PRIMERS; DNA TRANSPOSABLE ELEMENTS; DNA, BACTERIAL; GENES, BACTERIAL; HUMANS; MICROBIAL SENSITIVITY TESTS; MOLECULAR SEQUENCE DATA; PLASMIDS; PROMOTER REGIONS (GENETICS); TRANSFORMATION, GENETIC;

EID: 46249089546     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/AAC.00393-08     Document Type: Article

References (38)

1. Bergogne-Berezin, E., and K. J. Towner. 1996. Acinetobacter spp. as nosocomial pathogens: microbiological, clinical, and epidemiological features. Clin. Microbiol. Rev. 9:148-165.
2. OXA-58 gene as a source of high-level resistance to carbapenems in Acinetobacter baumannii. Antimicrob. Agents Chemother. 51:2324-2328.
3. Bettegowda, C., X. Huang, J. Lin, I. Cheong, M. Kohli, S. A. Szabo, X. Zhang, L. A. Diaz, Jr., V. E. Velculescu, G. Parmigiani, K. W. Kinzler, B. Vogelstein, and S. Zhou. 2006. The genome and transcriptomes of the antitumor agent Clostridium novyi-NT. Nat. Biotechnol. 24:1573-1580.
4. Bou, G., G. Cervero, M. A. Dominguez, C. Quereda, and J. Martinez-Beltran. 2000. Characterization of a nosocomial outbreak caused by a multiresistant Acinetobacter baumannii strain with a carbapenem-hydrolyzing enzyme: high-level carbapenem resistance in A. baumannii is not due solely to the presence of β-lactamases. J. Clin. Microbiol. 38:3299-3305.
5. Brown, S., and S. Amyes. 2006. OXA (beta)-lactamases in Acinetobacter: the story so far. J. Antimicrob. Chemother. 57:1-3.
6. Canduela, M. J., L. Gallego, E. Sevillano, C. Valderrey, F. Calvo, and J. Perez. 2006. Evolution of multidrug-resistant Acinetobacter baumannii isolates obtained from elderly patients with respiratory tract infections. J. Antimicrob. Chemother. 57:1220-1222.
7. Carver, T. J., K. M. Rutherford, M. Berriman, M. A. Rajandream, B. G. Barrell, and J. Parkhill. 2005. ACT: the Artemis Comparison Tool. Bioinformatics 21:3422-3423.
8. Chen, T. L., L. K. Siu, R. C. Wu, M. F. Shaio, L. Y. Huang, C. P. Fung, C. M. Lee, and W. L. Cho. 2007. Comparison of one-tube multiplex PCR, automated ribotyping and intergenic spacer (ITS) sequencing for rapid identification of Acinetobacter baumannii. Clin. Microbiol. Infect. 13:801-806.
9. Clinical and Laboratory Standards Institute. 2007. Performance standards for antimicrobial susceptibility testing, 6th informational supplement. M100-S17. CLSI, Wayne, PA.
10. Coelho, J., N. Woodford, J. Turton, and D. M. Livermore. 2004. Multiresistant Acinetobacter in the UK: how big a threat? J. Hosp. Infect. 58:167-169.
11. OXA-23 in Acinetobacter baumannii. Antimicrob. Agents Chemother. 51:1530-1533.
12. Costa, S. F., J. Woodcock, M. Gill, R. Wise, A. A. Barone, H. Caiaffa, and A. S. Levin. 2000. Outer-membrane proteins pattern and detection of beta-lactamases in clinical isolates of imipenem-resistant Acinetobacter baumannii from Brazil. Int. J. Antimicrob. Agents 13:175-182.
13. del Mar Tomas, M., A. Beceiro, A. Perez, D. Velasco, R. Moure, R. Villanueva, J. Martinez-Beltran, and G. Bou. 2005. Cloning and functional analysis of the gene encoding the 33- to 36-kilodalton outer membrane protein associated with carbapenem resistance in Acinetobacter baumannii. Antimicrob. Agents Chemother. 49:5172-5175.
14. Donald, H. M., W. Scaife, S. G. Amyes, and H. K. Young. 2000. Sequence analysis of AR1-1, a novel OXA β-lactamase, responsible for imipenem resistance in Acinetobacter baumannii 6B92. Antimicrob. Agents Chemother. 44:196-199.
15. Dorsey, C. W., A. P. Tomaras, and L. A. Actis. 2006. Sequence and organization of pMAC, an Acinetobacter baumannii plasmid harboring genes involved in organic peroxide resistance. Plasmid 56:112-123.
16. Ellington, M. J., J. Kistler, D. M. Livermore, and N. Woodford. 2007. Multiplex PCR for rapid detection of genes encoding acquired metallo-beta-lactamases. J. Antimicrob. Chemother. 59:321-322.
17. Fernandez-Cuenca, F., L. Martinez-Martinez, M. C. Conejo, J. A. Ayala, E. J. Perea, and A. Pascual. 2003. Relationship between beta-lactamase production, outer membrane protein and penicillin-binding protein profiles on the activity of carbapenems against clinical isolates of Acinetobacter baumannii. J. Antimicrob. Chemother. 51:565-574.
18. Fournier, P. E., and H. Richet. 2006. The epidemiology and control of Acinetobacter baumannii in health care facilities. Clin. Infect. Dis. 42:692-699.
19. Franklin, C., L. Liolios, and A. Y. Peleg. 2006. Phenotypic detection of carbapenem-susceptible metallo-β-lactamase-producing gram-negative bacilli in the clinical laboratory. J. Clin. Microbiol. 44:3139-3144.
20. Gehrlein, M., H. Leying, W. Cullmann, S. Wendt, and W. Opferkuch. 1991. Imipenem resistance in Acinetobacter baumannii is due to altered penicillin-binding proteins. Chemotherapy 37:405-412.
21. Graber, K. R., L. M. Smoot, and L. A. Actis. 1998. Expression of iron binding proteins and hemin binding activity in the dental pathogen Actinobacillus actinomycetemcomitans. FEMS. Microbiol. Lett. 163:135-142.
22. Heritier, C., L. Poirel, T. Lambert, and P. Nordmann. 2005. Contribution of acquired carbapenem-hydrolyzing oxacillinases to carbapenem resistance in Acinetobacter baumannii. Antimicrob. Agents Chemother. 49: 3198-3202.
23. Hsueh, P. R., L. J. Teng, C. Y. Chen, W. H. Chen, C. J. Yu, S. W. Ho, and K. T. Luh. 2002. Pandrug-resistant Acinetobacter baumannii causing nosocomial infections in a university hospital, Taiwan. Emerg. Infect. Dis. 8:827-832.
24. Hu, W. S., S.-M. Yao, C.-P. Fung, Y.-P. Hsieh, C.-P. Liu, and J.-F. Lin. 2007. An OXA-66/OXA-51-like carbapenemase and possibly an efflux pump are associated with resistance to imipenem in Acinetobacter baumannii. Antimicrob. Agents Chemother. 51:3844-3852.
25. Lee, J. H., C. H. Choi, H. Y. Kang, J. Y. Lee, J. Kim, Y. C. Lee, S. Y. Seol, D. T. Cho, K. W. Kim, D. Y. Song, and J. C. Lee. 2007. Differences in phenotypic and genotypic traits against antimicrobial agents between Acinetobacter baumannii and Acinetobacter genomic species 13TU. J. Antimicrob. Chemother. 59:633-639.
26. Lim, Y. M., K. S. Shin, and J. Kim. 2007. Distinct antimicrobial resistance patterns and antimicrobial resistance-harboring genes according to genomic species of Acinetobacter isolates. J. Clin. Microbiol. 45:902-905.
27. Limansky, A. S., M. A. Mussi, and A. M. Viale. 2002. Loss of a 29-kilodalton outer membrane protein in Acinetobacter baumannii is associated with imipenem resistance. J. Clin. Microbiol. 40:4776-4778.
28. Mahgoub, S., J. Ahmed, and A. E. Glatt. 2002. Underlying characteristics of patients harboring highly resistant Acinetobacter baumannii. Am. J. Infect. Control 30:386-390.
29. Marchand, I., L. Damier-Piolle, P. Courvalin, and T. Lambert. 2004. Expression of the RND-type efflux pump AdeABC in Acinetobacter baumannii is regulated by the AdeRS two-component system. Antimicrob. Agents Chemother. 48:3298-3304.
30. Poirel, L., and P. Nordmann. 2002. Acquired carbapenem-hydrolyzing beta-lactamases and their genetic support. Curr. Pharm. Biotechnol. 3:117-127.
31. Poirel, L., and P. Nordmann. 2006. Carbapenem resistance in Acinetobacter baumannii: mechanisms and epidemiology. Clin. Microbiol. Infect. 12:826-836.
32. OXA-58 in Acinetobacter baumannii. Antimicrob. Agents Chemother. 50: 1442-1448.
33. Queenan, A. M., and K. Bush. 2007. Carbapenemases: the versatile β-lactamases. Clin. Microbiol. Rev. 20:440-458.
34. Rothman, R. E., M. D. Majmudar, G. D. Kelen, G. Madico, C. A. Gaydos, T. Walker, and T. C. Quinn. 2002. Detection of bacteremia in emergency department patients at risk for infective endocarditis using universal 16S rRNA primers in a decontaminated polymerase chain reaction assay. J. Infect. Dis. 186:1677-1681.
35. Sambrook, J., and D. W. Russell. 2001. Molecular cloning: a laboratory manual, 3rd ed. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.
36. Smith, M. G., T. A. Gianoulis, S. Pukatzki, J. J. Mekalanos, L. N. Ornston, M. Gerstein, and M. Snyder. 2007. New insights into Acinetobacter baumannii pathogenesis revealed by high-density pyrosequencing and transposon mutagenesis. Genes Dev. 21:601-614.
37. Walther-Rasmussen, J., and N. Hoiby. 2006. OXA-type carbapenemases. J. Antimicrob. Chemother. 57:373-383.
38. Woodford, N., M. J. Ellington, J. M. Coelho, J. F. Turton, M. E. Ward, S. Brown, S. G. Amyes, and D. M. Livermore. 2006. Multiplex PCR for genes encoding prevalent OXA carbapenemases in Acinetobacter spp. Int. J. Antimicrob. Agents 27:351-353.