Pharmacophore-based design, synthesis, and biological evaluation of novel chloro-pyridazine piperazines as human rhinovirus (HRV-3) inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 21, Issue 3, 2011, Pages 1057-1059

  Wang, Hongliang ^a,b   Xiao, Junhai ^b   Gao, Dapeng ^a,b   Zhang, Xian ^a,b   Yan, Hui ^b   Gong, Zehui ^b   Sun, Tinmin ^a   Li, Song ^b  

^a SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

^b BEIJING INSTITUTE OF PHARMACOLOGY AND TOXICOLOGY   (China)

Author keywords

Anti HRV activity; Chloro pyridazine piperazines; Pharmacophore

Indexed keywords

CHLOROPYRIDAZINE PIPERAZINE DERIVATIVE; PIPERAZINE DERIVATIVE; PYRIDAZINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; DRUG ACTIVITY; DRUG DESIGN; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVE SITE; HUMAN RHINOVIRUS; HYDROGEN BOND; MOLECULAR MODEL; NONHUMAN; PHARMACOPHORE; VIRUS CAPSID; VIRUS INHIBITION; VIRUS PARTICLE;

ANTIVIRAL AGENTS; BINDING SITES; COMPUTER SIMULATION; DRUG DESIGN; HUMANS; MODELS, CHEMICAL; MODELS, MOLECULAR; PIPERAZINES; PYRIDAZINES; RHINOVIRUS; VIRAL PROTEINS;

HUMAN RHINOVIRUS SP.; MIRIDAE;

EID: 78751650641     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2010.12.001     Document Type: Article

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