In vitro activity of pleconaril and AG7088 against selected serotypes and clinical isolates of human rhinoviruses

Antiviral Research

Volumn 47, Issue 3, 2000, Pages 215-220

  Kaiser, Laurent ^a   Crump, Carolyn E ^a   Hayden, Frederick G ^a  

^a UNIVERSITY OF VIRGINIA   (United States)

Author keywords

AG7088; Capsid binding agents; Human rhinovirus; Pleconaril; Protease inhibitors

Indexed keywords

ANTIVIRUS AGENT; PLECONARIL; RUPINTRIVIR; UNCLASSIFIED DRUG;

ANTIVIRAL ACTIVITY; ARTICLE; COMMON COLD; CYTOPATHOGENIC EFFECT; HUMAN; HUMAN CELL; NONHUMAN; PRIORITY JOURNAL; RHINOVIRUS; SEROTYPE; VIRUS INHIBITION; VIRUS ISOLATION;

ANTIVIRAL AGENTS; CELL SURVIVAL; CELLS, CULTURED; COMMON COLD; HUMANS; ISOXAZOLES; OXADIAZOLES; PYRROLIDINONES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RHINOVIRUS; SPECTROPHOTOMETRY;

EID: 0033818230     PISSN: 01663542     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0166-3542(00)00106-6     Document Type: Article

References (15)

1. Abdel-Rahman S.M., Kearns G.L. Single-dose pharmacokinetics of a pleconaril (VP63843) oral solution and effect of food. Antimicrob. Agents Chemother. 42:1998;2706-2709.
2. Abdel-Rahman S.M., Kearns G.L. Single oral dose escalation pharmacokinetics of pleconaril (VP 63843) capsules in adults. J. Clin. Pharmacol. 39:1999;613-618.
3. Arruda E., Crump C.E., Marlin S.D., Merluzzi V.J., Hayden F.G. In vitro studies of the antirhinovirus activity of soluble intercellular adhesion molecule-1. Antimicrob. Agents Chemother. 36:1992;1186-1191.
4. Arruda E., Crump C.E., Rollins B.S., Ohlin A., Hayden F.G. Comparative susceptibilities of human embryonic fibroblasts and HeLa cells for isolation of human rhinoviruses. J. Clin. Microbiol. 34:1996;1277-1279.
5. Arruda E., Pitkaranta A., Witek T.J., Doyle C.A., Hayden F.G. Frequency and natural history of rhinovirus infections in adults during autumn. J. Clin. Microbiol. 35:1997;2864-2868.
6. Hayden F.G., Hassman H.A., Coats R., Menendez R., Bock T. Pleconaril treatment shortens duration of picornavirus respiratory illness in adults. Abstracts of the 39th Interscience Conference on Antimicrobial Agents and Chemotherapy. 1999;American Society for Microbiology, San Diego.
7. Kearns G.L., Abdel-Rahman S.M., James L.P., Blowey D.L., Marshall J.D., Wells T.G. et al. Single-dose pharmacokinetics of a pleconaril (VP63843) oral solution in children and adolescents. Antimicrob. Agents Chemother. 43:1999;634-638.
8. Matthews D.A., Smith W.W., Ferre R.A., Condon B., Budahazi G., Sisson W. et al. Structure of human rhinovirus 3C protease reveals a trypsin-like polypeptide fold, RNA-binding site, and means for cleaving precursor polyprotein. Cell. 77:1994;761-771.
9. Matthews D.A., Dragovich P.S., Webber S.E., Fuhrman S.A., Patick A.K. et al. Structure-assisted design of mechanism-based irreversible inhibitors of human rhinovirus 3C protease with potent antiviral activity against multiple rhinovirus serotypes. Proc. Natl. Acad. Sci. US. 96:1999;11000-11007.
10. Ohlin A., Hoover-Litty H., Sanderson G., Paessens A., Johnston S.L., Holgate S.T. et al. Spectrum of activity of soluble intercellular adhesion molecule-1 against rhinovirus reference strains and field isolates. Antimicrob. Agents Chemother. 38:1994;1413-1415.
11. Patick A.K., Binford S.L., Brothers M.A., Jackson R.L., Ford C.E., Diem M.D. et al. In vitro antiviral activity of AG7088, a potent inhibitor of human rhinovirus 3C protease. Antimicrob. Agents Chemother. 43:1999;2444-2450.
12. Rollins B.S., Elkhatieb A.H., Hayden F.G. Comparative anti-influenza virus activity of 2′-deoxy-2′-fluororibosides in vitro. Antiviral Res. 21:1993;357-368.
13. Skehan P., Storeng R., Scudiero D., Monks A., McMahon J., Vistica D. New colorimetric cytotoxicity assay for anticancer-drug screening. J. Natl. Cancer Institute. 82:1990;1107-1112.
14. Turner R.B., Wecker M.T., Pohl G., Witek T.J., McNally E., St.Georges R. et al. Efficacy of Tremacamra, a soluble intercellular adhesion molecule 1, for experimental rhinovirus infection: a randomized clinical trial. J. Am. Med. Assoc. 281:1999;1797-1804.
15. Werner G., Rosenwirth B., Bauer E., Seifert J.M., Werner F.J., Besemer J. Molecular cloning and sequence determination of the genomic regions encoding protease and genome-linked protein of three picornaviruses. J. Virol. 57:1986;1084-1093.