Inflammatory alterations in a novel combination model of blunt chest trauma and hemorrhagic shock

Journal of Trauma - Injury, Infection and Critical Care

Volumn 70, Issue 1, 2011, Pages 189-196

  Seitz, Daniel H ^a   Perl, Mario ^a   Liener, Ulrich C ^a   Tauchmann, Björn ^a   Braumüller, Sonja T ^a   Brückner, Uwe B ^a   Gebhard, Florian ^a   Knöferl, Markus W ^a  

^a UNIVERSITY OF ULM   (Germany)

Author keywords

Blood loss; Immunologic response; Lung contusion; Physiologic alterations

Indexed keywords

INTERLEUKIN 12; INTERLEUKIN 18; INTERLEUKIN 6; MACROPHAGE INFLAMMATORY PROTEIN 2; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD PRESSURE MONITORING; BREATHING RATE; HEART RATE; HEMORRHAGIC SHOCK; KUPFFER CELL; MALE; MONOCYTE; MOUSE; NONHUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; SPLEEN CELL; THORAX BLUNT TRAUMA;

ANIMALS; BLOOD PRESSURE; CHEMOKINE CXCL2; DISEASE MODELS, ANIMAL; HEART RATE; INTERLEUKINS; LEUKOCYTE COUNT; MACROPHAGES; MALE; MICE; MICE, INBRED C3H; SHOCK, HEMORRHAGIC; SPLEEN; THORACIC INJURIES; TUMOR NECROSIS FACTOR-ALPHA; WOUNDS, NONPENETRATING;

EID: 78751629860     PISSN: 00225282     EISSN: 15298809     Source Type: Journal    
DOI: 10.1097/TA.0b013e3181d7693c     Document Type: Article

References (29)

1. LoCicero J III, Mattox KL. Epidemiology of chest trauma. Surg Clin North Am. 1989;69:15-19.
2. Guo-Shou Z, Xiang-Jun B, Cheng-Ye Z. Analysis of high risk factors related to acute respiratory distress syndrome following severe thoraco-abdominal injuries. Chin J Traumatol. 2007;10:275-278.
3. Scarborough K, Slone DS, Uribe P, Craun M, Bar-Or R Bar-Or D. Reduced mortality at a Community Hospital Trauma Center: the impact of changing trauma level designation from II to I. Arch Surg. 2008;143:22-27.
4. Shorr RM, Crittenden M, Indeck M, Hartunian SL, Rodriguez A. Blunt thoracic trauma. Analysis of 515 patients. Ann Surg. 1987;206:200-205.
5. Eastridge BJ, Salinas J, McManus JG, et al. Hypotension begins at 110 mm Hg: redefining "hypotension" with data. J Trauma. 2007;63:291-297.
6. Xu YX, Ayala A, Chaudry IH. Prolonged immunodepression after trauma and hemorrhagic shock. J Trauma. 1998;44:335-341.
7. Knöferl MW, Liener UC, Seitz DH, et al. Cardiopulmonary, histologi-cal, and inflammatory alterations after lung contusion in a novel mouse model of blunt chest trauma. Shock 2003;19:519-525.
8. Knöferl MW, Liener UC, Perl M, Brückner UB, Kinzl L, Gebhard F. Blunt chest trauma induces delayed splenic immunosuppression. Shock. 2004;22:51-56.
9. Seitz DH, Perl M, Mangold S, et al. Pulmonary contusion induces alveolar type 2 epithelial cell apoptosis: role of alveolar macrophages and neutrophils. Shock. 2008;30:537-544.
10. Knöferl MW, Angele MK, Diodato MD, et al. Female sex hormones regulate macrophage function after trauma-hemorrhage and prevent increased death rate from subsequent sepsis. Ann Surg. 2002;235:105-112.
11. Claridge JA, Enelow RI, Young JS. Hemorrhage and resuscitation induce delayed inflammation and pulmonary dysfunction in mice. J Surg Res. 2000;92:206-213.
12. Le Tulzo Y, Shenkar R, Kaneko D, et al. Hemorrhage increases cytokine expression in lung mononuclear cells in mice: involvement of cat-echolamines in nuclear factor-kappaB regulation and cytokine expres-sion. J Clin Invest. 1997;99:1516-1524.
13. Knöferl MW, Angele MK, Ayala A, Cioffi WG, Bland KI, Chaudry IH. Do different rates of fluid resuscitation adversely or beneficially influ-ence immune responses after trauma-hemorrhage? J Trauma. 1999;46: 23-33.
14. Wang P, Hauptman JG, Chaudry IH. Hemorrhage produces depression in microvascular blood flow which persists despite fluid resuscitation. Circ Shock 1990;32:307-318.
15. Bruns B, Lindsey M, Rowe K, et al. Hemoglobin drops within minutes of injuries and predicts need for an intervention to stop hemorrhage. J Trauma. 2007;63:312-315.
16. Wisbach G, Tobias S, Woodman R, Spalding A, Lockette W. Preserving cardiac output with beta-adrenergic receptor blockade and inhibiting the Bezold-Jarisch reflex during resuscitation from hemorrhage. J Trauma. 2007;63:26-32.
17. Hurt RT, Zakaria ER, Matheson PJ, Cobb ME, Parker JR, Garrison RN. Hemorrhage-induced hepatic injury and hypoperfusion can be prevented by direct peritoneal resuscitation. JGastrointestSurg. 2009;13:587-594.
18. Irwin RJ, Lerner MR, Bealer JF, Brackett DJ, Tuggle DW. Cardiopul-monary physiology of primary blast injury. J Trauma. 1997;43:650-655.
19. Perl M, Gebhard F, Brückner UB, et al. Pulmonary contusion causes impairment of macrophage and lymphocyte immune functions and increases mortality associated with a subsequent septic challenge. Crit Care Med. 2005;33:1351-1358.
20. Schneider CP, Schwacha MG, Samy TSA, Bland KI, Chaudry IH. Androgen-mediated modulation of macrophage function after trauma-hemorrhage: central role of 5{alpha}-dihydrotestosterone. J Appl Physiol. 2003;95:104-112.
21. Nydam TL, Moore EE, McIntyre RC Jr, et al. Hypertonic saline attenuates TNF-alpha-induced NF-kappaB activation in pulmonary ep-ithelial cells. Shock. 2009;31:466-472.
22. Perl M, Gebhard F, Braumüller S, et al. The pulmonary and hepatic immune microenvironment and its contribution to the early systemic inflammation following blunt chest trauma. Crit Care Med. 2006;34: 1152-1159.
23. Frink M, Hsieh YC, Thobe BM, et al. TLR4 regulates Kupffer cell chemokine production, systemic inflammation and lung neutrophil in-filtration following trauma-hemorrhage. Mol Immunol. 2007;44:2625-2630.
24. Frink M, Thobe BM, Hsieh YC, et al. 17beta-Estradiol inhibits keratinocyte-derived chemokine production following trauma-hemorrhage. Am J Physiol Lung Cell Mol Physiol. 2007;292:L585-L591.
25. Ayala A, O'Neill PJ, Uebele SA, Herdon CD, Chaudry IH. Mechanism of splenic immunosuppression during sepsis: key role of Kupffer cell mediators. J Trauma. 1997;42:882-888.
26. Suzuki T, Shimizu T, Yu HP, et al. Tissue compartment-specific role of estrogen receptor subtypes in immune cell cytokine production follow-ing trauma-hemorrhage. J Appl Physiol. 2007;102:163-168.
27. Marcu AC, Paccione KE, Barbee RW, et al. Androstenetriol immuno-modulation improves survival in a severe trauma hemorrhage shock model. J Trauma. 2007;63:662-669.
28. Vega D, Badami CD, Caputo FJ, et al. The influence of the type of resuscitation fluid on gut injury and distant organ injury in a rat model of trauma/hemorrhagic shock. J Trauma. 2008;65:409-414.
29. Martinon F, Mayor A, Tschopp J. The inflammasomes: guardians of the body. Annu Rev Immunol. 2009;27:229-265.