The impact of vitamin A supplementation on the immune system of vitamin A-deficient children

International Journal for Vitamin and Nutrition Research

Volumn 80, Issue 3, 2010, Pages 188-196

  De Azevedo Paiva, Adriana ^a   Rondó, Patricia Helen ^b   Vaz de Lima, Lourdes Rehder ^c   De Freitas Oliveira, Carmem ^c   Ueda, Mirthes ^a   Gonçalves Carvalho, Cecilia ^d   Reinaldo, Luis Gustavo ^d  

^a FEDERAL UNIVERSITY OF PIAUÍ   (Brazil)

^b UNIVERSITY OF SÃO PAULO   (Brazil)

^c INSTITUTO ADOLFO LUTZ   (Brazil)

^d FEDERAL UNIVERSITY OF CAMPINA GRANDE   (Brazil)

Author keywords

Anemia; Ferritin; Immunity; Preschool children; Vitamin A

Indexed keywords

COMPLEMENT COMPONENT C3; COMPLEMENT COMPONENT C4; FERRITIN; IMMUNOGLOBULIN A; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; RETINOL;

ANEMIA; ARTICLE; B LYMPHOCYTE; BLOOD CELL COUNT; CD4 LYMPHOCYTE COUNT; CD8+ T LYMPHOCYTE; CELLULAR IMMUNITY; CHILD; FEMALE; FERRITIN BLOOD LEVEL; HUMAN; HUMAN CELL; HUMORAL IMMUNITY; IMMUNE SYSTEM; IMMUNOPHENOTYPING; MAJOR CLINICAL STUDY; MALE; NATURAL KILLER CELL; PHASE 4 CLINICAL TRIAL; PRESCHOOL CHILD; PROSPECTIVE STUDY; RETINOL DEFICIENCY; SINGLE DRUG DOSE; T LYMPHOCYTE; VITAMIN BLOOD LEVEL; VITAMIN SUPPLEMENTATION;

ANEMIA; ANEMIA, IRON-DEFICIENCY; BIOLOGICAL MARKERS; BLOOD CELL COUNT; BRAZIL; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; CHILD; CHILD, PRESCHOOL; COHORT STUDIES; CROSS-SECTIONAL STUDIES; DIETARY SUPPLEMENTS; FEMALE; FERRITINS; HUMANS; IMMUNE SYSTEM; MALE; PATIENT DROPOUTS; PREVALENCE; VITAMIN A; VITAMIN A DEFICIENCY;

EID: 78751624974     PISSN: 03009831     EISSN: None     Source Type: Journal    
DOI: 10.1024/0300-9831/a000017     Document Type: Article

References (40)

1. Palafox, N.A., Gamble, M.V., Dancheck, B. et al. (2006) Vitamin A deficiency, iron deficiency, and anaemia among preschool children in the Republic of the Marshall Islands. Nutrition 19, 405-408. (Pubitemid 36444686)
2. Sommer, A. and West, Jr. K.P. (1996) Vitamin A deficiency: health, survival and vision. Oxford University Press, New York.
3. McLaren, D.S. and Frigg, M. (2001) Sight and life manual on vitamin A deficiency disorders (VADD). Second Edition, Task Force Sight and Life, Switzerland.
4. Maggini, S., Wintergerst, E.S., Beveridge, S. and Homing, D.H. (2007) Selected vitamins and trace elements support immune function by strengthening epithelial barriers and cellular and humoral immune responses. British Journal of Nutrition 98, S29-S35.
5. Pino-Lagos, K., Benson, M.J. and Noelle, R.J. ( 2008) Retinoic acid in the immune system. Ann. N.Y. Acad. Sci. 1143, 170-187.
6. Micronutrient Initiative. United Nations Children's Fund [homepage on the Internet]. Vitamin and mineral deficiency: a global progress report [cited 2006 Nov 15]. Available from: http://www.micronutrient.org.
7. Beaton, G.H., Martorell, R., Aronson, U. et al. (1993) Effectiveness of vitamin A supplementation in the control of young child morbidity and mortality in developing countries. ACC/SCN State-of-The-Art Series, Nutrition Policy Discussion Paper n. 13, United Nations, Geneva.
8. Stephensen, C.B. (2001) Vitamin A, infection, and immune function. Ann. Rev. Nutr. 21, 1671-92.
9. Semba, R.D., Ndugwa, C., Perry, R.T. et al. (2005) Effect of periodic vitamin A supplementation on mortality and morbidity of human immunodeficiency virus-infected children in Uganda: A controlled clinical trial. Nutrition 21, 25-31.
10. Ross, A.C. and Stephensen, C.B. (1996) Vitamin A and retinoids in antiviral responses. FASEB J 10,979-985.
11. Semba, R.D. (1998) The role of Vitamin A and related retinoids in immune function. Nutr. Rev55, S38-S48.
12. Levy, J. (1998) Immunonutrition: the pediatric experience. Nutrition 14, 641-647.
13. Stephensen, C.B., Jiang, X. and Freytag, T. (2004) Vitamin A deficiency increases the in vivo development of IL-10-positive Th2 cells and decreases development of Th1 cells in mice. J. Nutr. 134, 2660-2666.
14. Kang, S.G., Lim, H.W., Andrisani, O.M., Broxmeyer, H.E. and Kim, C.H. (2007) Vitamin A Metabolites Induce Gut-Homing FoxP3-Regulatory T Cells. J. Immunol. 179, 3724-3733.
15. Oppenheimer, S.J. (2001) Iron and its relation to immunity and infectious disease. J. Nutr. 131, 616S-635S.
16. Dallman, P.R. (1977) White blood cells. In: Pediatrics. (Rudolph, A.M., ed.), 16th ed., pp. 1176-1179, Appleton Century-Crafts, New York.
17. Barreto-Lins, M.H.C., Campos, (first initials?), Azevedo (first initials??) et al. (1988) A re-examination of the stability of retinol in blood and serum, and effects of a standardized meal. Clin. Chem. 34, 2308-2310.
18. Tanumihardjo, S.A., Permaesih, D., Muhilal, (init?). (2004) Vitamin A status and hemoglobin concentrations are improved in Indonesian children with vitamin A and deworming interventions. Eur. J. Clin. Nutr. 58, 1223-1230.
19. Erhardt, J.G., Mack, H., Sobeck, U. et al. (2002) β-Carotene and α-tocopherol concentration and antioxidant status in buccal mucosal cells and plasma after oral supplementation. Br. J. Nutr. 87, 471-475.
20. Nicholson, J., Kidd, P., Mandy, F. et al. (1996) Three-color supplement to the NIAID DAIDS guideline for flow cytometry immunophenotyping. Cytometry 26, 227-230.
21. Paiva, A.A., Rondó, P.H.C., Gonçalves-Carvalho, C.M.R. et al. (2006) Prevalencia de deficiencia de vitamina A e fatores associados em pré-escolares de Teresina, Piaú, Brasil. Cad. Saúde Publica 22, 109-118.
22. Madatuwa, T.M., Mahawithanage, S.T., Chandrika, U.G. et al. (2007) Evaluation of the effectiveness of the national vitamin A supplementation programme among school children in Sri Lanka. Br. J. Nutr.. 97, 153-9.
23. Tomkins, A. (2000) Malnutrition, morbidity and mortality in children and their mothers. Proc. Nutr. Soc. 59, 135-146.
24. Vilamor, E. and Fawzi, W.W. (2000) Vitamin A supplementation: implications for morbidity and mortality. J. Infec. Dis. 182, S122-S133.
25. Tomkins, A. (2001) Nutrition and maternal morbidity and mortality. Br. J. Nutr. 85, S93-S99.
26. Thapa, S., Choe, M.K. and Retherford, R.D. (2005) Effects of vitamin A supplementation on child mortality: evidence from Nepal's 2001 Demographic and Health Survey. Trop. Med. Int. Health 10, 782-789.
27. Long, K.Z., Rosado, J.L. and DuPont, H.L. et al. (2007) Supplementation with vitamin A reduces watery diarrhoea and respiratory infections in Mexican children. Br. J. Nutr. 97, 337-43.
28. Rahman, M.M., Mahalanabis, D. Alverez, J.O. et al. (1997) Effects of early vitamin A supplementation on cell-mediated immunity in infants younger than 6 mo. Am. J. Clin. Nutr. 65, 144-148.
29. Jason, J., Archibald, L.K., Nwanyanwu, O.C. et al. (2002) Vitamin A levels and immunity in humans. Clin. Diagn. Lab. Immunol. 9, 616-621.
30. Blomhoff, H.K. (2004) Vitamin A regulates proliferation and apoptosis of human T-cells and B-cells. Biochem. Soc. Trans. 32, 982-984.
31. Semba, R.D., Ward, M.B.J., Griffin, D.E. et al. (1993) Abnormal T-cell subset proportions in vitamin A deficiency children. Lancet 341, 5-8.
32. Padula, G., Salceda, S.A. and Seoane, A.I. (2009) Protein-energy malnutrition contributes to increased structural chromosomal alteration frequencies in Argentinean children. Nutr. Res. 29, 35-40.
33. Leal, J.Y., Castejón, H.V., Romero, T. et al. (2006) Serum levels of interferon-gamma and interleukine-10 in anemic children with vitamin A deficiency. Arch. Latinoam. Nutr. 56, 329-334.
34. Oliveira, J.M., Michelazzo, F.B., Stefanello, J. et al. (2008) Influence of iron on vitamin A nutritional status. Nutr. Rev. 66, 141-147.
35. Arruda, S.F., Siqueira, E.M. and de Valencia F.F. (2009) Vitamin A deficiency increases hepcidin expression and oxidative stress in rat. Nutrition 25, 472-478.
36. Wintergerst, E.S., Maggini, S. and Hornig, D.H. (2007) Contribution of selected vitamins and trace elements to immune function. Ann. Nutr. Metab. 51, 301-323.
37. Li, T.X. and Li, Y. (2007) Synergistic effect of zinc and vitamin A on T cell functions. Biomed. Environ. Sci. 20, 131-134.
38. Chen, Q. and Ross, A.C. (2005) Vitamin A and immune function: retinoic acid modulates population dynamics in antigen receptor and CD38-stimulated splenic B cells. Proc. Natl. Acad. Sci.USA 102, 14142-14149.
39. Klein, U., Rajewsky, K. and Kuppers, R. (1998) Human immunoglobulin (Ig)M+IgD+ peripheral blood B cells expressing the CD27 cell surface antigen carry somatically mutated variable region genes; CD27 as a general marker for somatically mutated (memory) B cells. J. Exp. Med. 188, 1679-1689.
40. Thurnham, D.I., Mburu, A.S., Mwaniki, D.L. et al. (2008) Using plasma acute-phase protein concentrations to interpret nutritional biomarkers in apparently healthy HIV-1-seropositive Kenyan adults. Br. J. Nutr. 100, 174-182.