The role of the calcium transporter protein plasma membrane calcium ATPase PMCA2 in cerebellar Purkinje neuron function

Functional Neurology

Volumn 25, Issue 3, 2010, Pages 153-158

  Empson, Ruth M ^a,b   Akemann, Walther ^b   Knöpfel, Thomas ^b  

^a UNIVERSITY OF OTAGO   (New Zealand)

^b RIKEN BRAIN SCIENCE INSTITUTE   (Japan)

Author keywords

Ataxia; Calcium; Cerebellum; Plasma membrane Ca2+ ATPase

Indexed keywords

PLASMA MEMBRANE CALCIUM TRANSPORTING ADENOSINE TRIPHOSPHATASE; PLASMA MEMBRANE CALCIUM TRANSPORTING ADENOSINE TRIPHOSPHATASE 2; UNCLASSIFIED DRUG;

ACTION POTENTIAL; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; CALCIUM CELL LEVEL; CALCIUM HOMEOSTASIS; CELL FUNCTION; CEREBELLAR ATAXIA; CEREBELLUM; CONTROLLED STUDY; FEMALE; MALE; MEMBRANE POTENTIAL; MOUSE; NONHUMAN; PHENOTYPE; POTASSIUM CURRENT; PURKINJE CELL; REVIEW;

ACTION POTENTIALS; ANIMALS; BIOPHYSICS; CALCIUM; CEREBELLUM; ELECTRIC STIMULATION; HUMANS; MICE; MICE, KNOCKOUT; PATCH-CLAMP TECHNIQUES; PLASMA MEMBRANE CALCIUM-TRANSPORTING ATPASES; PURKINJE CELLS;

EID: 78751618994     PISSN: 03935264     EISSN: 19713274     Source Type: Journal    
DOI: None     Document Type: Review

References (29)

1. Berridge MJ, Bootman MD, Roderick HL. Calcium signalling: dynamics, homeostasis and remodelling. Nat Rev Mol Cell Biol 2003;4:517-529
2. 2+ pump of the plasma membrane. J Biol Chem 1992;267:2115-2118
3. Strehler EE, Zacharias DA. Role of alternative splicing in generating isoform diversity among plasma membrane calcium pumps. Physiol Rev 2001;81:21-50
4. 2+ clearance from neurons. Front Biosci 2002;7:d1255-d1279
5. 2+ pump isoforms in intact cells. J Biol Chem 2003;278:24500-24508
6. 2+ pump in rat brain. Patterns of alternative splices seen by isoform-specific antibodies. J Biol Chem 1997;272:23741-23747
7. Hillman DE, Chen S, Bing R, Penniston JT, Llinas R. Ultrastructural localization of the plasmalemmal calcium pump in cerebellar neurons. Neuroscience 1996;72:315-324
8. 2+-ATPase isoform 2. J Biol Chem 1998;273:18693-18696
9. 2+ ATPase 2 contributes to short-term synapse plasticity at the parallel fiber to Purkinje neurone synapse. J Neurosci 2007;27:3753-3758
10. Wanaverbecq N, Marsh SJ, Al-Qatari M, Brown DA. The plasma membrane calcium-ATPase as a major mechanism for intracellular calcium regulation in neurones from the rat superior cervical ganglion. J Physiol 2003:550:83-101
11. 2+-ATPase in the regulation of resting calcium concentration in rat ventricular myocytes. J Physiol 1999;515:109-118
12. Fierro L, DiPolo R, Llano I. Intracellular calcium clearance in Purkinje cell somata from rat cerebellar slices. J Physiol 1998;510:499-512
13. Hartmann J, Konnerth A. Determinants of postsynaptic Ca2+ signaling in Purkinje neurons. Cell Calcium 2005;37:459-466
14. Zhao S, Chen N, Yang Z et al. Ischemia deteriorates the spike encoding of rat cerebellar Purkinje cells by raising intracellular Ca2+. Biochem Biophys Res Commun 2008;366:401-407
15. Knöpfel T, Vranesic I, Staub C, Gähwiler BH. Climbing fibre responses in olivo-cerebellar slice cultures. II. Dynamics of cytosolic calcium in Purkinje cells. Eur J Neurosci 1991;3:343-348
16. Gatto C, Milanick MA. Inhibition of the red blood cell calcium pump by eosin and other fluorescein analogues. Am J Physiol 1993;264:C1577-C1586
17. Crepel F, Dupont JL, Gardette R. Selective absence of calcium spikes in Purkinje cells of staggerer mutant mice in cerebellar slices maintained in vitro. J Physiol 1984;346:111-125 (Pubitemid 14058467)
18. Donato R, Page KM, Koch D et al. The ducky(2J) mutation in Cacna2d2 results in reduced spontaneous Purkinje cell activity and altered gene expression. J Neurosci 2006;26:12576-12586
19. Chen X, Kovalchuk Y, Adelsberger H et al. Disruption of the olivo-cerebellar circuit by Purkinje neuron-specific ablation of BK channels. Proc Natl Acad Sci U S A 2010;107:12323-12328
20. Kodama T, Itsukaichi-Nishida Y, Fukazawa Y et al. A CaV2.1 calcium channel mutation rocker reduces the number of postsynaptic AMPA receptors in parallel fiber-Purkinje cell synapses. Eur J Neurosci 2006;24:2993-3007
21. Shin SL, Hoebeek FE, Schonewille M, De Zeeuw CI, Aertsen A, De Schutter E. Regular patterns in cerebellar Purkinje cell simple spike trains. PLoS One 2007;2:e485
22. Holt GR, Softky WR, Koch C, Douglas RJ. Comparison of discharge variability in vitro and in vivo in cat visual cortex neurons. J Neurophysiol 1996;75:1806-1814
23. Walter JT, Alviña K, Womack MD, Chevez C, Khodakhah K. Decreases in the precision of Purkinje cell pacemaking cause cerebellar dysfunction and ataxia. Nat Neurosci 2006;9:389-397
24. Alviña K, Khodakhah K. The therapeutic mode of action of 4-aminopyridine in cerebellar ataxia. J Neurosci 2010;30:7258-7268
25. + channels to rat Purkinje neurone function. J Physiol 2003;548:53-69
26. Empson RM, Turner PR, Nagaraja RY, Beesley PW, Knöpfel T. Reduced PMCA2 expression slows calcium dynamics in mouse cerebellar Purkinje neurons and alters the precision of motor coordination. J Physiol 2010;588:907-922
27. Wulff P, Schonewille M, Renzi M et al. Synaptic inhibition of Purkinje cells mediates consolidation of vestibulo-cerebellar motor learning. Nat Neurosci 2009;12:1042-1049
28. Miyakawa H, Lev-Ram V, Lasser-Ross N, Ross WN. Calcium transients evoked by climbing fiber and parallel fiber synaptic inputs in guinea pig cerebellar Purkinje neurons. J Neurophysiol 1992;68:1178-1189
29. 2+ kinetics in rodent Purkinje cells: role of parvalbumin and calbindin D28k. J Physiol 2003;551:13-32