Attenuated reovirus displays oncolysis with reduced host toxicity

British Journal of Cancer

Volumn 104, Issue 2, 2011, Pages 290-299

  Kim, M ^a,c   Garant, K A ^b   Zur Nieden, N I ^a,d   Alain, T ^a,e   Loken, S D ^a,f   Urbanski, S J ^a   Forsyth, P A ^a   Rancourt, D E ^a   Lee, P W K ^b   Johnston, R N ^a  

^a UNIVERSITY OF CALGARY   (Canada)

^b DALHOUSIE UNIVERSITY   (Canada)

^c University of Ulsan   (South Korea)

^d UNIVERSITY OF CALIFORNIA   (United States)

^e MCGILL UNIVERSITY   (Canada)

^f Nanaimo Regional General Hospital   (Colombia)

Author keywords

attenuated; mammalian reovirus; oncolysis; persistent infection; reduced toxicity; sigma1

Indexed keywords

TRUNCATED DELTA1 PROTEIN; UNCLASSIFIED DRUG; VIRUS PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; CELL CULTURE; CONTROLLED STUDY; EMBRYONIC STEM CELL; HUMAN; HUMAN CELL; IN VIVO STUDY; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; ONCOLYSIS; PRIORITY JOURNAL; REOVIRUS; REOVIRUS INFECTION; SEQUENCE ANALYSIS; STOP CODON; TOXICITY; VIRUS ATTENUATION;

ANIMALS; BASE SEQUENCE; BLOTTING, WESTERN; CELL LINE; DNA PRIMERS; HUMANS; IMMUNOHISTOCHEMISTRY; MICE; MICE, SCID; MICROSCOPY, ELECTRON; ONCOLYTIC VIROTHERAPY; PROTEIN BIOSYNTHESIS; REOVIRIDAE; TRANSCRIPTION, GENETIC; TRANSPLANTATION, HETEROLOGOUS; VIRULENCE;

EID: 78751535763     PISSN: 00070920     EISSN: 15321827     Source Type: Journal    
DOI: 10.1038/sj.bjc.6606053     Document Type: Article

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