Reovirus variants selected during persistent infections of L cells contain mutations in the vital S1 and S4 genes and are altered in viral disassembly

Journal of Virology

Volumn 71, Issue 2, 1997, Pages 1362-1369

  Wetzel, J Denise ^a,b   Wilson, Gregory J ^a,b   Baer, Geoffrey S ^b   Dunnigan, Lisa R ^a,b   Wright, Justin P ^a,b   Tang, David S H ^a,b   Dermody, Terence S ^a,b  

^a VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

^b VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

VIRUS RNA;

AMINO ACID SUBSTITUTION; ARTICLE; HUMAN; HUMAN CELL; PRIORITY JOURNAL; REOVIRUS; VIRUS ASSEMBLY; VIRUS CAPSID; VIRUS INFECTIVITY; VIRUS ISOLATION; VIRUS MUTATION;

EID: 0031026434     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/jvi.71.2.1362-1369.1997     Document Type: Article

References (42)

1. Ahmed, R., W. M. Canning, R. S. Kauffman, A. H. Sharpe, J. V. Hallum, and B. N. Fields. 1981. Role of the host cell in persistent viral infection: coevolution of L cells and reovirus during persistent infection. Cell 25:325-332.
2. Ahmed, R., and B. N. Fields. 1982. Role of the S4 gene in the establishment of persistent reovirus infection in L cells. Cell 28:605-612.
3. Ahmed, R., and A. F. Graham. 1977. Persistent infections in L cells with temperature-sensitive mutants of reovirus. J. Virol. 23:250-262.
4. Ahmed, R., L. A. Morrison, and D. M. Knipe. 1996. Persistence of viruses, p. 219-249. In B. N. Fields, D. M. Knipe, and P. M. Howley (ed.), Fields virology. 3rd ed. Lippincott-Raven. Philadelphia, Pa.
5. Bass, D. M., D. Bodkin, R. Dambrauskas, J. S. Trier, B. N. Fields, and J. L. Wolf. 1990. Intraluminal proteolytie activation plays an important role in replication of type 1 reovirus in the intestines of neonatal mice. J. Virol. 64:1830-1833.
6. Bassel-Duby, R., D. R. Spriggs, K. L. Tyler, and B. N. Fields. 1986. Identification of attenuating mutations on the reovirus type 3 S1 double-stranded RNA segment with a rapid sequencing technique. J. Virol. 60:64-67.
7. Bodkin, D. K., M. L. Nibert, and B. N. Fields. 1989. Proteolytie digestion of reovirus in the intestinal lumens of neonatal mice. J. Virol. 63:4676-4681.
8. Borsa, J., B. D. Morash, M. D. Sargent, T. P. Copps, P. A. Lievaart, and J. G. Szekely, 1979. Two modes of entry of reovirus particles into L cells. J. Gen. Virol. 45:161-170.
9. Borsa, J., M. D. Sargent, P. A. Lievaart, and T. P. Copps. 1981. Reovirus: evidence for a second step in the intracellular uncoating and transcriptase. activation process. Virology 111:191-200.
10. Borzakian, S., T. Couderc, Y. Barbier, G. Attal, I. Pelletier, and F. Colbere-Garapin. 1992. Persistent poliovirus infection: establishment and maintenance involve distinct mechanisms. Virology 186:398-408.
11. Brown, E. G., M. L. Nibert, and B. N. Fields. 1983. The L2 gene of reovirus serotype 3 controls the capacity to interfere, accumulate deletions and establish persistent infection, p. 275-287. In R. W. Compans and D. H. L. Bishop (ed.), Double-stranded RNA viruses. Elsevier Biomedical, New York.
12. Chang, C. T., and H. J. Zweerink. 1971. Fate of parental reovirus in infected cell. Virology 46:544-555.
13. Chen, W., and R. S. Baric. 1996. Molecular anatomy of mouse hepatitis virus persistence: coevolution of increased host cell resistance and virus virulence. J. Virol. 70:3947-3960.
14. Coombs, K. M., B. N. Fields, and S. C. Harrison. 1990. Crystallization of the reovirus type 3 Dearing core. Crystal packing is determined by the λ2 protein. J. Mol. Biol. 215:1-5.
15. Dermody, T. S., J. D. Chappell, J. G. Hofler, W. Kramp, and K. L. Tyler. 1995. Eradication of persistent reovirus infection from a B-cell hybridoma. Virology 212:272-276.
16. Dermody, T. S., M. L. Nibert, J. D. Wetzel, X. Tong, and B. N. Fields. 1993. Cells and viruses with mutations affecting viral entry are selected during persistent infections of L cells with mammalian reoviruses. J. Virol. 67:2055-2063.
17. Dryden, K. A., G. Wang, M. Yeager, M. L. Nibert, K. M. Coombs, D. B. Furlong, B. N. Fields, and T. S. Baker. 1993. Early steps in reovirus infection are associated with dramatic changes in supramolecular structure and protein conformation: analysis of virions and subviral particles by cryoelectron microscopy and image reconstruction. J. Cell Biol. 122:1023-1041.
18. Furlong, D. B., M. L. Nibert, and B. N. Fields. 1988. Sigma 1 protein of mammalian reoviruses extends from the surfaces of viral particles. J. Virol. 62:246-256.
19. Gallagher, T. M., C. Escarmis, and M. J. Buchmeier. 1991. Alteration of the pH dependence of coronavirus-induced cell fusion: effect of mutations in the spike glycoprotein. J. Virol. 65:1916-1928.
20. Hooper, J. W., and B. N. Fields. 1996. Role of the μ1 protein in reovirus stability and capacity to cause chromium release from host cells. J. Virol. 70:459-467.
21. Kaplan, G., A. Levy, and V. R. Racaniello. 1989. Isolation and characterization of HeLa cell lines blocked at different steps in the poliovirus life cycle. J. Virol. 63:43-51.
22. Kauffman, R. S., R. Ahmed, and B. N. Fields. 1983. Selection of a mutant S1 gene during reovirus persistent infection of L cells: role in maintenance of the persistent state. Virology 131:79-87.
23. Laemmli, U. K. 1970. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227:680-685.
24. Martinez, C. G., R. Guinea, J. Benavente, and L. Carrasco. 1996. The entry of reovirus into L cells is dependent on vacuolar proton-ATPase activity. J. Virol. 70:576-579.
25. Maxfield, F. R. 1982. Weak bases and ionophores rapidly and reversibly raise the pH in endocytic vesicles in cultured mouse fibroblasts. J. Cell Biol. 95:676-681.
26. Miller, J. E., and C. E. Samuel. 1992. Proteolytic cleavage of the reovirus sigma 3 protein results in enhanced double-stranded RNA-binding activity: identification of a repeated basic amino acid motif within the C-terminal binding region. J. Virol. 66:5347-5356.
27. Nibert, M. L., J. D. Chappell, and T. S. Dermody. 1995. Infectious subvirion particles of reovirus type 3 Dearing exhibit a loss in infectivity and contain a cleaved σ1 protein. J. Virol. 69:5057-5067.
28. Nibert, M. L., T. S. Dermody, and B. N. Fields. 1990. Structure of the reovirus cell-attachment protein: a model for the domain organization of σ1. J. Virol. 64:2976-2989.
29. Nibert, M. L., and B. N. Fields. 1992. A carboxy-terminal fragment of protein μ1/μ1C is present in infectious subvirion partcles of mammalian reoviruses and is proposed to have a role in penetration. J. Virol. 66:6408-6418.
30. Nibert, M. L., L. A. Schiff, and B. N. Fields. 1991. Mammalian reoviruses contain a myristoylated structural protein. J. Virol. 65:1960-1967.
31. Nibert, M. L., L. A. Schiff, and B. N. Fields. 1996. Reoviruses and their replication, p. 1557-1596. In B. N. Fields. D. M. Knipe, and P. M. Howley (ed.), Fields virology, 3rd ed. Lippincott-Raven, Philadelphia, Pa.
32. Ohkuma, S., and B. Poole. 1978. Fluorescence probe measurement of the intralysosomal pH in living cells and the perturbation of pH by various agents. Proc. Natl. Acad. Sci. USA 75:3327-3331.
33. Rubin, D. H., D. B. Weiner, C. Dworkin, M. I. Greene, G. G. Maul, and W. V. Williams. 1992. Receptor utilization by reovirus type 3: distinct binding sites on thymoma and fibroblast cell lines result in differential compartmentalization of virions. Microb. Pathog. 12:351-365.
34. Schiff, L. A., M. L. Nibert, M. S. Co, E. G. Brown, and B. N. Fields. 1988. Distinct binding sites for zinc and double-stranded RNA in the reovirus outer capsid protein sigma 3. Mol. Cell. Biol. 8:273-283.
35. Shepard, D. A., J. G. Ehnstrom, and L. A. Schiff. 1995. Association of reovirus outer capsid proteins σ3 and μ1 causes a conformational change that renders σ3 protease sensitive. J. Virol. 69:8180-8184.
36. Silverstein, S. C., C. Astell, D. H. Levin, M. Schonberg, and G. Acs. 1972. The mechanism of reovirus uncoating and gene activation in vivo. Virology 47:797-806.
37. Smith, R. E., H. J. Zweerink, and W. K. Joklik. 1969. Polypeptide components of virions, top component and cores of reovirus type 3. Virology 39:791-810.
38. Sturzenbecker, L. J., M. Nibert, D. Furlong, and B. N. Fields. 1987. Intracellular digestion of reovirus particles requires a low pH and is an essential step in the viral infectious cycle. J. Virol. 61:2351-2361.
39. Virgin, H. W., IV, R. Bassel-Duby, B. N. Fields, and K. L. Tyler. 1988. Antibody protects against lethal infection with the neurally spreading reovirus type 3 (Dearing). J. Virol. 62:4594-4604.
40. Weiner, H. L., M. L. Powers, and B. N. Fields. 1980. Absolute linkage of virulence and central nervous system tropism of reoviruses to viral hemagglutinin. J. Infect. Dis. 141:609-616.
41. Wetzel, J. D., J. D. Chappell, A. B. Fogo, and T. S. Dermody. 1997. Efficiency of viral entry determines the capacity of murine erythroleukemia cells to support persistent infections by mammalian reoviruses. J. Virol. 71:299-306.
42. Wilson, G. J., J. D. Wetzel, W. Puryear, R. Bassel-Duby, and T. S. Dermody. 1996. Persistent reovirus infections of L cells select mutations in viral attachment protein σ1 that alter oligomer stability. J. Virol. 70:6598-6606.