Towards non-peptide ANG II AT1 receptor antagonists based on urocanic acid: Rational design, synthesis and biological evaluation

Amino Acids

Volumn 40, Issue 2, 2011, Pages 411-420

  Agelis, George ^a   Resvani, Amalia ^a   Matsoukas, Minos Timotheos ^a   Tselios, Theodore ^a   Kelaidonis, Konstantinos ^a   Kalavrizioti, Dimitra ^b   Vlahakos, Demetrios ^c   Matsoukas, John ^a  

^a UNIVERSITY OF PATRAS   (Greece)

^b UNIVERSITY OF PATRAS   (Greece)

^c NATIONAL AND KAPODISTRIAN UNIVERSITY OF ATHENS   (Greece)

Author keywords

AT1 receptor; Molecular modelling; Pharmacophore; Urocanic acid

Indexed keywords

2 BENZYL TETRAZOLE DERIVATIVE; 2 BUTYL 4 CHLORO 1 [[2' (1H TETRAZOL 5 YL) 4 BIPHENYLYL]METHYL] 5 IMIDAZOLECARBOXYLIC ACID; 3 BENZYL TETRAZOLE DERIVATIVE; 4 BENZYL TETRAZOLE DERIVATIVE; ANGIOTENSIN 1 RECEPTOR; ANGIOTENSIN 1 RECEPTOR ANTAGONIST; UNCLASSIFIED DRUG; UROCANIC ACID;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIHYPERTENSIVE ACTIVITY; ARTICLE; BINDING AFFINITY; BIOLOGICAL ACTIVITY; CONTROLLED STUDY; DRUG CONFORMATION; DRUG DESIGN; DRUG MECHANISM; DRUG RECEPTOR BINDING; DRUG SYNTHESIS; HUMAN; HUMAN CELL; HYPERTENSION; IN VITRO STUDY; IN VIVO STUDY; MALE; MOLECULAR MODEL; NONHUMAN; PHARMACOPHORE; PRIORITY JOURNAL; RAT; STRUCTURE ACTIVITY RELATION;

ANGIOTENSIN RECEPTOR ANTAGONISTS; ANIMALS; CELL LINE; DRUG DESIGN; HUMANS; KINETICS; MALE; MODELS, MOLECULAR; PROTEIN BINDING; RABBITS; RATS; RECEPTORS, ANGIOTENSIN; STRUCTURE-ACTIVITY RELATIONSHIP; UROCANIC ACID;

EID: 78751508595     PISSN: 09394451     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00726-010-0651-y     Document Type: Article

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